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PERBEDAAN KADAR KOLESTEROL TOTAL PASIEN PENYAKIT JANTUNG KORONER DENGAN DIABETES MELITUS DAN TIDAK DIABETES MELITUS Sari, Desy Puspita; Pratiwi, Dewi Indah Noviana; Yuliana, Ida
Jurnal Berkala Kedokteran Vol 11, No 1 (2015): Februari 2015
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.191

Coronary heart disease (CHD) is the major cause of deathÂ in the world.CHD is constriction or occlusion of arteries which supply blood flow to heart muscle with the result lack of blood oxygen supply because atherosclerosis process or spasm or both. The incidence of atherosclerosis at large artheries increase in diabetes melitus (DM) patients.DM is a major risk factor for CHD pathogenesis. One of risk factor for CHD in DM patients is theÂ increase ofÂ cholesterol level, a lipid metabolism abnormality.This study aimed to analyze the comparation of total cholesterol between CHD with DM and without DM in RSUD Ulin Banjarmasin period June-August 2014. This study was analytic observational with cross-sectional approach and used consecutive sampling. The total ofÂ sample was 60 patients which contain 30 CHD with DM patients and 30 CHD without DM patients. The result showed the mean of CHD with DM patientsâs cholesterol total level was 230,50 mg/dL and the mean of CHD without DM patientâs was 197,47 mg/dL.The data anlysis result using independent T-test showed that there is significant difference of cholesterol total level between CHD with DM patients and CHD witout DM patients (p=0,007) in RSUD Ulin Banjarmasin.Â Keywords: coronary heart disease (CHD), diabetes melitus (DM), total cholesterol

Molecular Docking of the Interaction between Citrus amblycarpa Extract Contents and Inflammatory Proteins of Hepatic Steatosis Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Idhafi, Nasrul; Febriansyah, Muhammad; Budiarman, Andi Azizah Maulidia
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin proteins, respectively. Similar to curcumin–adiponectin complex interaction, neoeriocitrin–adiponectin interaction involves GLY 223, PRO41, and VAL93 residues. Thus, the most potent inhibitor of hepatic sterosis marker was neoeriocitrin.

Correlation Between RET-He and Quality of Life in Chronic Kidney Disease Patients with Routine Hemodialysis: A Study at Ulin General Hospital Banjarmasin Fariz, Adlan; Rudiansyah, Mohammad; Kurniaatmaja, Enita Rakhmawati; Wulandari, Nanik Tri; Pratiwi, Dewi Indah Noviana
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.132

Background: The 2018 Riskesdas report revealed that the incidence of chronic kidney disease (CKD) affects 0.38% of Indonesia’s population. Anemia frequently complicates CKD, especially in patients undergoing regular hemodialysis. Reticulocyte hemoglobin equivalent (RET-He) assesses hemoglobin content in reticulocytes, indicating iron availability for erythropoiesis in the bone marrow. CKD significantly impacts patients' socio-economic status, heightening morbidity and mortality while diminishing quality of life. The relationship between RET-He and the quality of life in CKD patients on routine hemodialysis remains unclear. Objective: To investigate the correlation between RET-He and quality of life in CKD patients undergoing routine hemodialysis. Methods: A cross-sectional observational analytical study with data from medical records of CKD patients receiving routine hemodialysis between October 1st and October 30th, 2021. The Spearman correlation test was used for analysis. Results: This study included 92 patients, consisting of 40 males and 52 females, with a median age of 50 years and RET-He values at 31. Quality of life metrics included physical function (800, range: 0-1000), physical limitations (300, range: 0-400), body pain (175, range: 75-255), general health (475, range: 225-600), vitality (320, range: 200-400), social function (175, range: 75-200), emotional limitations (300, range: 100-300), and mental health (380, range: 160-500). The correlation analysis revealed no significant relationships: physical function (p=0.359), physical limitations (p=0.813), body pain (p=0.373), general health (p=0.547), vitality (p=0.616), social function (p=0.828), emotional limitations (p=0.482), and mental health (p=0.136). Conclusion: There is no significant correlation between RET-He levels and the quality of life in CKD patients undergoing regular hemodialysis.

