ATE122238T1 - Bifunktionelle antikörperkonstruktionen und verfahren zur selektiven tötung von zellbeständen. - Google Patents
Bifunktionelle antikörperkonstruktionen und verfahren zur selektiven tötung von zellbeständen.Info
- Publication number
- ATE122238T1 ATE122238T1 AT88108793T AT88108793T ATE122238T1 AT E122238 T1 ATE122238 T1 AT E122238T1 AT 88108793 T AT88108793 T AT 88108793T AT 88108793 T AT88108793 T AT 88108793T AT E122238 T1 ATE122238 T1 AT E122238T1
- Authority
- AT
- Austria
- Prior art keywords
- component
- antibody
- lymphocyte
- bifunctional
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6020587A | 1987-06-10 | 1987-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE122238T1 true ATE122238T1 (de) | 1995-05-15 |
Family
ID=22028021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88108793T ATE122238T1 (de) | 1987-06-10 | 1988-06-01 | Bifunktionelle antikörperkonstruktionen und verfahren zur selektiven tötung von zellbeständen. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0294703B1 (de) |
| AT (1) | ATE122238T1 (de) |
| DE (1) | DE3853740T2 (de) |
| ES (1) | ES2073394T3 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US6121424A (en) * | 1991-11-25 | 2000-09-19 | Enzon, Inc. | Multivalent antigen-binding proteins |
| WO1989006544A1 (en) * | 1988-01-15 | 1989-07-27 | Centocor, Inc. | Heteroligating antibodies and therapeutic uses thereof |
| US4925648A (en) * | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
| US5173293A (en) * | 1989-02-23 | 1992-12-22 | Becton Dickinson And Company | Anti-T-cell antibodies as adjuvants |
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
| FR2649119A1 (fr) * | 1989-06-30 | 1991-01-04 | Centre Nat Rech Scient | Procede de pilotage de retrovirus en utilisant des complexes bifonctionnels |
| AU6290090A (en) * | 1989-08-29 | 1991-04-08 | University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| US5650150A (en) * | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| EP1489100B1 (de) | 1997-12-08 | 2016-06-15 | Merck Patent GmbH | Heterodimäre Fusionsproteine zur Verwendung für gezielte Immuntherapie und allgemeine Immunerregung |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| JP4793971B2 (ja) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| EP1228214A2 (de) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietinformen mit verbesserten eigenschaften |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| DE60129695T2 (de) | 2000-06-29 | 2008-06-05 | Merck Patent Gmbh | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| AU2002248571B2 (en) | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| PT1383785E (pt) | 2001-05-03 | 2011-06-28 | Merck Patent Gmbh | Anticorpo recombinante específico de tumores e utilização deste |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| ES2438965T3 (es) * | 2002-04-23 | 2014-01-21 | Roger Williams Hospital | Composiciones y métodos para administrar células madre |
| WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
| WO2005044858A1 (en) | 2003-11-07 | 2005-05-19 | Ablynx N.V. | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
| CA2505316C (en) | 2002-11-08 | 2014-08-05 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| CN100432105C (zh) | 2002-12-17 | 2008-11-12 | 默克专利有限公司 | 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合 |
| EP1587838B1 (de) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutische polypeptide, deren homologe, deren fragmente und deren verwendung bei der modulierung der thrombozytenvermittelten aggregation |
| CA2551915C (en) | 2003-12-30 | 2015-06-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Il-7 fusion proteins |
| JP2008504008A (ja) | 2003-12-31 | 2008-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質 |
| PL1706428T3 (pl) | 2004-01-22 | 2010-02-26 | Merck Patent Gmbh | Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza |
| US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| CN101072793B (zh) | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| WO2006122787A1 (en) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Serum albumin binding proteins |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| AU2006332155B2 (en) | 2005-12-30 | 2013-01-10 | Cancer Research Technology Limited | Anti-CD19 antibodies with reduced immunogenicity |
| BRPI0620648B1 (pt) | 2005-12-30 | 2022-12-20 | Merck Patent Gesellschaft Mit Beschrãnkter Haftung | Variante de il-12 p40, proteínas il-12, il-23 e de fusão, composição farmacêutica e uso da mesma |
| EP2421896A1 (de) | 2009-04-22 | 2012-02-29 | Merck Patent GmbH | Antikörperfusionsproteine mit modifizierten fcrn-bindungsstellen |
