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All Journal Journal of Nutrition College Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Agromedicine and Medical Sciences SRIWIJAYA JOURNAL OF MEDICINE Journal of Health Sciences Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Kesmas Untika Luwuk: Public Health Journal Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) Jurnal Teknologi Sumberdaya Mineral
Zahrah Febianti
Biochemistry Department, Faculty Of Medicine, University Of Jember
Dentistry Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antimicrobial in vitro Study of Cosmos caudatus H.B.K Leaves Extract Towards Methicillin-Resistant Staphylococcus aureus (MRSA) Febianti, Zahrah
Journal of Agromedicine and Medical Sciences Vol 1, No 2 (2015)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Cosmos caudatus H.B.K leaves is known to have many active substances with antimicrobial effect such as saponin, flavonoid, poliphenol, volatile oil, costunolide, and 4,4’-bipyridin. This research is conducted to prove the antimicrobial effect of Cosmos caudatus leaves extract on gram positive Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro. The sample of this research is served by Microbiology Laboratorium of Brawijaya University. An experimental study with tube dilution method was carried out. The treated groups are groups of bacteria treated with Cosmos caudatus leaves extract with a range concentrations of 14%; 12%; 10%; 8%; and 6%. The control group is groups treated with 0% extract. The result indicates that the MIC (Minimal Inhibitory Concentration) can not be observed due to the extract’s turbid green colour. The MBC (Minimal Bactericidal Concentration) is 14% for MRSA. Data analysis with CI=95% shows a significant difference of effects on the number of MRSA colonies growth (Anova, p = 0,000) with the change of extract concentrations. The correlation regression test shows a strong association between the extract concentration and the number of colonies growth (Correlation, r = -0,754, p=0,000). Cosmos caudatus leaves extract has antimicrobial effect on MRSA.Keywords : Cosmos caudatus leaves estract, Methicillin-Resistant Staphylococcus aureus (MRSA), antimicrobial.
Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4 Widiatmaja, Danang Tejamukti; Mufida, Diana Chusna; Febianti, Zahrah
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i1.155

