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Ayuningtyas Istiqomah
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Medicine & Pharmacology

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Kajian Literatur: Suplementasi Vitamin D Mengurangi Tingkat Keparahan serta Mencegah dan Mengobati COVID-19 Ayuningtyas Istiqomah; Wahyu Utami
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p02

Abstract

Supplementation can play a supporting role in COVID-19 patients, one of which is the provision of vitamin D supplementation. This study aims to discuss and examine the existing evidence regarding the effect of vitamin D supplementation in reducing severity and preventing/treating COVID-19. The method used is a literature study from various library sources that can be accessed using the PubMed and Google Scholar databases with the keywords [(“Vitamin D” OR “Vitamin D2” OR “Vitamin D3”) AND (“COVID-19” OR “Coronavirus Disease 2019” OR “SARS CoV 2”)]. Sixty-eight studies met the inclusion and exclusion criteria and are therefore included in this literature review. This study shows that the lower the level of vitamin D in the body, the higher the severity of COVID-19. In addition, the use of vitamin D supplementation has a positive effect on COVID-19 by reducing the risk of being infected with COVID-19, reducing the risk of death, and reducing the severity of COVID-19. This could be because vitamin D can enhance the innate immune system which is the body's first line of defense against pathogens and regulate the adaptive immune system to reduce cytokine storms, and has a potential protective role against acute respiratory distress syndrome by inhibiting the renin-angiotensin pathway. Therefore, vitamin D supplementation can be used as an additional treatment for COVID-19.
Co-Authors Wahyu Utami