Article Per Year (5 Year)
p-Index From 2020 - 2025
1.332
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Sriwijaya Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Radiyati Umi Partan
Rheumatology Division, Departement Of Internal Medicine, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Korelasi Jumlah Cairan Sendi dengan Derajat Nyeri pada Pasien Osteoartritis Genu Alderiantama Akhmad; Radiyati Umi Partan; Fatmawati Fatmawati
Majalah Kedokteran Sriwijaya Vol 51, No 1 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i1.8550

Abstract

Latar Belakang: Osteoartritis (OA) adalah penyakit kronik yang ditandai dengan berkurangnya kartilago di sendi yang mengakibatkan tulang-tulang bergesekan. Gejala yang paling sering dirasakan pasien OA adalah nyeri dan kekakuan pada sendi. OA memicu terjadinya penumpukan cairan pada sendi. Cairan sendi secara tidak langsung berperan menimbulkan nyeri pada artritis. Nyeri pada pasien OA dapat diukur menggunakan Visual Analog Scale (VAS). Penelitian ini dilakukan untuk mengetahui korelasi jumlah cairan sendi dengan derajat nyeri pada pasien OA genu.Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Sampel penelitian ini adalah pasien OA genu yang mengalami effusi sendi serta memenuhi kriteria inklusi dan eksklusi di Klinik Su’adah pada tahun 2018.Hasil: Dari 80 pasien, didapatkan 73,8% pasien OA genu adalah perempuan dan 30% berusia 56-60 tahun, dan 80% memiliki IMT >25 kg/m2. Rata-rata jumlah cairan sendi pasien OA sebanyak 18,59 mL (+ 1,49) dan rata-rata derajat nyeri adalah 6,33 (+ 0,24). Hasil analisis menggunakan uji korelasi Pearson menunjukkan bahwa terdapat korelasi positif lemah yang signifikan (r= 0,327             , p= 0,003).Kesimpulan: Terdapat korelasi positif lemah dan signifikan antara jumlah cairan sendi dengan derajat nyeri pada pasien OA genu.
Korelasi Antara Gula Darah 2 Jam Postprandial Danhba1c di Laboratorium Klinik Graha Spesialis RSMH Palembang Kemas Ya’kub R; Radiyati Umi Partan; Moh Habib
Majalah Kedokteran Sriwijaya Vol 46, No 1 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i1.2677

Abstract

Pemeriksaan gula darah merupakan pemeriksaan yang dilakukan untuk menegakkan diagnosis diabetes melitus. Hasil pemeriksaan gula darah pasien tidak cukup menggambarkan kondisi gula darah pasien, sehingga diperlukan pemeriksaan lain dengan menilai kadar HbA1c. Tujuan penelitian ini adalah untuk menganalisis korelasi antara kadar gula darah 2 jam postprandial dan nilai HbA1c.Jenis penelitian yang dilakukan adalah observasional analitik dengan desain cross sectional. Populasi penelitian adalah pasien yang melakukan pemeriksaan gula darah di Laboratorium Klinik Graha Spesialis RSMH Palembang. Dengan metode purposive sampling, diperoleh 121 orang sampel penelitian. Diperoleh kadar gula darah 2 jam postprandial tidak normal sebanyak 65,3% dan normal sebanyak 34,7%. Usia terbanyak subjek penelitian dengan kadar gula darah 2 jam postprandial tidak normal adalah 15-64 tahun (52,3%). Jenis kelamin terbanyak subjek penelitian dengan kadar gula darah 2 jam postprandial tidak normal adalah laki-laki (34,7%). HbA1c subjek penelitian tidak normal sebanyak 61,2% dan normal 38,8%. Usia terbanyak subjek penelitian dengan nilai HbA1c tidak normal adalah 15-64 tahun (31,5%). Jenis kelamin terbanyak subjek penelitian dengan nilai HbA1c tidak normal adalah laki-laki (31,4%).Perbandingan antara laki-laki dengan perempuan adalah 1,02:1. Rerata  simpangan baku kadar gula darah 2 jam postprandial dan nilai HbA1c berturut-turut adalah 191,1  89,3 mg/dl dan7,0  1,98 %. Hasil tabulasi silang antara kadar gula darah 2 jam postprandialdan nilai HbA1c menunjukkan bahwa pada subjek penelitianyang memiliki kadar gula 2 jam postprandial tidak normal, diperoleh sebanyak 15 (12,4%) orang memiliki nilai HbA1c normal dan 64 (52,9%) orang memiliki nilai HbA1c tidak normal. Terdapat korelasi yang kuat antara kadar gula darah 2 jam postprandialdan nilai HbA1c (r=0,638; p=0,0005).
Telmisartan Prevents Myocardial Fibrosis via Decreasing Fraction of Colagen Type 1 Volume in Myocardial Tissue in Wistar Rats-Induced High Salt Intake Radiyati Umi Partan; Rachmat Hidayat; Mgs Irsan Saleh; Nita Parisa; Evi Lusiana; Nia Savitri Tamzil; Ayeshah Augusta Rosdah; Muhammad Reagen
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.6

