Article Per Year (5 Year)
p-Index From 2020 - 2025
0.562
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Gizi Kerja dan Produktivitas Journal of Health and Nutrition Research
Vevi Maritha
Pharmacy Study Program, Universitas Of PGRI, Madiun, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Potential Pharmaceutical Biotechnology Products in the Form of Formulations and Preparations of Telang Flower Kombucha Dish Soap (Clitoria ternatea L) as an Antibacterial from Beef (Bos taurus) Isolate Firman Rezaldi; Eva Nurvadilah; Candra Junaedi; Ucu Wandi Somantri; M. Fariz Fadillah; Vevi Maritha; Ratna Fitry Yenny; Diyan Yunanto Setyaji
Journal of Health and Nutrition Research Vol. 3 No. 1 (2024)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v3i1.237

Abstract

This research aims to see the potential of each formulation and preparation of dishwashing soap with the active ingredient telang flower kombucha in inhibiting the growth of pathogenic bacteria isolated from beef. This research is a laboratory experiment, namely by making a dishwashing soap base without the active substance of telang flower kombucha. Make a dishwashing soap base that adds the active substance of butterfly pea flower kombucha at concentrations of 20%, 30% and 40%. Biochemical identification results have shown that beef samples contain gram-positive bacteria in the form of Staphylococcus aureus and Listeria monocytogenes, as well as gram-negative bacteria in the form of Salmonella thyposa and Escherichia coli. The results of this research have also proven that pharmaceutical biotechnology products in the form of formulations and dishwashing soap preparations with the active ingredient telang flower kombucha have a positive correlation in inhibiting the growth of the four test bacteria. Based on the one-way ANOVA statistical test at each P value <0.05, it proves that telang flower kombucha dish soap at a concentration of 40% according to post hoc analysis is not significantly different from concentrations of 20% and 30% as a pharmaceutical and antibacterial biotechnology product. isolated from beef. The conclusion of this research is that the formulation and preparation of dishwashing soap at a concentration of 40% proved to be the most effective as a pharmaceutical biotechnology product in inhibiting the growth of the four test bacteria.
Antibakteri Keracunan Bahan Pangan Pada Formulasi Sediaan Sabun Mandi Kombucha Bunga Telang Sebagai Produk Bioteknologi Farmasi Dari 3 Lokasi Budidaya Maya Fadhillah; Firman Rezaldi; Ratna Fitry Yenny; Vevi Maritha; Novi Ayuwardani; Erni Suminar
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 10 No 1 (2024): Agustus 2024
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/ejbst.v10i1.586

Abstract

Pharmaceutical biotechnology products in the form of formulations and liquid bath soap preparations of butterfly pea flower kombucha can be used as a pharmaceutical or cosmetic preparation that has antibacterial properties that cause food poisoning and have previously been tested on formulations and preparations of hand washing soap made from the active ingredient of butterfly pea flower kombucha, so that in research The author is interested in using 3 locations for cultivating butterfly pea flower plants. This research aims to create a formulation and preparation of liquid bath soap using the active ingredient telang flower kombucha obtained from three cultivation locations, namely Pekuncen village, Cilegon city, Cinangka Anyer village, Serang district, and Banjarwangi village, Pandeglang district, Banten.  This research is an experimental laboratory, namely by making a liquid bath soap base without active substances, making a liquid bath soap base with the active ingredient of telang flower kombucha at concentrations of 20%, 30% and 40% obtained from 3 cultivation locations, and providing bath soap market as a positive control. The method for testing pharmaceutical preparations (cosmetics/liquid bath soap) is through disc diffusion. Data regarding the average diameter of the inhibition zone were analyzed through one-way ANOVA if there were significant differences followed by post hoc analysis. The results of this research have proven that each butterfly pea flower was cultivated from 3 locations and also made into a formulation and preparation of liquid kombucha bath soap. positively correlated in inhibiting the growth of the four tested bacteria. Based on one-way ANOVA analysis with each P value <0.05, further tests can be carried out in the form of post hoc analysis where the formulation and preparation of liquid bath soap made from the active ingredient of telang flower kombucha from 3 cultivation locations at a concentration of 40% is significantly different from a concentration of 20 % and 30% as an antibacterial that causes food poisoning, both produced from cultivation locations in Pekucen village, Cilegon city, Banten, Cinangka village, Serang district, Banten, and Banjarwangi village, Pandeglang district, Banten.
Studi Bioteknologi Komputasi (Bioinformatika) Senyawa Vitexin Pada Kombucha Bunga Telang Vitexin Sebagai Antioksidan dan Antikanker M. Fariz Fadillah; Firman Rezaldi; Raisa Fadila; Muhammad Andry; Barolym Tri Pamungkas; Syariful Mubarok; Susiyanti Susiyanti; Vevi Maritha
Jurnal Gizi Kerja dan Produktivitas Vol 5, No 1 (2024): May
Publisher : Fakultas Kedokteran Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/jgkp.v5i1.24993