| PT2491056T (pt) | 2009-10-22 | 2021-10-26 | Univ Of Twente | Vhh para aplicação na reparação de tecidos, regeneração de órgãos, substituição de órgãos e engenharia de tecidos |
| US11001631B2 (en) | 2016-02-05 | 2021-05-11 | Orionis Biosciences BV | Clec9A binding agents |
| US11248057B2 (en) | 2016-03-07 | 2022-02-15 | Vib Vzw | CD20 binding single domain antibodies |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| EP3577133A1 (de) | 2017-02-06 | 2019-12-11 | Orionis Biosciences NV | Gezielte chimäre proteine und verwendungen davon |
| US20200354424A1 (en) | 2018-01-26 | 2020-11-12 | Orionis Biosciences, Inc. | Xcr1 binding agents and uses thereof |
| JP2021513361A (ja) | 2018-02-05 | 2021-05-27 | オリオニス バイオサイエンシーズ，インコーポレイテッド | 線維芽細胞結合物質およびその使用 |
| CA3133648A1 (en) | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Fibroblast activation protein binding agents and use thereof |
| PE20220568A1 (es) | 2019-05-21 | 2022-04-20 | Novartis Ag | Moleculas de union a cd19 y usos de las mismas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8626412D0 (en) * | 1986-11-05 | 1986-12-03 | Clark M R | Antibodies |
| US4882424A (en) * | 1987-05-11 | 1989-11-21 | Dana-Farber Cancer Institute, Inc. | Activation antigen |
-
1988
- 1988-06-01 AT AT88108793T patent/ATE122238T1/de not_active IP Right Cessation
- 1988-06-01 DE DE3853740T patent/DE3853740T2/de not_active Expired - Fee Related
- 1988-06-01 EP EP88108793A patent/EP0294703B1/de not_active Expired - Lifetime
- 1988-06-01 ES ES88108793T patent/ES2073394T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2073394T3 (es) | 1995-08-16 |
| JPS643128A (en) | 1989-01-06 |
| DE3853740T2 (de) | 1995-11-09 |
| EP0294703A3 (en) | 1990-06-27 |
| DE3853740D1 (de) | 1995-06-14 |
| EP0294703A2 (de) | 1988-12-14 |
| EP0294703B1 (de) | 1995-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE122238T1 (de) | Bifunktionelle antikörperkonstruktionen und verfahren zur selektiven tötung von zellbeständen. | |
| DE69033705D1 (de) | Hybride immunglobuline | |
| DE69014474D1 (de) | Antikörper gegen TNF-Bindungsprotein I und deren F(ab)-Fragmente. | |
| DE69028412D1 (de) | Verfahren zum transport von molekülen in eukaryotenzellen | |
| DE3880763D1 (de) | Im wesentlichen fluessigkeitsundurchlaessige polymere warenbahn mit mikroblaeschen und verfahren und vorrichtung fuer deren herstellung. | |
| ATE190724T1 (de) | Polymere phosphoniumsalze, die chemilumineszenzverstärkung von 1,2-dioxetanen hervorrufen, und deren verwendung. | |
| FR2624665B1 (fr) | Materiau d'etancheite electrique au milieu environnant et procede d'etancheite utilisant ce materiau | |
| DE3686433D1 (de) | Verfahren und geraet zum bewegen und herstellen von unterirdischen durchlaessen im boden. | |
| ES2043609T3 (es) | Composiciones de interleucina-2. | |
| DE68901878D1 (de) | Verfahren zur faerbung von nichtradioaktiven markierten nukleinsaeuren und zusammensetzung zum gebrauch in diesem verfahren. | |
| PT85992A (de) | Verfahren zur bestimmung von anti-hiv, mittel dazu und ihre verwendung in diesem verfahren | |
| CA2011479A1 (en) | Process for the adhesive binding of paper layers | |
| DE68918823D1 (de) | Vorrichtung zum Ausschneiden von Tab-Anordnungen und zum Formen von deren Anschlüssen. | |
| PT87809A (pt) | Promotoren zur expression von freemd-dna in methylotrophen bakterien deren gewinnung und deren verwendung | |
| DE58904672D1 (de) | Verfahren zur herstellung einer festphasenmatrix. | |
| DE69224907D1 (de) | Polyacrylamid-matrix-gel | |
| TR23834A (tr) | Parafin bakimindan zengin petrollerde ve petrol fraksiyonlarinda(i) akis duezelticisi olarak atilik ve/ veya metakrilik asit esterlerinin seckin...... | |
| DE68917944D1 (de) | O.R.I.-gehemmte Motorbrennstoffzusammensetzung, und einlagerungsbeständiges Konzentrat. | |
| DE58906771D1 (de) | Neue Copolymere, deren Mischungen mit Poly(meth)acrylsäureestern und deren Verwendung zur Verbesserung der Fliessfähigkeit von Rohölen in der Kälte. | |
| DE3852118D1 (de) | Protease-ähnliche zytotoxische lymphozyten-spezifische moleküle und verfahren. | |
| ATE42640T1 (de) | Verfahren zum immobilisieren von substanzen an kunststoffestphasen und kunststoffestphasen zur verwendung in immunosorbentassays. | |
| ATE98997T1 (de) | Aus nukleinsaeuren von menschlichen papillomaviren bestehende hybridisierungsproben und methoden fuer deren anwendung. | |
| DE68907243D1 (de) | Antriebsvorrichtung zum nacheinander in betriebnehmen von lasten. | |
| KR860008779A (ko) | 항체 형성 화합물의 제조방법 | |
| ATE77654T1 (de) | Verfahren zur faerbung von nichtradioaktiven markierten nukleinsaeuren und zusammensetzung zum gebrauch in diesem verfahren. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |