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All Journal Jurnal Ecosolum BIOTROPIA - The Southeast Asian Journal of Tropical Biology AGRIVITA, Journal of Agricultural Science Indonesian Journal of Pharmaceutical Science and Technology JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Jurnal Hasil Penelitian Industri At-Ta'dib: Jurnal Ilmiah Prodi Pendidikan Agama Islam Jurnal Pendidikan dan Pengajaran Guru Sekolah Dasar (JPPGuseda) Jurnal Ilmu Sosial dan Ilmu Politik Malikussaleh (JSPM) Narra J Journal of Patchouli and Essential Oil Products SINTHOP: Media Kajian Pendidikan, Agama, Sosial dan Budaya Heca Journal of Applied Sciences Malacca Pharmaceutics Leuser Journal of Environmental Studies Grimsa Journal of Science Engineering and Technology Jurnal At-Tamwil: Kajian Ekonomi Syariah
Khairan Khairan
Jurusan Farmasi, FMIPA, Universitas Syiah Kuala, Darussalam Banda Aceh, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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PEMANFAATAN MINYAK BIJI ALPUKAT (Avocado seed oil) UNTUK SINTESIS MEMBRAN POLIURETAN (Utilization of Avocado Seed Oil for Polyurethane Membrane Synthesis) Fitriani, Fitriani; Khairan, Khairan; Marlina, Marlina
Jurnal Hasil Penelitian Industri Vol 29, No 1 (2016)
Publisher : Baristand Industri Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (23.353 KB)

Abstract

Avocado seed oil has been used for the synthesis of polyurethane membrane, which is reactedwith 1,6-hexamethylene diisocyanate (HMDI). The main objective of this research is manufacture ofpolyurethane membranes from avocado seed oil, as a filter of this membrane use as a filter of metals fromwater such as mercury (Hg) etc.. Polyurethane membrane was synthesized by the crosslink method betweenHMDI and avocado seed oil. The results showed that the optimum ratio condition HMDI and avocado seedoil is 1.8: 5 (w/v). The result showed that flux value work at the optimum condition is 88 L/m2.h.bar, withrejection coefficient of 98.87%. Analysis with Fourier Transform Infrared (FTIR) showed that of functionalN-H group at 3314.996 cm-1, and did not reveal any FTIR of -NCO functional group at 2270 cm-1. Theabsence of absorption -NCO group proves membrane synthesis was successful. Mechanical tests andDifferential Thermal Analysis (DTA) showed that the membrane was the characteristics of a hard and rigid.Scanning Electron Microscope- Energy Dispersive X-ray (SEM-EDX) assay showed that the membranesurface is not homogeneous and membrane capable for filtering heavy metals from water contaminatedwith mercury (Hg).
FUNGICIDAL ACTIVITY OF GARLIC (ALLIUM SATIVUM) BULBS EXTRACTS AGAINST PLANTS PHATOGENIC FUNGI Khairan, khairan; Aulina, Aulina; Bahi, Muhammad; Nova Eriana, Cut; Sriwati, Rina
JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Vol 19, No 1 (2019): MARCH, JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/j.hptt.11923-32

Abstract

Fungicidal activity of garlic (Allium sativum) bulbs extracts against plants phatogenic fungi. Garlic (Allium sativum Linn) has been known to containing organosulphur compounds. These compounds are convinced to possess antibacterial, antifungal, and anticancer activities. The aim of this study is to determine fungicidal activity of garlic bulb extracts against some plants phatogenic fungi. The paper disc agar difussion technique was used to determine fungicidal activity of garlic bulbs extracts. The results showed that in general garlic bulbs extracts provides fungicidal activities. Calculated EC50 values indicated that ethyl acetate garlic bulbs extract was most active against Colletotrichum capsici, Fusarium oxysporum f. sp.capsici, and Sclerotium rolfsi by EC50 values of 48,6; 50,3; and 51.3% respectively. Meanwhile methanolic garlic bulbs extract was the most active against Sclerotium rolfsi with EC50 values of 24,3%.
Penggunaan Cadar di Kalangan Mahasiswi: Studi Tentang Makna, Motivasi, dan Diskriminasi Soleman, Soleman; Khairan, Khairan; Syahputra, Nanda; Alfia, Reni Septri; Mahmani, Sri; Munawita, Munawita
SINTHOP: Media Kajian Pendidikan, Agama, Sosial dan Budaya Vol. 2 No. 2 (2023): Juli-Desember
Publisher : Lembaga Aneuk Muda Peduli Umat, Bekerjasama dengan Pusat Jurnal Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/sinthop.v2i2.3987

