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All Journal Jurnal Media Analis Kesehatan Jurnal Biomedika Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) MDJ (Makassar Dental Journal) Jurnal Medika Hutama Ebers Papyrus
Uleng Bahrun
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Analysis of Interleukin-17 Levels in Patients with Thrombocytopenia Lidwina Septie Christyawardani; Mansyur Arief; Uleng Bahrun
Biomedika Vol 13 No 1 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i1.707

Abstract

Thrombocytopenia or platelet deficiency is a condition, in which platelet level in the blood circulation is below normal, which is less than 150,000 cells/µl. Thrombocytopenia is classified into some conditions, including decreased platelet production, increased need for platelets, and other thrombocytopenia. The need for increased platelets can be subdivided into primary immune thrombocytopenia, secondary immune thrombocytopenia, non-primary ITP, and thrombocytopenia that are not immune-mediated. Several cytokines play a role in the process of thrombocytopenia, one of which is Interleukin-17 (IL-17) that will be further discussed in this study. A previous study reported that IL-17 production increased in ITP and cITP patients. The objective of this study was to analyze the IL-17 levels and figure out the differences in IL-17 levels in the serums of patients with primary ITP and secondary ITP. The samples were taken from Wahidin Sudirohusodo Hospital and the specimens were examined in the Research Unit Laboratory of the Faculty of Medicine, Universitas Hasanuddin/Hospital of Universitas Hasanuddin. The comparative test resulted in p-value = 0.005, where p <α = 0.05; and therefore, there was a significant difference between IL 17 levels in ITP and non-primary ITP.
Analysis of Interleukin-4 in Thrombocytopenia Autoimmune Patients Sitti Nurfaizah; Mansyur Arief; Uleng Bahrun
Biomedika Vol 13 No 2 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i2.708

Abstract

Thrombocytopenia is a disease characterized by a decreased platelet count. Some of the causes are decreased platelet production, increased platelet use, such as due to infection, and autoimmune causes, namely the loss of tolerance of the immune system to self-antigens on the surface of the platelets and megakaryocytes marked with a platelet count <100,000 / μL and based on the pathomechanism classified as primary Immune Thrombocytopenia (ITP) and secondary, as well as several other causes. IL-4, one of the cytokines produced by Th2 which stimulates B cells to increase antibody production. The aim of this study was to compare IL-4 levels in primary ITP patients and non-primary ITP tombocytopenia. This study involved 30 primary ITP subjects and 30 non-ITP primary tombocytopenia subjects obtained based on data medical records, examination of IL-4 cytokine levels by the ELISA method. The results of this study that the IL-4 levels of the primary non ITP tombocytopenia subject group were higher than the primary ITP subject group, which means that there were differences in IL-4 levels in the primary ITP subject group and the non-ITP primary tombocytopenia subject group.
PNEUMATIC TUBE TERHADAP DARAH RUTIN DAN LAKTAT DEHIDROGENASE Liong Boy Kurniawan; Asvin Nurulita; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1087

Abstract

The transportation of laboratorial samples with pneumatic tube system spends less time than when were handled by courier.Pneumatic tube system produces minor vibrations on sample due to the velocity changes during transportation and may cause changeson the blood cells and haemolysis. The aim of this study is to know the effect of sample transportation with pneumatic tube on bloodcells and its effect on hemolysis. A cross sectional study was performed at Dr. Wahidin Sudirohusodo Hospital, Makassar in July 2013.Routine blood, electrolyte and LDH were tested in 12 out-patients. The researchers collected two (2) samples, for each EDTA tube (routineblood tests) and serum (electrolyte and LDH). The samples were transported using pneumatic tube and the paired samples were sentby courier. The result then were analyzed with Paired T-Test. There were no significant difference of routine blood test results betweensamples sent by pneumatic tube and courier except RDW. RDW were higher in samples which were sent by pneumatic tube comparedto those brought by the courier (18.72±2.70% vs 17.83±2.36%, p=0.007). The electrolyte levels sent by both methods there were nosignificant difference, but the LDH levels were higher in samples sent by pneumatic tube (472.08±100.44 U/L vs 331.25±94.19 U/L,p=0.000). Based on this study, in common can be concluded that the pneumatic tube system does not effect on the routine blood testresults, except on RDW and does not cause changes due to haemolysis (on electrolyte) except the LDH levels elevates. So based on thisstudy, it is recommended to send samples for LDH test only by courier.
ANGKA BANDING LIPID DI INFARK MIOKARD Liong Boy Kurniawan; Uleng Bahrun; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.437

