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All Journal Jurnal Ilmu Kesehatan Masyarakat Nurse and Health: Jurnal Keperawatan The Indonesian Journal of Infectious Diseases Medica Hospitalia Narra J
Adria Rusli, Adria
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENGARUH TINGKAT SPIRITUALITAS TERHADAP KUALITAS HIDUP PASIEN HIV/AIDS Fitri, Desi Yulia; Indawati, Eli; Suliati, Suliati; Rusli, Adria; Murtiani, Farida
Jurnal Ilmu Kesehatan Masyarakat Vol 19 No 3 (2023)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ikesma.v19i3.37292

Abstract

Perkembangan epidemi infeksi Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) menjadi masalah di seluruh dunia termasuk Indonesia. Penderita HIV/AIDS dalam kehidupan sehari-hari dituntut untuk mampu menghadapi masalah yang kompleks, baik fisik, psikis, maupun spiritual. Kompleksitas masalah yang dihadapi berdampak pada kualitas hidup penderita HIV/AIDS. Tujuan penelitian ini mengetahui pengaruh tingkat spiritualitas terhadap kualitas hidup pasien HIV/AIDS. Metode kuantitatif dengan rancangan penelitian deskriptif korelasional menggunakan pendekatan cross sectional. Sampel penelitian ini adalah pasien baru HIV yang pengobatan ARV sebanyak 44 pasien. Hasil penelitian menunjukkan rata-rata skor spiritualitas adalah 111,5 dan sebagian besar dengan tingkat spiritualitas kategori baik. Rata-rata skor kualitas hidup adalah 108,23 dan sebagian besar dengan tingkat kategori baik. Hasil uji statistic P value = 0,000 berarti ada pengaruh tingkat spiritualitas terhadap kualitas hidup pasien HIV/AIDS dengan korelasi kuat kearah postif.
Effect of Fixed‐Dose Combinations Antituberculosis and Separate Formulations on Clinical Symptoms, Weight Gain, Adverse Effect and Plasma Concentration in Tuberculosis and HIV Coinfection Cases Sundari, Titi; Mariana, Nina; Permatasari, Debby Intan; Rusli, Adria; Sitompul, Pompini Agustina; Rosamarlina, Rosamarlina; Widiantari, Aninda Dinar; Maemun, Siti; Lisdawati, Vivi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.867

Abstract

BACKGROUND: Fixed Dose Combination (FDC) was aimed to simplify TB therapy and facilitate physician and patient compliance. OBJECTIVE: We aimed to evaluate the effect of FDC antituberculosis and separate formulations (SF) on clinical symptoms, weight gain, adverse effect and plasma concentration in TB/HIV cases during the intensive phase. METHOD: Prospective cohort study was conducted in public hospital, Jakarta. We recruited TB-HIV patients in May 2018-May 2019. Patients (over than 18 years old) diagnosed with TB-HIV who consumed either FDC or SF and had not received antiretroviral. A total of 36 subjects were included in this study, 20 subjects in FDC group and 16 subjects in SF group. RESULT:  There was not significant different between FDC and SF groups with an improvement of clinical symptoms (P = 0.70) and weight gain (P = 1.00). Gastrointestinal syndrome was 75% in FDC group; 62.5 % in SF group. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration after 2 weeks therapy in FDC group were 5.49 mg/L (±3.40 mg/L), 1.35 mg/L (±1.20 mg/L), 19.87 mg/L (±17.00 mg/L), respectively. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration in SF group were 6.42 mg/L (±4.80mg/L), 0.87 mg/L (±0.70 mg/L), 5.03 mg/L (±7.60 mg/L), respectively. CONCLUSION: There was not significant different between FDC and SF groups on improvement of clinical symptoms and weight gain in intensive phase of therapy, the highest of adverse effects was gastrointestinal syndrome, and all subjects had normal reference ranges of rifampicin concentrations, and isoniazid and pyrazinamide below the normal range.
VIRAL LOAD AND OPPORTUNISTIC INFECTION AS THE INDICATOR OF QUALITY-OF-LIFE PEOPLE WITH HIV/AIDS Yuliaty, Rina; Rohman; Rayasari, Fitrian; Kurniasih, Dian Noviati; Aini, Nur; Shahroh, Yuni; Rusli, Adria; Maemun, Siti; Saadulloh, Dadang; Yunitri, Ninik
Nurse and Health: Jurnal Keperawatan Vol 13 No 2 (2024): Nurse and Health: Jurnal Keperawatan
Publisher : Institute for Research and Community Service of Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/nhjk.v13i2.690

Abstract

Background: Human immunodeficiency virus (HIV) is a significant concern in the field of global health. However, studies on the relationship between viral load, opportunistic infections, and quality-of-life among them are limited. Objectives: This study aims to determine the relationship between viral load count, the presence of opportunistic infection, and the quality-of-life among people living with HIV. Methods: A cross-sectional study was used involving 35 respondents recruited through convenience sampling. The quality-of-life of individuals living with HIV was assessed using the World Health Organization Quality-of-Life instrument for HIV. Statistical analysis using descriptive statistics, including mean, standard deviation, and proportion, and bivariate analysis with p-value<0.05. Results: Of the 35 participants, the majority were male (57.1%), with a mean age of 41.63 (9.09), and had a low education level (51.4%). The mean quality-of-life score was 86.88 (12.27), with a mean duration of ARV treatment of 7.23 years (5.36), undetectable viral load (68.6%), living with opportunistic infections (80%), and with tuberculosis being the most common (52.63%). There was a significant correlation between viral load and overall quality-of-life (p-value 0.04). Conclusion: The results of viral load testing and the identification of opportunistic infections can serve as indicators to assess the quality-of-life among people living with HIV. The outcomes of this study have practical implications for enhancing healthcare services in clinical settings. This information can guide the implementation of targeted interventions to strengthen social relationships and these individuals' environmental quality-of-life.
Hubungan Dukungan Keluarga Dengan Kepatuhan Terapi Antiretroviral Pada Orang Dengan HIV Khamid, Abdul; Azzam, Rohman; Yunitri, Ninik; Rayasari, Fitrian; Astuti, Widya; Rusli, Adria; Maemun, S.KM, M.Epid, Siti
The Indonesian Journal of Infectious Diseases Vol. 10 No. 2 (2024): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v10i2.201

