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Selfi Handayani
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Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Perbedaan Rasio Rentang Lengan-Tinggi Badan pada Mahasiswa Laki-laki dan Perempuan FK Universitas Sebelas Maret Budiastuti, Annisa; Handayani, Selfi; ., Hardjono
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Height is an important clinical indicator to derive Body Mass Index (BMI) and also to estimate Basal Metabolic Rate (BMR). However, height measurement in someone who cannot stand properly like the elderly or lower ekstremity abnormality may become difficult. Therefore, estimating height with another antropometric measurement may become a solution. In another study, arm span showed the highest correlation with standing height. The different morfologic between male and female also important to find the different estimating height formula. Objectives: This research aimed to know arm span to height ratio data in students from Medicine Faculty 2008 of Sebelas Maret University and the differences of arm span to height ratio between male and female. Methods: This research was an analytical observational research with cross sectional approach. The sample data collected using purposive sampling method within inclusion and exclusion criteria. From the population, 60 samples (30 males and 30 females) chose by simple random sampling method, then measured their height and arm  span. Height measured in anatomical position using microtoise staturmeter. Arm span measured using ruler tape from the longest finger in right hand to the longest finger in left hand. All data analyzed using normality test Kolmogorov-Smirnov and followed with t-independent test if the distribution data showed normal. Results : T-independent test result p = 0.03 (p < 0.05). Conclusion: This study found a difference in arm span to height ratio between male and female students in Faculty of Medicine 2008, Sebelas Maret University, Surakarta Keywords: arm span, height, anthropometric measurement, student 
Efek Nefroprotektor Ekstrak Daun Kemangi (Ocimum sanctum) Terhadap Kerusakan Sel Ginjal Mencit (Mus musculus) Yang Diinduksi Parasetamol Basith, M Abdul; Listyaningsih, Endang; Handayani, Selfi
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Today, consuming paracetamol as an analgesic antipyretic drugs has  increased. Paracetamol which used in inappropriate dose has bad effect to our body, such as nefrotoxic. Basil leaf extract has antioxidant as a protection of free radicals and reducing NAPQI which produced by paracetamol. The objectives of this research are to know the nefroprotector effect and this research will shown the multilevel dose of basil leaf extract as a nefroprotector in the renal cell damage induced by parasetamol. Methods: This was experimental laboratory with the post test only controlled group design. Sample group consisted of male mice Swiss Webster, 2-3 month, + 20 g. Samples divided into 4 groups, each group has seven mice. Mice for control group (K) and the first treatment group (P1) were given aquades for 14 days. The second treatment group (P2) will be given basil leaf extract dose I for 14 days. The third treatment group (P3) will be given basil leaf extract dose II for 14 days. Paracetamol will be given to P1, P2, and P3, with dose 0,1 ml/20 gr weight of mice on the day 12, 13, and 14. Finally on day 15th, mice are sacrificed with neck dislocation then the renal of mice was made preparations with paraffin blocks methods and Hematoxillin Eosin staining. Renal cell damage observed and counted a mount of scored on renal histological karyopyknosis, karyorrhexis, and karyolysis. Data are analized by One-Way ANOVA test (α= 0,05) and continued by Post Hoc Multiple Comparisons test (LSD) (α = 0,05). Results: Result of One-Way ANOVA shown that there was a significant of degree between 4 groups. Result of LSD method there was a significant of degree between K-P1, K-P2, P1-P2, and P1-P3 groups; and also it wasn’t a significant of degree between K-P3 and P2-P3. Conclusions: The basil leaf extracts was able to decrease the renal cell damaging of mice and the increase of basil leaf extracts dose followed by the increase of protection effect to the renal cell damaging of mice which is induced by paracetamol.   Keywords: basil leaf extract, paracetamol, renal cell damage. 