Abstract

Lipid profiles are used as the regular tests which performed to predict and evaluate the risk of coronary heart disease. The routine lipid tests include total cholesterol, LDL, HDL and triglyceride level. The total cholesterol/HDL and LDL/HDL ratio are often used as predictors of coronary heart disease. This study was performed to know the lipid level and ratio by comparing the condition in myocardial infarction patients and young adult controls and to observe the percentage of their lipid level and ratio exceeding the recommended optimal value. A retrospective study was performed using secondary data of 73 myocardial infarction patients, whom hospitalized in the Intensive Cardiac Care Unit Dr. Wahidin Sudirohusodo Hospital Makassar from June 2010 to July 2011 and 21 healthy young adult as controls. The mean level of the total cholesterol, LDL, HDL, triglyceride, ratio of total cholesterol/HDL and LDL/HDL of myocardial infarction patients are compared with the control subjects were 209.99±51.70 vs 151.42±27.90 mg/dL (p=0.000), 141.18±41.92 vs 76.76±20.45 mg/dL (p=0.000), 36.96±10.47 vs 47.05±8.24 mg/dL (p=0.000), 132.27±65.67 vs 142.14±54.93 mg/dL (p=0.155), 5.99±1.71 vs 3.26±0.59 (p=0.000) and 4.06±1.45 vs 1.66±0.44 (p=0.000), respectively. It was shown that the percentage of myocardial infarction patients with total cholesterol, LDL level, total cholesterol/HDL and LDL/HDL ratio exceeding recommended optimal value were 57.53%, 63.01%, 73.97% and 86.30%, respectively. The level of total cholesterol and LDL, ratio of total cholesterol/HDL and LDL/HDL in myocardial infarction patients were significantly higher, but the HDL level was lower compared to the control subjects. The percentage of myocardial infarction patients with LDL/HDL ratio exceeding recommended optimal value was higher than the other lipid levels and ratio. Therefore, it is concluded that the LDL/HDL ratio is better in predicting coronary heart disease than other routine lipid markers.
ANGKA BANDING NETROFIL/LIMFOSIT DI POPULASI DEWASA MUDA Arie Yanti; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1110

Abstract

Previous studies have shown that neutrophil/lymphocyte ratio in bacteremia is higher than nonbacteremia, therefore it could beused as a marker to distinguish both conditions in patients with sepsis .Another study on oncology patients in ICU showed a correlationbetween the severity of clinical course and the increase of neutrophil/lymphocyte ratio. In physiological condition, neutrophil/lymphocyteratio <5, while in pathological conditions (severe infection or systemic inflammation) neutrophil/lymphocyte ratio increases >6.Neutrophil/lymphocyte ratio is a sensitive, fast, cost effective and applicable laboratory test for routine use, therefore this test result canbe used as the parameter to assess clinical condition of patients. However, a reference value of neutrophil/lymphocyte ratio has neverbeen defined, especially in Makassar City, South Sulawesi Province. The aim of this study was to know the neutrophil/lymphocyte ratioin a healthy young adult population. A cross sectional study was conducted from March to April 2014, involving residents (specialisticcandidates in Medical Faculty, Hasanuddin University, who underwwent medical checkup and voluntarily joined this study. Samplesconsisted of 198 persons who fulfilled the inclusion criteria with an age range between 24-40 years old, comprising 84 males (42.42%)and 114 females (57.58%). The neutrophil/lymphocyte ratio for all samples was 1.95 (1.15-4.74). Mann Whitney test showed thatthere was no significant difference of neutrophil/lymphocyte ratio between males and females, 1.88 (1.25-4.74) vs 1.95 (1.15-4.12),p=0.65 and neither between the age group 21-30 years old and 31-40 years old, 1.95 (1.21-4.74) vs 1.94 (1.15-4.09), p=0.82.
AIR KEMIH (URIN) BEREOSINOFIL DENGAN DUGAAN RADANG SELA GINJAL MENDADAK/NEFRITIS INTERSTISIAL AKUT (NIA) Felly G Sahureka; Fitriani Mangarengi; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1041

