Papers by Dr. Sanjay V chavan
Organic & biomolecular chemistry, Jan 7, 2011
This communication describes a general synthetic route to bicyclic amino acid-carbohydrate-conjug... more This communication describes a general synthetic route to bicyclic amino acid-carbohydrate-conjugates, which would be useful as conformationally restricted hydroxyethylamine (HEA) transition-state isosteres. The synthesis was achieved in 12 steps starting from D-glucose. The striking features of this system are the bicyclic rigid core displaying an α-amino acid side chain and hydroxyethylamine moiety--both of which would be potentially important for receptor interactions, leading to various biomedical responses, as described in the literature. Crystal structure investigation suggested extensive intermolecular hydrogen-bonding interactions in this system, involving the backbone amide and hydroxyl groups.
Journal of Advances in Microbiology Research , 2025
Coccinia grandis (L) is the most valuable plant and is used to treat a variety of illnesses. Vari... more Coccinia grandis (L) is the most valuable plant and is used to treat a variety of illnesses. Various therapeutic disorders are treated with bioactive compounds originating from plants. Investigating antibacterial and antioxidant activity using disc diffusion and DPPH scavenging, respectively, is the goal of the current work. All four bacterial species were active against the crude extract. Gram-negative bacteria include Proteus vulgaris and Escherichia coli, while gram-positive bacteria include Staphylococcus aureus and Bacillus subtilis. The leaves extract has strong antibacterial activity against S. aureus and E. coli, as evidenced by the most notable inhibitory zones they showed. Conversely, P. vulgaris and B. subtilis showed mild inhibitory zones, indicating that the leaves have a moderate antibacterial action on these bacteria.The micro broth dilution method was used to find the aqueous extract's least inhibitory concentration (MIC). The extracts were serially diluted twice for MIC (200, 100, 50, 25, and 12.5 ÎŒg/ml). For 18 to 24 hours, the tubes were incubated for bacteria at 370C, and any growth that was evident was monitored.
Indian Journal of Advances in Chemical Science, 2024
Coccinia grandis (L) is an important medicinal plant having its great medicinal value in trebles,... more Coccinia grandis (L) is an important medicinal plant having its great medicinal value in trebles, the compound 5,7-dihydroxy-2-(4-hydroxyphenol)-3-{(3S,4S,5S,6R)-3,4,5-trihydroxy-6methyltetrahydro-2H-pyran-2yl]oxy}-5,6,7,8-tetrahydrd-4Hchlomen-4-one was isolated and it is characterized by ultraviolet, infrared, nuclear magnetic resonance, and mass spectroscopy. Thinlayer chromatography profiling was confirmed a single compound present in the fraction from column chromatography and that's why the characterized bioactive compound enhances to drug delivery.
International Journal of Research and Analytical Reviews (IJRAR), 2025
A valuable medicinal plant, Coccinia grandis L. is abundant in bioactive chemicals that were extr... more A valuable medicinal plant, Coccinia grandis L. is abundant in bioactive chemicals that were extracted from its leaves using ethanol. Four compounds were identified by UV, IR, NMR, and mass spectroscopy. They are named Compound-1, Compound-2, Compound-3, and Compound-4. According to molecular docking and DFT analysis, compound-2 is more stable and active against both Gram-positive and Gram-negative bacteria than the other three compounds, which is why the isolated bioactive compounds will be used in drug delivery. All four compounds were initially isolated from C. grandis L leaves and are active against microbes.
Journal of Emerging Technologies and Innovative Research (JETIR), 2025
Plant-source bioactive compounds are crucial potential drugs against therapeutic dieses. The pres... more Plant-source bioactive compounds are crucial potential drugs against therapeutic dieses. The present study investigated four bioactive compounds isolated from Wrightia tinctoria R.Br. leaves, named compound-1, compound-2, compound-3, and compound-4. These compounds are identified by TLC and separated by HPLC, while compounds are characterised by UV, FT-IR, 1HNMR, 13CNMR, and mass spectroscopy. All four compounds exhibit potent antibacterial and antioxidant activity. MEP, EHOMO, ELUMO, and global properties of all isolated compounds are computed by DFT methods. The molecular docking study showed that most of the isolated compounds, especially compounds 3 and 4, interact strongly with 4PYP, with the highest binding energies maintaining the high cytotoxic activity of these compounds against HepG-2 cells in the experimental part. Bioactivity Score, Drug-Likeness, and ADMET studies supported the potential biological activities of most isolated compounds, especially compounds 3 and 4, and also created attention for developing them to act as good candidates.
