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All Journal Pharmascience Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Jurnal Biomedika JHECDs: Journal of Health Epidemiology and Communicable Diseases Jurnal Paradigma: Pemberdayaan & Pengabdian Kepada Masyarakat
Dian Nurmansyah
Universitas Borneo Lestari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hyperglicemia as Predisposition Factor of Oral Candidiasis on patient with Diabetes Mellitus Dian Nurmansyah; Elma Stasya; Dewi Ramadhani; Normaidah Normaidah; Aldiana Astuti
Biomedika Vol 13 No 1 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i1.703

Abstract

Diabetes mellitus is a disease characterized by hyperglycemia or an increase in blood glucose levels. The state of hyperglycemia is one of the supporting factors for oral candidiasis infection. The purpose of this study was to determine the correlation of hyperglycemia with the incidence of Candida albicans infection in patients with Diabetes mellitus. this study was conducted on 30 respondents. Blood glucose levels and Candida albicans culture were measured using the germ tube test method. Data analysis to see the correlation using the Chi-Square test obtained Sig. (0.015 0.00.050) and it can be stated there is a correlation between variables. From the results of data analysis, it can be concluded that there is a correlation between hyperglycemia and Candida albicans infection which causes oral candidiasis in DM patients.
Studi In Silico Senyawa Hylocereus polyrhizus dan Allium sativum terhadap Enzim HMG-CoA Reduktase Normaidah Normaidah; Dian Nurmansyah
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11639

Abstract

Ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak bawang putih (Allium sativum) diketahui mampu menurunkan kadar kolesterol total darah dalam studi in vivo. Penambatan molekul dapat dilakukan dalam memprediksi senyawa yang bertanggung jawab berdasarkan nilai docking. Tujuan dari penelitian ini adalah mengetahui zat aktif potensial dari H. polyrhizus dan A. sativum yang berperan penting dalam penurunan kadar kolesterol darah melalui jalur inhibisi enzim HMG-CoA reduktase dalam uji in silico. Reseptor yang digunakan adalah enzim HMG-CoA reduktase (PDB ID: 1HW9) dengan ligan natif simvastatin yang dipreparasi menggunakan YASARA. Struktur senyawa aktif sebanyak 19 senyawa dari buah H. polyrhizus 17 dari A. sativum digambar menggunakan MarvinSketch pada pH 7,4 dengan 10 bentuk konformasi. Proses penambatan molekul dilakukan menggunakan program PLANTS dan divisualisasi dengan Discovery Studio Visualizer. Ligan natif menunjukkan nilai RMSD sebesar 1,5265 Å dengan nilai docking -79,1320. Senyawa 4, dan 17 pada buah H. polyrhizus serta senyawa 36 pada A. sativum menunjukkan kedekatan relative dengan ligan natif lebih dari 95%. Senyawa ini diprediksi mampu menurunkan kadar kolesterol total darah dengan penghambatan enzim HMG-CoA reduktase secara penambatan molekul. Kata Kunci: Buah Naga Merah, Bawang Putih, Vitamin E, Antilipidemia, Kolesterol Total  The red dragon fruit extract (Hylocereus polyrhizus) and garlic extract (Allium sativum) are able to decrease the total blood cholesterol levels in in vivo study. The molecular docking can predict the responsible compound based on the docking value. The purpose of this study is to determine the potential active substances of H. polyrhizus and A. sativum which play an important role in reducing blood cholesterol levels through the HMG-CoA reductase enzyme inhibition pathway in the in silico study. The receptor in this study was the enzyme HMG-CoA reductase (PDB ID: 1HW9) with the native ligand simvastatin and prepared using YASARA. The structure of the active compound (19 compounds from H. polyrhizus and 17 compouns from A. sativum) were drawn using MarvinSketch at pH 7.4 with 10 conformations. The molecular docking process was carried out using the PLANTS program and visualized with the Discovery Studio Visualizer. The native ligand showed RMSD value of 1.5265 Å with a docking value of -79.1320. The compounds 4 and 17 in H. polyrhizus fruit and compounds 36 in A. sativum showed relative closeness with native ligands of more than 95% of the docking score. Based on molecular docking, these compounds are to be able to decrease the total blood cholesterol levels by inhibiting the HMG-CoA reductase enzyme.
An overview of Microfilariae on patients who have received treatment in Batuah Village, Kotawaringin Timur District 2015 Dian Nurmansyah; Muhammad Fahmi; Rifqoh Rifqoh; Puspawati Puspawati; Putri Kartika Sari; Muhammad Arsyad; Aldiana Astuti
JHECDs: Journal of Health Epidemiology and Communicable Diseases Vol 4 No 2 (2018): JHECDs Vol. 4, No. 2, Desember 2018
Publisher : Balai Litbangkes Tanah Bumbu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.552 KB) | DOI: 10.22435/jhecds.v4i2.378

