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All Journal Jurnal Keperawatan The Journal of Experimental Life Sciences (JELS) Indonesian Journal of Cardiology Majalah Patologi Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Nursing Science Update Journal of Global Pharma Technology
Djanggan Sargowo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek Pemberian Ekstrak Etanolik Kulit Manggis dan Xanton terhadap NO, TNF-α, dan IL-1, pada Penyembuhan Ulkus Lambung Ika Kustiyah Oktaviyanti; Djanggan Sargowo; Aris Widodo; Karyono Mintarum
Majalah Patologi Indonesia Vol 22 No 1 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

ABSTRAK Latar belakang NSAID dapat menyebabkan ulkus lambung dan menunda penyembuhan ulkus lambung. Pada paparan indometasin, dapat terjadi ulkus lambung. Penyembuhan ulkus terdiri atas fase inflamasi, proliferasi dan regenerasi. Apabila inflamasi berlangsung lama, akan menunda penyembuhan ulkus lambung. Kulit buah manggis mengandung xanton yang merupakan antioksidan alami dan antiinflamasi. Dengan Pemberian ekstrak kulit manggis dan xanton ini diharapkan dapat mempercepat penyembuhan ulkus lambung. Metode Eksperimental dengan randomized post test control only, menggunakan tikus wistar yang dipapar indometasin 30 mg/kgBB dosis tunggal menggunakan sonde lambung. 4 jam kemudian sebagian diberi ekstrak kulit manggis 200 mg/kgBB dan sebagian diberi xanton dosis 35 mg/kgBB, setiap hari selama 7 hari. Tikus dibagi dalam masing-masing 3 kelompok dan didekapitasi pada hari ke-3, ke-6 dan ke-12, untuk diambil lambungnya. Lambung dibagi dua, sebagian untuk pemeriksaan histopatologi, sebagian untuk pemeriksaan ELISA, guna mengetahui kadar NO, TNF-α, dan IL-1. Hasil Terdapat penurunan tingkat keparahan ulkus dengan pemberian ekstrak kulit manggis maupun xanton. Pengaruh Ekstrak Kulit Manggis terhadap tingkat keparahan ulkus lambung lebih baik dibanding xanton. Terdapat peningkatan kadar NO dengan pemberian Ekstrak Kulit Manggis maupun xanton dibanding kontrol, karena baik Ekstrak Kulit Manggis maupun xanton mengandung antioksidan yang dapat menangkap scavenging radikal sehingga NO yang bebas meningkat. Terdapat penurunan TNF-α, dan IL-1 dengan pemberian Ekstrak Kulit Manggis maupun xanton dikarenakan efek antiinflamasi Ekstrak Kulit Manggis dan xanton. Kesimpulan Ekstrak kulit manggis maupun xanton dapat mempercepat penyembuhan ulkus lambung yang dilihat dengan pengamatan mikroskopik, melalui efeknya sebagai antioksidan dan antiiflamasi. Kata kunci : ekstrak kulit manggis, ulkus lambung, NO, TNF-α, IL-1 ABSTRACT Background NSAIDs can cause ulcers gastric and suspend the healing of gastric ulcers. Gastric ulcers can occur on the exposure indomethacin. Ulcer healing consists of the inflammatory phase, proliferation and regeneration. If the inflammation lasts a long time, it will suspend the healing of gastric ulcers. Mangosteen rind contains of xanton which is a natural antioxidant and anti-inflammatory. By administration of mangosteen peel extract and xanton, it is expected to accelerate the healing of gastric ulcers. Methods Randomized experimental post-test control only, using Wistar rats which were exposed with indomethacin 30 mg / kg single dose using a gastric sonde. 4 hours later mostly were given with the mangosteen peel extract 200 mg / kg and most were given with xanton dose of 35 mg / kg, every day for 7 days. Rats were divided into 3 groups, and were decapitated on day 3, the 6th and the 12th, in order to take the gaster. The gaster is divided into two, partly for histopathological examination, partly for ELISA, in order to determine the levels of NO, TNF-α, and IL-1. Results There is a decrease in the severity of the ulcer with mangosteen peel extract and xanton. Effect of Mangosteen peel Extract the severity of gastric ulcers better than xanton. On the other side, there are increased levels of NO by administration of mangosteen peel extract and xanton compared to the controls, as well Mangosteen Peel Extract and xanton which contains of antioxidants that can take radical scavenging thus the NO increases freely. There is a decrease in TNF-α, and IL-1 by administration of mangosteen peel extract and anti-inflammatory effects due xanton Mangosteen peel Extract and xanton. Conclusion Xanton and mangosteen peel extract can accelerate the healing of gastric ulcers which were seen by microscopic observation, through its effect as an antioxidant and antiiflamasi. Key words: mangosteen peel extract, gastric ulcer, NO, TNF-α, IL-1
HUBUNGAN TIM DINAMIS DENGAN KEMAMPUAN PERAWAT IGD MELAKUKAN CPR DI RUMAH SAKIT RUJUKAN PERTAMA NUSA TENGGARA BARAT Tony Suharsono; Lalu Aries Fahrozi; Djanggan Sargowo
Jurnal Keperawatan Vol. 6 No. 2 (2015): Juli
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.065 KB) | DOI: 10.22219/jk.v6i2.2870

