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All Journal BALI MEDICAL JOURNAL (BMJ) Health Information : Jurnal Penelitian Journal of Health Quality Development (JHQD) Jurnal Kesehatan dr. Soebandi Jurnal Ilmiah Kesehatan Sandi Husada
Veny Hadju, Veny
Faculty of Medicine, Hasanuddin University, Makassar-Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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ANTI-PLASMODIUM FALCIPARUM IN VITRO ACTIVITY OF CALOPHYLLUM BICOLOR EXTRACT: Morphology and Ultra Structure Kaseke, Martha Marie; Hadju, Veny; Karim, Syafruddin; Nurdin, Armyn
BALI MEDICAL JOURNAL Vol 4 No 3 (2015)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.546 KB)

Abstract

Background: Anti-malarial resistance of Plasmodium, such as chloroquine becoming a health problem worldwide. This research aims to evaluate the in vitro anti-plasmodium activity of hexane fraction extract of Calophyllum bicolor (C. bicolor) against culture of Plasmodium falciparum (P. falciparum) 3D7 and determine its inhibitor concentration of 50% (IC50); to observe the microscopic changes of P. falciparum after exposed to the hexane fraction of C. bicolor extract and to observe the ultra structure changes of P. falciparum 3D7 after being exposed to hexane fraction of C. bicolor extract. Method: This research applied quasi experimental with post-test only control group design. Anti malarial activity test of hexane fraction of C. bicolor extract towards Plasmodium falciparum 3D7 2% was undertaken over 48 hours with in vitro incubation technique. The level of parasitemia was observed using binocular optical microscope with 1000x magnification by counting the infected erythrocytes with Giemsa color technique. Then it was analyzed to determine the level of inhibitor concentration of 50% (IC50) of the C. bicolor extract. The next step is to observe the changes of parasite’s morphologic and ultra structure after the 24 and 48 hours incubation of the parasite P. falciparum 3D7 with hexane fraction of C. bicolor, IC50. Then, the morphologic change of P. falciparum 3D7 was observed with optical binocular microscopy and the ultra structure changes with Transmission Electron Microscopy (TEM). The changes of morphologic and ultra structure were analyzed qualitatively. Results: The research revealed that hexane fraction of the C. bicolor extract inhibited the growth of the parasite P. falciparum 3D7 with the value of -49.00±2.54, 12.53±3.13, 23.01±1.10, 27.68±4.23, 48.65±18.71, 70.82±4.67, 80.52±6.17% with the hexane extract concentration of 0, 0.001, 0.01, 0.1, 1, 10, 100, and 1000 µg/mL. This research also found that the inhibitor concentration of 50% (IC50) of hexane fraction of C. bicolor extract was 3.94 µg/mL in 10-7 which could change the morphologic and ultra structure of P. falciparum 3D7. There were several changes in morphology of the parasite over 24 hour incubation compared with the control group, i.e. the nucleus of young tropozoid became thicker, darker, and smaller; the skizon were condensate, thicker, darker, karyorrhexis and demolition of membrane. Hexane fraction of C. bicolor extract also changes the ultra structure over 24 hour incubation, i.e. vacuole membrane boundary and hemozoin were unclear. Over 48 hours of incubation the nucleus and cytoplasm bigger than those in the control group. Conclusion: Hexane fraction of the C. bicolor extract showed a strong anti plasmodium activity towards the in vitro culture of P. falciparum 3D7 at the level of (IC50) 3.94 µg/mL. The Hexane fraction of C. bicolor extract could change the morphology and ultra structure of P. falciparum 3D7 in vitro.
Tinjauan Sistematis Pendekatan Terapi Spiritual Alquran pada Pasien Skizofrenia Rosyanti, Lilin; Hadju, Veny; Hadi, Indriono; Syahrianti, Syahrianti
Health Information : Jurnal Penelitian Digitalisasi Versi Cetak
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (762.643 KB) | DOI: 10.36990/hijp.v10i1.103

Abstract

Schizophrenia is a major psychiatric disorder characterized by changes in perception, thought, affect, and behavior. Some therapeutic approaches in schizophrenic patients are psychoreligious or psychospiritual therapy. Psychoreligious / psychospiritual therapy will generate self-confidence and a sense of optimism. These two things (self-confidence and optimism) are important for healing from a disease in addition to drug therapy and other medical measures. Al-Quran therapy is a healing therapy and solution for physical, spiritual and social diseases for Muslims. Listening to and reading the Qur'an scientifically has a calming effect, promotes relaxation, and eliminates negative physical and mental disorders, stimulates the release of endorphins in the brain, which has a positive effect on mood and memory, focuses on positive thoughts and experiences, distracts negative thoughts , reduce stress, anxiety, and depression, become a non-pharmacological treatment to complement existing therapies.
Basil Seeds Infused Water Increases Hemoglobin Levels in Adolescent Women in Jember Widiyanti, Febrina Artha; Arifuddin, Sharvianty; Ahmad, Mardiana; Hadju, Veny; Nontji, Werna; Aryandy, Andi
Jurnal Kesehatan dr. Soebandi Vol 11 No 2 (2023): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v11i2.507

