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All Journal Majalah Obstetri dan Ginekologi Asian Journal of Health Research
Nooryanto, Mukhammad
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Evaluation of anti-Mullerian hormone as parameter of ovarian function in patients with systemic lupus erythematosus: A systematic review and meta-analysis Nooryanto, Mukhammad; Wulandari, Wulandari
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.196-206

Abstract

HIGHLIGHTS Systemic lupus erythematosus (SLE) patients show a strong correlation between Anti-Mullerian Hormone (AMH) levels and ovarian function. Lower AMH levels indicate higher risk of impaired ovarian function and diminished reserve, as revealed by this meta-analysis. The comprehensive synthesis of available data in this study has important clinical implications for the management and counseling of systemic lupus erythematosus (SLE) patients.   ABSTRACT Objective: The assessment of ovarian function in patients with systemic lupus erythematosus (SLE) holds paramount importance for both clinicians and patients. This systematic review and meta-analysis delves into the role of anti-Mullerian hormone (AMH) as a key marker in evaluating ovarian function among SLE patients. Our study aimed to provide valuable insights for clinicians managing ovarian function assessments and to offer practical recommendations for differences in therapy for patient care. Materials and Methods: Studies comparing serum AMH levels between patients with systemic lupus erythematosus and healthy controls, as well as serum AMH levels between SLE patients, are necessary. PRISMA guidelines were used for this systematic review. Databases like PubMed, SCOPUS, EuropePMC, ProQuest, and Cochrane Central were searched using specific terms ("Anti-Mullerian Hormone" or "Ovarian Function" and "Systemic Lupus Erythematosus") for publications between 2000 and 2023. After removing duplicates, authors screened remaining articles based on abstracts, then reviewed selected abstracts in full-text. Studies meeting criteria were included based on unanimous agreement among investigators, with any disagreements resolved through author consensus. Results: There were 12 eligible studies. In this research, we identified a link between SLE and diminished levels of AMH. Furthermore, it was observed that SLE patients undergoing cyclophosphamide (CYC) treatment also exhibited lowered AMH levels Conclusion: The systematic review underscores the heightened risk of reduced ovarian reserve in SLE patients. Importantly, CYC treatment emerged as a factor contributing to compromised ovarian reserve. For individuals with systemic lupus erythematosus, particularly women in their reproductive years, assessing serum AMH levels can serve as a pivotal tool to inform therapeutic decisions and preserve ovarian health. Our study contributes to enhanced clinical understanding and patient care within the realm of SLE and reproductive health.
Retrospective Analysis: Infant Health Outcomes Born to Mother with Systemic Lupus Erythematosus Nooryanto, Mukhammad; Wulandari
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.241

Abstract

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects young women and presents risks during pregnancy, potentially impacting infant health. This study analyzes infant health outcomes such as birth weight, APGAR score (AS), preterm birth, NICU admission, and mortality in infants born to mothers with SLE. Material and Methods: A retrospective analysis was performed on data from infants born to mothers with SLE between 2023–2025. Data were analyzed using descriptive, bivariate, and multivariate tests with p < 0.05 considered significant. The study was conducted at General Hospital Dr. Saiful Anwar. Results: Of the subjects, 78.57% had mild SLE, 14.28% had moderate SLE, and 7.15% had severe SLE. Significant associations were found between pregnancy status and SLE severity (p = 0.000), delivery method (p = 0.005), blood loss (p = 0.035), birth weight (p = 0.022), and APGAR score (p = 0.005). Cesarean sections were more common in mild to moderate SLE cases. NICU admission was significantly associated with SLE severity (p = 0.002), and fetal mortality was higher in severe SLE cases (p = 0.001). The R-square values for the variables showed that 61.9% of the variation in Apgar score, 73.3% in blood loss, and 73.6% in mortality were explained by factors such as blood loss, grade of SLE, gravida, MEX SLEDAI, maternal age, and mode of delivery. Conclusion: SLE severity significantly influences maternal and neonatal outcomes, including delivery method, blood loss, birth weight, and APGAR score.
Co-Authors WULANDARI Wulandari Wulandari