Abstract

Latar Belakang Peran penting perawat dalam penanganan cardiac arrest dan kemampuan kemampuan melakukan high quality CPR adalah kemampuan yang wajib dimiliki oleh perawat.Tujuan penelitian ini adalah untuk mengetahui hubungan antara tim dinamis dengan kemampuan perawat IGD dalam melakukan CPR. Metode observasional analitik dengan pendekatan cross sectional menggunakan purposive sampling. Jumlah sampel 52 perawat IGD dari tiga rumah sakit rujukan pertama di NTB. Alat ukur lembar observasi dan manequin GD/CPR180S, untuk mengetahui kemampuan CPR dan parameter tim dinamis. Hasil penelitian menunjukkan bahwa rata-rata responden hanya melakukan 4 hal dari indikator CPR yang berkualitas dan 5 dari 6 indikator tim dinamis dalam proses CPR. Hasil analisa bivariat dengan menggunakan korelasi pearson menunjukkan Pv 0,000 dan r 0,637. Tim dinamis mempunyai hubungan yang erat dengan kemampuan perawat melakukan CPR. Berdasar dari penelitian ini, sebaiknya pelatihan CPR dilakukan dengan pendekatan tim.
Potensi Xanton Terhadap Status Oksidan dan Antioksidan pada Tikus Model Aterosklerosis Dwi Laksono Adiputro; M Aris Widodo; Rachmad Romdoni; Djanggan Sargowo
Jurnal Kardiologi Indonesia Vol. 33, No. 4 Oktober - Desember 2012
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v33i4.22

Abstract

Introduction.  Xanthones, which have potent antioxidative and antiinflammatory, and various other bioactivities,  are rich in a tropical fruit tree, mangosteen, Garcinia mangostana. The effect of xanthoneson oxidant level and antioxidant activity in hypercholesterolemic rats is still unknown.Objectives. To clarify an effect of xanthoneson oxidant level  and antioxidant activity in hypercholesterolemic rats.Methods. A total of 32 Wistar rats were divided into four groups (n=8), include control, hypercholesterolemic diet groups, hypercholesterolemic diet + xanthoneat dose 35; 70; and 140 mg/kg body weight. Control group receive standart diet for 60 days. Hypercholesterolemic diet group receive standart diet plus yellow egg, sheep oil, cholic acid, and pig oil for 60 days per oral. Analysis of blood hydrogen peroxide level, aorta glutathione peroxidase activity, and aorta catalase activity, were done using spectrophotometric. The ANOVA test were used to analyze the different levels of hydrogen peroxide, glutahione peroxidase activity, and catalase activity.Result. Hypercholesterolemic diet increase blood hydrogen peroxide level significantly compared to control group (p<0.05). Xanthone decrease blood hydrogen peroxide level significantly at all dose compared to control group (p<0.05). There is no significant difference of aorta glutahione  peroxidase activity in all groups (p>0.05). Xanthone modulate an activity of catalase in aorta at dose 140 mg/kg body weight.Conclusion. Xanthone has potency to decreaseblood oxidant level and modulate aorta catalase activity.
Improvement of level MDA and SOD Using of Ganoderma Lucidum as Adjunctive Treatment for Statin Based Therapy in High Risk Patient Based on Framingham Score vitriyaturrida vitriyaturrida; M Saifur Rohman; Djanggan Sargowo; Dadang Hendrawan
Jurnal Kardiologi Indonesia Vol 39 No 3 (2018): Indonesian Journal of Cardiology: July-September 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i3.820