Abstract

Latar belakang: Laju kasus HIV/AIDS di Indonesia dari laporan 34 provinsi di Indonesia sudah sangat mengkhawatirkan. Kumulatif kasus HIV sampai dengan Maret 2023 sebanyak 377.650 orang, sedangkan kasus AIDS sebanyak 145.037 orang. Tujuan penelitian ini untuk mengetahui hubungan dukungan keluarga dengan kepatuhan terapi ARV. Metode: Penelitian observasional dengan desain potong lintang dengan jumlah sampel sebesar 37 partisipan yang dipilih dengan teknik purposive sampling. Variabel independen adalah dukungan keluarga dimensi informasional, instrumental, emosional, dan penghargaan. Variable dependentnya kepatuhan terapi ARV. Hasil: Rata-rata usia responden 42,8 tahun, sebagian besar laki-laki (81,1%), berpendidikan SMA (68,5%), menikah (70,3%), memiliki komorbid (67,6%), dan berada pada stadium dua (56,8%) dengan cara penularan Non IDU (83,8%). Analisis lanjut membuktikan bahwa tidak ada hubungan yang signifikan antara dimensi dukungan keluarga dan kepatuhan pasien HIV (p>0,05). Kesimpulan: Tidak ada hubungan antara dukungan keluarga dan kepatuhan pasien HIV. Kepatuhan terhadap terapi ARV juga dipengaruhi oleh sosial demografi, fasilitas kesehatan, karakteristik pengobatan, penyakit, teman, dan Kelompok Dukungan Sebaya, serta faktor internal dalam diri Orang Dengan HIV AIDS (ODHIV), yaitu motivasi diri untuk tetap hidup dan melakukan aktifitas yang baik.
Biomarkers for predicting COVID-19 mortality: A study at Sulianti Saroso Infectious Disease Hospital, Indonesia Maemun, Siti; Widiantari, Aninda D.; Murtiani, Farida; Herlina, Herlina; Tanjungsari, Dian W.; Wijiarti, Kunti; Pratiwi, Tiara Z.; Matondang, Faisal; Rusli, Adria; Rivaldiansyah, Rivaldiansyah; Tampubolon, Maria L.; Mariana, Nina; Setiawaty, Vivi; Purnama, Tri B.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1936

Abstract

The high transmissibility and mortality rates of the COVID-19 pandemic pose significant challenges. Patients can deteriorate rapidly, making it crucial to identify laboratory biomarkers for high-risk individuals. The aim of this study was to evaluate the predictive value of various laboratory parameters, including C-reactive protein (CRP), D-dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and procalcitonin (PCT), in predicting COVID-19 mortality. A retrospective cohort study was conducted at Sulianti Saroso Infectious Disease Hospital, where COVID-19 patients were categorized into survivors and non-survivors. The Mann-Whitney test was used to assess group differences, while receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of each biomarker, with Youden's index (J) determining optimal cut-off values. Kaplan-Meier analysis was used to compare median survival times, and Cox regression assessed hazard rates and the relationship between biomarkers and mortality. A total of 1,598 patients were analyzed, the majority of whom were admitted with oxygen saturation levels >95% and classified as having mild to moderate disease severity. Among them, 216 patients died, resulting in a mortality rate of 13.52%. Significant variations in mortality rates were observed along the survival functions for NLR, ferritin, D-dimer, CRP, and PCT (p<0.001). The survival curves for these biomarkers demonstrated distinct trends across tertiles over time. Among hematological markers, NLR was significantly associated with mortality (p<0.001), with a 1.5–2.2% increased risk per unit increase. Biochemical markers (complete blood count) proved to be more effective than hematological parameters (NLR, ferritin, PT, D-dimer, CRP, PCT) when evaluating individual prognostic performance. Bivariate analysis of CRP, D-dimer, ferritin, NLR, PT, and PCT between survivors and non-survivors showed significant differences. Notably, NLR and PCT were highly relevant for predicting disease prognosis and mortality, with sensitivity and specificity values exceeding 80%.
Co-Authors Abdul Khamid, Abdul Azzam, Rohman Fitri, Desi Yulia Herlina Herlina Indawati, Eli Instiaty, Instiaty Kunti Wijiarti, Kunti Kurniasih, Dian Noviati Maemun, S.KM, M.Epid, Siti Maemun, Siti Matondang, Faisal Murtiani, Farida Nina Mariana, Nina Nur Aini Permatasari, Debby Intan Pratiwi, Tiara Z. Purnama, Tri B. Purwantyastuti Purwantyastuti Rayasari, Fitrian Rina Yuliaty, Rina Rivaldiansyah, Rivaldiansyah Rohman rosamarlina, rosamarlina Saadulloh, Dadang Shahroh, Yuni Sitompul, Pompini Agustina Suliati Suliati Tampubolon, Maria L. Tanjungsari, Dian W. Titi Sundari Vivi Lisdawati Vivi Setiawaty Widiantari, Aninda D. Widiantari, Aninda Dinar widya astuti Yunitri, Ninik