Efek Pemberian Sari Buah Belimbing Manis (Averrhoa carambola Linn.)terhadap Kerusakan Histologis Hepar Tikus Putih(Rattus norvegicus) yang Diinduksi Parasetamol Cahyaningrum, Handayani Putri; Listyaningsih, Endang; Handayani, Selfi
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Star fruit (Averrhoa carambola Linn.) juice contains flavonoids, epicatechins, proanthocyanidins, and tanins that can protect liver from free radicals. The objectives of this research were to know the effect of star fruit (Averrhoa carambola Linn.) juice to liver histological damage of albino rat induced by paracetamol. Methods: This was laboratory experimental research with post test only controlled group design. Samples were 28 male rats from Wistar type, 2-3 months old and + 200 g of each weight. Samples were divided into 4 groups of 7 rats each. Sampling technique used in this research was incidental sampling. The control group (K) and the first treatment group (P1), rats were administered aquadest for 14 days. The second treatment group (P2), rats were administered star fruits juice with the concentration of 50% 2ml/200 g body weight of rat and the third group (P3), rats were administered star fruits juice with the concentration of 100% 2ml/200 g body weight of rat for 14 days. Paracetamol was administered to groups of P1, P2, and P3 on the 12th, 13th, and 14th day. On the 15th day, rats were sacrificed and their livers were made for preparation with paraffin block method which were stained HE. Liver histological features were assessed based on quantifying of pyknosis, karyorhexis, and karyolysis. Data were analyzed using the One-Way ANOVA test (α = 0.05) and continued with Post Hoc Multiple Comparisons (LSD) test (α = 0.05). Results: Statistically, the One-Way ANOVA test showed that there were significant differences of liver damage score between K – P1, K – P2, K – P3, P1 – P2, P1 – P3, and P2 – P3. Conclusion: Star fruit juice decreased the liver histological damage of albino rat (Rattus norvegicus) induced by paracetamol. Key words: star fruit juice, paracetamol, liver histological damage, albino rat 
Pengaruh Elektroakupunktur Titik Zusanli (ST 36) dan Zhongwan (CV 12) terhadap Perbaikan Gambaran Histologis Duodenum Tikus Putih (Rattus norvegicus) yang Terpapar Bising Intermitten Fajarini, Nur Dwi; Balgis, .; Handayani, Selfi
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Intermittent noise can induce stress that stimulates HPA axis to cause damage of duodenum. Acupuncture has already indicated to treat duodenal ulcer. This research studied the effect of electroacupuncture of Zusanli (ST 36) and Zhongwan (CV 12) acupoints to repair histological structure of white rat (Rattus norvegicus) duodenum exposed by intermittent noise. Methods: This was laboratory experimental research with the post test only controlled group design. Subjects were 28 male white rats (Rattus norvegicus), wistar strain, divided into 4 groups randomly. They were control group (K) which was not treated, experimental group 1 (P1) exposed by noise, experimental group 2 (P2) exposed by noise and allowed to have physiologic recovery for 30 days, and experimental group 3 (P3) exposed by noise and treated with electroacupuncture for 30 days. Noise exposure was conducted for 2 weeks with intensity of 95 dB intermittently, 1 hour on, 1 hour off, for 12 hours daily. Electroacupuncture was done by pricking acupuncture needle perpendicularly at Zusanli (ST 36) and Zhongwan (CV 12) acupoints, then, connected to 2 mA electrostimulation at 10 Hz continuous wave for 15 minutes, 10 times for therapy. At the end of experiment their duodenums were taken and prepared for histological  study by paraffin block method and stained with Hematoxillin Eosin (HE). The histological structure of duodenal mucosa was observed and assessed for the damage with Barthel Manja mucosal integrity score. The data were analized by One-Way ANOVA test (α=0.05) and continued by Post Hoc Multiple Comparisons using Least Significant Differences (LSD) test (α=0.05). Results: One Way Anova test showed significant differences of duodenal mucosa damage among the four groups p=0.000. LSD test showed significant differences between K-P1 (p=0.000), K-P2 (p=0.000), K-P3 (p=0.000), P1-P2 (p=0.007), P2-P3 (p=0.000), but not between P1-P3 (p=0.235). Conclusions: Electroacupuncture of Zusanli (ST 36) and Zhongwan (CV 12) acupoints repaired histological structure of white rat (Rattus norvegicus) duodenum exposed by intermittent noise. Keywords: Intermittent noise, Electroacupuncture,  Zusanli and Zhongwan acupoints, Duodenum 
