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All Journal Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Global Medical and Health Communication 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Mandala of Health : A Scientific Journal Linggamas: Jurnal Pengabdian Masyarakat
Wisesa, Sindhu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Etanolic extract of Ling Zhi Mushroom (Ganoderma lucidum) improves lipid profile, CRP and histopathological of liver in dislipidemia model rats Soegianto, Jap Yulius Billy; Samodro, Pugud; Wisesa, Sindhu; Hernayanti, Hernayanti; Setyono, Joko; Arjadi, Fitranto
Biogenesis: Jurnal Ilmiah Biologi Vol 11 No 2 (2023)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v11i2.38896

Abstract

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Effect of Sleep Deprivation on the Number of Prefrontal Cortex Neuroglia Cells in Male White Rats (Rattus norvegicus) Arjadi, Fitranto; Kuncoro, Prasetyo Tri; Gumilas, Nur Signa Aini; Harini, Ika Murti; Mustofa, Mustofa; Wisesa, Sindhu
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10743

Abstract

Stress induced by sleep deprivation can increase inflammation and oxidative stress, destroying the pyramidal and neuroglia cells in the prefrontal cerebral cortex and interrupting cognitive and behavioral functions. This study aims to observe the difference in the number of pyramidal and neuroglia cells in the prefrontal cortex of male white rats (Rattus norvegicus) after stress induction by paradoxical sleep deprivation (PSD) and total sleep deprivation (TSD). This study was conducted in the Anatomy Laboratory of the Faculty of Medicine, Universitas Jenderal Soedirman, from November 2019 to February 2020. The method of this study was a posttest-only design with a control group approach using ten rats for each group; that was control (K.I.), PSD (KII), and TSD (K.I.). PSD and TSD groups received sleep deprivation treatment for eight days for 20 hours/day and 24 hours/day, respectively. The mean pyramidal cell number decreased in the PSD (66.67±24.55) and TSD (65.90±34.91) compared to the control (77.10±26.11) group, but no significant differences were found between all groups (p>0.05). The mean neuroglial cell number was lower in the PSD (97.78±28.17) and TSD (75.80±22.39) compared to the control (126.00±48.81). Post-hoc Bonferroni test showed a significant difference between control and TSD (p<0.05) but not between control and PSD or PSD and TSD (p>0.05). In conclusion, there was a significant difference in the number of neuroglial cells but not pyramidal cells in the prefrontal cortex of male white rats (Rattus norvegicus) after stress induction with total sleep deprivation (TSD).
Inhibition breast carcinogenesis via PI3K/AKT pathway using bioactive compounds of Strychnine tree (Strychnos nux-vomica): in silico study Rispriandari, Aulia Ayu; Sarmoko, Sarmoko; Setyono, Joko; Wisesa, Sindhu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28242

Abstract

Breast cancer poses a significant global health challenge, with a notable prevalence in Indonesia. Given the intricate nature of breast cancer progression and classification, precise treatment strategies are imperative, particularly targeting signaling pathways like PI3K/AKT, pivotal in cell growth, proliferation, survival, and apoptosis. Bioactive compounds from the Strychnine tree demonstrate potential in enhancing apoptotic effects and inhibiting breast carcinogenesis. This potential is explored through in silico studies. This research aims to analyze potential targets of Strychnine tree compounds, along with binding energy and stability between ligands and receptors. Employing bioinformatics target analysis, molecular docking, and molecular dynamics simulation, the study reveals AKT1 as a potential target of Strychnine tree compounds. These compounds inhibit AKT1 at both active and allosteric sites, displaying notably low binding energy scores. For example, brucine exhibits a binding energy of -10.83 kJ/mol at the active site, surpassing the standard capivasertib. However, lupeol, with a binding energy of -11.14 kJ/mol, falls short of the MK-2206 standard at the allosteric site. Molecular dynamics simulations expose fluctuations in parameters like RMSD, RMSF, and binding energy within the initial 5 ns. In conclusion, Strychnine tree compounds, such as brucine and lupeol, showcase potential AKT1 inhibition at both active and allosteric sites, enhancing apoptotic effects. However, the stability of these compounds in binding to their receptors within the first 5 ns of the simulation warrants further investigation for prolonged interactions.   
Implementasi Edukasi Gizi Interaktif sebagai Upaya Pencegahan Komplikasi Penyakit Kronis pada Lansia di Posyandu Mawar IV Desa Purwosari Wisesa, Sindhu; Sari, Octavia Permata; Candrawati, Susiana; Wicaksono, Madya Ardi; Ihtiaringtyas, Suci; Soraya, Aristi Intan
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.14367