Abstract

Myocardial fibrosis is a pathological condition that responsible for initiation of heart failure. Neurohormonal endogen, angiotensin II, has a potential role to activate endothelin I, TGF-β1, myocardial fibroblast, extracelullar matrix deposition, structural changes and decreasing of cardiac function. Fibrotic process is also influenced by PPAR γ. Telmisartan has a potential effect to inactivate angiotensinergic system and to activate PPAR γ. It is expected that telmisartan has optimal effect to protect myocardial fibrosis. To know the role of variation dose of telmisartan to decrease collagen type 1 fraction volume in cardiac tissue of Wistar rats. Ten-week-old male Wistar Rat (n = 30) were randomized into five groups, and each group consisted of 6 rats. Group 1 : negative control. Group 2 : rats were induced by intake Nacl 8% doses 2% body weight for eight weeks. Group 3 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 3 mg/kgBB for eight weeks. Group 4 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 6 mg/kgBB for eight weeks. Group 5 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 12 mg/kgBB for eight weeks. Collagen volume fraction was assessed by immunohistochemistry and ImageJ program. ANOVA test followed pos hoc test was used to analyzed each variable. Collagen volume fraction significantly decreased in group 3, 4 and 5 compared in group 2. Telmisartan decreases collagen type 1 volume fraction of myocardial tissue .
The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet Radiyati Umi Partan; Rachmat Hidayat; Yeni Agustin; Mgs Irsan Saleh; Nita Parisa; Evi Lusiana; Nia savitri Tamzil; Ayeshah Agusta Rosdah; Abdulwahab Hakimi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.10

Abstract

Background Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing. Aim of Study Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18. Results Lerek fruit extract 100 mg/kgBW was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control. Conclusion Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level. Keywords: Lerek fruit extract – body weight- triglyserida - leptin
Cardiac Septal Defects in Children: Hemodynamics, Clinical Manifestations and Detection Ria Nova; Sukman Tulus Putra; Siti Nurmaini; Radiyati Umi Partan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.393

Abstract

Cardiac septal defect in children is one of the congenital heart defects characterized by atrial septal defects (ASD), ventricular septal defects (VSD) and defects in both atrial and ventricular septum (AVSD). The hemodynamic changes that occur are caused by a left to the right shunt. Differences in location, size of the defect and pulmonary vascular resistance make hemodynamic differences and clinical manifestations between the three types of cardiac septal defects. Detection of cardiac septal defects can be done by clinical examination by listening to the characteristic heart sounds and murmurs for each defect. However, clinical examination alone is often still difficult to determine the type of cardiac septal defect so that several supporting examinations such as photothorax, ECG, echocardiogram and cardiac catheterization need to be done to help establish the diagnosis.
The Role of Histone Deacetylase and Histone Deacetylase Inhibitors in Rheumatoid Arthritis Rina Kriswiastiny; Radiyati Umi Partan; Hermansyah; Surya Darma; Muhammad Reagan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.423

Abstract

Rheumatoid Arthritis or RA disease is a chronic inflammatory and systemic disease associated with broad synovitis resulting in erosion of the articular cartilage and marginal bone causing joint damage. RA is an autoimmune disease with the discovery of an autoantibody, namely rheumatoid factor. The relevant antibody is anti-citrullinated protein (ACPA) antibody. Citullination on the introduction of several proteins such as fibrin, vimentin, fibronectin, collagen type II, which is expressed in the synovial membrane during inflammation by ACPA. In a recent study increased HDAC activity in the synovial tissue of RA patients has increased. Histone deacetylase or abbreviated as HDAC is an enzyme that is important in regulating gene transcription by altering the acetylation of histone proteins which results in an important regulation of repression in the implementation of inflammation. HDAC enzyme inhibitor (HDACi) is an HDAC enzyme inhibitor that can provide benefits for the treatment of various diseases including malignancy and inflammation. In inflammatory disease HDACi overcomes inflammatory cytokines such as TNF-α, IL-6 and IL-1β. One of the HDAC classes is HDAC1 which is highly expressed in the synovial fibroblasts of RA patients. HDACi can burden swollen joints, reduce mononuclear cell infiltration, request pannus orders, inhibit bone and cartilage damage.
Electrocardiography Predictive Value on Coronary Slow Flow Phenomenon Erwin Sukandi; Yudhie Tanta; Taufik Indrajaya; Ali Ghanie; Muhammad Irsan Saleh; Irfannuddin; Radiyati Umi Partan; Zulkhair Ali
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.454

