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SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT Noor Pratiwi, Artie; Mahfudh, Nurkhasanah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized bynucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantrolinemonohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determinedbased on the melting range data and TLC. Identification of the structure of the compoundssynthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is acolorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with anoptimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount ofyield product, there is an optimal yield in the mole ratio of 1:1.

Halal assurance system training and its implementation with the Muhammadiyah halal pledge Mahfudh, Nurkhasanah; Ikawati, Retty; Salamah, Nina; Ahda, Mustofa
Community Empowerment Vol 6 No 5 (2021)
Publisher : Universitas Muhammadiyah Magelang

The implementation of Law Number 33 of 2014 concerning Halal Product Guarantee requires all products circulating in Indonesia to have a halal certificate. Micro businesses must also keep up with these developments. The 2020 Job Creation Law states that the obligation to be halal certified is based on statements from micro and small business actors. Muhammadiyah responded to this scheme by setting a halal pledge for micro and small businesses. To support the statement of the halal pledge which is based on understanding, training activities and assistance for the halal production process are carried out for micro and small businesses. The results of this activity revealed a significant increase in the understanding of MSMEs with an average pre-test score of 36 Â± 6.9 and an average post-test score of 72 Â± 14.1. In addition, participants were also able to compile the Muhammadiyah halal pledge application form.

SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT Artie Noor Pratiwi; Nurkhasanah Mahfudh
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized bynucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantrolinemonohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determinedbased on the melting range data and TLC. Identification of the structure of the compoundssynthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is acolorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with anoptimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount ofyield product, there is an optimal yield in the mole ratio of 1:1.

Groundwater and indoor air quality of urban village housing: study in Janturan, Warungboto, Yogyakarta Mahfudh, Nurkhasanah; Prasasti, Dian; Ananda, Anugrah Tri; Rahmawati, Frida; Sulistyawati, Sulistyawati; Muchlis, Muchlis; Murtyas, Solli Dwi; Hagishima, Aya
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23865

Water and air are important elements for life. The presence of pathogenic bacteria in the surrounding environment can cause health problems resulting from the low quality of water and air. The purpose of this study is to measure the quality of groundwater and air based on microbiological parameters in urban village housing. This research was conducted in a descriptive survey, and a purposive sampling technique was carried out. Groundwater and air samples were taken from six residents' houses located in the Janturan area. The water quality test used the most probable number (MPN) method and the air quality test used the agar filter method using a microbiological air sampler (MAS) to trap microbes. The results of the MPN test for total coliform bacteria from six samples of groundwater showed that three samples were positive for coliform bacteria which exceeded the threshold according to Indonesian standard<50 MPN/100 ml. Assay of E. coli bacteria showed that all samples of groundwater positively contained E. coli bacteria which exceeded the threshold of 0 MPN/100 ml. The results of indoor air quality measurements from 6 residents' houses showed that five houses have air quality did not meet the standard for indoor air germ numbers based on Indonesian standard, less than 700 CFU/m3 (colony forming units per metres cubic) and 1 house that got the number of airborne germs, in the normal range, namely 356 CFU/m3. It was concluded that the water quality and air quality in the urban village did not meet health requirements.

Variability and pharmacological potential of bajakah (Spatholobus sp.) as an indigenous medicinal plant: a review Mahfudh, Nurkhasanah; Utami, Dwi; Nashihah, Siti; Ahda, Mustofa; Andika, Andika; Sabilla, Giriani Ayu
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23791

Bajakah (Spatholobus sp.) is an indigenous Indonesian plant that has been traditionally used as medicine, especially in Kalimantan Island, Indonesia. The variability and potential of bajakah as a traditional Indonesian medicinal plant have attracted research attention. This review article describes the traditional use, distribution, and pharmacological activity of bajakah. An integrative review method was employed, following procedures such as literature search, data analysis, and result presentation. Understanding the variations is important to understand the therapeutic potential and differences in active compound content among different types of bajakah. Furthermore, the chemical composition of bajakah has been identified, including alkaloids, flavonoids, tannins, saponins, and triterpenoids, which can potentially exhibit pharmacological effects and mechanisms of action associated with its traditional use. This review provided additional insights into the potential of bajakah as an herbal medicinal in the future. Therefore, this review article provides an overview of the traditional use distribution, and pharmacological activity of bajakah as a promising traditional medicine. Further research, including clinical studies, is needed to scientifically validate the therapeutic potential of bajakah and further understand the mechanisms of action and potential side effects associated with it.

REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF KALANGKALA PLANT (Litsea angulata) Enti Rikomah, Setya; Mahfudh, Nurkhasanah; Yuliani, Sapto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1245

Kalangkala plants are native to Kalimantan and belong to the genus Litsea, family Lauraceae. Traditionally, it is used to treat diarrhea, boils, dyspepsia, diabetes, pain, asthma, fever, arthritis, traumatic injuries, gastroenteritis, edema, and stomachaches. This review article aims to explain the phytochemical components and pharmacological activities of the kalangkala plant. Databases from Google Scholar, ScienceDirect, and PubMed were searched for articles published from 2016 to 2024. The keywords used were Kalangkala, Litsea, and Litsea angulata. The results showed that Litsea angulata contains phytochemical compounds including saponins, alkaloids, flavonoids, tannins, steroids, triterpenoids, terpenoids, carotenoids, coumarin, ?-pinene, (S)-cis-verbenol and ?-sitosterol. The pharmacological activity of Litsea angulata includes antioxidant, antibacterial, antidiabetic, and spermacidal activities and is toxic. Antioxidant activity of kalangkala plant from various parts of the plant, namely branches, bark, leaves, seeds, fruits, leaves, and fruit seeds. Antibacterial activity in plant parts, namely branches, bark, leaves, seeds, and essential oils from leaves, and antidiabetic activity in the fruit seeds of the kalangkala plant. Litsea angulata is the most widely reported phytochemical component for its pharmacological activity, namely flavonoids. Flavonoids are found in various parts of plants, including the seeds, bark, and leaves. Pharmacological activity as an antioxidant, antibacterial, and antidiabetic. Further research is needed to identify the phytochemical components responsible for the pharmacological activity in the discovery of new drugs. Keywords: Kalangkala, Litsea, Litsea angulata

Readiness Society to Enter the Era of Halal Drug Certification Mandatory in Terms of Knowledge, Perceptions, and Attitudes Ahmad Azrul Zuniarto; Nurkhasanah Mahfudh; Dyah Aryani Perwitasari; Siti Pandanwangi
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.7771

The halal lifestyle trend is currently developing in various regions of the world, not only in areas where the majority of the population is Muslim but also where the population is Muslim minority. This study aims to determine the level and correlation of public knowledge, perceptions, and attitudes toward halal medicine and correlation with demographic data. This cross-sectional study was conducted online using a validated questionnaire, conducted in January-February 2023 on 600 respondents in six provinces of Java Island, using a purposive sampling method with inclusion criteria over 17 years old and exclusion criteria not being a doctor or pharmacist. The Spearman test was used to correlate knowledge-perception-attitude, and the Chi-square test was used to correlate demographic data with knowledge, attitude, and perception. The results showed that the level of public knowledge was sufficient (mean score 33.74 ± 2.37), the perception was sufficient (mean score 35.91 ± 3.47) and the attitude was sufficient (mean score 31.17 ± 4.25) towards halal medicine. Age, education, and place of work affect knowledge; and place of work affects perception. It is concluded that the community has sufficient knowledge, perceptions, and attitudes, knowledge-perception is significantly correlated, knowledge-attitude is weak and perception-attitude is strongly correlated

Chemical Compound Profile of Bajakah Kalalawit (Uncaria gambir Roxb) Stem Extract Using Liquid Chromatography High-Resolution Mass Spectrometry Fawaid, Ainun; Mahfudh, Nurkhasanah
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7942

Uncaria gambir Roxb., commonly known as Bajakah Kalalawit, is a plant endemic to Kalimantan, Indonesia, with potential medicinal properties. While previous studies have investigated the phytochemical composition of U. gambir leaves, limited information exists regarding the constituents of its stem extract. This study aimed to comprehensively characterize the chemical composition of U. gambir stem extract using Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS). Ethanol (96%) was employed as the solvent for maceration extraction (1 : 5, plant material : solvent ratio) for three days. Subsequently, the dried extract was subjected to LC-HRMS analysis. Compounds with an Area Under the Curve (AUC) value greater than or equal to 1% were considered as major constituents. The results revealed the presence of 18 distinct chemical compounds in the U. gambir stem extract, providing valuable insights into its phytochemical profile and laying the foundation for further investigations into its potential pharmacological activities.

The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.

The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.

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