Abstract

Streptococcus pneumoniae or pneumococcus is the main cause of community acquired pneumoniae (CAP). Infection of pneumococcal can be prevented by vaccines, like PPV and PCV. Those vaccines have several weaknesses, like, limited to several strain of bacteria and invasive. Nowadays, development of pneumococcal vaccines used the antigenic component of which occur on the bacteria, like epitope. One of the epitopes that can be used as vaccine candidate is epitope from RrgB protein of bacteria’s pili. One of the RrgB protein’s epitope that has been identified having antigenic property is epitope protein RrgB 255-270 of Streptococcus pneumoniae bacteria’s pili. That epitope will stimulate immune system to produce antibody against the antigen supported by cytokine, like IL-4. This research aim is to knowing the effect of intranasal immunization epitope protein RrgB 255-270 Streptococcus pneumoniae to IL-4 level. Wistar rat’s nasal rinse sample IL-4 levels measured by ELISA method. The mean of K1 is 28,852± 18 ng/L, K2 is 20.630 ± 9 ng/L and K3 is 18.519 ± 6 ng/L. Result of Welch ANOVA test shows that p-value of this research is 0.299. That can be concluded that the effect of intranasal immunization epitope protein RrgB 255-270 S. pneumoniae give non-significant difference (p-value > 0.05).
Pengaruh Pemberian Ekstrak Tauge Kacang Hijau (Vigna Radiata (L.)) terhadap Ketebalan Tunika Intima-Media Aorta Abdominalis pada Tikus Wistar Jantan yang diberi Stres Fisik (The Effect of Mung Bean (Vigna radiata (L.)) Sprout Extract on Tunica Intima-Me Galuh Dharanindya Ica Manohara; Rena Normasari; Zahrah Febianti
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Mung bean (Vigna radiata (L.)) sprout contains antioxidants especially vitamin E that can prevent oxidative stress and maintain cell membranes from lipid peroxidation, so the development of atherosclerosis can be inhibited. This study investigated the effect of mung bean sprout on the aorta abdominalis tunica intima-media thickness of male wistar rats induced by physical stress. It was a true experimental study with Post-test Only Control Group Design. Twenty five male wistar rats aged 2-3 months, divided into 5 groups: K1, K2, P1, P2 and P3. K1 was a normal group without treatment. The other groups were given physical stress such as swimming test for ten days. P1, P2, and P3 group were treated by 25, 50, and 100 mg/200g/day of mung bean sprout extract simultaneously. At the end of treatment, the aorta abdominalis were taken and prepared for histopathology examination. The result showed the average of tunica intima-media thickness in K1 30,25±1,65 µm; K2 32,45±5,02 µm; P1 31,65±2,63 μm; P2 30,35±4,73 μm and P3 30,45±3,21 μm. Data analysis using One Way ANOVA showed a significancy of p=0,839. In conclusion, there was no effect of the mung bean sprout extract on tunica intima-media thickness of male wistar rats induced by physical stress.   Keywords: Mung bean, physical stress, tunica intima-media
Uji Toksisitas Akut Ekstrak Buah Bruguiera gymnorrhiza pada Tikus (Rattus norvegicus) (Acute Toxicity Test of Bruguiera gymnorrhiza Fruit Extract In Rats (Rattus norvegicus)) Salman Al Farisi; Al Munawir; Zahrah Febianti
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Bruguiera gymnorrhiza (bakau) fruit has a great potency as a traditional medicine, but the safety has not known yet, therefore a test to determine the toxic effects of this fruit into living thing is needed. This research aimed to determine the acute toxicity effect of Bruguiera gymnorrhiza fruit extracts in rats based on Loomis criteria. This research was an experimental research laboratory with Post Test Only Control Group Design. Ten rats were divided into two groups. The control group was fed with a standard food while the treatment group was given Bruguiera gymnorrhiza (bakau) fruit extract at a dose of 5.000 mg/kg BB. After 24 hours, two groups were observed by calculating the number of the dead rats, if there was no dead rat, they were sacrificed for an autopsy for liver histopathological examination. The result of this research showed there was no dead rat during the treatment process . Histopathological examination of rat liver cells showed no necrosis, degeneration, inflammation, fibrosis, and cirrhosis. Conclusion of this research was Bruguiera gymnorrhiza (bakau) fruit had no toxic effects and could be clasified as “Practical Not Toxic” in Loomis criteria .   Keywords: Bruguierra gymnorrhiza (bakau) fruit , the acute toxicity effect, rat
The Correlation Between The Use of Personal Protective Equipment (PPE) and Soil-Transmitted Helminths Infection in the Workers of Kaliputih Plantation Jember Regency Ivan Iqbal Baidowi; Yunita Armiyanti; Zahrah Febianti; Yudha Nurdian; Bagus Hermansyah
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9625

Abstract

This study aimed to investigate the correlation between the use of Personal Protective Equipment (PPE) and the status of Soil-Transmitted Helminths infection in the workers of Kaliputih plantation in Jember Regency. The research method applied was Analytic observational with a Cross-sectional approach. The population, as well as the sample, were all workers of Kaliputih Plantation, Sumber Bulus Village, Ledokombo District, Jember Regency, by the total of 63 people. The sampling technique was the Total sampling. Laboratory analysis on faecal samples of respondents were conducted at the Parasitology Laboratory, Faculty of Medicine, University of Jember. Furthermore, the research data were analyzed using Chi-Square analysis or Fisher’s Exact Test. The results demonstrated that the prevalence of STH infection in Kaliputih Plantation workers was 25%. This figure was supported by the good awareness of the use of Personal Protective Equipment (PPE) of workers (91.67%). In addition, the Soil-Transmitted Helminths species that infested the plantation workers were Ascaris lumbricoides, found in 6 people (16.67%), and Hookworm, found in 3 people (8.33%). Finally, the result of Chi-square analysis showed a significance value of <0.05. Therefore, it can be concluded that the use of PPE in Kaliputih plantation workers had a significant correlation with the STH infection status. Keywords: Correlation, PPE, Soil-Transmitted Helminths Infection
Antimicrobial in vitro Study of Cosmos caudatus H.B.K Leaves Extract Towards Methicillin-Resistant Staphylococcus aureus (MRSA) Zahrah Febianti
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cosmos caudatus H.B.K leaves is known to have many active substances with antimicrobial effect such as saponin, flavonoid, poliphenol, volatile oil, costunolide, and 4,4’-bipyridin. This research is conducted to prove the antimicrobial effect of Cosmos caudatus leaves extract on gram positive Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro. The sample of this research is served by Microbiology Laboratorium of Brawijaya University. An experimental study with tube dilution method was carried out. The treated groups are groups of bacteria treated with Cosmos caudatus leaves extract with a range concentrations of 14%; 12%; 10%; 8%; and 6%. The control group is groups treated with 0% extract. The result indicates that the MIC (Minimal Inhibitory Concentration) can not be observed due to the extract’s turbid green colour. The MBC (Minimal Bactericidal Concentration) is 14% for MRSA. Data analysis with CI=95% shows a significant difference of effects on the number of MRSA colonies growth (Anova, p = 0,000) with the change of extract concentrations. The correlation regression test shows a strong association between the extract concentration and the number of colonies growth (Correlation, r = -0,754, p=0,000). Cosmos caudatus leaves extract has antimicrobial effect on MRSA.Keywords : Cosmos caudatus leaves estract, Methicillin-Resistant Staphylococcus aureus (MRSA), antimicrobial.
Peran Protein Hemaglutinin Pili Streptococcus Pneumoniae 54 Kda Sebagai Adhesin Diana Chusna Mufida; Adellia Fira Fa'idha; Zahrah Febianti
Jurnal Ilmiah Kesehatan Vol 13 No 2 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.062 KB) | DOI: 10.33086/jhs.v13i2.1442