Abstract

Coronary Slow Flow Phenomenon (CSFP) is characterized by the slow flow of contrast in one or more epicardial coronary vessels without evidence of coronary artery stenosis during coronary angiography procedures. CSFP is fairly common at the time of elective angiography with an incidence of around 7% and accounts for about 4% of hospitalized unstable angina cases. Coronary angiography is currently still the only effective way to detect CSFP, but this procedure is an invasive procedure with high costs, there is a risk of allergy to contrast. Electrocardiography (ECG), as a widely available, inexpensive, and simple modality is felt to be an attractive alternative in early detection of this abnormality. The ECG parameters on CSFP discussed in this study include; p-wave dispersion, QT interval dispersion, QRS intrinsic (Tpeak-Tenddeflection duration), and QRS fragmentation. Further studies are needed on the ECG image in CSFP so that in the future ECG can be a cheaper and non-invasive diagnostic modality for CSFP compared to coronary angiography.
Gynaecologic History During Adolescence to Predict Endometriosis Earlier Hartati; Dwiana Ocviyanti; Ramzi Amin; Yusuf Effendi; Zen Hafy; Radiyati Umi Partan; Rafika Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.465

Abstract

Background. Endometriosis is a chronic gynecological disorder that generally affects women of reproductive age which is characterized by implantation of endometrial tissue, both glands and stroma outside the uterus. Research shows that the initial onset of endometriosis patients begins in adolescence. The high prevalence with atypical symptoms leads to long term delay in establishing the appropriate diagnosis. Further developments in the field of early endometriosis screening will greatly assist clinicians, especially general practitioners in areas with limited health facilities, in early detection of endometriosis. Methods. Using the electronic databases, comprehensive literature searches were conducted with the specific keywords. Full-text manuscripts published were reviewed for relevancy and importantly, reference lists were cross-checked for additional relevant studies. Results. Dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, dyschezia, and glycoprotein were found dominantly in all analyzed literature. The occurrence of endometriosis affects the functioning of women in multiple aspects of life. Endometriosis places a significant burden on teens and adult women, their families, and society as a whole. Conclusion. Combination of structured past history taking, and several biomarker level might be useful as a screening tool that easy to use and cost effective, as early diagnosis is expected to prevent further progression of endometriosis especially in adolescence.
Telmisartan Prevents Myocardial Fibrosis via Decreasing Fraction of Colagen Type 1 Volume in Myocardial Tissue in Wistar Rats-Induced High Salt Intake Radiyati Umi Partan; Rachmat Hidayat; Mgs Irsan Saleh; Nita Parisa; Evi Lusiana; Nia Savitri Tamzil; Ayeshah Augusta Rosdah; Muhammad Reagen
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.6

Abstract

Myocardial fibrosis is a pathological condition that responsible for initiation of heart failure. Neurohormonal endogen, angiotensin II, has a potential role to activate endothelin I, TGF-β1, myocardial fibroblast, extracelullar matrix deposition, structural changes and decreasing of cardiac function. Fibrotic process is also influenced by PPAR γ. Telmisartan has a potential effect to inactivate angiotensinergic system and to activate PPAR γ. It is expected that telmisartan has optimal effect to protect myocardial fibrosis. To know the role of variation dose of telmisartan to decrease collagen type 1 fraction volume in cardiac tissue of Wistar rats. Ten-week-old male Wistar Rat (n = 30) were randomized into five groups, and each group consisted of 6 rats. Group 1 : negative control. Group 2 : rats were induced by intake Nacl 8% doses 2% body weight for eight weeks. Group 3 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 3 mg/kgBB for eight weeks. Group 4 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 6 mg/kgBB for eight weeks. Group 5 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 12 mg/kgBB for eight weeks. Collagen volume fraction was assessed by immunohistochemistry and ImageJ program. ANOVA test followed pos hoc test was used to analyzed each variable. Collagen volume fraction significantly decreased in group 3, 4 and 5 compared in group 2. Telmisartan decreases collagen type 1 volume fraction of myocardial tissue .
The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet Radiyati Umi Partan; Rachmat Hidayat; Yeni Agustin; Mgs Irsan Saleh; Nita Parisa; Evi Lusiana; Nia savitri Tamzil; Ayeshah Agusta Rosdah; Abdulwahab Hakimi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.10

Abstract

Background Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing. Aim of Study Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18. Results Lerek fruit extract 100 mg/kgBW was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control. Conclusion Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level. Keywords: Lerek fruit extract – body weight- triglyserida - leptin
Co-Authors Abdulwahab Hakimi Alderiantama Akhmad Ali Ghanie Ayeshah A Rosdah Dwiana Ocviyanti Erwin Sukandi Fatmawati Hartati Hermansyah Irfannuddin Irfannuddin Jayawarsa, A.A. Ketut Kemas Ya’kub R Kms Yusuf Effendi Mgs Irsan Saleh Moh Habib Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Nita Parisa RACHMAT HIDAYAT Rafika Novianti Ramzi Amin, Ramzi Ria Nova Rina Kriswiastiny Siti Nurmaini Sukman Tulus Putra Surya Darma Taufik Indrajaya Yeni Agustin Yudhie Tanta Yundari, Yundari Zen Hafy Zulkhair Ali