Abstract

This article aims to describe the meanings, motivations, and discrimination related to the use of veils among students at UIN Ar-Raniry. This research utilizes a qualitative descriptive approach, and data were obtained from various sources, including field observations, direct interviews with informants, and relevant scholarly literature. The findings of this study indicate that female students interpret the use of veils in various ways, such as self-defense, an expression of obedience to God, and an understanding of Islamic law. They also view the veil as a means to protect themselves from unwanted attention, as part of their journey of religious conversion, and as a way to maintain modesty and behavior in accordance with Islamic teachings. Motivations behind the use of veils by female students include a desire to draw closer to Islamic teachings, self-protection, and social influence. This reflects a combination of psychological, social, and spiritual factors in their decision to wear the veil. This study also reveals that some female students experience discrimination and negative stereotypes as a result of wearing veils, including being perceived as extremists or terrorists. These experiences indicate that the use of veils in an academic environment can also trigger prejudice and negative social reactions. Abstrak Artikel ini bertujuan untuk mendeskripsikan makna, motivasi, dan diskriminasi terkait penggunaan cadar di UIN Ar-Raniry. Penelitian ini menggunakan pendekatan deskriptif kualitatif, dan data diperoleh dari berbagai sumber, termasuk observasi lapangan, wawancara langsung dengan informan, dan literatur ilmiah yang relevan. Hasil kajian ini menunjukkan bahwa mahasiswi memaknai penggunaan cadar secara beragam seperti pertahanan diri, ekspresi ketaatan kepada Tuhan, dan pemahaman terhadap hukum Islam. Mereka juga melihat cadar sebagai cara untuk melindungi diri dari perhatian yang tidak diinginkan, sebagai bagian dari perjalanan hijrah mereka, dan sebagai sarana untuk menjaga kesopanan serta perilaku yang sesuai dengan ajaran Islam. Motivasi di balik pemakaian cadar oleh mahasiswi meliputi keinginan mendekatkan diri pada ajaran Islam, perlindungan diri, dan pengaruh sosial. Ini mencerminkan perpaduan faktor psikologis, sosial, dan spiritual dalam keputusan mereka untuk bercadar. Kajian ini juga menunjukkan bahwa beberapa mahasiswi juga mengalami diskriminasi dan stereotip negatif akibat pemakaian cadar, termasuk dianggap sebagai ekstremis atau teroris. Pengalaman tersebut mengindikasikan bahwa penggunaan cadar dilingkungan akademis juga dapat memicu prasangka dan reaksi sosial yang negatif.
Characterizing the Size Distribution of Silver Nanoparticles Biofabricated Using Calotropis gigantea from Geothermal Zone Kemala, Pati; Khairan, Khairan; Ramli, Muliadi; Mauer Idroes, Ghazi; Mirda, Erisna; Setya Ningsih, Diana; Tallei, Trina Ekawati; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.21

Abstract

This research aims to synthesize silver nanoparticles (AgNPs) using an aqueous leaf extract of Calotropis gigantea obtained from the geothermal manifestation Ie Seu-Um, Aceh Besar, Aceh Province, Indonesia. The C. gigantea leaf extract was mixed with AgNO3 solutions at concentrations of 2, 5, and 9 mM, respectively. The mixture was stirred at 80 rpm by a magnetic stirrer for 48 hours in the dark. The change in solution color indicated the reduction of Ag+ to Ag0. The resulting AgNPs synthesized using C. gigantea leaf extract (AgNPs-LCg) exhibited cloudy grey, reddish dark brown, and light brown colors when synthesized with AgNO3 concentrations of 2, 5, and 9 mM, respectively. The particle sizes of AgNPs-LCg had maximum frequencies at 246.98 nm (synthesized using AgNO3 2 mM), 93.02 nm (synthesized using AgNO3 5 mM), and 171.25 nm (synthesized using AgNO3 9 mM). The zeta potential values of AgNPs-LCg using 2, 5, and 9 mM AgNO3 were -41.9, -40.1, and -31.4 mV, respectively. Based on the solution color, nanoparticle size, and stability value of AgNPs, it can be concluded that the use of AgNO3 at 5 mM is optimal for the green synthesis process of AgNPs-LCg.
Clinical and oral microbiome pattern of halitosis patients with periodontitis and gingivitis Ningsih, Diana S.; Idroes, Rinaldi; Bachtiar, Boy M.; Khairan, Khairan; Tallei, Trina E.; Kemala, Pati; Maulydia, Nur B.; Idroes, Ghazi M.; Helwani, Zuchra
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.163