LITERATURE REVIEW: POLA KEPEKAAN SALMONELLA TYPHI TERHADAP ANTIBIOTIK PADA PASIEN DEMAM TIFOID ANAK Batosamma, Novatalia; Muthmainah, Noor; Rahmiati, Rahmiati; Pratiwi, Dewi Indah Noviana; Hayatie, Lisda
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11476

Typhoid fever is one of the major health problems in the world, especially in developing countries. The highest typhoid fever morbidity is found in children, especially school age children. Patients often self-medicate with antibiotics, the main antibiotic of choice for typhoid fever in Indonesia is chloramphenicol but in some places resistance to the chloramphenicol group has been reported. When writing, related literature is examined using search results from Google Scholar and PubMed - MEDLINE, two medical journal databases. articles from 2012 to 2019 that were published in English. This literature study contained a total of 8 papers. The article published in this literature review shows the presence of resistant isolates in the Salmonella thypi antibiotic susceptibility test in the main therapy given. In some cases, they have resistance to ceftriaxone, cefuroxime, amoxicillin, ampicillin, ciprofloxacin, augmentin, fluoroquinolones, azithromycin, and nalidixic acid. Some of the drugs mentioned as sensitive to S. Typhi are Cefixime, ceftriaxone, chloramphenicol, ofloxacin, cefepime, quinolones, and third generation cephalosporins.

KORELASI KADAR MASSA OTOT DAN KUALITAS HIDUP PADA PASIEN YANG MENJALANI HEMODIALISIS RUTIN DI RSUD ULIN BANJARMASIN Ariewardana, Angger; Rudiansyah, Mohammad; Pratiwi, Dewi Indah Noviana; Cahyawati, Wiwit Agung Sri Nur; Marisa, Dona
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13180

Abstract: Chronic Kidney Disease (CKD) is defined as kidney damage or a decrease in the gromerular filtration rate that occurs for 3 months or more, manifesting as kidney damage and requiring kidney replacement therapy, namely hemodialysis. CKD sufferers often experience an energy imbalance due to anorexia which increases energy needs while energy reserves are depleted. Muscle mass levels function as bone moving organs. Muscle mass will be measured using the BIA (Bioimpedance Analysis). Low muscle mass is often associated with low quality of life. Quality of life is an assessment of several aspects of life. Hemodialysis therapy will affect quality of life including lack of energy, fatigue and stress. Quality of life can be measured using the SF-36 questionnaire. This study was to regulate the correlation among muscle mass levels and the level of quality of life of routine hemodialysis patients at RSUD Ulin Banjarmasin. The research method uses analytical observational with a cross-sectional approach. The technique for taking subjects was simple random sampling of 60 subjects. Data collection was carried out by direct measurements and interviews of muscle mass levels and quality of life. Data analysis used the Komolgorov-Smirnov normality test and continued with test called Pearson correlation test. The results of data analysis showed a strong significant correlation (p=0.000, r=0.706). The results of the study concluded that muscle mass levels had a significant correlation with the level of quality of life of hemodialysis patients at RSUD Ulin Banjarmasin. Keywords: Muscle mass, quality of life, hemodialysis, BIA (Bioimpedance analysis), questionnaire QOL Short Form-36. Abstrak: Penyakit ginjal kronis (PGK) didefinisikan sebagai kerusakan ginjal atau penurunan laju filtrasi gromerulus yang terjadi selama 3 bulan atau lebih bermanifestasi sebagai kerusakan ginjal dan memerlukan terapi pengganti ginjal yaitu hemodialisis. Penderita PGK sering mengalami ketidakseimbangan energi akibat anoreksia yang meningkatkan kebutuhan energi sementara asupan energi cadangan habis. Kadar massa otot berfungsi sebagai organ penggerak tulang. Massa otot dapat diukur salah satunya dengan menggunakan alat BIA (Bioimpedance analysis). Rendahnya massa otot kerap dihubungkan dengan rendahnya kualitas hidup. Kualitas hidup merupakan penilaian beberapa aspek dalam kehidupan. Terapi hemodialisis akan mempengaruhi kualitas hidup meliputi kekurangan energi, kelelahan, dan stress. Kualitas hidup dapat diukur salah satunya menggunakan kuesioner SF-36. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar massa otot dan kualitas hidup pasien hemodialisis rutin di RSUD Ulin Banjarmasin. Metode penelitian menggunakan observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan subjek dengan simple random sampling sebanyak 60 subjek. Pengambilan data dilakukan dengan pengukuran dan wawancara langsung kadar massa otot dan kualitas hidup. Analisis data menggunakan uji normalitas Komolgorov-Smirnov dan dilanjutkan dengan uji korelasi Pearson. Hasil analisis data terdapat korelasi bermakna kuat (p=0,000, r=0,706). Hasil penelitian menyimpulkan kadar massa otot terdapat korelasi bermakna dengan kualitas hidup pasien hemodialis di RSUD Ulin Banjarmasin. Kata-kata kunci: Massa otot, kualitas hidup, hemodialisis, BIA (bioimpedance analysis), kuesioner QOL Short form-36.

