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All Journal INDONESIAN JOURNAL OF PHARMACY
Peter Proksch
Institut für Pharmazeutische Biologie and Biotechnologie, Henrich-Heine Universität Düsseldorf, Universitätsstrasse 1 Geb. 26.23, 40225, Düsseldorf, Germany
Medicine & Pharmacology

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Chemical investigation on Pseudoceratina purpurea collected from Banyuwangi Indonesia Triana Hertiani; RuAngelie Edrada; Rob W.M. Van Soest; Werner E.G. Muller; Sudarsono .; Peter Proksch
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.691 KB) | DOI: 10.14499/indonesianjpharm0iss0pp17-26

Abstract

Chemical investigation on marine sponge Pseudoceratina purpurea collected from Banyuwangi, Indonesia has been performed. This study was aimed to isolate and to identify structures of the sponge secondary metabolites as well as to test their cytotoxicity activity on mouse lymphoma cell line L5178Y.Isolation procedure was performed by using different chromatography techniques. NMR spectroscopy and mass spectrometry methods were used to identify the compounds chemical structures. Cytotoxicity of the isolates was tested on mouse lymphoma cell line L5178Y by using the microculture tetrazolium (MTT) assay.This study yielded five known tyrosine-derived alkaloids, two of which, aplysamine-2 (1) and aeroplysinin-1 (2) showed growth inhibition of mouse lymphoma cell line L5178Y with IC50 value of 1.7 mg/mL and 0.57 mg/mL, respectively.Key words: Pseudoceratina purpurea, sponge, alkaloids.
Co-Authors rob W.M. van Soest RuAngelie Edrada Sudarsono . Triana Hertiani Werner E.G. Muller