Abstract

It is well known from previous research on the importance of antioxidants to inhibit the progression of coronary heart disease in high-risk patients based on framingham scores. Statins are routinely administered in high-risk patients based on the Dyslipidemia 2016 ESC guidelines but the effects of adding Ganoderma are known to have antioxidant effects, in patients who have received statins. This study aims to assess the effect of antioxidants through measurement of SOD and MDA in patients given a combination of Ganoderma lucidum with statins.Method: A total of 24 patients with high-risk patients based on the Framingham score > 20% were selected as sample of study. Patients with respondents who had never received statin therapy or ACEi or ARB or CCB or beta blocker, or did not routinely consume the drug for 2 weeks were excluded from this study. The addition of Ganoderma lucidum dose of 3x250 mg was added to statins as the first group and Ganoderma lucidum dose of 3x250 mg was added to the Statin combination of Angiotensin Converting Enzym inhibitors (ACE inhibitors) or Angiotensin Receptor Blockers (ARB) and or Calcium Channel Blockers (CCB) and or Beta blockers as second group for 90 days. SOD and MDA levels were measured before and after the administration of Ganoderma Lucidum with the ELISA method.Result: After the administration of Ganoderma Lucidum with standard therapy, there was a decrease in MDA levels and an increase in SOD levels after 90 days in two groups. Conclusion: The addition of Ganoderma Lucidum to standard therapy can reduce oxidant levels in high-risk patients based on framingham scores. Keyword: Superoxyde-dismutase, Malondyaldehide, Oxidative Stress, Antioxidant, Ganoderma Lucidum, Statin
ROLE OF SIGNAL TRANSDUCTION ERK1/2 ON THE PROLIFERATION OF ENDOTHELIAL PROGENITOR CELL (EPC) OF PATIENTS WITH STABLE ANGINA PECTORIS INDUCED BY GROWTH FACTORS (Peran Transduksi Sinyal ERK1/2 terhadap Persiapan Proliferasi Endothelial Progenitor Cell (EPC) Pasien Angina Pektoris Stabil yang Diinduksi oleh Faktor Pertumbuhan) Yudi Her Oktaviono; Djanggan Sargowo; Mohammad Aris Widodo; Yanni Dirgantara; Angliana Chouw; Ferry Sandra
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1235