HUBUNGAN KADAR ALBUMIN DAN KEKUATAN OTOT GENGGAMAN Farsya, Aqila Layyina; Rudiansyah, Mohammad; Pratiwi, Dewi Indah Noviana; Muttaqien, Fauzan; Bakhriansyah, Mohammad
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13212

Abstract: Hemodialysis (HD) is one of the treatments for chronic kidney disease (CKD). CKD patients can experience increased permeability at the glomerular level. This can cause a decrease in albumin levels and handgrip strength (HGS). This study aimed to determine the relationship between albumin levels and handgrip strength in patients undergoing routine hemodialysis at RSUD Ulin Banjarmasin. This study type is analytical observational with a cross-sectional design. Subjects were selected by a simple random sampling method. Albumin levels were measured in the clinical pathology laboratory, while HGS was measured using a Camry electronic hand dynamometer model EH101. The research subjects were patients aged 18-60 years who underwent routine hemodialysis twice a week for at least 3 months. The research results from 72 subjects showed that the female gender group, age 51-60 years, and HD duration of 3-36 months were the most common. The proportion of normal albumin levels was 81%, while hypoalbuminemia was 19%. The proportion of normal HGS was 17%, while 83% were weak. The Fisher's Exact test results showed no relationship (p=0.439) between albumin levels and handgrip strength in patients undergoing hemodialysis. Keywords: albumin levels, handgrip strength, hemodialysis Abstrak: Hemodialisis (HD) merupakan salah satu terapi terapi penyakit ginjal kronik (PGK). Pasien PGK dapat megalami peningkatan permeabilitas di glomerulus. Hal itu dapat menyebabkan penurunan kadar abumin dan kekuatan otot genggaman. Tujuan penelitian ini yaitu untuk mengetahui hubungan kadar albumin dan kekuatan otot genggaman pada pasien yang menjalani hemodialisis rutin di RSUD Ulin Banjarmasin. Jenis penelitian ini berupa analitik observasional dengan rancangan cross sectional. Pengambilan sampel dilakukan dengan simple random sampling. Kadar albumin diukur di laboratorium patologi klinik, sedangkan kekuatan otot genggaman diukur menggunakan camry electronic hand dynamometer model EH101. Subjek penelitian adalah pasien berusia 18-60 tahun yang menjalani hemodialis rutin 2 kali dalam seminggu minimal 3 bulan. Hasil penelitian dari 72 subjek menunjukkan bahwa kelompok jenis kelamin perempuan, usia 51-60 tahun, dan lama HD 3-36 bulan paling banyak ditemukan. Proporsi kadar albumin normal sebesar 81%, sedangkan hipoalbuminemia sebesar 19%. Proporsi kekuatan otot genggaman normal sebesar 17%, sedangkan lemah sebesar 83%. Hasil uji Fisher’s exact menunjukkan bahwa tidak terdapat hubungan (p=0.439) kadar albumin dan kekuatan otot genggaman pada pasien yang menjalani hemodialisis. Kata-kata kunci: albumin, kekuatan otot genggaman, hemodialisis

