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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Bioscientia Medicina : Journal of Biomedicine and Translational Research
Vera Muharrami
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Perbandingan Tingkat Sedasi Klonidin Syrup 2 mcg/kgBB dengan Diazepam Syrup 0.4 mg/kgBB sebagai Premedikasi pada Pasien Anak yang Menjalani Pembedahan dengan General Anestesi Vera Muharrami; A. Sani P. Nasution; Nazaruddin Umar
Jurnal Ilmu Kedokteran Vol 5, No 2 (2011): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (74.13 KB) | DOI: 10.26891/JIK.v5i2.2011.111-117

Abstract

Introduction: Anxiety in children undergoing surgery is characterized by subjective feeling of tension, apprehension,nervousness and worry that may be expressed in various forms. Clonidine, an alpha 2-adrenoceptor agonist, has beenshown to be as a preanesthetic medication in childrens. The current study was designed to investigate the differencesof level sedation clonidine syrup and diazepam syrup as a premedicant in children.Methods: In a randomized, double-blind, controlled clinical trial, 40 children, aged 2-12 yr, undergoing electivesurgery received 2 micrograms/kg clonidine syrup or 0.4 mg/kg diazepam syrup orally. These agents were administered120 min before the estimated time of induction of general anesthesia and noted the children’s level of sedation. Thelevel of sedation were compared among the two groups. PASS <1 demanded rescue intravenous sedation.Result: Clonidine syrup 2 mcg/kgBB provided better quality of sedation after 60 min of premedicant but it wasn’tsignificant(1.8±0.92) and diazepam syrup (0.80±0.89; p>0.05) and number of patients with rescue intravenous diazepamacceptance were same both clonidine group compared to diazepam, there was no significant difference between twogroups, 10% of clonidine group patients, 10 % of diazepam group patients (p>0.05). No clinically significanthypotension or bradycardia was observed after preanesthetic medications of diazepam and clonidine syrup.Discussion: These data indicate that, even in pediatric surgery, the 2 micrograms/kg syrup clonidine is an effectivepremedication. However, the safety and optimal dose of clonidine in this setting remain to be determined.
Anesthetic Management of a Pediatric Patient with Popliteal Pterygium Syndrome Undergoing Labiopalatoplasty: A Case Report Peter Leonardo; Novita Anggraeni; Vera Muharrami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1200

Abstract

Background: Popliteal pterygium syndrome (PPS) is a rare congenital disorder characterized by multiple anomalies, including orofacial, musculoskeletal, and genitourinary defects. Airway management in PPS patients can be challenging due to associated craniofacial abnormalities. This case report describes the anesthetic management of a 5-month-old infant with PPS undergoing labiopalatoplasty. Case presentation: A 5-month-old male infant, weighing 5.9 kg, presented for labiopalatoplasty. He had a diagnosis of PPS with associated labiopalatoschisis, ankyloblepharon filiforme, pterygium in the popliteal fossa, cryptorchidism, and syndactyly. Airway assessment revealed a patent airway with a cleft lip and palate. Anesthesia was induced with sevoflurane and maintained with sevoflurane and nitrous oxide. Direct laryngoscopy was unsuccessful, and videolaryngoscopy was used to facilitate tracheal intubation. Conclusion: This case highlights the challenges of airway management in infants with PPS. A thorough preoperative airway assessment and the availability of alternative intubation techniques, such as videolaryngoscopy, are crucial for successful anesthetic management in these patients.
Co-Authors A. Sani P. Nasution Nazaruddin Umar Novita Anggraeni Peter Leonardo