Abstract

Sel Progenitor Endotel (EPC) merupakan kelompok sel yang memiliki kekuatan angiogenik yang kemudian dikenal sebagai pilihanpengobatan seluler untuk mengimbas perbaikan lapisan intima pembuluh darah. Berdasarkan beberapa kajian sebelumnya, jumlahEPC di pasien angina pektoris stabil lebih rendah dibandingkan dengan individu yang sehat. Di samping itu, EPC juga dikenal sebagaiperamal independen terhadap perjalanan penyakit jantung koroner. Tujuan penelitian ini adalah untuk mengetahui peran transduksiisyarat ERK1/2 terhadap proliferasi EPC yang diambil dari darah tepi pasien angina pektoris stabil dengan imbasan pemberian faktorpertumbuhan. Penelitian ini merupakan kajian percobaan melalui uji laboratoris dengan pendekatan atau rancangan control grouptime series design. Penelitian dilakukan di Laboratorium Prodia Stem Cell Indonesia di Jakarta pada bulan Januari 2014. Sampeldarah tepi diambil dari delapan (8) subjek relawan pasien angina pektoris stabil yang memenuhi patokan kesertaan dan sebagaipembanding digunakan delapan (8) unit darah tepi yang diambil dari orang yang bukan pasien angina pektoris. Metode sel mononuklear(MNC) dari delapan (8) pasien angina pektoris stabil diisolasi selama satu (1) atau tiga (3) hari di medium tertentu dengan atautanpa penambahan suplemen. EPC yang dihasilkan dan dicat dengan metode pengecatan imunofluoresens untuk mendeteksi CD34,Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) dan CD133. Pemeriksaan proliferasi sel XTT digunakan untuk menilaipertumbuhan EPC setelah kultur antara 1−3 hari, sedangkan perhitungan Colony Forming Unit (CFU) digunakan untuk menilai fungsiEPC kelompok yang terbentuk setelah dikultur antara 1−3 hari. Analisis western blot dilakukan untuk mendeteksi aktifasi ERK1/2.Hasil mengecat imunofluoresens mengukuhkan seluruh petanda membran EPC termasuk CD34, VEGR2 dan CD133. Jumlah rerata EPCyang berdaya hidup di pasien angina pektoris stabil lebih rendah dibandingkan dengan pembandingnya, yaitu masing-masing 5,77×103dan 23,40×103. Jumlah EPC baik kelompok pasien angina pektoris stabil dan yang pembanding meningkat secara bermakna denganperangsangan faktor pertumbuhan. Hasil western blot menunjukkan bahwa ERK1 diekspresikan lebih tinggi pasien angina pektoris stabildibandingkan pembanding. Fosforilasi ERK2 terdeteksi di kelompok pembanding dan menguat secara bermakna seiring waktu denganperangsangan faktor pertumbuhan. Fosforilasi ini dihambat oleh U0126. Di pasien angina pektoris stabil, fosforilasi ERK2 terdeteksipada perangsangan faktor pertumbuhan setelah kultur selama tiga (3) hari.
PERBEDAAN KEBERHASILAN TERAPI FIBRINOLITIK PADA PENDERITA ST-ELEVATION MYOCARDIAL INFARCTION (STEMI) DENGAN DIABETES DAN TIDAK DIABETES BERDASARKAN PENURUNAN ST-ELEVASI Ni Made Dewi Wahyunadi; Djanggan Sargowo; Tony Suharsono
Journal of Nursing Science Update (JNSU) Vol. 5 No. 1 (2017)
Publisher : Department of Nursing, Faculty of Health Sciencce, Universitas Brawijaya

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Abstract

ST-elevation myocardial infarction (STEMI) adalah kondisi yang terjadi akibat rupturnya plak aterosklerosis yang menyebabkan oklusi total pada arteri koroner. Salah satu tindakan reperfusi yang dapat dilakukan pada pasien STEMI adalah pmberian fibrinolitik yang sebaiknya diberikan dalam waktu <12 jam setelah munculnya nyeri dada. Keberhasilan terapi fibrinolitik dapat dipengaruhi oleh beberapa hal salah satunya adalah pasien menderita diabetes atau tidak. Tujuan penelitian ini adalah membedakan keberhasilan terapi fibrinolitik pada penderita STEMI dengan diabetes dan tidak diabetes berdasarkan penurunan ST-elevasi. Metode dalam penelitian ini analitik observasional dengan pendekatan cross sectional prospective. Jumlah sampel 34 responden diambil dengan pendekatan consecutive sampling. Pengukuran dilakukan dengan cara observasi langsung ke pasien dan mengobservasi catatan rekam medis pasien STEMI dengan diabetes dan tidak diabetes diemergensi jantung PJT RSUP Sanglah Denpasar, ICCU RSUD Badung dan ICU BRSU Tabanan. Uji analisis yang digunakan untuk membedakan keberhasilan terapi fibrinolitik pada penderita STEMI dengan diabetes dan tidak diabetes adalah uji Fisher. Hasil analisis uji Fisher menunjukkan bahwa terdapat perbedaan keberhasilan terapi fibrinolitik yang signifikan pada pasien diabetes dan tidak diabetes (p<0.000), dimana keberhasilan terapi fibrinolitik pada pasien diabetes (10%) lebih sedikit dibandingkan pada pasien yang tidak diabetes (79%). Dapat disimpulkan bahwa terdapat perbedaan keberhasilan terapi fibrinolitik yang signifikan pada pasien diabetes dan tidak diabetes, dimana dalam penelitian ini keberhasilan terapi fibrinolitik ini kemungkinan juga dipengaruhi oleh waktu pemberian fibrinolitik dan faktor resiko STEMI lain yang dialami oleh pasien seperti hipertensi, obesitas, hiperlipidemia dan merokok.Kata kunci: STEMI, terapi fibrinolitik, diabetes dan tidak diabetes, penurunan ST-elevasi
PATIENT'S CHEST DISCOMFORT ASSOCIATED WITH DELAY IN REPERFUSION THERAPY ACUTE CORONARY SYNDROME Elizabeth Yun Yun Vinsur; Djanggan Sargowo; Tony Suharsono
Journal of Nursing Science Update (JNSU) Vol. 6 No. 1 (2018)
Publisher : Department of Nursing, Faculty of Health Sciencce, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.088 KB) | DOI: 10.21776/ub.jik.2018.006.01.13