Pengaruh Elektroakupunktur Titik Zusanli (ST 36) dan Sanyinjiao (SP6) terhadap Ketebalan Korteks Adrenal Tikus (Rattus norvegicus) yang Dipapar Bising Intermiten Luthfiyanto, Muhammad; Muthmainah, .; Handayani, Selfi
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Noise exposure triggers stress and thickens adrenal cortex. Electroacupuncture on Zusanli (ST 36) and Sanyinjiao (SP 6) acupoints is known to reduce stress and improve the hypothalamic-pituitary-adrenal (HPA) axis. This study aimed to know the effect of electroacupuncture (EA) at Zusanli (ST 36) and Sanyinjiao (SP 6) acupoints towards adrenal cortex thickness of rats (Rattus norvegicus) exposed by intermittent noise. Methods: This study was a laboratory experimental study with the post-test only control group design. The subject of this study was male Wistar rats (Rattus norvegicus), 1-2 months old, and 200-250 grams of body weight. Twenty seven rats were taken by consecutive sampling. The rats were divided into 3 groups randomly, each group consisted of 9 rats. The Control Group (KK) was untreated, the treatment group 1 (KP1) was exposed by the noise, the treatment group 2 (KP2) was exposed by the noise and treated with electroacupuncture. Noise exposure was conducted for about 8 hours/day intermittently during 21 days respectively, while electroacupuncture treatment was done every 3 days, so there were 7 times of electroacupuncture treatment. Electroacupuncture was conducted at Zusanli (ST 36) and Sanyinjiao (SP 6) acupoints at 2 Hz of frequency in a continuous wave for 15 minutes that its intensity was adjusted until local muscle contractions were seen.  On the 22nd day, rats were sacrificed by neck dislocation and rat’s adrenal glands were taken and stained with Hematoxylin-Eosin for histological study. The thickness of rat’s adrenal cortex was observed under light microscope with 400x magnification. The data were analyzed by One Way ANOVA test and LSD test (α = 0.05). Results: The average of cortex adrenal thickness in KK,  KP1 and KP2 were 454.93 ± 2.03 µm, 565.59 ± 0.97 µm and 479.65 ± 1.34 µm, consecutively. One Way ANOVA test showed significant differences among the three groups with p=0.000 (p<0.05). LSD test also showed significant differences between KK-KP1, KK-KP2, KP1-KP2 with each of p=0.000 (p<0.05). Conclusion: Electroacupuncture at Zusanli (ST 36) and Sanyinjiao (SP 6) acupoints affected to prevent the thickening of adrenal cortex of rats (Rattus norvegicus) exposed by intermittent noise. Keywords: electroacupuncture, Zusanli (ST 36), Sanyinjiao (SP 6), noise, adrenal cortex’s thickness. 
Pengaruh Elektroakupuntur Titik Weishu (BL 21) dan Zusanli (ST 36) terhadap Perbaikan Mukosa Pylorus Tikus yang Dipapar Bising Intermittent Bawono, Paksi Suryo; Balgis, .; Handayani, Selfi
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Noise is a stressor which can negatively effect to the body. Intermittent noise will give more influence to stomach, namely in the form of an increase in the production of stomach acid that interferes with the mechanism of gastric cytoprotection. Electro-acupuncture on Weishu (BL 21) and Zusanli (ST 36) acupoints has potential to repair damaged mucosal pylorus due to noisy stress. This research aimed to know the influence of electro-acupuncture on Weishu (BL 21) and Zusanli (ST 36) acupoints against pyloric mucosal repair of rats exposed to intermittent noise. Methods: This study was laboratory experimental group post-test only designs. Subjects were Rattus norvegicus with inclusion criteria male, Wistar strain, weight 250-300 g, and 2 months old. Subjects were randomly drawn 28 rats, divided into: Group K (control), P1(no time to recover and no electro-acupuncture stimulation), P2 (given time to recover naturally for 30 days) and P3 (stimulated with electro-acupuncture). After adapted for 7 days all subjects of the groups, except group K, were exposed to intermittent noise at 95 dB with one-hour exposure settings, one-hour break for 12 hours within 14 days. Stimulation on Weishu acupoint (BL 21) was conducted at 2-3mA, 1ms duration, 50Hz frequency for 15min, 3mm pierced into the skin. While Stimulation on Zusanli accupoint ( ST 36 ) was done at 2-3mA with 0.5ms duration at 4Hz frequencies  for 20min, plugging 