Papers by Vincent Vincent
Akibat hukum peraturan Bank Indonesia no. 17/3/PBI/2015 tentang kewajiban penggunaan rupiah di wilayah Negara Kesatuan Republik Indonesia = Legal impact of Bank Indonesia Regulation no. 17/3/PBI/2015 regarding mandatory use of rupiah in the territory of Republic of Indonesia
Nowadays, it can be seen that economic development from a certain state,become one of the essenti... more Nowadays, it can be seen that economic development from a certain state,become one of the essential aspects that can be used as an indicator to measure how advanced and well established a certain state. It is an undeniable ambition from the Association of Southeast Asian Nations (hereinafter ASEAN) state members to follow the European Union (EU) state members to realize a integration not only in the field of economy, including but not limited to politic, technology, and etc. The ASEAN ambition is the realization of an integration between the ASEAN state members, namely through the ASEAN Economic Community (hereinafter AEC). As matter of course, Indonesia as the member of the ASEAN will be facing the MEA effects and to feel the impact of the AEC directly. In order to face the AEC, Indonesia must be in a conducive and qualified condition of including and not limited to the economic field, politic, technology, and etc. Therefore, Indonesia must ready to face the competition that wil be...
Novel protease and polymerase inhibitors for the treatment of hepatitis C virus infection
Expert Opinion on Investigational Drugs, 2007
Chronic hepatitis C virus (HCV) infection remains a global health concern with nearly 200 million... more Chronic hepatitis C virus (HCV) infection remains a global health concern with nearly 200 million carriers worldwide. Present treatment consists of the use of pegylated interferon plus the purine analogue ribavirin. Serious side effects and the fact that an overall 40-50% of patients do not accomplish sustained virological response with the present treatment warrant the need for novel anti-HCV therapies. The HCV serine protease and the RNA-dependent RNA polymerase have shown to be excellent targets for selective antiviral therapy. Early clinical studies have resulted in encouraging results. However, and not unexpectedly, preclinical evidence suggests that the virus may become rapidly resistant to such inhibitors. Therefore, combination therapy of drugs with different mode of action and resistance profiles may be required. This review focuses on the present status of these two families of HCV inhibitors that are in development.
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Papers by Vincent Vincent