Abstract

 Acute Coronary Syndrome (ACS) is a group of symptoms that are classify as unstable angina (ATS), ST-Segment Elevation Myocardial Infarction (STEMI) and non ST-Segment Elevation Myocardial Infarction (NSTEMI). Main objective to provide timely reperfusion therapy is essential to improve survival. Initial and rapid intervention after the occurrence of coronary artery disease is associated with better clinical outcomes, but it is hampered by the nature of the patient's seeking decisions Patients expect the type of heart attack they often see in medical movies and television: like chest pain that grips and causes it to fall to the floor. This study aims to analyze the chest discomfort experienced by patients associated with delay in reperfusion therapy of Acute Coronary Syndrome. The method used is observational analytic with cross sectional approach. Nonprobability sampling with time quota technique obtained sample of 60 respondents. The results obtained as many as 55% of patients come more than 120 minutes after the onset of discomfort in the chest. The patient's delay in coming to the associated hospital is an accompanying symptom factor at onset with p = 0.048, and OR = 4.596 (1.014-20.828). There were no significant differences in the scores of knowledge, behavior, and beliefs based on the ACS response index between patients who came <120 minutes and> 120 minutes. The conclusions of this study present the accompanying symptom presentations at onset with the time interval between the appearances of the SKA symptoms until arriving at the IGD door. Seeing the results of this study suggests the need for efforts from medical staff to optimize the interpretation of "chest pain characteristics" to patients and families or who are susceptible about specific and non-specific cardiac signs. Keywords: acute coronary syndrome, prehospital delay, onset to door, reperfusion
Lipoprotein-Associated Phospholipase A2 Activity increase the Sensitivity of Framingham Score for detecting the incidence of Acute Myocardial Infarction in sub-population of Indonesian Male Patients Andi Wahjono; Saifur Rohman; Miryanti Cahyaningtias; Rina Yudha; Yanna Indrayana; Mifetika lukitasari; Rusdianto Rusdianto; Aditya Kurniawan; Djanggan Sargowo; Sasmojo Widito; Dadang Hendrawan; Jayarani Fatimah Putri; widodo Ph.D
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cardiovascular disease. Framingham score is currently a widely used risk stratification tool for detecting the incidence of acute myocardial infarction (AMI), although it is not very sensitive. Adding Lp-PLA2 to the Framingham score can raise the odds ratio (OR) for AMI, but requires further research.Objectives: In this study, we examine the role of Lp-PLA2 in increasing the sensitivity of the Framingham score for detecting the incidence of AMI.Methods: This study was a case-control study of 97 male patients, 60 of whom had AMI and were treated in the intensive care unit as test subjects, and 37 of whom were non-AMI patients with normal treadmill test used as controls.Results:Lp-PLA2 activity was found to be higher in the AMI group than that in the control group (83.97 ± 27.15 nmol/ml/min vs. 55.04 ± 31.99 nmol/ml/min). Eighteen patients (30%) with AMI were included in the high-risk category according to the Framingham score; this number increased to 36 patients after the addition of Lp-PLA2 activity to the Framingham score. Analysis using a receiver operating characteristic (ROC) showed a cut-off value for Lp-PLA2 activity associated with AMI of approximately 74.21 nmol/ml/min with an accuracy of 67%. The OR for detecting AMI incidence increased after the addition of Lp-PLA2 activity from 1:01 (CI 95%, 0.414–2.48) to 4.67 (CI 95%, 1.88-11.61).Conclusions:   The addition of Lp-PLA2 activity may increase the sensitivity of the Framingham score for detecting the incidence of AMI.
Hibiscus Sabdariffa Linn) terhadap NF-ĸβ, TNF-α dan ICAM-1 pada Human Umbilical Vein Endothelial Cells (HUVECs) Cultured yang dipapar Low Density Lipoprotein (LDL) Teroksidasi Dwi Sarbini; Djanggan Sargowo; Muhammad Saifur Rohman
The Journal of Experimental Life Science Vol. 1 No. 2 (2011)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1353.389 KB) | DOI: 10.21776/ub.jels.2011.001.02.07

