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All Journal Majalah Kesehatan FKUB CRJIM (Clinical and Research Journal in Internal Medicine)
Faridah, Amirah
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Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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HUBUNGAN AKTIVITAS PRODUKSI SHORT CHAIN FATTY ACID (SCFA) PADA SINDROM METABOLIK DAN DERAJAT FIBROSIS HATI PADA PASIEN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) Mustika, Syifa; Pratomo, Bogi; Faridah, Amirah
Majalah Kesehatan Vol. 11 No. 4 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.04.2

Abstract

Saluran pencernaan dan hati memiliki interaksi anatomis dan fungsional yang kuat, yang disebut dengan gut-liver axis (GLA). GLA terdiri dari komponen-komponen yang kompleks, apabila terjadi perubahan pada salah satu komponen seperti disbiosis mikrobiota usus, maka dapat berpengaruh terhadap fungsi hati. Disbiosis mikrobiota usus dapat dinilai dari perubahan hasil fermentasi mikrobiota usus yaitu asam lemak rantai pendek (short chain fatty acid/SCFA) yang terdiri dari asetat, propionat, dan butirat. Penelitian ini bertujuan untuk mengidentifikasi hubungan aktivitas produksi SCFA dengan sindrom metabolik dan derajat fibrosis hati, serta membandingkan aktivitas produksi SCFA pasien non-alcoholic fatty liver disease (NAFLD) dengan subjek kontrol. Studi cross-sectional terhadap 27 pasien NAFLD dan 10 subjek kontrol dengan sampel penelitian berupa feses. Derajat fibrosis hati diukur menggunakan transient elastography dan kadar SCFA diukur menggunakan teknik pemeriksaan gas chromatography. Analisis data dengan uji Chi-square, independent t-test dan uji korelasi Spearman. Hasil menunjukkan terdapat hubungan antara kadar SCFA dengan sindrom metabolik dengan korelasi negatif (r = -0,381, p = 0,020), terdapat hubungan antara kadar SCFA dengan derajat fibrosis hati pasien NAFLD dengan korelasi negatif (r = -0,665, p = 0,001), dan didapatkan penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol (total SCFA p = 0,001, asam asetat p < 0,001, asam propionat p = 0,005, asam butirat p < 0,001). Kesimpulan, terdapat penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol. Semakin rendah kadar SCFA berhubungan dengan semakin tinggi risiko terjadinya sindrom metabolik dan semakin tinggi derajat fibrosis hati pada pasien NAFLD.
Role of Surveillance Colonoscopy With Mortality Event due to Colorectal Cancer and Cancer Stage Findings in Inflammatory Bowel Disease Patients Akbar, Muhamad; Bhaskara, Rezdy; Wibowo, Bogi; Mubarak, Husni; Tama, Yhang; Faridah, Amirah
Clinical and Research Journal in Internal Medicine Vol. 5 No. 2 (2024): Volume 5 No 2, November 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.02.03

Abstract

Background: Patients with Inflammatory bowel disease (IBD), both due to ulcerative colitis (UC) and Crohn’s disease (CD), are at higher risks of having colorectal cancer (CRC). Various guidelines have recommended surveillance using a colonoscopy. However, evidence of its usefulness for prognosis remains a subject of discussion. Aim: To determined the difference in mortality rate due to CRC and cancer stage between patients IBD who undergo routine surveillance and whoes do not. Methods: Studies performed searches on database of Science Direct, PUBMED, EBSCO, and Cochrane for research types of randomized controlled trials (RCTs), cohort, or case-controls that evaluate the role of surveillance on patients with IBD regarding to mortalities due to CRC and cancer stage findings. Data were then analyzed using the fixed/random effect model based on heterogeneity to evaluate the odds ratio (ORs) with a 95% confidence interval, calculated using the Mantel-Haenszel method. Results: Based on five observational studies that evaluated 3,215 patients with Inflammatory Bowel Disease by surveillance, compared with 4,465 control patients, it was found that patients undergoing surveillance have significantly lower mortality due to CRC (15.1%) than the control patients (23.8%) (OR 0.36 (95% CI: 0.24–0.52), p < 0.00001). There are more patients with end-stage colorectal cancer without surveillance (37%) than those with surveillance (20%) (OR 0.28 (95% CI: 0.20–0.41), p < 0.00001). Conclusion: Patients with inflammatory bowel disease who undergo routine colonoscopy surveillance will have a lower mortality rate and be found with earlier-stage cancer than patients who do not undergo routine colonoscopy examination.
Co-Authors Bhaskara, Rezdy Bogi Pratomo Husni Mubarak Syifa Mustika Tama, Yhang Tamaulina Br Sembiring Wibowo, Bogi