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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Journal of General Procedural Dermatology and Venereology Indonesia Cermin Dunia Kedokteran Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia Jurnal MedScientiae Cermin Dunia Kedokteran
Larisa Paramitha
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The role of oral vitamin D in several skin diseases Astri Adelia; Larisa Paramitha; Adhimukti T Sampurna; Windy Keumala Budianti; Farida Zubier
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 2, No 1 (2017): August
Publisher : Universitas Indonesia

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Abstract

Vitamin D has many benefits for body and skin health. One of them is to regulate the immune system, both cellular and humoral. The pathogenesis of many skin diseases is associated with disturbance in regulation of cellular immune system. Research on the relationship between blood level of vitamin D and several diseases in dermatology is currently very advanced. Oral vitamin D is known to have many functions that play a role in the pathogenesis of several diseases of the skin. Therefore, its current use as a primary or supplemental therapy has been widely studied. Knowledge on various skin diseases with indication of oral vitamin D use is important to be understood, especially in association with some chronic diseases requiring long-term therapy. The effects of using oral vitamin D analogues are minimal, but hypervitaminosis D might cause uncomfortable symptoms for patients. Therefore, it is important to understand and regulate the amount of doses of oral vitamin D supplements prescribed. Keywords: oral vitamin D, skin disease
Acquired vulvar lymphangioma: Report of two cases Indah Widyasari; Hafiza Fathan; Larisa Paramitha Wibawa; Herman Cipto; Adhimukti T Sampurna; Sondang P Sirait
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 1, No 2 (2016): June
Publisher : Universitas Indonesia

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Vulvar lymphangioma is a rare case and often being misdiagnosed as genital wart. This acquired disorder manifests as dilatation of superficial lymph vessel due to obstruction. It is caused by urogenital infection and most often occurs following surgery and radiotherapy of cervical cancer. The diagnosis is established based on clinical and histopathological features. Treatment aimed to eliminate the cause of obstruction. This article reports two cases of vulvar lymphangioma found in our Hospital. First case was a 43-year-old female with a history of surgery and radiation for cervical cancer 10 years ago presented with vesicular skin lesion in genital area, oozing copious clear fluid since 4 years ago. There are multiple lenticular vesicles containing clear fluid in vulvar area accompanied with bilateral lymphedema of lower extremities. Histopathological features demonstrated dilated superficial lymph vessels. Second case was a 44-year-old female with enlargement of lower abdomen with vesicular lesion containing clear fluid in genital area since 3 years ago. Abdominal USG showed enlarged inguinal lymph node. Histopathological features demonstrated dilated superficial lymph vessels. The treatment for both cases were gradual electrosurgery. In both cases, vulvar dermis’ superficial lymph node dilatation caused the skin lesions. Obstruction of lymph vessel due to radiation and surgery for cervical cancer in the first case and of inguinal lymph node in the second case lead to increased lymphatic pressure in the dermis and later on the dilatations. The treatment in both cases using electrical excision produced good responses; however, we should be attentive on recurrent case. Keywords: acquired vulvar lymphangioma, dilatation of dermal lymph vessels, electrosurgery
The epidemiology of skin cancer at Dr. Cipto Mangunkusumo National Central General Hospital from 2014 to 2017 Larisa Paramitha Wibawa; Melody Febriana Andardewi; Inge Ade Krisanti; Riesye Arisanty
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 4, No 1 (2019): December 2019
Publisher : Universitas Indonesia

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Background: The incidence of skin cancer has been increasing over the past decades globally. At present, there is no valid national cancer data in Indonesia. The purpose of this study is to evaluate the increment of skin cancer cases at Dr. Cipto Mangunkusumo National General Hospital, Jakarta.Methods: In this retrospective descriptive study, we evaluated all pigmented skin tumor cases from June 2014 to June 2017. Data were obtained from the Department of Anatomical Pathology and medical records at Dr. Cipto Mangunkusumo National General Hospital. Data were compared with previous reports.Results: From 263 skin cancer cases, the most frequent skin cancer was basal cell carcinoma (BCC; 66.9%), followed by squamous cell carcinoma (SCC; 27.4%), and malignant melanoma (MM; 5.7%). Most of the skin cancer were predominantly in the female population. In BCC and SCC, most of the patients were within the age group above 60 years (n = 106 and 18, respectively). In MM, the incidence is greater in age group of 41–50 years (n = 5). For BCC and SCC, the distribution sites of lesions were mostly in sun-exposed areas, whereas the distribution sites of MM were mostly in non-sun-exposed areas. Median diameters of BCC, SCC, and MM were 2, 4, and 6.5 cm, respectively. There was an increase of BCC incidence from 1996 to 2017. Conclusion: In comparison with other types, the incidence of BCC in Dr. Cipto Mangunkusumo National General Hospital is increasing. A well-documented skin cancer registry is required to establish national data of skin cancer in Indonesia. Keywords: epidemiology, incidence, basal cell carcinoma, malignant melanoma, squamous cell carcinoma
The absence of prophylactic antibiotics administration and the surgical site infections rate in Mohs micrographic surgery Riva Ambardina Pradita; Larisa Paramitha Wibawa
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 4, No 2 (2020): June 2020
Publisher : Universitas Indonesia

