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All Journal Indonesian Journal of Medicine Journal of Health Policy and Management Cermin Dunia Kedokteran Jurnal Kefarmasian Indonesia
Zuraida Zulkarnain, Zuraida
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Chemistry Health Professions Medicine & Pharmacology Public Health

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Association between Gender and Anxiety among Covid-19 Patients: A Meta-Analysis Zulkarnain, Zuraida; Nuryati, Arum; Upix, Desif; Misi, Adilla; Siswanto, Andi; Handariati, Atik; Rohmani, Alfiana Nur Nur; Saryanto, Saryanto; Dara, Zadia
Journal of Health Policy and Management Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.726 KB)

Abstract

Background: The COVID-19 outbreak rapidly spread worldwide, with a significant number of cases and deaths causing anxiety, especially among the sufferers. Biologically, males and females show different psychological responses to the events at hand. This study aimed to examine the association between gender and anxiety among COVID-19 patients.Subjects and Method: This study was a meta-analysis. The articles were obtained from data­bases PubMed and Scopus using keywords "Anxiety" OR "anxiety disorder" AND "COVID-19 Patients" OR "Patients with COVID-19" OR "Hospitalized" AND "Risk factors" OR "deter­mi­­nants" OR "Gender" OR "Factors associa­ted". The articles included in this study were full-text with a cross-sectional design, dis­cuss-ed the association between gender and anxiety among COVID-19 patients, published in Eng­lish, studies located in Asia. The final results were pre­sented in Adjust Odds Ratio (aOR) or Standar­dized Mean Difference (SMD). Data analysis was performed using Revman 5.3 software, with generic inverse variance data type for categorical outcome group (CtOG) articles and continuous data type for continue outcome group (CnOG).Results: 9 articles were analyzed, including 4 articles CtOG and 5 articles CnOG. The  forest plot of both categorical and continue outcomes showed consistent result that among COVID-19 patients  who hospitalized with mild to severe symptoms. Female patients significantly had higher anxiety event (aOR= 2.19; 95% CI= 1.60 to 2.99; p<0.001; I2= 0% and SMD= 0.35; 95% CI= 0.21 to 0.49; p<0.001; I2= 12%).Conclusion: Among COVID-19 patients, the female gender has a significantly higher risk of suffering from anxiety than the male gender.Keywords: anxiety, COVID-19Correspondence: Zuraida Zulkarnain. Research and Develop­ment Center of Traditional Medicinal and Me­dicinal Plants, Karanganyar, Central Java. Mobile: 081393933862. e-mail: zuraida.zu@­gmail.com.Journal of Health Policy and Management (2021), 06(02): 94-106https://doi.org/10.26911/thejhpm.2021.06.02.02 
Dasar Terapi Tumor dan Kanker di Rumah Riset Jamu ‘Hortus Medicus’ Tawangmangu Zulkarnain, Zuraida
Cermin Dunia Kedokteran Vol 42, No 11 (2015): Kanker
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.537 KB) | DOI: 10.55175/cdk.v42i11.950