Abstract

Halitosis is caused by a bacterial proteolytic process that induces the production of volatile sulfur compounds, odor-causing gases. The aim of this study was to determine the clinical oral hygiene state and oral microbiome pattern of halitosis patients with periodontitis and gingivitis. The oral hygiene state of halitosis patients with periodontitis and gingivitis was assessed using the oral hygiene index simplified (OHI-S), decay missing filled teeth (DMFT), and tongue biofilm. The dorsum of the tongue and subgingival swabs were cultured for bacteria, and bacterial morphology was evaluated using Gram staining. Evaluation of the bacterial genus using the Bergey's systematic bacteriology diagram as a guide. A total of ten patients with periodontitis and gingivitis were included. Our data indicated that the scores of OHI-S and DMFT were different significantly between halitosis patients with periodontitis and gingivitis (both had p<0.001) while tongue biofilm score was not different between groups. On the dorsum of the tongue, periodontitis patients had a significant higher oral microbiome population (85.65x106 CFU/mL) compared to those with gingivitis (0.047x106 CFU/mL) with p=0.002. In contrast, the number of microbiomes in the subgingival had no significant different between periodontitis and gingivitis. On the dorsum of the tongue, six bacterial genera were isolated from periodontitis cases and seven genera were detected from gingivitis patients. On subgingival, 10 and 15 genera were identified from periodontitis and gingivitis, respectively. Fusobacterium, Propionibacterium, Eubacterium and Lactobacillus were the most prevalent among periodontitis cases while Porphyromonas was the most prevalent in gingivitis patients. In conclusion, although OHI-S and DMFT are different between periodontitis and gingivitis, overlapping of bacterial genera was detected between periodontitis and gingivitis cases.
Optimizing antimicrobial synergy: Green synthesis of silver nanoparticles from Calotropis gigantea leaves enhanced by patchouli oil Kemala, Pati; Khairan, Khairan; Ramli, Muliadi; Helwani, Zuchra; Rusyana, Asep; Lubis, Vanizra F.; Ahmad, Khairunnas; Idroes, Ghazi M.; Noviandy, Teuku R.; Idroes, Rinaldi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.800

Abstract

Silver nanoparticles (AgNPs) synthesized from plant extracts have gained attention for their potential applications in biomedicine. Calotropis gigantea has been utilized to synthesize AgNPs, called AgNPs-LCg, and exhibit antibacterial activities against both Gram-positive and Gram-negative bacteria as well as antifungal. However, further enhancement of their antimicrobial properties is needed. The aim of this study was to synthesize AgNPs-LCg and to enhance their antimicrobial and antifungal activities through a hybrid green synthesis reaction using patchouli oil (PO), as well as to characterize the synthesized AgNPs-LCg. Optimization was conducted using the response surface method (RSM) with a central composite design (CCD). AgNPs-LCg were synthesized under optimal conditions and hybridized with different forms of PO—crude, distillation wastewater (hydrolate), and heavy and light fractions—resulting in PO-AgNPs-LCg, PH-AgNPs-LCg, LP-AgNPs-LCg, and HP-AgNPs-LCg, respectively. The samples were then tested for their antibacterial (both Gram-positive and Gram-negative bacteria) and antifungal activities. Our data indicated that all samples, including those with distillation wastewater, had enhanced antimicrobial activity. HP-AgNPs-LCg, however, had the highest efficacy; therefore, only HP-AgNPs-LCg proceeded to the characterization stage for comparison with AgNPs-LCg. UV-Vis spectrophotometry indicated surface plasmon resonance (SPR) peaks at 400 nm for AgNPs-LCg and 360 nm for HP-AgNPs-LCg. The Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of O-H, N-H, and C-H groups in C. gigantea extract and AgNP samples. The smallest AgNPs-LCg were 56 nm, indicating successful RSM optimization. Scanning electron microscopy (SEM) analysis revealed spherical AgNPs-LCg and primarily cubic HP-AgNPs-LCg, with energy-dispersive X-ray spectroscopy (EDX) confirming silver's predominance. This study demonstrated that PO in any form significantly enhances the antimicrobial properties of AgNPs-LCg. The findings pave the way for the exploration of enhanced and environmentally sustainable antimicrobial agents, capitalizing on the natural resources found in Aceh Province, Indonesia.
Uncovering anti-inflammatory potential of Lantana camara Linn: Network pharmacology and in vitro studies Khairan, Khairan; Maulydia, Nur B.; Faddillah, Vira; Tallei, Trina E.; Fauzi, Fazlin M.; Idroes, Rinaldi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.894