The Influence of inflammatory factors (IL-6, CRP, NLPR, D-Dimer, LDH) on the PaO2/FiO2 ratio, in patients with severe and critical degrees of COVID-19 Harnoto, Yulia Octaviany; Assagaf, Ali; Pratiwi, Dewi Indah Noviana; Isa, Mohamad; Nurrasyidah, Ira; Kusumawardhani, Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.1014

BACKGROUND: Several types of inflammatory biomarkers that are important in severe and critical Covid-19 infections include: levels of IL-6, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-Dimer and neutrophil-lymphocyte platelet ratio (NLRP), which are independent variables. Meanwhile, the severity of Covid-19 infection can be determined by measuring the PaO2 /FiO2 ratio. However, the relationship between the PaO2/FiO2 ratio as the dependent variable is not yet known. AIMS: To analyze the relationship between PaO2/FiO2 ratio and inflammatory biomarkers in COVID-19 patients METHOD: An analytic observational study with a retrospective, cross-sectional approach. The research sample consisted of PCR-confirmed severe and critical COVID-19 patients who were treated in the isolation room of the Ulin Hospital in Banjarmasin from August–December 2021, who met the inclusion and exclusion criteria. Data analysis used the Spearman test to see the relationship between the PaO2/FiO2 ratio and various inflammatory markers. RESULT: 52 severe and critical patients were observed according to the research flow. The number of male and female subjects (32/20) was found. The mean age was 55.38 years. The correlation test found that: there was no significant relationship between the PaO2/FiO2 ratio and IL-6 (p = 0.964), but there was a negative correlation between the PaO2/FiO2 ratio and: a).CRP (p = 0.038), b).LDH ( p<0.001), c).NLPR (p = 0.013), and d). D-dimer (p<0.001). The inflammatory biomarkers NLPR, LDH, and D-dimer are important independent variables for the severity of COVID-19, namely the PaO2/FiO2 ratio. CONCLUSION: There are a significant correlation between the PaO2/FiO2 ratio to measure the severity of Covid-19 and several inflammatory biomarkers CRP, LDH, NLPR and D-dimer

Pengaruh Ekstrak Kulit Limau Kuit (Citrus Amblycarpa Hassk) Terhadap Perlemakan Hepar Tikus (Rattus Norvegicus) Yang Diberi Diet Tinggi Lemak Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Maghfirah, Yolanda Sajjida; Amalia, Aysca Fakhira
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 10, No 2 (2023): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v10i2.11053