Abstract

Tujuan penelitian ini adalah mengetahui efek dan mekanisme kerja ekstrak teh Rosella merah (Hibiscus sabdariffa Linn) terhadap aktifasi NF-ĸβ dan ekspresi protein TNF - α serta ICAM-1 yang menjadi mediator inflamasi pada aterosklerosis. Penelitian ini menggunakan kultur sel endotel yang diisolasi dari vena umbilikalis manusia ( HUVECs). Kelompok kontrol digunakan HUVECs tanpa paparan ox-LDL (kontrol negatif) dan HUVECs yang dipapar 40 µgml-1 Ox-LDL (kontrol positif). Kelompok perlakuan adalah HUVECs yang dipapar dengan berbagai dosis teh Rosella merah (0,01 mgml-1, 0,005 mgml-1 dan 0,001 mgml-1) dan diberikan selama 2 jam sebelum dipapar ox-LDL. Pengukuran aktifasi NF-ĸβ dilakukan setelah 30 menit paparan Ox-LDL menggunakan imunohistokimia. Ekspresi protein TNF-α dan ICAM-1 diukur setelah 24 jam dipapar Ox-LDL menggunakan imunohistokimia. Berdasarkan analisis ANOVA (p<0.01) terdapat efek penghambatan ekstrak teh Rosella merah (Hibiscus sabdariffa Linn) terhadap aktifasi NF-ĸβ dan ekspresi protein TNF -α serta ICAM-1 yang manjadi mediator terjadinya inflamasi pada aterosklerosis melalui penghambatan aktifasi NF-ĸβ. Terdapat hubungan negatif antara aktifasi NF-ĸβ dan ekspresi protein TNF -α serta ICAM-1 dengan dosis ekstrak teh Rosella merah (Analisis Spearman's [p<0,01, Correlation Coeff = -1]). Kata Kunci: atherosklerosis, ICAM-1, NF-ĸβ, Ox-LDL, Rosella merah (Hibiscus sabdariffa Linn), TNF-α
Co-Authors ADITYA KURNIAWAN Andi Wahjono Angliana Chouw Dadang Hendrawan Dwi Laksono Adiputro Dwi Sarbini Elizabeth Yun Yun Vinsur Ferry Sandra Heni Pujiastuti Ika Kustiyah Oktaviyanti Jayarani Fatimah Putri Karyono Mintarum Lalu Aries Fahrozi M Aris Widodo M Saifur Rohman Mifetika Lukitasari Miryanti Cahyaningtias Mohammad Aris Widodo Muhammad Saifur Rohman Ni Made Dewi Wahyunadi Rachmad Romdoni Rina Yudha Rusdianto Rusdianto Saifur Rohman Sasmojo Widito Tony Suharsono vitriyaturrida vitriyaturrida widodo Ph.D yanna indrayana Yanni Dirgantara Yudi Her Oktaviono, Yudi Her