Biospectra (Plant Science), 2024
A variety of products, including test papers, pH paper strips, acid-base indicators, and medicati... more A variety of products, including test papers, pH paper strips, acid-base indicators, and medications, were made using floral extract. Many pigments, including minerals, flavonoids, and anthocyanin, are found in floral extracts. These pigments are highly sensitive to pH changes. The ethanolic and aqueous extracts of the petals of the Calotropis gigantea flower (Rui) were made in the current study. In various pH ranges of buffer solutions, noticeable color differences of flower extract of C. gigantea are observed. Many color pigments found in aqueous and ethanolic floral extract of C. gigantea are extremely sensitive to different chemical as per their pH variations. The synthetic indicators which are commonly used in our laboratory and the natural indicators which are prepared from aqueous and ethanolic floral extracts, provide almost identical outcomes. Using the same extracts, the pH paper and indicator have been prepared. The pH paper prepared is environmentally friendly, biodegradable and is helpful for laboratory work. This kind of research is a cheap, efficient, and natural substitute for artificial litmus paper, dye and Chemicals. C. gigantea extract indicator is more cost-effective and yield results with the same accuracy as synthetic indicators in acid base type titrations
American Institute of Physics (AIP), 2021
The adult species of freshwater crabs (Berytephusa Cuniclaris) were collected from the Northern r... more The adult species of freshwater crabs (Berytephusa Cuniclaris) were collected from the Northern region of Maharashtra, India, and isolated, refrigerated in the laboratory. The living crabs were euthanized at-30ÂșC by thermal shock for 15 minutes. The crabs were then clearly dissented and the tissue was extracted from the crab's abdomen, the crude extract obtained from their tissue. The crude extract was completely dried off in the microwave and pulverized then a cold maceration process was used by immersing the powder into the ethyl alcohol for maintaining the stability of the bioactive compounds at low temperature and vacuum-packed for 21 days at room temperature. Stirring was given infrequently due to raising up the speed of extraction of the bioactive compound diffuses from the cell in anticipation of equilibrium reached. The repetitive filtration was done to refine the compound and concentrated with rotator evaporators to eliminate the excess amount of ethanol which form a pure product. The current study is described the first time in India with the help of an advanced analytical tool like UV, FTIR, NMR, LCMS, Single-crystal analysis, and antimicrobial potencies that the crab is beneficial to human as well as a medicinal source due to the presence of bioactive compounds like cortisol, aldosterone, isoleucine, and estradiol with the most isolated compounds dexamethasone, testosterone, and norethisterone have existed in the cluster form.
Bioorganic and Medicinal Chemistry Reports, 2024
For screening purposes, there has been interest in creating natural product scaffolds that closel... more For screening purposes, there has been interest in creating natural product scaffolds that closely resemble drug-like compounds utilizing combinatorial chemical approaches. Various screening techniques are being developed to improve the data mining and drug development campaigns' usage of natural materials. From the tissue extract of the freshwater crab Barytelphusa cunicularis, four chemicals were shown to have biological activity against both grampositive and gram-negative bacteria, including E. coli and B. subtilis, and S. aureus. Four pathogens were used in this study: A. niger, M. furfur, A. flavus, and P. Chrysosporium. Flavus and P. Chrysosporium, but poorly against A. Niger and M. Furfur. To further the development of potential therapeutics, structure-activity relationship (SAR) analysis via a virtual screening protocol was conducted. Bioactivity assessments confirmed the compounds' efficacy against both bacterial and fungal targets. Molecular docking analyses revealed that all four organic compounds exhibit favorable absorption, distribution, metabolism, excretion, and toxicity (ADME/T) properties and bind with the protein DNA gyrase at diverse sites. In conclusion, the compounds' notable activity with DNA gyrase suggests their potential for drug design exploration.
International Journal of Advanced Chemistry Research , 2025
The four bioactive compounds were isolated from the leaves of C. grandis (L) and characterised us... more The four bioactive compounds were isolated from the leaves of C. grandis (L) and characterised using spectroscopic data from UV, IR, 1HNMR, 13CNMR, and mass spectroscopy before the bioactive fraction's TLC profile was examined. The antibacterial activity of methanol leaf extract was investigated using four bacterial strains: E. coli, P. vulgaris, S. aureus, and B. subtilis. The extract shown action against these strains. Four isolated compounds were used in the molecular docking investigation, which looked at the structure-activity relationship. Since compounds 1, 2, 3, and 4 have antibacterial qualities, it is necessary to investigate how these compounds attach to anti-bacterial (3WGN.pdb) receptor proteins. Since the primary target of inorganic nitrite's antioxidant effects in lipopolysaccharide-induced oxidative stress in macrophage cells and animals is NADPH oxidase, the crystal structure of NAD (P) H Oxidase (NO) is (2CDU.pdb) used as an antibacterial receptor protein. Their potential as future medications is increased by the fact that each of the four discovered compounds has a structure and activity relationship with its targeted protein.
Books by Dr. Sanjay V chavan
LAP LAMBERT Academic Publishing , 2023
Investigation of Freshwater Crab Natural Products and Their Biological Efficiency to Structure Ac... more Investigation of Freshwater Crab Natural Products and Their Biological Efficiency to Structure Activity Relationship
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Papers by Dr. Sanjay V chavan
Books by Dr. Sanjay V chavan