3mm into the skin. Next day, all of the subjects were sacrificed by cervical dislocation. Pylorus were taken and histological preparations were made by HE staining. The results were assessed with the Barthel index. Henceforth, the data obtained were tested by statistical tests One Way ANOVA ( α = 0.05 ) followed by LSD . Results: Based on statistics analysis, there was a significant difference between the groups K-P1, K- P2, K-P3, P1-P2 and P1-P3. In contrast, there was no significant difference between P2 and P3. Conclusion: There was not statistically proven effects of Weishu point electro-acupuncture (BL 21) and Zusanli (ST 36) against gastric mucosa repair rat intermittent noise, but when seen in the data were the result of a decrease in the degree of mucosal damage. Keywords: Electro-acupunctur Weishu (BL 21) and Zusanli (ST 36) acupoints , intermittent noise , pylorus 
Gambaran Histologis Sel Ginjal Mencit (Mus musculus) yang diinduksi Parasetamol ditambahkan Ekstrak Daun Kemangi (Ocimum sanctum) Basith, Abdul; Listyaningsih, Endang; Handayani, Selfi
Syifa'Medika Vol 7, No 1 (2016): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v7i1.1388

Abstract

Penggunaan parasetamol sebagai obat analgetik antipiretik dewasa ini semakin meningkat. Parasetamol yang digunakan dengan dosis berlebih dapat menyebabkan efek nefrotoksik. Ekstrak daun kemangi (Ocimum sanctum) mengandung antioksidan yang dapat menangkal radikal bebas dan mengurangi terbentuknya NAPQI yang dihasilkan metabolisme parasetamol. Penelitian ini bertujuan untuk mengetahui gambaran histologis sel ginjal mencit (mus musculus) yang diinduksi parasetamol dan penelitian ini untuk mengetahui efek peningkatan dosis dari ekstrak daun kemangi dapat mengurangi kerusakan sel ginjal mencit yang diinduksi parasetamol. Sampel berupa mencit jantan, galur Swiss webster berumur 2-3 bulan, + 20 gr. Sampel sebanyak 28 ekor dibagi dalam 4 kelompok, masing-masing kelompok terdiri dari 7 ekor mencit. Kelompok kontrol (K) dan kelompok perlakuan 1 (P1), mencit diberi aquades selama 14 hari. Kelompok perlakuan 2 (P2), mencit diberi ekstrak daun kemangi dosis I selama 14 hari. Kelompok perlakuan 3 (P3), mencit diberi ekstrak daun kemangi dosis II. Parasetamol dosis 0,1 ml/ 20 grBB mencit diberikan pada kelompok P1, P2, dan P3 pada hari ke-12, 13, dan 14. Hari ke-15, mencit dikorbankan kemudian ginjal mencit dibuat preparat dengan metode blok parafin dan pengecatan Hematoksilin Eosin (HE). Kerusakan sel ginjal diamati dan dinilai dari gambaran histologis berupa penjumlahan inti piknosis, karioreksis, dan kariolisis. Kerusakan sel ginjal tertinggi pada kelompok P1 (parasetamol) dengan jumlah 75.43 ±5.192 dan kerusakan paling sedikit berada di kelompok K (aquades) dengan jumlah 16.43 ± 2.637.Jumlah kerusakan pada kelompok P2 (dosis I + paracetamol) is 21.29 ± 2.289 dan jumlah kerusakan pada kelompok P2 (dosis II + paracetamol) is 18.29 ± 2.563. Ekstrak daun kemangi dapat mengurangi kerusakan sel ginjal mencit dan peningkatan dosis dari ekstrak daun kemangi dapat mengurangi kerusakan sel ginjal mencit yang diinduksi parasetamol.
Perbedaan Pemilihan Waktu Cold Water Immersion Terhadap Timbulnya Delayed Onset Muscle Soreness Setelah Latihan Submaksimal Arpin, Wilson; Gozali, Dhoni Akbar; Hastami, Yunia; Handayani, Selfi
Journal of Sport Science and Education Vol 5, No 1 (2020)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v5n1.p33-38

Abstract

This study aims to knowing the differences in effectiveness of the timing cold water immersion against the onset of delayed onset muscle soreness after submaximal exercise. This research is an experimental study with posttest-only with control group design. The pain of delayed onset muscle soreness measured by Visual Analog Scale. The subjects were 30 samples, which split into 3 groups. Data analysis to determine the result of this study used the one way ANOVA with α determined at 0.05. The result of this study indicate that there are significant differences in each group, the group that received the immersion had a lower pain scale than the control group, also the group that was treated 1 hour after exercise showed better results than the 4 hours, CWI after 1 hour after exercise can inhibit migration of neutrophils which are the main cells of secondary damage that will induce pain. The conclusion of this study is cold water immersion after 1 hour after exercise is better than the 4 hours.