Abstract

Kanker merupakan penyakit tidak menular yang menjadi masalah kesehatan sampai saat ini. Jumlah penderita kanker terus bertambah dari tahun ke tahun terutama di negara berkembang. Penelitian tentang khasiat dan cara kerja agen khemopreventif telah banyak dilakukan. Sejak tahun 2000 Rumah Riset Jamu (RRJ)‘Hortus Medicus’ menggunakan dan sedang mengembangkan beberapa tanaman obat, seperti temu mangga (Curcuma mangga), daun teh hijau (Camelia sinensis), benalu (Scurulla sp), kunir putih (Kaemferia rotunda), bidara upas (Merremia mammosa), temulawak (Curcuma xanthorrhiza), kunyit (Curcuma longa) dalam terapi tumor dan kanker baik sebagai agen khemopreventif maupun terapi komplementer dan alternatif. Review artikel dan publikasi jurnal nasional dan internasional ini bertujuan untuk memberikan informasi tentang kajian ilmiah dari tanaman obat yang bermanfaat sebagai agen khemopreventif yang selama ini digunakan di RRJ ‘Hortus Medicus’.Cancer is a disease that becomes a health problem nowadays. Research on the efficacy and the effectiveness of chemopreventive agents have been carried out. Since year 2000, Rumah Riset Jamu (RRJ) 'Hortus Medicus' uses and is developing several medicinal plants, such as temu mangga (Curcuma mangga), daun teh hijau (Camelia sinensis), benalu (Scurulla sp), kunir putih (Kaemferia rotunda), bidara upas (Merremia mammosa), temulawak (Curcuma xanthorrhiza), kunyit (Curcuma longa) for tumor and cancer therapy either as chemoprevention, complementary and alternative therapies. This paper is a review to provide scientific information on medicinal plants used in RRJ 'Hortus Medicus' as chemopreventive agent.
Efek Dua Sediaan Ramuan Jamu pada Pasien Obesitas: Studi Klinis dengan Desain Paralel, Random dan Tidak Tersamar Zulkarnain, Zuraida; Nisa, Ulfatun; Wijayanti, Enggar; Fitriani, Ulfa
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1596

Abstract

Obesity is a co-morbidity of cardiovascular disease, diabetes, and other metabolic diseases, which the prevalence increases every year. The use of herbal medicine is an alternative choice to overcome obesity. Clinical observation of decoction of herbal medicine (Dutch teak, kemuning, rhei radix and tempuyung) has been conducted for obesity therapy which has been proven to be effective in reducing body weight and body mass index (BMI). Innovation in steeping form is considered more practical than stew. Randomized open label pararel design research was carried out to assess the equal efficacy of the herbs in stew and steeping form. The number of subjects in each group were 30 subjects, they were patients of of Rumah Riset Jamu (RRJ) Hortus Medicus during June-October 2016 who met the inclusion criteria. BW and BMI are measured on Day-0, 28 and 56, while body height is measured once at Day-0. Both stew and steeping groups drank herbs twice a day for 56 days. At the end of the study, it was found that the mean of declining BW of the decoction group was 67.35 kg to 66.37 kg, while the steeping group 67.41 kg to 66.45 kg. BMI of stew group was decreased 26.85 kg / m2 to 26.46 kg / m2, while in steeping group 26.67 kg / m2 to 26.29 kg / m2. Statistic test result to compare BW and BMI of both two groups before and after treatment showed no significant differences in the two groups (p> 0.05). The ability of herbal medicines in steeping or stew forms can reduce the BW and BMI equally.
Uji Klinik Keamanan Ramuan Jamu Penurun Kolesterol Zulkarnain, Zuraida; Triyono, Agus; Ardiyanto, Danang; Saryanto, Saryanto
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3186

Abstract

Research on the safety of Jamu (herbal medicine) formula is important to guarantee its use in community. The Jamu Saintification development program has been resulted a cholesterol-lowering herb containing of 7 plants. This study aimed to determine the safety of the cholesterol-lowering herb. This study is a phase one of clinical trial with a pre-post group design, a single arm, involving 50 subjects with mild hypercholesterolemia without any complications and comorbidities. The intervention was conducted for 28 days at the Hortus Medicus Herbal Medicine Research House (RRJ) in 2014. Outcome parameters included clinical signs and symptoms, liver function laboratory tests (SGOT, SGPT), renal function (ureum, creatinine) and routine blood counts (hemoglobin, leukocyte, platelets, hematocrit). Subjects were requested to boil the herb everyday and drank it twice a day. The data were analyzed descriptively and statistically using SPSS. The results showed increasing in bowel frequencies of 92% subjects and abdominal pain in bowel movements of 34% subjects. These effects were still in a normal range and can be tolerated by the subjects. The paired t test analysis showed no differences in average laboratory parameters on day (D)-14 and D-28 compared to the baseline (p > 0.05). The cholesterol-lowering herbal medicine does not change the function of the liver, kidneys and blood, with mild side effects of increasing the frequencies of bowel movements and stomachaches.
Studi Klinis Ramuan Jamu Antihipertensi pada Pasien Hipertensi Derajat I Triyono, Agus; Zulkarnain, Zuraida; Mana, Tofan Aries
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3720

