Psychological changes in postpartum mothers often show uncertain emotions after giving birth, especially sadness and irritability. These psychological problems can be faced by postpartum mothers by cultivating psychological well-being. One way to improve the psychological well-being of postpartum mothers is by cultivating a self-compassionate attitude to reduce symptoms of depression, anxiety and worry in order to achieve the psychological well-being of postpartum mothers. This research aims to determine the relationship between self-compassion and the level of psychological well-being of postpartum mothers in Pekalongan Regency. This research uses descriptive correlation with a cross sectional approach. The samples taken using a purposive sampling technique were 79 postpartum mothers in Pekalongan Regency. Data were collected using the Self-Compassion Scale (SWD) questionnaire & Psychological Well-Being questionnaire. Data analysis used the Spearman rank test. This research showed that there were 53 people experiencing high self-compassion (67.1%), and 46 people with low psychological well-being (58.2%). The results of the analysis show that there is a relationship between self-compassion and the level of psychological well-being of postpartum mothers, P value = 0.000 (p <0.05). The conclusion of this research is that there is a relationship between self-compassion and the level of psychological well-being of postpartum mothers in Pekalongan Regency. From these results it is hoped that nurses can help improve self-compassion and psychological well-being of postpartum mothers by means of health education.