Abstract

Hampir seluruh populasi lansia memiliki setidaknya satu penyakit kronis. Penyakit kronis dan komplikasinya menyebabkan penurunan produktivitas dan kualitas hidup, serta meningkatkan beban ekonomi. Asupan gizi seimbang terbukti mencegah komplikasi penyakit kronis. Program Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan kesadaran asupan gizi seimbang pada lansia melalui edukasi interaktif menggunakan model makanan. Kegiatan dilaksanakan pada tanggal 2 Agustus 2024 di Desa Purwosari yang dihadiri oleh 40 lansia dan kader Posyandu. Hasil pretest dan posttest menunjukkan peningkatan pengetahuan secara signifikan pada lansia yang mengikuti kegiatan PkM. Edukasi gizi berperan krusial dalam mengubah pola pikir dan perilaku masyarakat terkait asupan makanan. Penggunaan model makanan membantu peserta memahami porsi yang tepat, serta meningkatkan minat dan retensi informasi, sehingga diharapkan melalui program ini, lansia di Desa Purwosari dapat memperbaiki pola makan dan mencegah komplikasi penyakit kronis.
ISOLAT PROTEIN WHEY MENINGKATKAN SATIETY DAN MENGURANGI ASUPAN KALORI MELALUI INDUKSI SINYAL ANOREKSIGENIK Wisesa, Sindhu; Soraya, Aristi Intan; Wahyudin, Wahyudin
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.11838

Abstract

Restriksi kalori merupakan strategi yang efektif dalam menurunkan berat badan, tetapi sulit diimplementasikan pada individu overweight atau obesitas dengan masalah overeating. Kurangnya asupan kalori dan penurunan lemak tubuh meningkatkan sinyal lapar (hunger) pada hipotalamus, sehingga dapat memicu konsumsi makan yang berlebih. Asupan protein menunjukkan peningkatan satiety lebih baik daripada karbohidrat atau lemak, sehingga diet tinggi protein dapat menurunkan total asupan kalori. Isolat protein whey merupakan olahan susu dengan jumlah protein yang tinggi dengan harga yang relatif murah, berpotensi digunakan dalam manajemen penurunan berat badan karena dapat meningkatkan satiety. Review ini bertujuan untuk menelaah efektivitas dan mekanisme protein whey dalam meningkatkan satiety pada orang dewasa. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) digunakan dalam review. Kata kunci “whey”, “protein”, “isolate”, “satiety”, dan “adult” digunakan untuk mencari artikel pada database Pubmed dan ScienceDirect. Sebanyak tujuh studi hasil uji klinik ditemukan setelah skrining. Isolat protein whey meningkatkan satiety, menurunkan rasa lapar, dan mengurangi jumlah asupan makan lebih baik daripada karbohidrat atau placebo, terutama jika dikonsumsi bersamaan dengan makanan. Kadar serum adiponectin dan plasma glucagon-like peptide-1 (GLP-1) meningkat setelah konsumsi isolat protein whey. Tidak terdapat perbedaan satiety antara asupan isolat protein whey dengan asupan isolat protein kedelai, kacang polong, kentang, beras, β-lactoglobulin, α-lactalbumin, atau campuran asam amino. Isolat protein whey meningkatkan satiety dan menurunkan rasa lapar pada orang dewasa melalui peningkatan sinyal adiponectin dan GLP-1, sehingga menurunkan total asupan kalori dan berpotensi digunakan dalam manajemen penurunan berat badan.
INFEKSI SOIL TRANSMITTED HELMINTHS PADA ANAK USIA SEKOLAH DASAR: PERILAKU JAJAN DAN PERILAKU HIGIENE Sari, Octavia Permata; Susiawan, Lieza Dwianasari; Wisesa, Sindhu; Harini, Ika Murti; Setiawati, Setiawati
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12213

