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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmascience As-syifaa Jurnal Farmasi Jurnal Mandala Pengabdian Masyarakat Jurnal Abdi Masyarakat Indonesia JURNAL PENGABDIAN MASYARAKAT YAMASI KOPEMAS

Hendra Herman

Fakultas Farmasi Universitas Muslim Indonesia

Author-ID : 2644972

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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UJI EFEK ANTIINFLAMASI FRAKSI KLOROFORM DAUN JOHAR (Cassia siamea Lamk.) DENGAN METODE RAT HIND PAW EDEMA Sitti Amirah; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Johar (Cassia siamea Lamk.) leaves widely used as a traditional medicine. Johar leaves contain chemical compounds such us alkaloids, tannins, saponins, flavonoids, sitosterol and barakol which have effect of treatment for several diseases including inflammatory. This study aims to determine anti-inflammatory effect of chloroform fraction C.siamea leaves. This study was conducted using 15 Wistar rats were divided into 5 groups: control group who were given suspension of Na.CMC 1% w / v, the comparison group were given diclofenac sodium suspension 0.35 mg / kg, the test group dose of 75 mg / kg, the test group dose of 150 mg / kg and a test group of 300 mg / kg. Evaluation of anti-inflammatory activity was done by measured initial volume of the foot all test animal then given the drug orally according to dosage of its group. After 30 minutes, each group made inflammatory by induced karagen 1% 0.1 mL by intraplatar. Furthermore, inflammation’s degrees was measured every hour for 8 hours. The results obtained show that after 2 hours, inflammatory of the control group Na.CMC had increased much higher compared to the other groups. This is shows that Na.CMC doesn’t have effects anti-inflammation. The comparison group diclofenac sodium gave the best inhibitory effect that have been shown from an increase volume of feet smaller than the test group chloroform fraction of Johar leaves. While in chloroform fraction of Johar leaves test group, group with dosage 75 mg/kg gave an inhibitory effect better than the other test group dosage.

GAMBARAN PENGGUNAAN OBAT ANTIDIABETIK PADA PENGOBATAN PASIEN DIABETES MELITUS TIPE II RAWAT JALAN DI RSUP DR WAHIDIN SUDIROHUSODO MAKASSAR Hardianty Malinda; Rahmawati Rahmawati; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Diabetes mellitus is a chronic disesase characterized by high blood sugar levels in the body. This research aims to present the use of antidiabetic medication for type 2 diabetes mellitus in outpatient at RSUP Dr. Wahidin Sudirohusodo Makassar. This is a descriptive survey in the form of retrospective search. The results showed that the use of drugs by drug class and type of antidiabetic drugs sulfonylurea (glibenclamide 12.4%, glimepiride 7.2%, gliclazide 3.9%), biguanide (metformin 43.8%0, inhibitor α-glucosidase (acarbose 3.3%), thiazolidinedione (pioglitazone 0.7%), the combination of OHO (gliburida-metformin 0.7%), vildagliptin-metformin 0.7%), rapid insulin 8.5%, insulin detemir 13.1%, insulin glargine 4.6%, and insulin premix 13.1%.

EVALUASI ADVERSE DRUG REACTIONS DAN EFEKTIVITAS PENGGUNAAN KETOROLAK PADA PASIEN PASCA BEDAH SARAF DI RUMAH SAKIT UMUM PENDIDIKAN DR. WAHIDIN SUDIROHUSODO MAKASSAR Hendra Herman; Zullies Ikawati; Rina Handayani
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Pain is often experienced by patients treated in the hospital and is the most frequently reported events in post-surgical patients. Ketorolac associated with the incidence of adverse reactions include, the incidence of acute renal failure and bleeding disorders. The purpose of the study was to observe and report on the profile of adverse reactions include the use of ketorolac on renal function and hemostasis as well as the effectiveness of the analgesic ketorolac. A total of 20 patients who received ketorolac compared to the value of the glomerular filtration rate (GFR), bleeding time (BT), Blood Clotting Time (CT), prothrombin time (PT) and International Normalized Ratio (INR) between before and after patients received ketorolac. Compared to the value of the Visual Analog Scale (VAS) ranging V day I to day administration of ketorolac. One of 20 patients (5%) who use ketorolac for 5 days had decreased GFR by 66.70%.. Whereas for hemostasis testing showed that ketorolac can influence hemostatic seen from increasing on BT (0,04; p <0,05), CT (0,02; p <0,05), PT value (0,03, p <0,05), as well as an increase in INR value (0,03; p <0:05) but still in normal range. Comparison of the mean VAS score from day one to day five showed that administration of ketorolac can reduce pain and disappeared on day 4, where VAS values between days 4 and 5 showed no statistical difference (0,56; p> 0,05). Conclusion. incidence of renal damage incident occurred at 5%, and may affect hemostatic function in patients. Resolution of pain may occur at day 4 ketorolac administration.Key word : Evaluation, Adverse Effects, Effectiveness, Ketorolac, Post-Nerve Surgical Patient

