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All Journal Paediatrica Indonesiana Majalah Kesehatan FKUB Indonesian Journal of Obstetrics & Gynecology Science JOURNAL LA MEDIHEALTICO
Ema Alasiry, Ema
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The effect of bubble nasal continuous positive airway pressure application on saliva cortisol levels in full-term neonates Idrus, Noor Fadli; Febriani, Andi Dwi Bahagia; Alasiry, Ema
Paediatrica Indonesiana Vol 64 No 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.22-7

Abstract

Background Neonates with respiratory distress are commonly treated with bubble nasal continuous positive airway pressure (nCPAP) and undergo many procedures that cause stress-induced pain. Salivary cortisol is a biomarker of alteration in the hypothalamic-pituitary-adrenal axis caused by repeated and long-term exposure to stress. Objective To analyze the effect of bubble nCPAP use on salivary cortisol levels in full-term infants. Methods This study used a one-group pre-test­–post-test design to compare salivary cortisol levels before and 30 minutes after bubble nCPAP application. Salivary cortisol was measured using an ELISA method. Pain was also assessed at the same time points using the Neonatal Infant Pain Scale (NIPS) score. We included infants of 37 0/7 to 42 6/7 weeks’ gestational age with respiratory distress necessitating bubble nCPAP application. Infants with birth weight of <2,500 grams, major congenital anomalies, an APGAR score of <5 at 5 minutes, shock, and infants who had undergone surgery were excluded. Results A total of 38 subjects participated in this study. Prior to bubble nCPAP application, median cortisol levels were significantly lower (1.65 ng/mL) than after bubble nCPAP application (6.8 ng/mL) (p value?). There were no significant differences in cortisol increase based on gender, type of birth, or salivary cortisol sampling time. There were significant differences in pain level after the 30-minute nCPAP application. Conclusion An increase in cortisol levels and pain scale scores during administration of bubble nCPAP indicates a pain response in full-term neonates; therefore, this procedure should be accompanied by pain or stress management.
Hubungan 8 OHdG (8-Hydroxy-2- Deoxyguanosin) Urin Neonatus dan Preeklamsia Tannur, Sebastianus; Lukas, Efendi; Mailoa, Johnsen; Alasiry, Ema; Irianta, Trika; Chalid, Maisuri T.
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.582

Abstract

Pendahuluan: Preeklamsia merupakan penyakit dengan berbagai teori (disease of theory) yang menggambarkan ketidakpastian patofisiologi dan penyebabnya. preeklamsia bukan hanya menyebabkan komplikasi terhadap maternal namun juga menimbulkan komplikasi terhadap janin, baik jangka pendek maupun jangka panjang. Peningkatan jumlah radikal bebas merupakan tanda terjadinya stres oksidatif pada kehamilan dengan preeklamsia. 8-OHdG adalah produk utama yang dibentuk dari radikal hidroksil pada residu guanine DNA.Metode: Penelitian ini merupakan penelitian analitik yang dikembangkan dengan desain penelitian cross-sectional. Sampel penelitian adalah neonatus yang lahir dari wanita hamil dengan dan tanpa didiagnosa preeklamsia. Pengambilan sampel dilakukan secara purposive sampling. dilakukan di Rumah Sakit Wahidin Sudirohusodo,dan rumah sakit jejaring pendidikan. Pengujian/running sampel dilakukan di unit Laboratorium Penelitian RSPTN Universitas Hasanuddin dengan metode Elisa. Data dianalisis dengan uji Chi squae, uji Mann whitney dan uji Kruskal wallis Hasil: Hasil penelitian yang telah dilakukan terdapat sebanyak 82 orang yang terbagi menjadi 41 orang sampel yang merupakan kelompok dengan preklamsia dan 41 orang sampel kelompok kontrol (normal). Berdasarkan hasil penelitian yang telah dilakukan mengenai kadar 8-OHdG urin neonatus (8-hydroxy-2- deoxyguanosin) pada kehamilan dengan Preeklamsia diperoleh nilai rerata kadar 8-OHdG urin neonatus pada kehamilan normal sebesar 3.79±1.99, sedangkan kehamilan dengan preeklamsia sebesar 14.25±16.81. uji statistik chi-square menunjukkan nilai p sebesar 0.00 dimana nilai p<0.05 yang artinya terdapat perbedaan kadar 8-OHdG urin neonatus terhadap kejadian preeklamsia dan ibu hamil normal pada penelitian ini. Kesimpulan: Terdapat perbedaan yang signifikan bermakna kadar 8-OHdG urin neonatus yaitu lebih tinggi kadar pada ibu hamil penderita preeklamsia daripada ibu hamil normal.Relationship Between 8 OHdG (8-Hydroxy-2- Deoxyguai›osine) in Neonate Urine and PreeclampsiaAbstractIntroduction: Preeclampsia is a disease with various theories (disease of theory) that describes the uncertainty of its pathophysiology and causes. Preeclampsia not only causes complications for the mother but also causes complications for the fetus, both short and long term. An increase in the number of free radicals is a sign of oxidative stress in preeclampsia. 8-OHdG is the main product formed from hydoxyl radicals in DNA guanine residues. Method: The research was an analytical study developed with a cross-sectional research design. The research sample was neonates born to pregnant women with and without a diagnosis of preeclampsia. The sample was determined by using purposive sampling technique carried out at Wahidin Sudirohusodo Hospital and educational network hospitals. Sample testing was carried out at Hasanuddin University RSPTN Research Laboratory unit using Elisa method. Data were analyzed using Chi square test, Mann Whitney test, and Kruskal Wallis test. Results: The research was carried out to 82 people who were divided into 41 samples in the group with preeclampsia and 41 samples in the control group (normal). Based on the results of research that has been carried out regarding the level of 8-OHdG in neonate urine (8-hydroxy-2-deoxyguanosine) in pregnancies with preeclampsia, the mean value of 8-OHdG level in neonate urine in normal pregnancies is 3.79 z 1.99, while the one in pregnancies with preeclampsia it is 14.25 z 16.81. The chi-square statistical test shows a p value 0.00 which p value <0.05, which means that there is a difference in the level of 8-OHdG in neonate urine in the occurrence of preeclampsia and normal pregnant women. Conclusion: There is a significant difference between the level of 8-OHdG in neonate urine, where the level is higher in pregnant women with preeclampsia than in normal pregnant women.Key words: 8-OHdG, neonate urine, preeclampsia
DETEKSI BAKTERI ATIPIKAL DARI SWAB NASOFARING PENDERITA SEPSIS NEONATORUM DI RS WAHIDIN SUDIROHUSODO MENGGUNAKAN POLYMERASE CHAIN REACTION (PCR) MULTIPLEKS Fadhilah; Sjahril, Rizalinda; Hatta, Mochammad; Bahagia, Dwi; Alasiry, Ema; Tarini, Ni Made Adi
Majalah Kesehatan Vol. 11 No. 4 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.04.1