Akumulasi trigliserida di hepar dapat terjadi akibat diet tinggi lemak yang berlebihan, sehingga dapat menginduksi terjadi inflamasi dan stres oksidatif di hepar. Perlemakan hepar secara histopatologis ditandai oleh adanya steatosis. Tanaman Limau Kuit (Citrus amblycarpa Hassk) sebagai tanaman lokal Kalimantan Selatan memiliki manfaat dalam menghambat pembentukan akumulasi lemak berlebihan karena kulit jeruk Limau Kuit mengandung alkaloid, saponin, triterpenoid, tanin, dan flavonoid. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak kulit Limau Kuit (Citrus amblycarpa Hassk) terhadap perlemakan hepar tikus (Rattus norvegicus) yang diberi diet tinggi lemak. Metode penelitian adalah true experimental design dengan posttest with control group design dengan 6 kelompok, yaitu KI (diet standar + akuades, KII (diet tinggi lemak + akuades), KIII (diet tinggi lemak + orlistat), KIV (diet tinggi lemak + ekstrak kulit Limau Kuit 200 mg/KgBB), KV (diet tinggi lemak + ekstrak kulit Limau Kuit 300 mg/KgBB), dan KVI (diet tinggi lemak + ekstrak kulit Limau Kuit 400 mg/KgBB). Perlakuan diberikan selama 6 minggu. Perlemakan hepar dinilai dari jumlah sel hepar yang mengalami perlemakan pada 5 lapangan pandang dari sediaan histologis hepar yang diwarnai HE dan perbesaran 400 x. Uji statistik menggunakan Kruskal-Wallis test. Hasil penelitian menunjukkan rerata perlemakan hepar KI 38,83 + 35,63, KII 24,00 + 21,46, KIII 20,40 + 13,90, KIV 42,40 + 11,93, KV 19,60 + 12,50, KVI 30,50 + 14,80, dengan p = 0,447. Kesimpulan penelitian ini adalah tidak ada perbedaan yang bermakna dari pemberian ekstrak kulit Limau Kuit terhadap perlemakan tikus (Rattus norvegicus) yang diberi pakan tinggi lemak (p > 0,05).Keywords: Diet tinggi lemak; Kulit jeruk Limau Kuit; Perlemakan hepar; Rattus norvegicus; Steatosis.

HUBUNGAN INDEKS MASSA TUBUH DAN TEKANAN DARAH Nurhayati, Nurhayati; Rudiansyah, Mohammad; Pratiwi, Dewi Indah Noviana; Mutaqqien, Fauzan; Bakhriansyah, Mohammad
Homeostasis Vol 7, No 3 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i3.14567

Abstract: Hemodialysis is a therapy for patients with kidney disease, both acute and chronic, which is used as a substitute for decreased kidney function. Body mass index (BMI) is a simple measuring tool to see the nutritional status of a person, both men and women. Blood pressure is the process when blood is distributed by the heart throughout the body. The research aims to determine whether there is a relationship between body mass index and blood pressure in patients undergoing routine hemodialysis at Ulin Regional Hospital, Banjarmasin. The method in this research is analytical observational with a cross sectional research design with the Pearson test. This study used patient subjects undergoing routine hemodialysis at the hemodialysis installation at Ulin Banjarmasin Regional Hospital in November 2023 using a simple random sampling technique according to the inclusion and exclusion criteria. Primary data was collected by measuring height, weight and blood pressure and secondary data in the form of numbers. Patient medical records obtained from the hemodialysis installation at Ulin Banjarmasin Regional Hospital. This research uses correlative data analysis techniques which begin with a normality test using the Kolmogorov-Smirnov technique because the number of subjects in this research was 50 people with a subject distribution of 65 people. The results of this study obtained a correlation value for body mass index and blood pressure with a value of p = 0.000 and a value of r = 0.06. Keywords: hemodialysis, chronic renal failure, acute renal failure, body mass index, blood pressure. Abstrak: Hemodialisis merupakan terapi untuk pasien penyakit ginjal baik yang akut maupun kronik yang digunakan sebagai pengganti fungsi ginjal yang menurun. Indeks massa tubuh (IMT) ialah alat ukur sederhana untuk melihat status gizi seseorang baik laki-laki maupun perempuan. Tekanan darah merupakan proses ketika darah dialirkan oleh jantung keseluruh tubuh. Penelitian memiliki tujuan untuk mengetahui apakah ada hubungan antara indeks massa tubuh dan tekanan darah pada pasien yang menjalani hemodialisis rutin di RSUD Ulin Banjarmasin. Metode pada penelitian ini yaitu observasional analitik dengan desain penelitian cross sectional dengan uji pearsone. Penelitian ini menggunakan subjek pasien yang menjalani hemodialisis rutin di instalansi hemodialisis RSUD Ulin Banjarmasin pada November 2023 dengan menggunakan teknik simple random sampling sesuai kriteria inklusi dan eksklusi. Pengambilan data primer dilakukan dengan melakukan pengukuran tinggi badan, berat badan serta tekanan darah dan data sekunder berupa nomor rekam medik pasien yang didapatkan dari instalasi hemodialisis RSUD Ulin Banjarmasin. Penelitian ini menggunakan teknik analisis data korelatif yang diawali dengan uji normalitas dengan teknik kolmogorov- Smirnov dikarenakan jumlah subjek dalam penelitian ini sebanyak 50 orang dengan distribusi subjek sebanyak 65 orang. Hasil penelitian ini didapatkan nilai korelasi indeks massa tubuh dan tekanan darah dengan nilai p = 0,000 dan nilai r = 0,06. Kata-kata kunci: hemodialisis, gagal ginjal kronik, gagal ginjal akut, indeks massa tubuh, tekanan darah