Abstract

The diagnosis of AIN is performed by the evaluation of clinical signs and symptoms, laboratory tests, radio imaging and biopsyas a gold standard. In most cases, biopsy wasn't performed because it is invasive for the patients, while the diagnosis is just based onthe clinical sign and symptom, and the immunosuppressive therapy is carried out only after the biopsy. Eosinophyluria found in theAIN patients is the parameter that can be measured non invasively, so that urine eosinophyl test was suggested for the diagnosis/earlydetection of AIN. That background cause us to analyze the urine eosinophyl count in suspected AIN patients. A cross sectional studywas conducted from June to August 2008 on 50 suspect AIN patients and 50 of non AIN at the Laboratory of Clinical Pathology,dr.Wahidin Sudirohusodo Hospital Makassar. Urine eosinophyl test performed by Hansel method, samples were analyzed with SPSSfor Windows version 12.0 using T test and Chi-square test. From 50 suspect AIN patients, they consist of 50% men and 50% womenwith the age distribution between 4 and 72 years old. T test analysis showed that the urine eosinophyl count was higher in suspect AIN(2.820 ± 1.955) compare with the non AIN (0.620 ± 0.923), p < 0.001. The Chi-square test showed that there was a significantrelation between eosinophyluria of the suspect AIN patients. That means there is a significantly relation between eosinphyiluria withthe suspect AIN group, where was found the higher urine eosinophyl compare to those non AIN patients. From this study so far, it canbe suggested that urine eosinophyl test can be used for the diagnosis/early detection of AIN.
PLATELET-LYMPHOCYTE RATIO (PLR) MARKERS IN ACUTE CORONARY SYNDROME (Platelet Lymphocyte Ratio (PLR) sebagai Petanda Sindrom Koroner Akut) Haerani Harun; Uleng Bahrun; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1176

Abstract

Sindrom Koroner Akut (SKA) merupakan puncak manifestasi klinis aterosklerosis di arteri koroner. Inflamasi terjadi dari tahapawal pembentukan ateroma sampai ruptur plak dan trombosis. Trombosis memainkan peran penting dalam perjalanan penyakit SKA.Trombositosis dan limfopenia berhubungan dengan derajat inflamasi sistemik dan Rasio Platelet Limfosit (PLR) menjadi petanda baruyang melibatkan kedua tolok ukur hematologi tersebut. Penelitian ini merupakan penelitian retrospektif di Rumah sakit Dr. WahidinSudirohusodo Makassar dengan mengambil data pasien SKA UAP, STEMI, NSTEMI dan menilai PLR dari pemeriksaan darah rutin saatmasuk Rumah sakit. Data PLR dibandingkan berdasarkan jenis SKA, kemudian dibandingkan dengan kontrol sehat. Hasil penelitiandidapatkan 223 data pasien SKA UAP, STEMI dan NSTEMI masing-masing 89, 68, 66 data dan kontrol normal 198 data. Hasil ujistatistik Kruskal wallis menunjukkan perbedaan bermakna PLR antara pasien UAP, NSTEMI dan STEMI (p=0,011). Hasil uji post hocmenunjukkan perbedaan bermakna antara UAP dan NSTEMI (p=0,023), UAP dan STEMI (p=0,006), tetapi tidak berbeda bermaknaantara NSTEMI dan STEMI (p=0,827). Nilai PLR pasien SKA lebih tinggi dibandingkan dengan pembanding (p=0,037). Berdasarkanhasil penelitian didapatkan nilai PLR meningkat di SKA dibandingkan dengan kontrol normal. Nilai PLR di STEMI dan NSTEMI lebihtinggi dibandingkan UAP, kemungkinan berhubungan dengan pembentukan trombus dan infark miokard.
ANALISIS FERITIN DAN AST TO PLATELET RATIO INDEX SEBAGAI PETANDA DERAJAT FIBROSIS PENYAKIT HATI KRONIS (Analysis Ferritin and AST to Platelet Ratio Index as a Marker Degree of Fibrosis Chronic Liver Disease) Yulianti Yasin; Uleng Bahrun; Ibrahim Abdul Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1226