Abstract

Sepsis neonatorum merupakan penyebab signifikan kematian neonatorum dan morbiditas jangka panjang. Infeksi bakteri atipikal berperan penting dalam sepsis neonatorum, namun sulit dideteksi dengan teknik mikrobiologi konvensional. Penelitian ini bertujuan untuk mendeteksi bakteri atipikal yaitu Chlamydia trachomatis, Mycoplasma pneumonia, Legionella pneumophila dan Ureaplasma urealyticum dengan Polymerase Chain Reaction (PCR) multipleks dari swab nasofaring pasien sepsis neonatorum yang dirawat di RS Wahidin Sudirohusodo Makassar. Penelitian ini merupakan penelitian observasional deskriptif pada neonatus dengan dugaan sepsis. Neonatus yang diduga sepsis akan diambil swab nasofaring kemudian diperiksa untuk mendeteksi Chlamydia trachomatis, Mycoplasma pneumonia, Legionella pneumophila dan Ureaplasma urealyticum menggunakan PCR multipleks. Pemeriksaan pasien sepsis neonatorum yang dirawat di NICU RS Wahidin Sudirohusodo Makassar menggunakan sampel swab nasofaring pada bulan September 2022 hingga Juni 2023 menunjukkan bahwa dari 60 pasien yang diperiksa swab nasofaring, 8 (13,33%) pasien terdeteksi infeksi tunggal bakteri atipikal  yaitu Mycoplasma pneumonia, Chlamydia trachomatis dan Legionella pneumophila serta 12 pasien (20%) di antaranya adalah infeksi multipel yaitu Mycoplasma pneumoniae dan Chlamydia trachomatis; Legionella pneumophila dan Chlamydia trachomatis; Mycoplasma pneumoniae, Chlamydia trachomatis dan Legionella pneumophila. PCR merupakan modalitas yang menjanjikan untuk mendeteksi bakteri atipikal dari swab nasofaring pasien sepsis neonatorum yang sulit diidentifikasi dengan teknik konvensional. Hal ini sangat berguna untuk memberikan terapi yang cepat dan tepat pada pasien sepsis neonatorum.
The Relationship Between Maternal and Fetal Factors with Anorectal Malformations Akbar, Puang Hafsari; Darussalam, Andi Husni Esa; Baharuddin, Baharuddin; Alasiry, Ema; Gani, Aziz Beru
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2175

Abstract

Children with Anorectal Malformations (ARM) may experience lifelong physical impairment if not treated properly, and may adversely affect the personal and economic existence of affected individuals, as well as families and communities. The purpose of this study was to determine the factors of the incidence of anorectal malformations in neonates from maternal aspects and fetal aspects. By using research methods in the form of literature studies from the search results of 62 findings and 38 literature based on Electronic Based. The results of the discussion state that maternal risk factors that contribute to the incidence of ARM include exposure to teratogens such as cigarettes, alcohol, pesticides, drugs, and radiation during pregnancy. And fetal risk factors that contribute to the incidence of ARM include genetic and chromosomal factors, including related syndromes such as Down syndrome and VACTERL, which are the main causes of ARM.
Co-Authors Ahmad, Mardiana Akbar, Puang Hafsari Andi Nilawati Usman Arbie, Rina Sulisthia Bahagia, Dwi Baharuddin Baharuddin Budu - Bukhari, Agussalim Darussalam, Andi Husni Esa Efendi Lukas Fadhilah Febriani, Andi Dwi Bahagia Gani, Aziz Beru Idrus, Noor Fadli Mailoa, Johnsen Maisuri T. Chalid, Maisuri T. Mochammad Hatta Ni Made Adi Tarini Riza Linda Tannur, Sebastianus Trika Irianta