Abstract

Lantana camara Linn contains a diverse array of metabolites that exhibit therapeutic potential. The aim of this study was to evaluate the potential of L. camara leaves, which were collected at the Ie-Seu'um geothermal area in Aceh, Indonesia, as an anti-inflammatory through network pharmacology and in vitro analysis. The ethanolic extract derived from L. camara underwent identification utilizing gas chromatography-mass spectrometry (GC-MS) to verify chemical constituents for drug-likeness properties. The evaluation of anti-inflammatory activity included network pharmacology and a series of in vitro investigations using two methods: protein inhibition and albumin denaturation assays. The findings revealed that the extract contained a domination of terpenoids and fatty acids class, which met the evaluation criteria of drug-likeness. Network pharmacology analysis identified the top five key proteins (peroxisome proliferator-activated receptor gamma, prostaglandin G/H synthase 2, epidermal growth factor receptor, hypoxia-inducible factor 1-alpha, and tyrosine protein kinase-Janus kinase 2) involved in inflammation-related protein-protein interactions. Gene ontology enrichment highlighted the predominance of inflammatory responses in biological processes (BP), cytoplasm in cellular components (CC), and oxidoreductase activity in molecular functions (MF). In vitro analysis showed that the extract inhibited protein activity and protein denaturation with inhibitory concentration (IC50) values of 202.27 and 223.85 ppm, respectively. Additionally, the extract had antioxidant activity with DPPH- and ABTS-scavenging IC50 values of 140 ppm and 163 ppm, respectively. Toxicological assessment by brine shrimp lethality assay (BSLA), yielding a lethal concentration (LC50) value of 574 ppm (essentially non-toxic) and its prediction via ProTox 3.0 that indicated non-active in hepatotoxicity, carcinogenicity, immunotoxicity, mutagenicity, and cytotoxicity. These results suggested that L. camara holds noteworthy effectiveness as a potential candidate for complementary medicine in the realm of inflammatory agents, warranting further investigation in clinical settings.
Urban Air Quality Classification Using Machine Learning Approach to Enhance Environmental Monitoring Idroes, Ghazi Mauer; Noviandy, Teuku Rizky; Maulana, Aga; Zahriah, Zahriah; Suhendrayatna, Suhendrayatna; Suhartono, Eko; Khairan, Khairan; Kusumo, Fitranto; Helwani, Zuchra; Abd Rahman, Sunarti
Leuser Journal of Environmental Studies Vol. 1 No. 2 (2023): November 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v1i2.99

Abstract

Urban areas worldwide grapple with environmental challenges, notably air pollution. DKI Jakarta, Indonesia's capital city, is emblematic of this struggle, where rapid urbanization contributes to increased pollutants. This study employed the CatBoost machine learning algorithm, known for its resistance to overfitting and capability to handle missing data, to predict urban air quality based on pollutant levels from 2010 to 2021. The dataset, sourced from Jakarta's air quality monitoring stations, includes pollutants such as PM10, SO2, CO, O3, and NO2. After preprocessing, we used 80% of the data for training and 20% for testing. The model displayed high accuracy (0.9781), precision (0.9722), and recall (0.9728). The feature importance chart revealed O3 (Ozone) as the top influencer of air quality predictions, followed by PM10. Our findings highlight the dominant pollutants affecting urban air quality in Jakarta, Indonesia and emphasizing the need for targeted strategies to reduce their concentrations and ensure a cleaner and healthier urban environment.
Ensuring Accuracy: Critical Validation Techniques in Geochemical Analysis for Sustainable Geothermal Energy Development Idroes, Ghazi Mauer; Suhendrayatna, Suhendrayatna; Khairan, Khairan; Suhartono, Eko; Prasetio, Rasi; Riza, Medyan
Leuser Journal of Environmental Studies Vol. 2 No. 1 (2024): April 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v2i1.176