Abstract

Manfaat minuman probiotik kombucha bunga telang sebagai produk hasil dari proses fermentasi menggunakan teknologi bioteknologi mengandung berbagai senyawa bioaktif atau metabolit sekunder yang berperan penting dalam menjalankan berbagai aktivitas farmakologinya sehingga memiliki potensi sebagai bahan aktif obat maupun kosmetik. Salah satu senyawa yang berperan penting dan diuji pada penelitian ini adalah vitexin yang berasal dari golongan flavonoid dan memiliki aktivitas sebagai antioksidan maupun antikanker. Tujuan dari penelitian ini adalah untuk membuktikan bahwa senyawa vitexin memiliki aktivitas dalam menangkal radikal bebas dan kanker secara in silico sebagai gambaran awal untuk pengembangan kandidat bahan aktif obat baru. Metode penelitian yang digunakan berbasis laboratorium kering menggunakan software bioinformatika. Adapaun software yang digunakan pada penelitian ini ialah Discovery Studio 2021, ChemDraw Ultra 8.0, ChemDraw Ultra 8.0 dan MGL Tools 1.5.7.   Langkah pertama yang dilakukan ialah mengunduh struktur protein (3ZBF) dari Protein Data Bank (PDB) dan membuat struktur ligan (vitexin). Selanjutnya dilakukan preparasi protein untuk mencegah kemungkinan gangguan dalam proses ikatan antara ligan dan reseptor serta preparasi ligan untuk mencapai bentuk optimal dari ligan yang memiliki konformasi terbaik. Langkah berikutnya adalah validasi docking dengan cara melakukan docking ligan bawaan terhadap protein untuk membandingkan ligan hasil proses docking (ligan validasi) dengan ligan bawaan dan melihat nilai Root Mean Square Deviation (RMSD). Hasil penelitian yang diperoleh yakni senyawa vitexin memiliki nilai energi bebas -6.97 kkal/mol, nilai konstanta inhibisi 7800 nM dan dapat berinteraksi pada asam amino protein ROS, antara lain GLU2027, MET 2029, LEU2086, ASP2033 dan GLY2032 dengan nilai RMSD 1.383 Å. Kesimpulan dari penelitian ini adalah penambatan senyawa vitexin yang terkandung pada kombucha bunga telang terhadap inhibitor ROS memiliki nilai RMSD < 2 Å, mampu berinteraksi dengan asam amino GLY2032 yang merupakan penyebab terjadinya resistensi terhadap inhibitor ROS (Crizotinib)serta dapat memberikan gambaran awal sebagai kandidat obat baru yang diregulasi untuk memiliki aktivitas farmakologi sebagai antioksidan maupun antikanker.
Co-Authors Candra Junaedi Diyan Yunanto Setyaji Erni Suminar Eva Nurvadilah Firman Rezaldi Firman Rezaldi Firman Rezaldi M. Fariz Fadillah M. Fariz Fadillah Maya Fadhillah Muhammad Andry Novi Ayuwardani Pamungkas, Barolym Tri Raisa Fadila Ratna Fitry Yenny Ratna Fitry Yenny Susiyanti Susiyanti Syariful Mubarok Ucu Wandi Somantri