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Abstract

Background: The use of prophylactic antibiotics in dermatologic surgery, particularly in Mohs micrographic surgery (MMS), remains a gray area. Despite the low rate of surgical site infection (SSI), SSI can result in some significant morbidities. Thus, numerous dermatologists keep administering prophylactic antibiotics in MMS. Method: A search was conducted to identify clinically significant topics followed by literature review through the main available medical literature database. The three selected studies that met the inclusion and exclusion criteria were then critically assessed for their validity, importance, and applicability using the guidance from Centre for Evidence-Based Medicine for Critical Appraisal of Prognostic Studies. Results: Three articles showed a low SSI rate with a narrow confidence interval (CI): 0.91% (95% CI: 0.38%– 1.45%), 0.7% (95% CI: 0.21%–1.19%), and 0.72% (95%CI: 0.5%–0.9%).Conclusion: Based on the available studies, we conclude that the absence of prophylactic antibiotics is not related to the SSI incidence. Keywords: Mohs micrographic surgery, antibiotic, infection
Ultraviolet phototherapy for treatment of various dermatoses Irwan Saputra Batubara; Larisa Paramitha Wibawa; Erdina Pusponegoro; Windy Keumala Budianti; Githa Rahmayunita; Shannaz Nadia Yusharyahya
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202107

Abstract

Ultraviolet (UV) radiation has been applied to treat many chronic skin diseases. Based on the wavelength, UV radiation consists of three types, namely ultraviolet C (UVC), ultraviolet B (UVB), and ultraviolet A (UVA). The types of UV that are widely used in dermatology are narrowband ultraviolet B (NB-UVB), broadband ultraviolet B (BB-UVB), UVA1, and psoralen combined with UVA (PUVA). The interaction between UV and the skin determines the effectiveness of phototherapy. The biological effects of UV are used in the management of inflammatory skin diseases, malignancies, and various rare dermatoses. Apart from these benefits, UV increases the risk of photoaging and skin cancer. Therefore, further researches are necessary to enhance the effectiveness and safety of phototherapy. This literature review discusses the role of phototherapy in various dermatoses other than psoriasis and vitiligo.
Kriteria ABCDE untuk Deteksi Dini Keganasan Kulit Parikesit Muhammad; Adhika Ayu Lestari; Kara Adistri; Ridha Sarly Amalia; Larisa Paramitha Wibawa
Cermin Dunia Kedokteran Vol. 49 No. 11 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i11.322

Abstract

Tingginya insiden keganasan kulit yang ditemukan pada stadium lanjut membutuhkan kemampuan lebih baik untuk mengenali tanda dan gejala awal. Pengenalan dini gejala klinis kanker kulit berpigmen, terutama melanoma maligna, dapat dengan pemeriksaan lesi menggunakan kriteria ABCDE. Kriteria ini sederhana dan mudah digunakan, baik oleh tenaga medis maupun masyarakat awam. Makin banyak kriteria ABCDE yang terpenuhi, makin tinggi kemungkinan suatu lesi adalah kanker kulit. High incidence of skin malignancy found in advanced stages calls for a better clinical judgment to detect early signs and symptoms. Screening for early clinical findings of pigmented skin cancer, especially malignant melanoma, can use ABCDE criteria. The criteria are simple and easy to apply, either by medical professionals or general public. The more ABCDE criteria were met, the higher chance that a lesion is a skin cancer.
Challenge in diagnosis and management of lentigo maligna and lentigo maligna melanoma Anggraini, Ika; Miranda, Elisa; Wibawa, Larisa Paramitha; Krisanti, Roro Inge Ade; Sampurna, Adhimukti T
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Lentigo maligna (LM) is a subtype of melanoma in situ, which can evolve into lentigo maligna melanoma (LMM) if treated inadequately. LM and LMM are usually found on chronically sun damaged skin such as the face (cheek and nose) of the elderly on seventh or eight decades. Clinical manifestation of LM may be quite subtle, so early diagnosis is difficult to perform.The treatment of LM and LMM are challenging due to ill-defined clinical margin, predilection on the face with great size, and preponderance of the elderly, which are potential for recurrency and progressiveness from LM into LMM.
Vaginal microbiota in menopause Martinus, Martinus; Wibawa, Larisa Paramitha; Effendi, Evita Halim; Yusharyahya, Shannaz Nadia; Nilasari, Hanny; Indriatmi, Wresti
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