Abstract

Pili memiliki protein adhesin yang berperan dalam proses adhesi. Penelitian menunjukkan bahwa protein pili S. pneumoniae 54 kDa merupakan protein hemaglutinin. Tujuan penelitian ini adalah menguji peran protein hemaglutinin pili S. pneumoniae 54 kDa sebagai adhesin. Pili S. pneumoniae diisolasi menggunakan alat pili cutter. Hasil potongan pili dilakukan SDS-PAGE dan diidentifikasi berat molekul proteinnya. Protein berat molekul 54 kDa diisolasi sehingga menghasilkan protein larutan. Dilakukan uji adhesi pada larutan protein dengan konsentrasi bertingkat untuk mengetahui indeks ahesi. Uji korelasi Pearson diperoleh nilai p-value 0,036 (p < 0,05) dan koefisien korelasi R= -0,840, hasil ini menunjukkan bahwa kedua variabel memiliki hubungan yang signifikan, sangat kuat dengan arah hubungan negatif. Analisis regresi didapatkan R2 0,997, artinya 99,7 % konsentrasi protein pili 54 kDa S. pneumoniae mempengaruhi indeks adhesi, sehingga dapat disimpulkan protein hemaglutinin pili 54 kDa S. pneumoniae merupakan protein adhesin.
Faktor yang Berhubungan dengan Hipertensi: Studi Cross-sectional di Wilayah Pedesaan Klakah, Lumajang, Jawa Timur : Factors Associated with Hypertension: A Cross-sectional Study in Rural Area of Klakah, Lumajang, East Java Zahrah Febianti; Mauliya Sri Sukmawati Wahyudi; Cholis Abrori
Jurnal Kesmas Untika Luwuk : Public Health Journal Vol. 13 No. 1 (2022): Jurnal Kesmas Untika Luwuk : Public Health Journal
Publisher : Fakultas Kesehatan Masyarakat Universitas Tompotika Luwuk

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (905.948 KB) | DOI: 10.51888/phj.v13i1.102