Abstract

Geochemical analysis is a critical tool in geothermal exploration, providing valuable insights into reservoir characteristics. However, obtaining accurate and reliable geochemical data requires rigorous validation techniques. This review examines key factors affecting the accuracy of geochemical data and discusses best practices for ensuring quality. Proper sampling methods, including selection of representative locations, use of appropriate equipment, and adherence to robust protocols for sample collection, filtration, preservation, and storage, are essential for maintaining integrity. Analytical techniques must be carefully selected, with regular calibration and standardization of instruments using certified reference materials. Implementing comprehensive quality assurance and quality control procedures, such as analyzing blanks, duplicates, and spike samples, helps monitor precision and accuracy. Data interpretation should consider the complexities of the geological and hydrological settings, integrating multiple lines of evidence. By following established guidelines and continuously updating methods based on emerging technologies and inter-laboratory comparisons, geothermal teams can optimize the reliability of their geochemical data. Accurate and precise geochemical information, when combined with geological, geophysical, and hydrological data, enables informed decision-making and enhances the success of geothermal projects. As geothermal energy gains importance in the transition to sustainable resources, ensuring the accuracy of geochemical analysis will be crucial for effective exploration and development.
GC-MS Analysis Reveals Unique Chemical Composition of Blumea balsamifera (L.) DC in Ie-Jue Geothermal Area Maulydia, Nur Balqis; Khairan, Khairan; Tallei, Trina Ekawati; Estevam, Ethiene Castellucci; Patwekar, Mohsina; Mohd Fauzi, Fazlin; Idroes, Rinaldi
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 1 (2023): October 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i1.6

Abstract

Blumea balsamifera (L.) DC. or Sembung is a flowering plant belonging to the genus Blumea of the family Asteraceae. Many pharmacological activities of this plant show potential in human therapy. In this study, an investigation was conducted on the ethanolic extract of B. balsamifera collected from a geothermal area known as Ie-Jue, in Aceh Province, Indonesia. The results showed that the ethanolic extract of B. balsamifera contained secondary metabolites of flavonoids and tannins. Chemical constituents of ethanolic extracts B. balsamifera further analysis using gas chromatography-mass spectrometry (GC-MS) show that active compounds from this plant was Proximadiol (C15H28O2) with relative area 41.76%. This research underscores the compelling potential of the Ie-Jue geothermal area as a promising reservoir of flora owing to the plant's adaptability to geothermal extremities.
Co-Authors Abd Rahman, Sunarti Ahmad, Khairunnas Aini, Hanipah Aisya, Mauly Rahadatul Akmal Muhni Akmal Saputra Akyuni, Qurrata Alfia, Reni Septri Amalia Sutriana Amanda, Rosi Arini, Musfira Asep Rusyana Aulina, Aulina Azzahra, Putri Boy M. Bachtiar Claus Jacob, Claus Cut Irna Liyana Deliana, Fitri Diah, Muhammad Diana Setya Ningsih, Diana Eko Suhartono El-Shazly, Mohamed Essy Harnelly Estevam, Ethiene Castellucci Faddillah, Vira Fajar Fakri FARADILLA, FARADILLA Fauzi, Fazlin M. Fikrinda Fikrinda Fitriani Fitriani Ghazi Mauer Idroes Gholib Gholib, Gholib Harahap, Saima Putri Hasbi, Salsa Yubila Hewindati, Yuni Tri Hifnalisa Hifnalisa Hilda Maisyarah, Hilda Idroes, Ghalieb Mutig Idroes, Ghazi M. Idroes, Ghifari Maulana Illian, Didi Nurhadi Isnaini, Nadia Iswahyudi Jannah, Rizka Auliatul Juraida, Irma Kartini Hasballah KAZWAINI, KAZWAINI Kemala, Pati Khalijah Awang Kusumo, Fitranto Lala, Andi Lubis, Vanizra F. Mahdi Abrar Mahmani, Sri Maulana, Addrian Maulana, Aga Maulydia, Nur B. Maulydia, Nur Balqis Medyan Riza Mirda, Erisna Mohd Fauzi, Fazlin Mubaraq, Farhil Muhammad Bahi Muliadi Ramli Munawita, Munawita Munira, Alya Musvira, Intan Nadirah, Siti Ningsih, Diana S. Nova Eriana, Cut Noviandy, Teuku R. Nurul Husna Patwekar, Mohsina Prasetio, Rasi Purwaendah, Elisa Rawanita, Mesi Rina Sriwati Rinaldi Idroes Risyad, Syukri Rizki, Risnanda Farzia Roslizawaty Roslizawaty, Roslizawaty Salsabila, Indah Sari, Fadia Sariyanti, Lilis Siregar, Tongku N. Soleman, Soleman Sreeramanan Subramaniam Suhendrayatna Suhendrayatna Suryawati Suryawati Syafruddin Syafruddin Syahputra, Nanda Teuku Rizky Noviandy Thahar, Aufa Sabrina Triana Hertiani Trina E. Tallei, Trina E. TRINA EKAWATI TALLEI Wasistha, Nurainun Intan Zahriah, Zahriah Zubaidah R, Zubaidah Zuchra Helwani, Zuchra Zulfadli Zulfadli