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All Journal Journal of Biobased Chemicals (JOBC)
Indarto I
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Evaluation of Nutmeg Extract as a Natural Anti-Acne Agent Against P. acnest Sari, Indah; Angga Saputra Yasir; Indarto I; Sinta Bella Triyanti; Aida Febina Sholeha; Veni Putri Nurhayati
Journal of Biobased Chemicals Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v5i1.5590

Abstract

Acne vulgaris is a common inflammatory skin disorder primarily caused by the proliferation of Propionibacterium acnes. In response to increasing demand for natural and safer therapeutic alternatives, this study investigated the phytochemical composition, total flavonoid content, and antibacterial activity of the ethanolic extract of Myristica fragrans flesh. Phytochemical screening revealed the presence of flavonoids, terpenoids, tannins, saponins, and alkaloids—classes of compounds widely recognized for their antimicrobial properties. The total flavonoid content (TFC), determined using the aluminum chloride colorimetric method, was found to be 0.1582 ± 0.0044 mg quercetin equivalents per gram of dry extract. Antibacterial assays using the disc diffusion method demonstrated dose-dependent inhibition of both Staphylococcus aureus and P. acnes, with greater efficacy observed against P. acnes. These results suggest that nutmeg flesh extract possesses significant antibacterial potential, particularly as a candidate for anti-acne cosmetic formulations. Moreover, this study highlights the underexplored value of nutmeg flesh—a byproduct of spice processing—as a sustainable source of bioactive compounds for skincare applications.
Co-Authors Aida Febina Sholeha Angga Saputra Yasir Mochammad Imron Awalludin Sinta Bella Triyanti Veni Putri Nurhayati