Abstract

Hypertension is a risk factor for cardiovascular disease. Hypertension is one of the main causes of high mortality and morbidity in Indonesia. Utilization of medicinal herbs is an alternative for the treatment of hypertension. The study aimed to determine efficacy of the herbs combination (jamu) compared to hydrochlorothiazide (HCT) and evaluated the safety for hypertention stage I. This research method using an open-label randomized clinical trials with intervention for 56 days. Measurement of day-56 (D-56) showed that herbs decreased sistolic blood pressure to130.15 +17.59mmHg and diastolic at 83.82+9.53 mmHg. There was a significant decrease p = 0.000 (p 0.05), with p mean systolic blood pressure (p = 0.370) and mean diastolic blood pressure (p = 0.412)at D-56. Liver function parameters (SGOT, SGPT) and renal function (urea, creatinine) is still in normal range at the end of intervention. This study showed that herbs combination was an equally effective compared to HCT and safe for hypertension stage I.
Effect of Garlic Powder Supplementation on Total Cholesterol and Low Density Lipoprotein Level in Patient with Hypercholesterolemia: A Meta-Analysis Zulkarnain, Zuraida; Dewi, Yulia Lanti Retno; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.128 KB)

Abstract

Background: Hypercholesterolemia is a risk factor for cardiovascular disease that can cause death and disability, so it must be managed properly. Garlic flour (GP) is one of the dosage forms of garlic that has the potential to reduce cholesterol. This study is a systematic review and meta-analysis that aims to determine the effectiveness of GP in reducing total cholesterol (TC) and low density lipoprotein (LDL).Subjects and Method: Search articles through the Pubmed database, Google scholar, Proquest, Springer link, and Science direct with the appropriate keywords. Population= patients with hyper­cholesterolemia. Intervention= GP. Comparison= placebo. Outcome= TC and LDL. Inclusion crite­ria included complete articles in English or Indonesian published from 2010-2022, Randomized Con­trolled Trial (RCT) design, subjects >18 years old with hypercholesterolemia, the study had a complete fat profile outcome, duration of intervention 2 weeks-12 months. The flow of article selection is based on the PRISMA flow diagram. Meta-analysis using RevMan 5.3 with effect size standardized mean difference (SMD) and Random Effect Model (REM) analysis model.Results: A total of 10 articles were eligible for a meta-analysis. The GP group had TC levels 1.49 units lower than the placebo group (SMD = -1.49; 95% CI = -1.95 to -0.55; p = 0.005) and LDL levels 0.68 units lower than the placebo group (SMD= -0.68; CI95). %= -1.08 to -0.27; p=0.001). Subgroup analysis based on the length of the intervention showed that administration of GP <12 weeks only significantly reduced TC while administration > 12 weeks significantly reduced TC and LDL.Conclusion: GP is effective in lowering TC and LDL especially at 12 weeks or more.Keywords: garlic powder, hypercholesterolemia, RCTCorrespondence: Zuraida Zulkarnain. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java 57126. Mobile: 081393933862. Email: zuraida.zu@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 102-114https://doi.org/10.26911/theijmed.2022.07.01.11
Co-Authors Agus Triyono Anna Tjandrajani, Anna Arum Nuryati Arwin P. Akib, Arwin P. Bhisma Murti Danang Ardiyanto Dara, Zadia Enggar Wijayanti, Enggar Handariati, Atik Mana, Tofan Aries Misi, Adilla Rohmani, Alfiana Nur Nur Saryanto Saryanto Siswanto, Andi Ulfa Fitriani Ulfatun Nisa, Ulfatun Upix, Desif Yoga Yuniadi yulia lanti retno dewi