Abstract

Filariasis is a chronic infectious disease, caused by filarial worms in the lymph and lymph nodes cause lymphangitis and elephantiasis. Batuah Village is the area in Sampit with the largest percentage of microfilariae compared to the surrounding area. From 196 the number of Batuah villagers examined by the filariasis elimination officer of Kotawaringin Timur District Health Office in 2013 obtained 5 positive cases of filariasis with 2.55% microfilaria number which is dominated by filaria worm Brugia malayi. From the local health center has also conducted a mass drug treatment program with DEC medication, combined with albendazole for 12 days on 14-16 July 2014. The aim of this study was to determine the success rate of treatment conducted by the health officer against filariasis patients in the Batuah village. The method used in this microfilariae examination is a microscopic method. Capillary blood was taken on 4 filarial patients who tested positive on the previous examination who had been given DEC + Albendazole treatment, the result from 4 samples that examined 1 positive sample of 4 patients. The implementation of medication that has been done by public health office was successful because there was a decrease of microfilaria rate which was previously 2.55% to 0,51% (<1%).
IMUNOPATOLOGI DAN PERSPEKTIF LABORATORIUM KLINIK SARS - COV - 2 : A REVIEW Dian Nurmansyah; Aldiana Astuti
Klinikal Sains : Jurnal Analis Kesehatan Vol 8 No 2 (2020): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v8i2.1406

Abstract

Severe Acute Respiratory syndrome corona virus 2 ( SARS-Cov-2) is a virus from Nidoviridales family Coronaviridae that causes acute respiratory syndrome in humans. The virus discovered in wuhan, China in mid December 2019 and determined as a global pendemic by WHO The management of the patient becomes crucial in suppressing the mortality rate of patients with positive COVID-19. The actual viral infection is self-limited disease with supportive treatment. Good treatment support requires information and clarity of viral pathogenesis, laboratory results, patient clinical symptoms and in-depth analysis of virus characteristics and the body's immune response to infection
REVIEW : PATOGENESIS DAN DIAGNOSA LABORATORIUM DEMAM TIFOID Dian Nurmansyah; Nurmaidah Nurmaidah
Klinikal Sains : Jurnal Analis Kesehatan Vol 8 No 2 (2020): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v8i2.1409

Abstract

Typhoid fever caused by the pathogen bacteria named Salmonella typhi is known to have caused the death of more than 600,000 people worldwide. Understanding the pathogenesis and proper laboratory examination is very influential on the success of therapy. This literature review aims to collect literature related to pathogenesis and laboratory examination in typhoid fever. This literature review method uses the Systematic Literature Review (SLR) model based on pathogenesis and laboratory examinations. S. typhi infection begins with the entry of bacteria through the gastrointestine tract and can last up to 3 weeks. Laboratory tests for typhoid fever are bacterial culture, serological examination, molecular examination, and other investigations. Bacterial culture is a gold standard that has a sensitivity of up to 80% in blood. Serological tests can be performed such as Widal, ELISA, SDS-PAGE blotting, RDT or POCT tests using venous blood, capillary blood, even serum, and typhidot, and Tubex TF. Other investigations can be characterized by leukocytosis and eosinopenia. Blood chemistry tests also found an increase of AST and ALT 2-3 times the normal value.
PERBANDINGAN EFEKTIVITAS INFUSA DAN REBUSAN DAUN LANGSAT (Lansium domesticum L) DALAM MENURUNKAN KADAR GLUKOSA SECARA IN VITRO dian nurmansyah; Nafila nafila; Hayatush Shalihah; Amanah amanah
Klinikal Sains : Jurnal Analis Kesehatan Vol 10 No 1 (2022): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v10i1.2522

Abstract

Daun langsat (Lansium domesticum L) merupakan salah satu tanaman obat yang dapat mengobati penyakit diabetes. Diabetes Mellitus merupakan penyakit yang ditandai dengan kenaikan gula darah. Senyawa yang terkandung didalam daun langsat yang berfungsi dapat menurunkan kadar glukosa darah adalah flavonoid. Flavonoid bersifat protektif terhadap kerusakan sel β sebagai penghasil insulin serta dapat mengembalikan sensitifitas reseptor insulin pada sel dan bahkan meningkatkan sensitivitas insulin. Penelitian ini bertujuan untuk mengetahui perbedaan penurunan kadar glukosa secara in vitro dengan penambahan infusa dan rebusan daun langsat. Kadar glukosa diukur secara in-vitro menggunakan alat Sfektorfotometer UV-Vis dengan metode Nelson somoghy. Hasil uji skrining fitokima didapatkan senyawa flavonoid, alkaloid , tanin dan saponin positif. Hasil analisa data dengan menggunakan Independent T test didapatkan p-value 0.032 < 0.050. Dapat disimpulkan terdapat perbedaan bermakna pengukuran kadar glukosa secara in vitro dengan perlakuan pemberian infusa dan rebusan
IDENTIFIKASI Taenia solium PADA FESES WARGA DESA KARANG LANGIT DENGAN KEBIASAAN KONSUMSI DAGING BABI Dian Nurmansyah; Javercintya Angelica Maramis; Puspawati Puspawati Puspawati
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 5 No 2 (2023)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v5i2.109

