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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya MEDISAINS Universa Medicina Window of Health : Jurnal Kesehatan Medical and Health Journal
Qodri Santosa, Qodri
FK UNSOED
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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GLUTATHIONE S TRANSFERASE AND CATALASE GENE POLYMORPHISMS DID NOT TEND TO INFLUENCE THE SEVERITY OF HEMOGLOBIN E/β-THALASSEMIA Rujito, Lantip; Widodo, Yundandhika Rizki; Sakina, Ghaida; Santosa, Qodri; Hapsari, Ariadne Tiara
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (743.873 KB)

Abstract

BackgroundThalassemia, a monogenic genetic disease of red blood cells, is spread widely throughout the world. Glutathione S transferase (GST) enzymes have an antioxidant role in detoxification processes of toxic substances This study aimed to determine the role of the genetic modifier genes GSTT1 and GSTM1, and the catalase (CAT) gene in clinical degrees of hemoglobin (Hb)E/? thalassemia. MethodsSixty HbE/? Thalassemia patients were examined to determine their clinical pictures. Clinical score was based on age when thalassemia symptoms appeared, time of diagnosis, time of first blood transfusion, pre-transfusion hemoglobin concentration, frequency of transfusions, and enlargement of spleen. Ferritin concentration was also obtained from medical records. Gene polymorphisms of GSTT1, GSTM1, and CAT were measured using PCR and PCR-RFLP methods. Clinical scores were categorized into mild (0-3.5), moderate (4-7), and severe (7.5-10) degrees, while ferritin level was expressed in mg/dL. One way Anova was used to analyze the data. ResultsThe clinical appearance showed that severe, moderate, and mild degrees accounted for 42%, 45%, and 13%, respectively. The majority had a high ferritin level of more than 5000 mg/dL (67%). GSTT1 null, GSTM1 null, and CAT minor allele genotypes were 21.7%, 33.3%, and 12.1%, respectively. GSTT1, GSTM1, and CAT genotypes had no impact on the severity of thalassemia patients (p=0.091, p=0.082, and p=0.141, respectively).ConclusionGSTT1, GSTM1, CAT gene polymorphisms tend to be a minor aspect of severity of clinical outcome for HbE/â thalassemia patients and should be not considered a routine laboratory check.
Iron Status of Newborns and Umbilical Cord Blood Hepcidin Levels in Gender Differences Santosa, Qodri; Soemantri, AG; Hadisaputro, Soeharyo; Soejoenoes, Ariawan
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.545 KB) | DOI: 10.21776/ub.jkb.2020.031.01.12

Abstract

Fetal gender might affect the iron status of newborns. Hepcidin has an important role in the process of maternofetal iron transport. This study aims to compare the newborn iron status and the umbilical cord hepcidin levels between male and female gender. A cross-sectional study was conducted with subjects of 84 clinically healthy newborns. Written informed consent and ethical approval were carried out. Newborn iron status observed included (i) hematologic markers (RBC count, Hb, hematocrit, mean corpuscular volume (MCV) and red cell distribution width), and (ii) biochemical markers (serum iron (SI), serum ferritin (SF), soluble transferrin receptor (sTfR) and cord blood hepcidin). Hematologic markers were checked using Sysmex, XN-1000, while Hepcidin and sTfR were using ELISA. Serum iron was checked using IRON Flex®. Statistical analysis was tested with the independent t-test and the Mann-Whitney. All newborns and their mothers were in normal condition. The mean sTfR levels of newborns were significantly higher in the male group than females (38.3±9.06 vs. 34.3±8.16 nmol/L) with p=0.033. High sTfR levels reflect a low iron status. In conclusion, fetal gender differences influence the iron status of newborns, and male newborns have a potentially higher iron deficiency.
Korelasi Antara Lingkar Kepala Lahir Dengan Tumbuh Kembang Anak Di Desa Rempoah Banyumas Salsabila, Sabrina Dhia; Santosa, Qodri; Fatchurohmah, Wiwiek; Hapsari, Ariadne Tiara; Indriani, Vitasari
Window of Health : Jurnal Kesehatan Vol 5 No 01 (January 2022)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33368/woh.v0i0.674

Abstract

The golden period of children’s growth occurred in the first 1000 days and every disruption in this period would damage the number of cells and myelination that could not be achieved in the next period. Head circumference (HC) at birth was correlated with brain size to measure the brain’s growth and development. This study aimed to find the correlation between HC at birth and children’s growth and development. The research method used was cross-sectional. A total sample of 233 children at 6-60 months old in Posyandu Bina Kasih I-XI Rempoah Village, Baturaden District, was taken using total sampling. Research data used secondary data from previous study and were analyzed by Eta and spearman correlation tests. Results show 180 children who have normal nutritional status and 221 children with development based on their age. Median HC at birth value is 33 cm belongs in the normal category. Spearman test shows HC at birth is not correlated with nutritional status (p=0.412). Eta test shows HC at birth was statiscally significant correlated with development based on KIA book albeit with a very weak level of correlation(F calculated > F table; ETA=0.196). In conclusion, Head circumference at birth is correlated with development based on the KIA book, but does not correlated with nutritional status and head circumference.
HUBUNGAN BERAT BADAN LAHIR DENGAN STATUS GIZI DAN PERKEMBANGAN ANAK USIA 6 – 60 BULAN Andreanetta, Prisca Tiffany; Santosa, Qodri; Indriani, Vitasari; Arifah, Kurniawati; Fatchurohmah, Wiwiek
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P07

