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All Journal Media Dermato-Venereologica Indonesiana
Rinadewi Astriningrum
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Health Professions

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KOMORBIDITAS PADA AKNE Andira Hardjodipuro Hardjodipuro; Rinadewi Astriningrum; Irma Bernadette; Lili Legiawati; Sandra Widaty
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.334

Abstract

Akne vulgaris (AV) merupakan salah satu penyakit kulit yang paling sering ditemui, terutama pada remaja dan dewasa muda. Patogenesis terjadinya AV setidaknya diperankan oleh empat faktor penting, yaitu hiperproliferasi lapisan epidermis pada folikel, peningkatan produksi sebum, proses peradangan, dan kolonisasi Cutibacterium acnes. Proses tersebut juga dipengaruhi oleh berbagai faktor, antara lain faktor genetik, hormonal, psikologis, gaya hidup, dan lingkungan. Lesi AV bersifat polimorfik dan memiliki derajat keparahan yang beragam. Lesi tersebut diketahui memberikan dampak terhadap kualitas hidup penderitanya. Berbagai studi terkini melaporkan bahwa terdapat berbagai komorbiditas yang dapat memberikan beban tambahan atau memperburuk kondisi AV. Komorbiditas didefinisikan sebagai penyakit yang terjadi secara simultan. Berbeda dengan sindrom yang memiliki arti sekumpulan gejala yang terjadi serentak atau sekumpulan tanda yang menandakan suatu penyakit tertentu. Komorbiditas akne yang telah banyak diinvestigasi antara lain resistensi insulin, hipovitaminosis D, 1 hipervitaminosis B12, gangguan gastrointestinal, gangguan psikologis, disfungsi kelenjar tiroid, dislipidemia, defisiensi seng, dan hipovitaminosis A dan E.
KASUS RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA-MITIS YANG TERDIAGNOSIS PADA SAAT LANJUT USIA Inadia Putri Chairista; Shannaz Nadia Yusharyahya; Lili Legiawati; Rahadi Rihatmadja; Rinadewi Astriningrum
Media Dermato-Venereologica Indonesiana Vol 50 No 1 (2023): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i1.402

Abstract

Introduction: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare bullous disease caused by mutations in the COL7A1 gene encoding anchoring fibril collagen that maintains skin integrity. Case: Male, 67-year-old, presented with blisters and wound on various parts of the body, worsening in the recent year. They had been known to easily appear after trauma since. Vesicles-bullae, erosions-excoriations, milia, and atrophic scars were found on the axillae, groins, and limbs, as well as hyperkeratosis and anonychia of the hands and. Histopathological examination showed subepidermal cleft, milia and fibrosis, without immunoglobulin deposits on immunofluorescence. Discussion: Contrary to classical RDEB, blisters in mitis variant do not always cause impairment. The pronounced symptoms in advanced age might be mistaken for epidermolysis bullosa acquisita. Negative immunoglobulin deposition is the diagnostic key, confirming that blister does not result from an autoimmune process, but rather, from trauma to the abnormal skin, more so by flattening of the rete ridges in the elderly. In the absence of definitive therapy, treatment is symptomatic. Conclusion: The diagnosis RDEB-mitis might be missed in geriatric. Correct diagnosis has implication on management because not only does RDEB-mitis require no immunosuppressant, measures to minimize blister formation is more important to save patient from complication.
Co-Authors Andira Hardjodipuro Hardjodipuro Inadia Putri Chairista Irma Bernadette Lili Legiawati Rahadi Rihatmadja Sandra Widaty Shannaz Nadia Yusharyahya