Pendidikan Kesehatan Gigi dan Mulut serta Praktek Menggosok Gigi Pada Anak Berkebutuhan Khusus (ABK) Betty Saptiwi; Risya Cilmiaty; Widia Susanti; Selfi Handayani
Abdimas Universal Vol. 1 No. 2 (2019): Oktober
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.662 KB) | DOI: 10.36277/abdimasuniversal.v1i2.35

Abstract

Special Needs Children in SLB Anugerah, Colomadu, Karanganyar, Central Java, are still difficult to practice how to brush teeth correctly and still lack of understanding of oral health, so that the hygiene and dental health status and mouth are still lacking. Therefore it is necessary to fix it. The purpose of this activity is to carry out one component of the Higher Education Tri Dharma that is community service. The benefits of this service are for special needs students to increase their knowledge about oral health and improve their skills in brushing their teeth properly. The dedication method is a lecture on how to maintain dental and oral health as well as the practice of brushing teeth along with the target audience, all Special Needs Children in SLB Anugerah, Colomadu, Karanganyar. A total of 52 people were present. The results of the dedication showed that 42.3% of the targets were able to practice brushing teeth with enough categories and 57.7% were still in the poor category. Meanwhile, no one has been categorized as good. The conclusion of this dedication is, the practice of brushing Special Needs Children teeth in SLB Colomadu, Karanganyar is still in the category of sufficient and insufficient so that it is necessary to follow up this service activity by involving parents at home in monitoring the maintenance of dental and oral health of Special Needs Children.
Pembentukan dan Pelatihan Kader Kesehatan Anak Berkebutuhan Khusus tentang Protokol Kesehatan Masa Pandemi COVID-19 Risya Cilmiaty A. R.; Ida Nurwati; Selfi Handayani; Muthmainah Muthmainah; Dyah Ratna Budiani; Betty Saptiwi; Sarsono Sarsono; Martini Martini; Danus Hermawan; Jarot Subandono
Abdimas Universal Vol. 4 No. 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v4i1.141

Abstract

The incidence of COVID-19 in Indonesia is significantly increasing. In Indonesia, there were 965.283 confirmed cases and 27.453 people died of covid as of January 22, 2021. Meanwhile, the 7.505 confirmed cases and 352 death were from Surakarta. In this pandemic situation, the community must protect itself from being infected by the virus. Prevention is done by implementating the 5M health protocol, which are wearing mask, social distancing, and hand washing. Those health protocols are also part of clean and healthy lifestyle (PHBS). Special needs children (ABK) are those who have different characteristics than any other common children. Special health consideration should be given for those special needs child, including PHBS because of the special needs they are having and probable difficulties into implementing PHBS. The consideration can be given by their teacher, caretaker, parents, or trained social health workers in the hope of special needs children become independent into implementing the PHBS. The aim of this program is implementating social service program and helping special needs children to become independent in implementating PHBS and health protocol. The program was held by lecturing, demonstration, simulation, and supervised practice. This program hopefully will prevent either health issues or prevent the spreading of infective disease, specifically in this pandemic situation.
Co-Authors . Balgis . Muthmainah . Muthmainah Agus Sugeng Riyanto Agustina Wulandari Ahmad Isnaini Shidqi Nurhani Annisa Aghnia Rahma Annisa Budiastuti Arif Setyoko Arpin, Wilson Balgis . Balgis Balgis Betty Saptiwi Betty Saptiwi Danus Hermawan Dhoni Akbar Ghozali Dwi rahayu Dyah Ratna Budiani Endang listyaningsih Endang Listyaningsih Endang Listyaningsih Enrico Ananda Budiono Gozali, Dhoni Akbar Handayani Putri Cahyaningrum Harahap, Aletta Khaerunnisa Putri Hardjono . Hastami, Yunia Hernowo Setyo Utomo Ida Nurwati Itsna Ulin Nuha Jarot Subandono Kiyatno . Kusuma, Pranata Aji Lukman Aryoseto M Abdul Basith Maria Mumtaz Martini Martini Muhammad Afif Muhammad Luthfiyanto Muhammad Syauqi Ridhallah Muhana Fawwazy Ilyas Muthmainah Muthmainah Nanang Wiyono Nisa'u Luthfi Nur Azizah Nur Dwi Fajarini Paksi Suryo Bawono Raditya Perdana Aryasatya Reflioni, Silvi Risya Cilmiaty Risya Cilmiaty A. R. Sarsono Sarsono Siti Marufah Siti Munawaroh Siti Munawaroh slamet Riyadi Slamet Riyadi Susanti, Widia Syania Shabrina Widia Susanti Yundari, Yundari