According to WHO, 77% of all deaths from NCDs and 85% of premature deaths occur in low- and middle-income countries. The main challenge in preventing and controlling NCDs is that the main drivers and risk factors including poverty, air pollution, lack of physical activity, and the marketing and sale of tobacco, alcohol, and processed foods are all outside the scope of control of government health departments or national health systems. The responsibility to address these underlying determinants lies with various government sectors and departments, such as education, labor, transportation, trade, finance, environment, agriculture, and manufacturing. NCDs in women have major implications, various complications during pregnancy, childbirth, and postpartum in mothers with NCDs trigger higher mortality and morbidity in mothers and children. This shows the need to initiate a program that integrates various parties in efforts to overcome NCDs in the community in the form of "ONE-FOUR". This program is called "ONE-FOUR" because it combines the roles of 4 elements, namely lecturers, students, cadres, and midwives to assist mothers or women of reproductive age with NCDs. Through intensive assistance from various components, it is expected to reduce complications of NCDs which ultimately have an impact on reducing maternal and child mortality. This study aims to analyze the effectiveness of the ONE FOUR programs on increasing knowledge and attitudes of reproductive-age mothers with NCDs. Method: Data analysis used dependent t-test aka paired t-test. Conclusion: knowledge score test value Sig. (2-tailed) 0.000 0.05. In the Attitude test value Sig. (2-tailed) 0.000 0.05 it can be concluded that the application of the ONE-FOUR method in women of childbearing age is effective in increasing knowledge and attitudes about NCDs.