HUBUNGAN ANTARA GANGGUAN DEPRESI DAN KUALITAS HIDUP PADA PASIEN HEMODIALISIS DI RSUD ULIN BANJARMASIN Zulfikar, Muhammad Rakha; Rudiansyah, Mohammad; Pratiwi, Dewi Indah Noviana; Cahyawati, Wiwit Agung Sri Nur; Marisa, Dona
Homeostasis Vol 7, No 3 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i3.14535

Abstract: This research focuses on the relationship between depression and quality of life in hemodialysis patients at Ulin Regional Hospital, Banjarmasin. Chronic renal failure (CKD) is a progressive and irreversible failure in kidney function that affects various aspects of metabolism, fluid balance and electrolytes. Depression, as an ongoing emotional condition, affects a person's thoughts, emotions and behavior holistically. Deep mood generally reflects feelings of loss of hope. This study used the PHQ-9 to measure depressive symptoms and the QOL-SF36 to assess quality of life in hemodialysis patients. The sample for this study consisted of patients undergoing hemodialysis at the Ulin Regional Hospital, Banjarmasin. The research method was used by analytical observational with a cross sectional approach. The results showed a significant relationship between depression and quality of life (p = 0.04), with a weak negative correlation of -0.261. This confirms the correlation between depression and decreased quality of life in hemodialysis patients at Ulin Hospital, Banjarmasin. The conclusions of this study indicate that depression in these patients has an impact on reducing their quality of life. Keywords: depression, quality of life, hemodialysis, PHQ-9, QOL-SF-36. Abstrak: Penelitian ini fokus pada hubungan antara depresi dan kualitas hidup pada pasien hemodialisis di RSUD Ulin Banjarmasin. Gagal ginjal kronik (GGK) merupakan kegagalan progresif dan tak terbalik pada fungsi ginjal yang mempengaruhi berbagai aspek metabolisme, keseimbangan cairan, dan elektrolit. Depresi, sebagai kondisi emosional yang berkelanjutan, memengaruhi pikiran, emosi, dan perilaku seseorang secara menyeluruh. Mood dalam umumnya mencerminkan perasaan kehilangan harapan. Studi ini menggunakan PHQ-9 untuk mengukur gejala depresi dan QOL-SF36 untuk menilai kualitas hidup pada pasien hemodialisis. Sampel studi ini terdiri dari pasien yang menjalani hemodialisis di instalasi RSUD Ulin Banjarmasin. Metode penelitian yang digunakan adalah observasional analitik dengan desain pendekatan cross sectional. Hasil penelitian menunjukkan signifikansi hubungan antara depresi dan kualitas hidup (p = 0,04), dengan korelasi negatif lemah sebesar -0,261. Ini menegaskan adanya korelasi antara depresi dan penurunan kualitas hidup pada pasien hemodialisis di RSUD Ulin Banjarmasin. Kesimpulan studi ini mengindikasikan bahwa depresi pada pasien tersebut berdampak pada menurunnya kualitas hidup mereka. Kata-kata kunci: depresi, kualitas hidup, hemodialisis, PHQ-9, QOL-SF-36

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