The human vagina together with its resident, microbiota, comprise a dynamic ecosystem. Normal microbiota is dominated by Lactobacillus species, and pathogen microbiota such as Gardnerella species and Bacteroides species can occur due to decrease in Lactobacillus domination. Lactobacillus plays an essential role in keeping normal vaginal microbiota in balance. Vaginal microbiota adapts to pH change and hormonal value. Changes in the vaginal microbiota over a woman’s lifespan will influence the colonization of pathogenic microbes. They include changes in child, puberty, reproductive state, menopause, and postmenopause. Estrogen levels change will affect the colonization of pathogenic microbium, leading to genitourinary syndrome of menopause. Vulvovaginal atrophy is often found in postmenopausal women, and dominated by L. iners, Anaerococcus sp, Peptoniphilus sp, Prevotella sp, and Streptococcus sp. The normal vaginal microbiota’s imbalance in menopause will cause diseases such as bacterial vaginosis, and recurrent vulvovaginal candidiasis due to hormonal therapies. Changes in the vaginal microbiota due to bacterial vaginosis are characterized by decrease in H2O2-producing Lactobacillus. They are also caused by the increase in numbers and concentration of Gardnerella vaginalis, Mycoplasma hominis, and other anaerob species such as Peptostreptococci, Prevotella spp, and Mobiluncus spp.
Eccrine poroma: The prominent mimicker Shihab, Nahla; Kristanti, Inge Ade; Sampurna, Adhimukti T.; Wibawa, Larisa Paramitha
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Eccrine poroma (EP) is an adnexal benign tumor arising from the eccrine duct epithelium. The appearance of EP can mimic benign and malignant skin tumors, thus often making the diagnosis delayed or inaccurate. Case Illustration: We report two cases of EP, with clinical and dermoscopic features mimicking Bowen’s disease, verruca vulgaris, pyogenic granuloma, skin metastases of breast cancer, and amelanotic melanoma. Both patients were surgically excised and biopsied. Histopathology examination of both cases revealed eccrine poroma. Discussion: Both cases showed similarity with the theories, that EP is most found in middle age population and its predilection on extremities. The dermoscopy appearance of the first patient showed two major components, multiple red dots and lacunae mimicking glomerular vessels, and multiple whitish halos-likekeratosis. Red dots with whitish halos can be seen in dermoscopy of verruca vulgaris, while glomerular vessels and keratosis is usually found in Bowen’s disease. The dermoscopy examination of our second patient only showed some loop hemorrhagic and thrombosed vessels, which are quite inconclusive. Diagnoses were made with histopathology examination which revealed similar pattern of eccrine poroma in both cases. Conclusion: EP is a prominent mimicker, often misdiagnosed because it is uncommon in clinical practice, has variable clinical presentations and dermoscopic appearances. Hence, recognizing and diagnosing this disease becomes a challenge for dermatologist.
Dermoscopy-guided carbon dioxide laser destruction for nevus sebaceous: two case reports Wibawa, Larisa Paramitha; Ohara, Kuniaki
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Nevus sebaceous (NS) is a common hamartoma of the cutaneous adnexal structure, clinically appear as a well demarcated yellow-orange plaque, sometimes with verrucous surface. Dermoscopy may aid the diagnosis of NS and also guide carbon dioxide (CO2) laser therapy. Case Illustration: Two cases of brown and yellowish plaque on the face, with clinical appearance, dermoscopic, and histopathological findings consistent with NS. The patients consented to undergo serial CO­2laser destruction, aimed to reduce recurrences and shorten the duration of the downtime. Dermoscopy aided in locating the area and the depth of each treatment. Discussion: The dermoscopy finding of NS were already reported as milia-like structure and multiple whitish structures (dots) varying in size, with orange background. The dermoscopy findings of these two cases were in accordance with previous reports. CO2laser destruction was reported to produce satisfying results, but with known recurrences. With the knowledge of dermoscopy appearance, we could determine the area and depth of the lesion to prevent reoccurrence. After two years of follow-up, the area where the deep ablation was performed had not reoccurred. Conclusion: Dermoscopy may aid the diagnosis and therapeutic confirmation of NS.
Co-Authors Adhika Ayu Lestari Adhimukti T Sampurna Adhimukti T Sampurna Anggraini, Ika Astri Adelia Chairista, Inadia Putri Dina Evyana Erdina Pusponegoro Evita Halim Effendi Farida Zubier Githa Rahmayunita Hafiza Fathan Hanny Nilasari Herman Cipto Hoemardani, Aida SD Indah Widyasari Inge Ade Krisanti Irwan Saputra Batubara Isni Maulina Sukmara, Isni Maulina Kara Adistri Keumala Budianti, Windy Krisanti, Roro Inge Ade Krisanti, RR Inge Ade Kristanti, Inge Ade Kusumaningrat, I Gst. Ayu Mirah Larasati, Anindya Lili Legiawati Martinus, Martinus Melody Febriana Andardewi Miranda, Elisa Muhammad, Parikesit Nahla Shihab, Nahla Ohara, Kuniaki Parikesit Muhammad Purbasari, Lusiana Rakasiwi Ningrum, Rizki Irianti Ridha Sarly Amalia Riesye Arisanty Riva Ambardina Pradita Rosdiana, Dewi Selvina Sampurna, Adhimukti T Sampurna, Adhimukti T. Shannaz Nadia Yusharyahya Shannaz Nadia Yusharyahya Sondang P Sirait Sri L. Menaldi Sujudi, Yufanti Wahyudi, Danang T Windy Keumala Budianti Windy Keumala Budianti Wresti Indriatmi B. Makes Yudo Irawan