Abstract

Hipertensi masih menjadi masalah kesehatan global karena prevalensinya yang tinggi dan komplikasinya yang fatal. Di Puskesmas Klakah, Kabupaten Lumajang, prevalensi hipertensi menempati urutan pertama kasus tertinggi penyakit tidak menular.Identifikasi faktor risiko hipertensi sangat berguna untuk manajemen dan pencegahan komplikasi hipertensi. Faktor risiko hipertensi ini dapat berbeda dominasinya antara wilayah yang satu dengan wilayah yang lainnya. Penelitian ini bertujuan untuk mengidentifikasi faktor yang berhubungan dengan hipertensi di wilayah pedesaan, Puskesmas Klakah, Lumajang, Jawa Timur. Jenis penelitian ini adalah analitik observasional dengan rancangan cross sectional dan mengambil data sekunder dari rekam medis pasien Puskesmas Klakah periode Januari-Oktober 2020. Sampel penelitian ini berjumlah 62, yang terdiri dari 31 responden hipertensi dan 31 responden non hipertensi. Rekam medis dipilih dengan menggunakan metode purposive sampling. Data rekam medis yang dianalisis meliputi umur, jenis kelamin, pekerjaan, tinggi badan, berat badan, tekanan darah, kadar asam urat. Data dianalisis menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa sebagian besar penderita hipertensi di Puskesmas Klakah memiliki karakteristik usia >46-65 lansia, berjenis kelamin perempuan, memiliki aktivitas keseharian yang minimal, memiliki berat badan tidak obesitas, dan hiperurisemia. Hiperurisemia merupakan faktor yang berhubungan signifikan dengan hipertensi di masyarakat pedesaan yang tinggal di sekitar wilayah Puskesmas Klakah Kabupaten Lumajang dengan p=0.00, OR= 63,00 (95% CI = 12,87-308,18).   Hypertension still becomes a global health problem due to its high prevalence and fatal complications. At a rural area of Klakah, Lumajang Regency, the prevalence of hypertension was atthe first rank of non-communicable diseases. Identification of risk factors is very useful for managing and preventing hypertensioncomplications. The hypertension risk factors may differ in dominance from one region to another. This study aims to identify the factors associated with hypertension at the rural area of Klakah Health Center, Lumajang, East Java. This is observational analytic research with a cross-sectional design. It used datas from patients’ medical records at the Klakah Health Center from January-October 2020. The sample was 62 respondents consisting of 31   hypertensive respondents and 31 non-hypertensive respondents. Medical records were selected using purposive sampling. Medical record data analyzed included age, gender, occupation, height, weight, blood pressure, and uric acid levels. The data wereanalyzed using the chi-square test. The results showed that most of the hypertensive patients at Klakah Health Center were characterized by aged>46-65 elderly, female, having minimal daily activities, not being obese, and having hyperuricemia. This study showed that hyperuricemia is significantly associated with hypertension in rural areas of Klakah Health Center, Lumajang Regency withp=0.00, OR= 63,00 (95% CI = 12,87-308,18).     Hypertension still becomes a global health problem due to its high prevalence and fatal complications. At a rural area of Klakah, Lumajang Regency, the prevalence of hypertension was at the first rank of non-communicable diseases. Identification of risk factors is very useful for managing and preventing hypertension complications. The hypertension risk factors may differ in dominance from one region to another. This study aims to identify the factors associated with hypertension at the rural area of Klakah Health Center, Lumajang, East Java. This is observational analytic research with a cross-sectional design. It used datas from patients’ medical records at the Klakah Health Center from January-October 2020. The sample was 62 respondents consisting of 31 hypertensive respondents and 31 non-hypertensive respondents. Medical records were selected using purposive sampling. Medical record data analyzed included age, gender, occupation, height, weight, blood pressure, and uric acid levels. The data were analyzed using the chi-square test. The results showed that most of the hypertensive patients at Klakah Health Center were characterized by aged>46-65 elderly, female, having minimal daily activities, not being obese, and having hyperuricemia. This study showed that hyperuricemia is significantly associated with hypertension in rural areas of Klakah Health Center, Lumajang Regency with p=0.00, OR= 63,00 (95% CI = 12,87-308,18).
EFEK NEEM GUM (Azadiracthta indica) TERHADAP KADAR SGOT SGPT TIKUS WISTAR YANG DIINDUKSI DIAZINON Jauhar Firdaus; Zahrah Febianti; Muhammad Rijal Fahrudin Hidayat; Elly Nurus Sakinah
Journal of Nutrition College Vol 11, No 3 (2022): Juli
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v11i3.33384

