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All Journal Jurnal Ilmu Kefarmasian Indonesia Berkala Ilmiah Kimia Farmasi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Annisa, Fauziah Rahma
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Nursing Public Health Other

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Characteristic and therapeutic effect of lemongrass leaf encapsulation with a different ratio of chitosan and NaTPP Kurniawan, Florencia Livia; Komariah, Komariah; Octarina, Octarina; Anggreani, Febry; Annisa, Fauziah Rahma; Nurlidar, Farah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1570

Abstract

The lemongrass plant (Cymbopogon citratus) in Indonesia has great potential as a natural ingredient for medicines because it contains various compounds such as neral, citral, geranial acetate, flavonoids, and tannins. Previous research has demonstrated various pharmacological activities of kitchen lemongrass leaves, including antibacterial, antifungal, and anti-inflammatory properties. Encapsulation technology in the form of chitosan-NaTPP nanoparticles is used to maintain the activity of kitchen lemongrass leaf compounds. This research aims to determine the physical characteristics of the encapsulation of kitchen lemongrass leaf extract with several comparisons of chitosan and NaTPP by testing PSA (particle size analysis test), FTIR (functional group analysis test), viscosity, and stability, including pH and turbidity tests. Encapsulation with a 1:1 ratio of chitosan and NaTPP has a particle size of 524 nm and a PdI value of 0.481, classified as monodisperse (PdI <0.7). The pH value ranges from 6.46 to 7.30, and the viscosity value was 2.134–2.169 cP, which is still within mouthwash standards. The turbidity test showed stable encapsulation results. Therefore, encapsulation with a 1:1 ratio of chitosan and NaTPP is the most optimal choice and has potential for developing the therapeutic effect of mouthwash.
The, of The Inhibitory Effect of Encapsulated Lemongrass Leaf Extract with Chitosan against Staphylococcus aureus and Streptococcus pyogenes : Daya Hambat Ekstrak Daun Serai Dapur yang Terenkapsulasi dengan Kitosan terhadap Staphylococcus aureus dan Streptococcus pyogenes Komariah, Komariah; Rezky Anggraeni; Annisa, Fauziah Rahma; Febry, Febry
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i1.65116

Abstract

The lemongrass plant (Cymbopogon citratus) was a potential medicinal plant due to the presence of secondary metabolites such as neral, citral, geranial acetate, flavonoids, and tannins, which possess pharmacological activities including antibacterial, antifungal, and antiinflammatory. However, the antibacterial secondary metabolites contained in lemongrass leaves were unstable, hence required a substance capable of encapsulating or entrapping them using other natural compounds such as chitosan and tripolyphosphate (TPP). The chitosan and TPP ratio significantly affects crosslinking during the encapsulation process. Staphylococcus aureus and Streptococcus pyogenes are among the bacteria potentially causing infections in the oral cavity. The aim of this research was to determine the inhibitory effect of encapsulated lemongrass leaf extract with chitosan and TPP ratios of 1:1, 1:0.9, 1:0.8, and 1:0.7 against S.aureus and S.pyogenes. The research results showed inhibition zones formed on S. aureus and S. pyogenes for each encapsulation ratio of 1:1, 1:0.9, 1:0.8, 1:0.7, were 25.09±0.62 mm, 21.01±0.13 mm, 22.78±0.39 mm, 23.96±0.14 mm, and 24.38±0.45 mm, 21.99±0.34 mm, 22.44±0.48 mm, and 20.49±0.24 mm, respectively. Encapsulation of lemongrass leaf extract using chitosan and TPP ratios was effective in inhibiting the growth of S. aureus and S. pyogenes, with the best ratio at 1:1.   Keywords:  Lemongrass leaves, encapsulation, chitosan, antibacterial, Staphylococcus aureus and Streptococcus pyogenes
Pulmonary Tuberculosis Patients and Management in Dentistry at Puskesmas Palmerah Theresia, Tiarma Talenta; Lestari, Sri; Hibatillah, Ahmad Dzaki; Widyanto, Petronella; Tobing, Fiona Priscilia Dinata; Maringka, Stella Maria Fidela; Syaqila, Abigail Rifda; Annisa, Fauziah Rahma; Amanda, Nabila Risqy; Jordan, Bryan Matthew
PROMOTOR Vol. 8 No. 4 (2025): AGUSTUS
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v8i4.1251

Abstract

Background: Palmerah Health Center, located in Palmerah Subdistrict, West Jakarta, with a population of 233,917 people in 2022, faces challenges in dealing with infectious diseases like Tuberculosis (TB). Pulmonary TB, caused by Mycobacterium tuberculosis, primarily affects the lungs but can spread to other organs. Common symptoms of pulmonary TB include coughing with sputum for more than two weeks and shortness of breath. Objective: To understand the overview of pulmonary tuberculosis in the Palmerah area and the risk factors contributing to TB in the Palmerah region. Methodology: This study is an observational descriptive research with a cross-sectional design, using data from the online-based Tuberculosis Information System (SITB) at Palmerah Health Center and all its supporting health centers (Pustu) in Palmerah Subdistrict. Results: The highest number of pulmonary tuberculosis cases was found at Palmerah Health Center, followed by Palmerah Village Health Center. Pulmonary tuberculosis cases were more common in males. Conclusion: Pulmonary tuberculosis cases in Palmerah remain relatively high, with complex contributing factors. The TB case screening program conducted by the health centers shows good cross-sectoral support, but there are still barriers related to human resources and the community's knowledge and understanding of TB prevention.
Co-Authors Amanda, Nabila Risqy Anggreani, Febry Farah Nurlidar Febry, Febry Florencia Livia Kurniawan Hibatillah, Ahmad Dzaki Jordan, Bryan Matthew Komariah Komariah Maringka, Stella Maria Fidela Octarina Rezky Anggraeni Sri Lestari Syaqila, Abigail Rifda Theresia, Tiarma Talenta Tobing, Fiona Priscilia Dinata Widyanto, Petronella