Abstract

Taenia solium is a parasite class of cestode lives in the small intestine of humans to get the nutrition of its life. Humans are definitive host and intermediate host is pigs. Taenia solium infection is often found in areas where a lot consumed of raw or undercooked pork that contains cysticercus, or in areas with poor sanitation. If humans ingest proglottid or Taenia solium eggs, cysticercus cellulose larvae can grow in the host. This research was conducted of Karang Langit village on March 2021, the type of research used was survey descriptive with a cross sectional research design. The aim of this study to aware the presence of Taenia solium infection in the feces of the village. The research method used is native method. Based on the results of the research, no progglotid were found, nevertheless was found eggs of Taenia solium by 2,25%
POTENSI FILTRAT UMBI TALAS (Colocasia esculenta (L.) Schott) SEBAGAI ANTIKOAGULAN Maya Herliana Sasmitha; Shabrina Dewi Ramadhani; Muhammad Arsyad; Nafila Nafila; Dian Nurmansyah
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3719

Abstract

A Clinical laboratory is a health laboratory that carries out clinical specimen examination services with the type of blood test material. Blood that is used as an examination material sometimes requires additional substances that can inhibit blood clotting such as anticoagulants. Natural ingredients that are thought to have anticoagulant content are taro tuber filtrate (Colocasia esculenta (L.) Schott). This study aimed to determine the potential of taro tuber filtrate (Colocasia esculenta (L.) Schott) as an alternative anticoagulant. The method used in testing anticoagulant activity is Clotting Time in Vitro. Taro tubers are grated and filtered to obtain filtrate from taro tubers. Taro tuber filtrate test samples are divided into 5 concentrations of 10%, 30%, 50%, 70%, and 90%. Each concentration was carried out 4 times with each treatment given a blood sample of 1 mL. The results of the phytochemical screening test of taro tuber filtrate contain secondary metabolite compounds of flavonoids, alkaloids, and saponins that have anticoagulant activity. Based on the results of clotting time testing that 1 mL of blood mixed with 10% taro tuber filtrate clotted after the 15th hour, while concentrations of 30%, 50%, 70%, and 90% did not occur blood clots after observation for 6 days. Based on the results of research that has been done, it can be concluded that taro tuber filtrate (Colocasia esculenta (L.) Schott) has the potential as an alternative anticoagulant
PEMBERDAYAAN MASYARAKAT DALAM PEMANFAATAN BIJI PEPAYA (Carica papaya) SEBAGAI UPAYA PENGENDALIAN VEKTOR PENYAKIT DEMAM BERDARAH DENGUE Dian Nurmansyah
JURNAL PARADIGMA (PEMBERDAYAAN & PENGABDIAN KEPADA MASYARAKAT) Vol 4 No 1 (2022): JURNAL PARADIGMA VOLUME 4 NOMOR 1 APRIL 2022
Publisher : STIKES NGUDIA HUSADA MADURA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan masyarakat walaupun sudah dikendalikan lebih dari 20 tahun. Nyamuk Aedes sp sebagai vektor dapat membawa penyakit yang disebabkan oleh virus demam berdarah dengue. Program pengendalian vector penyakit terutama berbasis nyamuk telah dilaksanakan oleh Kementerian Kesehatan melalui berbagai program, seperti pemberian bubuk Abate. Penggunaan Abate terkadang tidak dapat dikontrol dengan baik, dengan alasan perubahan kualitas air baik rasa, bau dan warna. Biji papaya yang notabene dikatakan limbah ternyata dapat diolah dan digunakan sebagai anti jentik nyamuk alami yang aman dan murah. Buah pepaya mengandung zat atau unsur senyawa yang sering disebut papain. Papain mempunyai sifat sebagai anti toksik walaupun dalam dosis rendah, apabila masuk ke dalam tubuh larva nyamuk Aedes aegypti akan menimbulkan reaksi kimia dalam proses metabolisme tubuh yang dapat menyebabkan terhambatnya hormon pertumbuhan sehingga larva tidak bisa tumbuh menjadi instar IV. Bahkan akibat dari ketidakmampuan larva untuk tumbuh akibatnya terjadi kematian. Kegiatan ini dilaksanakan untuk memberdayakan masyarakat dalam pemanfaatan biji pepaya sebagai biolarvasida alami untuk mencegah penyebaran penyakit demam berdarah dengue yang diperantarai oleh nyamuk Aedes aegypti
Co-Authors Aldiana Astuti Dewi Ramadhani Elma Stasya Hayatush Shalihah Javercintya Angelica Maramis Maya Herliana Sasmitha Muhammad Arsyad Muhammad Arsyad Muhammad Fahmi Nafila nafila Normaidah, Normaidah Nurmaidah Nurmaidah Puspawati Puspawati Puspawati Puspawati Puspawati Putri Kartika Sari Rifqoh Rifqoh Shabrina Dewi Ramadhani Yoga Yuniadi