Abstract

Chronic liver disease is an endemic disease in Indonesia which is still a global health problem and detected when it’s developinginto fibrosis. The determination of fibrosis is important for the treatment and prognosis of chronic liver disease. AST to Platelet RatioIndex (APRI) score is the most common used to assess the degree of liver fibrosis. Ferritin is an iron deposit that found in the liver andthe levels depend on the degree of the cell damage. The aim of this study was to analyze ferritin levels as a marker of the fibrosis degreein the chronic liver disease. This cross-sectional study of 47 patients with chronic liver disease performed at Dr. Wahidin SudirohusodoGeneral Hospital between May–June 2012. The subjects are grouped into cirrhotic and noncirrhotic, based on the theory that in cirrhoticliver fibrosis was considered as an irreversible condition. AST to platelet ratio index score based on the Wai CT formulation, includingthe examination of AST by optimizing UV-test according to International Federation of Clinical Chemistry (IFCC) modified method onthe ABX Pentra 400, examination of platelet by impedance method on Sysmex XT 2000i and ferritin levels were measured by ECLIAmethod using Elecsys 2010 Analyzer. The Spearman correlation tests showed no association between ferritin levels and APRI in cirrhoticand non cirrhotic patients (p=0.704 and r=–0.057). In conclusion, ferritin can not be used as the marker in determining the degreeof fibrosis patients suffering chronic liver disease. Further studies are expected using a more valid method for determining the degree offibrosis such as liver biopsy or fibro scan.
ANALYSIS OF LABORATORY PARAMETERS AS SEPSIS MARKERS IN NEONATALS WITH HYPERBILIRUBINEMIA Bachtiar Syamsir; Rachmawati Muhiddin; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1154

Abstract

Hiperbilirubin di neonatus merupakan kondisi peningkatan bilirubin total (> 5mg/dL) di bayi baru lahir. Angka kejadian di bayicukup bulan mencapai 60%. Kejadian hiperbilirubin di bayi baru lahir salah satu penyebab terbanyak bayi harus mendapat perawatan.Kejadian hiperbilirubinemia di neonatus yang disebabkan oleh sepsis 3–8%. Tujuan penelitian ini untuk mengetahui hubunganpeningkatan petanda sepsis C-Reaktif Protein (CRP), Procalcitonin (PCT), rasio jumlah imature to total neutrofil (IT ratio) dan jumlahtrombosit di neonatus dengan hiperbilirubinemia dan menilai kenasabannya. Penelitian retrospektif dengan pendekatan potong lintangdengan mengambil data rekam medis pasien yang diperiksa kadar bilirubin total di RSUP Dr. Wahidin Sudirohusodo Makassar masawaktu Januari-Desember 2015. Patokan kesertaan, pasien dengan pemeriksaan petanda sepsis CRP, PCT, IT Ratio dan trombosit,dengan diagnosis akhir sepsis. Data dikelompokkan menjadi kelompok hiperbilirubin dan non-hiperbilirubin, diuji dengan Uji MannWhitnney atau Uji T Independen untuk melihat hubungan antara keempat petanda sepsis dengan kelompok bilirubin. Data kelompokhiperbilirubinemia kemudian diuji kenasaban Spearman untuk melihat kenasaban keempat petanda sepsis dengan kadar bilirubin.Diperoleh total 92 sampel yang memenuhi patokan kesertaan, kelompok hiperbilirunemia 67,4% dan non-hiperbilirubinemia 32,6%.Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna nilai keempat petanda sepsis diantara kedua kelompok (p>0,05),terdapat kenasaban negatif jumlah trombosit dengan sepsis hiperbilirubinemia (p<0,05; r.-0,261). Tidak dapat disimpulkan adanyahubungan CRP, PCT, IT ratio dan trombosit terhadap kejadian hiperbilirubinemia. Pada subjek dengan hiperbilirubinemia, makin tinggikadar bilirubin makin rendah jumlah trombosit.
KETOASIDOSIS DIABETIK DI DIABETES MELITUS TIPE 1 Zuhrinah Ridwan; Uleng Bahrun; Ruland DN Pakasi R
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1127