Abstract

Anemia is a condition of decreased hemoglobin levels, hematocrit and erythrocyte count and requires the availability of sufficient iron and protein so that hemoglobin synthesis can be carried out. Basil seeds are a good source of micronutrients and have excellent antioxidant potential for health and can be used as an attractive beverage with various benefits. This study aims to determine the effect of giving Basil Infused Water on increasing Hemoglobin levels which is expected to be a solution to prevent anemia in young women as a preparation for becoming a mother so that complications do not occur during a future pregnancy. Materials and This research was conducted at the Nuris Islamic Boarding School, Jember Regency. This research is a Quasy Experiment with a blinded pre-post test group design . The sample used was 52 young women. Sampling by purposive sampling in accordance with the inclusion criteria. Data analysis using statistical tests paired T-test and Independent T-Test . The study showed that there was an increase in hemoglobin levels in young women after being given intervention in the form of basil infused water for 90 days with a total of three times a week. The statistical test results showed that there was a mean difference of 1.6423 gr/dl and statistically significant with p = 0.000 where p <0.05 which means there was an increase in hemoglobin levels before and after being given basil seeds infused water . Keyword: Basil Seeds, Hemoglobin, Adolescent Women
Pengaruh Latihan Bantuan Hidup Dasar Terhadap Tingkat Pengetahuan dan Keterampilan dalam Menolong Korban Tenggelam pada Siswa Madrasah Aliyah Negeri 2 Kota Tidore Kepulauan Ade, Deliasani; Hadju, Veny; Perdana, Nurdin
Journal of Health Quality Development Vol. 4 No. 1 (2024): Juni 2024, JHQD
Publisher : Unit Publikasi Ilmiah Perkumpulan Intelektual Madani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51577/jhqd.v4i1.576

Abstract

Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan keterampilan siswa dalam menolong korban tenggelam sebelum dan sesudah dilakukan latihan BHD dan mengetahui efektifitas metode yang digunakan dalam mengukur tingkat pengetahuan dan keterampilan siswa untuk menolong korban tenggelam setelah dilakukan latihan BHD. Penelitian ini merupakan penelitian quasy experimen with pre-post test control group design. Sampel yang digunakan berjumlah 70 orang siswa, analisa data yang digunakan adalah analisa univariat dan bivariat. Responden terbagi menjadi dua kelompok yang terdiri dari kelompok perlakuan 35 orang dan kelompok kontrol 35 orang. Instrumen yang digunakan adalah kuesioner tentang tingkat pengetahuan BHD. Data yang dianalisis menggunakan ananalisa univariat dan bivariate. Hasil Penelitian ini menunjukan bahwa hasil uji statistic didapatkan adanya pengaruh latihan BHD terhadap tingkat pengetahuan menolong korban tenggelam pada siswa Madrasah Aliyah Negeri 2 Tidore Kepulauan kelas XI. Pada post test kelompok kontrol maupun kelompok intervensi didapatkan p value = 0,000. Hal tersebut berarti bahwa ada pengaruh namun tidak bermakna. Dengan demikian para siswa perlu adanya motivasi dan minat belajar yang tinggi, khususnya dalam melakukan BHD agar dapat melakukan hal hal yang positif khusunya BHD. Dalam hal ini mereka lebih terampil melakukan penanganan yang cepat dan tepat untuk menolong korban yang mengalami henti nafas dan henti jantung dalam konidisi darurat.
Determinants of chronic energy deficiency (CED) in pregnant women in stunting Irma, Irma; Rahman, Sugirah Nour; Ryska, Hasra; Hadju, Veny
Jurnal Ilmiah Kesehatan Sandi Husada Vol 14 No 1 (2025): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v14i1.1282

Abstract

Introduction: Chronic Energy Deficiency (CED) in pregnant women is a condition resulting from prolonged malnutrition, particularly insufficient energy and protein intake. This condition significantly increases the risk of maternal and infant mortality, low birth weight (LBW), and contributes to stunting in children. This study aims to identify the determinants influencing the incidence of CED among pregnant women in the stunting. Method: A cross-sectional observational study was conducted among 201 pregnant women selected through purposive sampling from 30 stunting-prone villages. Data collection involved Android-based questionnaires and anthropometric measurements using Mid-Upper Arm Circumference (MUAC). Statistical analyses included chi-square tests for bivariate analysis and logistic regression for multivariate analysis. Results: The prevalence of CED among the participants was 15.9%. Significant factors associated with CED included maternal age (p=0.000; OR=2.79; 95% CI: 1.67–4.64), employment status (p=0.016; OR=6.73; 95% CI: 1.58–27.94), antenatal care visits (p=0.004; OR=11.31; 95% CI: 2.71–28.19), pregnancy spacing (p=0.023; OR=6.80; 95% CI: 1.31–26.8), family smoking history (p=0.002; OR=0.45; 95% CI: 0.27–0.75), and family income (p=0.013; OR=5.24; 95% CI: 1.73–26.02). Conclusion: CED among pregnant women is significantly influenced by age, occupational status, antenatal care frequency, pregnancy interval, family exposure to cigarette smoke, and low household income. Strengthening antenatal care services, promoting family planning, enhancing nutrition education, and mitigating environmental risk factors such as secondhand smoke exposure are essential strategies to reduce CED and its adverse health outcomes.
Co-Authors Ade, Deliasani Ahmad, Mardiana Armyn Nurdin Aryandy, Andi Burhanuddin Bahar Hasra Ryska Hasriani, St. Indriono Hadi Irma Irma Lilin Rosyanti Martha Marie Kaseke Nurdin Perdana Rahman, Sugirah Nour SHARVIANTY ARIFUDDIN, SHARVIANTY Singrang, Andi Wardihan Suryani As’ad Syafruddin Karim, Syafruddin Syahrianti Syahrianti Werna Nontji, Werna Widiyanti, Febrina Artha