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All Journal Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Wicaksono, Muhammad Bimo Adi
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Penatalaksanaan Asma Varian Batuk Wicaksono, Muhammad Bimo Adi; Yunus, Faisal
Majalah Kedokteran Indonesia Vol 74 No 1 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.1-2024-1130

Abstract

Cough is one of the innate primitive reflexes that is part of the immune system to protect the body from foreign substances. Cough is a manifestation of symptom found in various lung diseases, both infectious and non-infectious lung diseases. Cough variant asthma is a phenotype of asthma with the only symptom of cough. In cough variant asthma, airway (bronchial) hyperresponsiveness is found without abnormalities in pulmonary function tests. Airway hyperresponsiveness is assessed from the bronchial provocation test by measuring provocation dose (PD20) or provocation concentration (PC20). Management of cough variant asthma is no different from classic asthma, which are inhalation of bronchodilators and corticosteroids. Partial response to inhalation therapy can be reversed by changing the treatment regimen, increasing the inhaled dose, or adding other drugs such as long-acting β2 agonists, sustained-release theophylline or leukotriene receptor antagonist (LTRA).
Prevalence and Affecting Factors of Arrhythmias in Stable Chronic Obstructive Pulmonary Disease at a Tertiary Hospital in Indonesia Gozali, Achmad; Wicaksono, Muhammad Bimo Adi; Yunus, Faisal; Ratnawati, Ratnawati; Basalamah, Muhammad Abbas; Amien, Bagus Radityo
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.131-139

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) represents an increasing global health burden. Among its significant comorbidities, cardiovascular complications, particularly arrhythmias, are of significant concern. Chronic obstructive pulmonary disease and arrhythmias share common risk factors, including advanced age and smoking. This study investigated the prevalence and contributing factors of arrhythmias in stable COPD patients. Methods: This cross-sectional study was conducted among stable COPD patients attending the Asthma-COPD Clinic at Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia, from January to April 2018. The inclusion criteria encompassed a clinical diagnosis of COPD and voluntary participation with written informed consent. Each participant underwent laboratory evaluation, electrocardiography (ECG), blood pressure measurement, and a structured interview. Patients were excluded if they had experienced acute COPD exacerbations during the assessment, had a history of other chronic lung diseases, suffered a recent myocardial infarction, had structural heart disease, were diagnosed with fibrillation, or declined to participate. Results: The prevalence of arrhythmias in stable COPD patients was 24.1%. The types included sinus bradycardia (2.41%), premature atrial contractions/PACs (3.61%), premature ventricular contractions/PVCs (8.43%), and sinus tachycardia (9.64%). The majority of arrhythmic patients were males, with an average age of 68 years old. These patients also had a history of heart disease, exhibited severe COPD symptoms, and demonstrated significant airflow obstruction (average pCO₂ of 36 mmHg). Conclusion: Decreased chloride levels were associated with an increased incidence of arrhythmias. However, no significant associations were observed with airflow limitation, sex, age, bronchodilator use, or arterial blood gas parameters.
Co-Authors Amien, Bagus Radityo Basalamah, Muhammad Abbas Faisal Yunus Gozali, Achmad Ratnawati Ratnawati