EFEK ANTIHIPERLIPIDEMI INFUS DAUN SAMBILOTO (Andrograpidis paniculata) PADA HEWAN COBA KELINCI ( Orictolagus cuniculus) DENGAN PARAMETER KOLESTEROL DAN TRIGLISERIDA Sukmawati Syarif; Aulia Wati; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.133

This research is done to know whether infuse of sambiloto leaf can reduce cholesterol and trigliserida value in the blood or not. For reducing cholesterol and trigliserida value in the blood, we want to know the most effective concentration of infuse of sambiloto leaf ( Andrograpidis paniculata).In this research, the method is used is draw up samples, substancions, experimental animals, treatment with experimental animal and measuring cholesterol and trigliserida value.All sample can reduce cholesterol and trigliserida value at concentration 10%, 15%, or 20%, sample with concentration 15% and 20% reduce cholesterol value is better than sample with concentration 10%. Sample with concentration 15% and 20% have reducing effect of trigliserida value same with simvastatin.Analyze using ANAVA (analys variant) with continuing test using LSD at belief standart 0,05, in conclusion, infuse of Sambiloto leaf can reduce not only cholesterol but also trigliserida value in male rabbits.Key Word : Antihiperlipidemi, Andrograpidis paniculata, cholesterol and trigliserida.

UJI EFEK DIURETIK INFUS BIJI JAGUNG (Zea Mays L), RAMBUT JAGUNG DAN KOMBINASI ANTARA KEDUANYA PADA KELINCI JANTAN (Oryctolagus Cuniculus) BERDASARKAN PARAMETER FREKUENSI URINASI DAN VOLUME URIN Hendra Herman; Rizqi Nur Azizah; Chikita Inaku
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Has been done research Diuretic effect test of seed corn infusem, hair Corn infuse and combination of both in order to determining diuretic effect with frequency urination and volume urine parameters. This research use trial animals as many as 15 male rabbits, divided into 5 groups and each group consisted of three tails, group I is control that given colloidal solution of Na.CMC 1 %, group II infuse corn (Zea mays L) 23 33 mg group III has Qvien seed corn infuse (Zee mays L ) 466,664 gr, group IV has Given combination of hair and sedd corn infuse and group V is comparator that given suspension of furosemid Treatment done orally with a dose of 20 / 2,5 kg for further observation and measurement frequency done diuretic and urine volume intervals of 1 hour for 5 hours after treatment The result showed that infuse of seed corn, hair corn and combination of both can increase the frequency of urination, and just infuse of seed corn and hair corn increase the volume win of rabbits This is supported by statistical analysis methods CRD (Completely Randomized Design) For the frequency of urination infuse of seed corn, hair corn, and combination of both did not significantly different with furecemid while for the volume urine hair corn infuse and seed corn infuse are significantly different with Na CMC and not significantly different with furosemidKey words: Diuretic, seed and hair corn Infuse

STUDI INTERAKSI OBAT PADA PENGOBATAN PASIEN STROKE YANG DISEBABKAN HIPERTENSI DI RSUP. Dr. WAHIDIN SUDIROHUSODO MAKASSAR Hendra Herman
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.113

This research concerning by means non-experimental with descriptive approach was to collect the data with retrospectively compared take from medical data then to search the drugs that interacting each other on strokes patient caused by hypertension at RSUP. DR. Wahidin Sudirohusodo in Makassar. The result of this research showed that strokes and hypertensions drug that interacting each other in 2007 and 2008 was the interaction between aspire and captopril where in 2007 was 48% and in 2008 was 54%, with pharmacokinetics interaction type is distributions interaction.Key Words : Drug Interacting, strokes, hypertensions.