Abstract

Type 1 Diabetes Mellitus (DMT1) is an autoimmune disease characterized by impaired carbohydrate, protein and lipid metabolismresulting in insulin deficiency either absolute or relative. The absolute insulin deficiency found in DMT1, is caused by a defect in thepancreatic ß cells leading to a defect in insulin synthesis by the pancreas gland. In this article, a case of type 1 DM in a child withketoacidosis diabetes has been reported. The diagnosis was based on classical symptoms, blood glucose level, C-peptide, metabolic acidosisand keton uria. The case reported is a 12 year old girl, with main complaints of 9 kg body weight loss since three (3) years ago. Thepatient always felt hungry, thirsty and was frequently urinating. In her family history no such case was denied. The patient had beentreated in the district general hospitals for five (5) days and was diagnosed as type 1 diabetes mellitus and was then referred to the Dr.Wahidin Sudirohusodo Hospital. The laboratory test results revealed as follows, random glucose level was 729 mg/dL, arterial blood gasanalysis showed metabolic acidosis, C-peptide was 0.1 ng/mL and urinalysis showed 150 mg/dL protein, 1000 mg/dL glucose, 150 mg/dL ketone and 250 RBC/uL. The patient was diagnosed as type 1 diabetes mellitus with diabetic ketoacidosis and received 0.5 U/kg/dayinsulin therapy. This case report aimed to determine the type 1 diabetes mellitus in a child is accompanied by diabetic ketoacidosis.
Co-Authors Amarensi M Betaubun Andi Ita Maghfirah Arie Yanti Arifa Moidady Asvin Nurulita Atmanto, Y. Kusumo Adi Arji Bachtiar Syamsir Besse Rosmiati Chelvi Wijaya Darmawaty ER Darmawaty Rauf Esa, Tenri Felly G Sahureka Fitriani Mangarengi Haerani harun HAM Akil Hardjoeno Hardjoeno Helena Leppong I Hutagalung Ibrahim Abdul Samad Idham Jaya Ganda Irene Edith Rieuwpassa Irfan Idris Iwan Joseph Juranah Juranah Lidwina Septie Christyawardani Liong Boy Kurniawan, Liong Boy M. Iqbal Basri Mansyur Arief Mansyur Arif Mutiah Dwi Humairah Mutmainnah Mutmainnah Nurdin Nurdin Rachmawati Muhiddin Rifai Amirudin Ruland DN Pakasi Ruland DN Pakasi R Ruland DN. Pakasi Ruland Pakasi Sheila Febriana Siti Rafiah Sitti Nurfaizah Sitti Rafiah Sriwati Atjo Susi Sevianty William Hamdani Yulianti Yasin Yuly Eko Prasetyo Yurdiansyah Latif Yurdiansyah Yurdiansyah Yuyun Widaningsih Zuhrinah Ridwan