Abstract

Periode emas kehidupan akan menentukan tumbuh kembang anak di masa yang akan datang. Berat badan lahir (BBL) merupakan salah satu faktor yang memengaruhi tumbuh kembang anak. Tujuan penelitian ini untuk mengetahui korelasi antara BBL dengan status gizi dan perkembangan anak usia 6 – 60 bulan. Penelitian ini menggunakan analisis observasional dengan pendekatan cross sectional study. Subjek penelitian yaitu anak – anak balita di Posyandu Bina Kasih I – XI Desa Rempoah pada bulan Oktober – November 2018 dengan menggunakan data sekunder. Uji korelasi BBL dengan status gizi menggunakan analisis Spearman dan korelasi BBL dengan perkembangan menggunakan uji Eta. Sebagian besar subjek penelitian memiliki status gizi normal (74%) dan perkembangan sesuai buku KIA (94,1%). Hasil korelasi bermakna dan signifikan secara statistik antara BBL dengan status gizi (p=0,042) dan BBL dengan perkembangan berdasar buku KIA (F=96,25). Kesimpulan penelitian ini yaitu terdapat korelasi antara BBL dengan status gizi dan perkembangan berdasar buku KIA. Hasil penelitian ini diharapkan dapat menjadi acuan tenaga medis dalam memberikan informasi kepada ibu hamil mengenai gizi salama masa hamilnya.
Investigating the level of Hba1c and insulin level in β-thalassemia patients Mujiburrahman, Husnan; Santosa, Qodri; Setyono, Joko; Roestijawati, Nendyah; Rujito, Lantip
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.18362

Abstract

Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.Objective: This study aimed to describe HbA1c and insulin levels of β-thalassemia patients. The study also tested whether there was a significant difference in insulin and HbA1c levels among patients with different β-thalassemia categories. Method: This research was an analytic observational study. The samples were taken by total sampling and involved 30 patients, and the examination was carried out using the patient's blood plasma.Result: The study found that samples had low HbA1c levels. There was no significant mean difference (p>0.05) between insulin and HbA1c in the mild, moderate, and severe clinical degree groups. There was no significant difference in average (p>0.05) insulin and HbA1c in the thalassemia sufferers with allele β+ and β0 types.Conclusion: There was a decrease in insulin and HbA1c in patients with β-thalassemia, which may be caused by damage pancreatic organ damage.
IMPACT OF MATERNAL WEIGHT GAIN AND INFLAMMATORY MARKERS ON NEONATAL IRON DEFICIENCY: A CROSS-SECTIONAL STUDY FROM A PEDIATRIC PERSPECTIVE Santosa, Qodri; Oliviany, Windy; Hafiidhaturrahmah, Hafiidhaturrahmah; Pratidina, Wening Gelar; Hapsari, Ariadne Tiara; Priyanto, Edy; Muntafiah, Alfi
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14481

Abstract

Background: Maternal health during pregnancy is crucial for neonatal outcomes, particularly regarding iron status. This study investigates the impact of maternal weight gain and inflammatory markers on neonatal iron deficiency in a cohort of mothers and their newborns. Methods: A cross-sectional study was conducted involving spontaneously delivered infants from single, full-term pregnancies, with Apgar scores ≥7 at the first minute and normal birth weights (≥2,500 to <4,000 grams). Maternal weight gain was categorized as "appropriate" or "inappropriate" based on the 2009 Institute of Medicine (IOM) recommendations. Maternal blood samples were collected during the third trimester, and infant iron status was assessed through hematological parameters and serum iron levels. Statistical analyses included the Mann-Whitney test and independent t-tests, with significance set at p < 0.05. Results: A total of 59.5% of mothers did not achieve appropriate weight gain, and 57.1% exhibited positive CRP levels, indicating inflammation. Infants born to mothers with appropriate weight gain had significantly better hematological parameters, including higher erythrocyte counts, hemoglobin, and hematocrit levels (p < 0.05). Conversely, infants of mothers with positive CRP levels demonstrated lower erythrocyte counts and hemoglobin levels, indicating a potential negative impact of maternal inflammation on iron transfer (p < 0.05). No significant differences in neonatal iron status were observed between infants born to anemic and non-anemic mothers. Discussion: The findings underscore the importance of monitoring maternal nutritional status and inflammatory markers during pregnancy. Adequate weight gain according to IOM guidelines is associated with improved neonatal iron status, while maternal inflammation negatively impacts iron transfer to the fetus. These results highlight the need for targeted interventions, including nutritional education and management of inflammatory conditions, to enhance maternal and neonatal health outcomes. Conclusion: This study contributes to the understanding of the relationships between maternal weight gain, inflammatory markers, and neonatal iron status. By addressing these factors, healthcare providers can improve outcomes for mothers and their newborns, ultimately promoting healthier populations.
Co-Authors Ag Soemantri Alfi Muntafiah Andreanetta, Prisca Tiffany Ariadne Tiara Hapsari Arifah, Kurniawati Edy Priyanto Hafiidhaturrahmah, Hafiidhaturrahmah Indriani, Vitasari Joko Setyono Lantip Rujito Mujiburrahman, Husnan Nendyah Roestijawati Oliviany, Windy Pratidina, Wening Gelar Sakina, Ghaida Salsabila, Sabrina Dhia Soeharyo Hadisaputro Soejoenoes, Ariawan Widodo, Yundandhika Rizki Wiwiek Fatchurohmah, Wiwiek