Abstract

ABSTRAKLatar belakang: Indonesia sebagai negara agraris 33,48 juta penduduknya bekerja di sektor pertanian dengan kasus keracunan pestisida tercatat 771 kasus pada tahun 2016. Diazinon menjadi salah satu pestisida golongan organofosfat yang cukup banyak digunakan di Indonesia yang memiliki efek neurotoksik dan berpotensi menyebabkan stres oksidatif pada hepar. Neem gum (Azadirachta indica) memiliki kandungan polisakarida dan antioksidan yang dapat mengikat radikal bebas untuk mencegah kerusakan pada hepar.Tujuan: Penelitian ini bertujuan untuk mengetahui efek neem gum terhadap kadar SGOT SGPT tikus wistar yang diinduksi diazinon.Metode: Penelitian ini merupakan penelitian eksperimental melalui pendekatan post test only dengan subjek tikus putih Rattus norvegicus strain wistar jantan sebanyak 25 ekor yang terbagi dalam 1 kelompok kontrol dan 4 kelompok perlakuan dosis larutan neem gum sebesar 3,75 gram/kgBB/hari, 7,5 gram/kgBB/hari, 15 gram/kgBB/hari, dan 30 gram/kgBB/hari.Hasil: Kadar SGOT dan SGPT tertinggi terdapat pada kelompok K dan kadar yang lebih rendah pada kelompok P1, P2, P3, dan P4 seiring penambahan dosis larutan neem gum yang diberikan. Hasil uji Anova kadar SGOT didapatkan signifikansi sebesar 0,013 dan uji Post Hoc terlihat perbedaan signifikan kadar SGOT kelompok P4 terhadap kelompok K sebesar 0,015.  Sedangkan hasil uji Anova kadar SGPT didapatkan signifikansi sebesar 0,014 dan uji Post Hoc terlihat perbedaan signifikan kadar SGPT kelompok P2, P3, dan P4 terhadap kelompok K berturut-turut sebesar 0,044, 0,034, dan 0,033.Simpulan: Larutan neem gum (Azadirachta indica) memiliki efek mencegah peningkatan kadar SGOT dan SGPT pada tikus yang diinduksi Diazinon.  Dosis yang dibutuhkan neem gum untuk mencegah peningkatan kadar SGOT sebanyak 30 gram/kgBB/hari dan dosis yang dibutuhkan untuk mencegah peningkatan kadar SGPT sebesar 7,5 gram/kgBB/hari, 15 gram/kgBB/hari, serta 30 gram/kgBB/hari dan tidak ada perbedaan efek yang signifikan diantara ketiga dosis tersebut. 
Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4 Danang Tejamukti Widiatmaja; Diana Chusna Mufida; Zahrah Febianti
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Vol 4, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.100

Abstract

Streptococcus pneumoniae atau pneumokokus merupakan penyebab penyakit community acquired pneumoniae(CAP). Penularan pneumokokus dapat dicegah oleh vaksin, seperti PPV dan PCV. Vaksin tersebut memiliki beberapa kelemahan seperti terbatas pada strain tertentu dan pemberian yang masih bersifat invasif. Pada penelitian ini dilakukan pengembangan vaksin dari epitope pneumokokus yang diberikan secara intranasal. Salah satu epitope yang dapat digunakan sebagai kandidat vaksin adalah epitope dari protein RrgB penyusun pili, seperti epitope protein RrgB 255-270 dari bakteri Streptococcus pneumoniae yang memiliki komponen antigenik tinggi. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian imunisasi intranasal epitope protein RrgB 255-270 Streptococcus pneumoniae terhadap kadar IL-4. Kadar IL-4 diukur dengan metode ELISA dari bilasan hidung tikus wistar yang diimunisasi dengan epitope protein RrgB 255-270 S. pneumoniae secara intranasal. Bilasan hidung yang didapat akan diproses menggunakan metode ELISA untuk menghitung kadar IL-4. Nilai rata-rata kadar IL-4 pada K1 adalah 28,852± 18 ng/L, rata-rata kadar IL-4 pada K2 adalah 20,630 ± 9 ng/L dan rata-rata pada K3 adalah 18,519 ± 6 ng/L. Hasil uji ANOVA Welch menunjukkan nilai p sebesar 0,299. Dapat disimpulkan bahwa imunisasi intranasal epitope protein RrgB 255-270 S. pneumoniae memberikan perbedaan yang tidak signifikan (dengan p > 0,05).
Co-Authors Adellia Fira Fa'idha Al Munawir Azham Purwandhono Bagus Hermansyah Cholis Abrori, Cholis Danang Tejamukti Widiatmaja Diana Chusna Mufida Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fanteri Aji Dharma Suparno Galuh Dharanindya Ica Manohara Hairrudin Hairrudin Handoko, Adelia Ika Rahmawati Sutejo Ivan Iqbal Baidowi Jauhani, Muhammad Afiful Jauhar Firdaus Kristianningrum Dian Sofiana Kusumastuti, Inke M. Ihwan Narwanto Mauliya Sri Sukmawati Wahyudi Muhammad Rijal Fahrudin Hidayat Nindya Shinta Rumastika Nurfahimi, Yudriani Putri, Elvia Rahmi Marga Rayyan, Muhammad Isra Rafidin Rena Normasari Salman Al Farisi Septyawati, Ratna Sugiyanta Sugiyanta Syahda Nabilla Aristawidya Utama, Bagas Wahyu Widiatmaja, Danang Tejamukti Yudha Nurdian Yunita Armiyanti