VARIASI EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) PADA GRANUL EFFERVECSENT SEBAGAI ANTIDIABETES Herwin Herwin; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

This study aims to product the preparation effevecsent granule using variation of ethanol extract avocado seed (Persea americana Mill.) as antidiabetic using granulation method. This study was conducted using two formulas using variation of ethanol extract avocado seed (Persea americana Mill.) 1% and 10%, PVP K30 4%, Sodium cyclamate 0.1%, citric acid 0.2965 gram, tartric acid 0.5931 gram and sodium bicarbonate 1.0083 gram. The test results of evaluation preparation effevecsent granule using variation of ethanol extract avocado seed (Persea americana Mill.) showing that formulas 2 (two) is the best the result farmaceutic evaluation obtained with value Densitas Bulk = 2.82, Incompressible Density = 0.353, Carr’s Indeks = 17.12, Silent Angle = 19.790, Flow Time = 0.7, Time of Stopping Foam = 1.15. The test results of antidiabetic at in vivo formulas 2 (two) preparation effevecsent granule of ethanol extract avocado seed (Persea americana Mill.) using male mice (Mus musculus) with weight 176.5 mg, Initial Glucose Level = 87.5, Initial Glucose Induction = 249.5 obtained time of giving theraphy of formula at first day = 248.5, second day = 133, five day = 109 and seven day = 75.5, so preparation effevecsent granule of ethanol extract avocado seed (Persea americana Mill.) effective as antidiabetic.

EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR Irma Santi; Hendra Herman; Andi Afifatun Nisa Al Ishak
As-Syifaa Jurnal Farmasi Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Infective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases.

POLA PENGOBATAN TUBERKULOSIS PARU DI BALAI BESAR KESEHATAN PARU MASYARAKAT MAKASSAR PERIODE JANUARI – JUNI 2011 Hendra Herman; Bayu Putra; Citra Dana
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

The research was about Tuberculosis Drugs Using System in the Balai Besar Kesehatan Paru Masyarakat Makassar (BBKPM) Period January 2011 – June 2011. The aim of this research was to describe about using system so obtained TBC drugs which used in the Tuberculosis Drugs Using-System in the Balai Besar Kesehatan Paru Masyarakat Makassar (BBKPM) Period January 2011 – June 2011. The data taking prospectly via all the tuberculosis patient medical record in the Tuberculosis Drugs Using System in the Balai Besar Kesehatan Paru Masyarakat Makassar (BBKPM) Period January 2011 – June 2011 obtained 30 patients. The result of this research can be concluded that from the regiment side, about 96,7% Tuberculosis patients which treatment in the Balai Besar Kesehatan Paru Masyarakat Makassar (BBKPM) Period January 2011 – June 2011 were category 1 and the residual was category 3. While the side of combination with the other drug, giving combination dominated about 96,7%. While if the give single drug about 3,3%. The frequency of the other drug usage was dextromethorphan about 90% and the smaller was pyridoxin about 10%.Key Word : Using System, Tuberculosis Drugs, BBKPM

PERBANDINGAN EFIKASI DAN KEAMANAN PENGGUNAAN FEBUXOSTAT DAN ALLOPURINOL PADA PASIEN GOUT Hendra Herman; Sukmawati Sukmawati; Andi Desiah Pranada
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.768

Febuxostat and allopurinol are xanthine oxidase inhibitors to reduce uric acid levels. The research aimed to determine the differences in efficacy and safety of using febuxostat and allopurinol for gout patients. This research was conducted using a narrative review method for articles obtained from the PubMed and Willey databases published in 2010-2021. From the article exploration, 5 articles were reviewed showing that the determination of drug efficacy was seen by monitoring the changes in uric acid levels for 6 months from the beginning of drug use. Febuxostat and allopurinol had good efficacy in achieving target uric acid levels < 6 mg/dL, however, febuxostat was superior to allopurinol in usual doses. Febuxostat 80 mg had superior efficacy to febuxostat 40 mg, while febuxostat 40 mg had superior efficacy to allopurinol 300 mg (p < 0.05). For safety, febuxostat and allopurinol possessed similar side effects in the form of upper respiratory tract infection, diarrhea, headache, nausea and vomiting.

Co-Authors Anak Agung Istri Sri Wiadnyani Andi Afifatun Nisa Al Ishak Andi Desiah Pranada Andi Maulana Kamri Anil Aryandi Aulia Wati Bayu Putra Bayu Putra Bayu Putra Chikita Inaku Citra Dana Dahlan, Andi Muhriani Fitri Nur Awaliyah Fahmi Fitriana Fitriana Hardianty Malinda Herwin Herwin Intan Puspita Ramadhani Irma Santi Mochammad Imron Awalludin Rachmat Kosman Rahmawati Rahmawati Rahmawati Rina Handayani Rizqi Nur Azizah Rizqi Nur Azizah Sitti Amirah Sitti Amirah Sukmawati Syarif, Sukmawati Triani Putri Ayu

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