Abstract

Soil Transmitted Helminths (STH) are a group of parasitic nematodes that pass through the soil in their life cycle. STH can infect the digestive system and cause harm to humans. One of the risk factors for STH is snacking behavior and poor hygiene behavior in school-aged children. This study aims to determine the relationship between snacking behavior and hygiene behavior with the incidence of STH infection in students at SDN Ciberem, Sumbang District, Banyumas Regency. This research is an analytical observational study with a cross-sectional design and was carried out using purposive sampling. The population of this study were students in grades 1-5 at SDN Ciberem with a sample size of 96 students. Data collection was carried out using questionnaires and fecal examination at the FK Unsoed Parasitology Laboratory using qualitative methods. The data obtained were analyzed using Fisher's Exact Test. In this study, it was found that 5 students (5.2%) were infected with Trichuris trichiura type STH. The Fisher's Exact test showed a significant relationship between STH infection with hand washing habits (p = 0.037), the condition of the snacks being served open (p = 0.026), and lots of flies around the snacks (p = 0.031), but there was no significant relationship with the habit of using footwear (p = 1.000), the habit of cutting nails (p = 0.256), and the frequency of snacks (p = 0.333). There is a significant relationship between the habit of washing hands, buying open snacks and snacks with lots of flies around them and the incidence of STH infection. Key words: STH, SD, snacking behavior, hygiene behavior, washing hands
Penggunaan Multimedia Interaktif Berbasis Komputer dalam Pembelajaran Anatomi: Systematic Review Wisesa, Sindhu
2-TRIK: TUNAS-TUNAS RISET KESEHATAN Vol 12, No 4 (2022): November 2022
Publisher : FORUM ILMIAH KESEHATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/2trik12409

Abstract

Computer-based interactive multimedia such as 3D atlases, augmented reality (AR), and virtual reality (VR) have recently been introduced for teaching anatomy alongside conventional methods that use lectures with 2D illustrated atlases or 3D anatomical models. In this review, the advantages and limitations of computer-based interactive multimedia in learning anatomy were explained systematically. Articles containing the use of interactive multimedia in learning anatomy were identified from Pubmed and selected articles published in the last ten years (2013-2022). Articles that fit the focus of the review were then screened and a total of nine articles met the inclusion criteria in this systematic review. All articles in the review agree that learning using computer-based interactive multimedia increases anatomical knowledge on a par with conventional methods. New technologies including 3D atlases, AR, and VR significantly increase motivation, interest, attention, engagement, and enjoyment in learning anatomy compared to conventional methods. However, these new technologies, especially VR, induce mild discomfort in some users and are out of reach in all learning centers due to higher costs than conventional methods. It can be concluded that computer-based interactive multimedia is recommended to be applied to certain learning centers as an alternative medium in teaching anatomy to accompany traditional methods.Keywords: anatomy learning; interactive multimedia; computer based application ABSTRAK Multimedia interaktif berbasis komputer seperti atlas 3D, augmented reality (AR), dan virtual reality (VR) belakangan ini diperkenalkan untuk pembelajaran anatomi mendampingi metode konvensional yang menggunakan kuliah dengan atlas bergambar 2D atau model anatomi 3D. Dalam review ini, keunggulan dan keterbatasan multimedia interaktif berbasis komputer pada pembelajaran anatomi dijelaskan secara sistematis. Artikel yang berisi tentang penggunaan multimedia interaktif dalam pembelajaran anatomi diidentifikasi dari Pubmed dan dipilih artikel yang dipublikasi dalam sepuluh tahun terakhir (2013-2022). Artikel yang sesuai dengan fokus review kemudian dilakukan screening dan sejumlah sembilan artikel memenuhi kriteria inklusi dalam review sistematik ini. Seluruh artikel dalam review sepakat menunjukkan bahwa pembelajaran menggunakan multimedia interaktif berbasis komputer meningkatkan pengetahuan anatomi setara dengan metode konvensional. Teknologi baru termasuk atlas 3D, AR, dan VR secara signifikan meningkatkan motivasi, ketertarikan, atensi, keterlibatan, dan kesenangan dalam pembelajaran anatomi dibandingkan dengan metode konvensional. Walaupun demikian, teknologi baru ini, khususnya VR, menginduksi ketidaknyamanan ringan pada sebagian pengguna dan tidak terjangkau pada seluruh pusat pembelajaran karena harga yang lebih mahal daripada metode konvensional. Dapat disimpulkan bahwa multimedia interaktif berbasis komputer direkomendasikan untuk diaplikasikan pada pusat pembelajaran tertentu sebagai media alternatif dalam pembelajaran anatomi mendampingi metode tradisional. Kata kunci: pembelajaran anatomi; multimedia interaktif; aplikasi berbasis komputer
Co-Authors . HERNAYANTI Fitranto Arjadi Harini, Ika Murti Ihtiaringtyas, Suci Joko Setyono Kuncoro, Prasetyo Tri Madya Ardi Wicaksono, Madya Ardi Mustofa Mustofa Nur Signa Aini Gumilas Octavia Permata Sari, Octavia Permata Rispriandari, Aulia Ayu Samodro, Pugud Sarmoko Sarmoko Setiawati Setiawati Soegianto, Jap Yulius Billy Soraya, Aristi Intan Susiana Candrawati Susiawan, Lieza Dwianasari Wahyudin Wahyudin