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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal of General Procedural Dermatology and Venereology Indonesia Indian Journal of Forensic Medicine & Toxicology MEDICINUS
Danu Yuliarto
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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A comparison of single-dose versus divided-dose of metronidazole on bacterial vaginosis among female sex workers in Surakarta Willa Damayanti; Rini Hastuti; Agung Triana Hartaty; Danu Yuliarto; Ardelia Dyah Ayu; Endra Yustin
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Abstract

Background: Bacterial vaginosis (BV) is the most common vaginal infection in sexually active women. Metronidazole (MTZ) is still one of the recommended regimens for BV either as a single-dose or divided-dose. In addition to its affordability and availability, oral metronidazole also produces fewer adverse effects. This study aimedto determine the efficacy of single-dose versus divided-dose metronidazole for BV among female sex workers (FSWs) in Surakarta.Methods: A single-blind randomized clinical trial was conducted in Surakarta. FSWswith BV (⩾3 Amsel criteria) were enrolled. The subjects were grouped into two, and treated with MTZ either as a single-dose of 2 gr (single-dose group) or 500 mg twice daily for one week (divided-dose group). After two weeks, we performed second vaginal swabs and reassessed the Amsel criteria, complaints and adverse events. Results: Out of 75 FSWs, 30 (42%) were diagnosed with BV. The efficacy between two groups was not significantly different. However, patients in the single-dose group were 2 times more likely to develop recurrent BV (OR = 2.000; 95% CI 0.146 – 27.447), and 1.5 times more likely to have vaginal discharge complaints (OR = 1,500; 95% CI 0,181-12,459) than divided-dose group.Conclusion: Single-dose and divided-dose metronidazole produce similar efficacy for treating BV in sexually active women. Single-dose metronidazole has a higher risk of BV recurrence and vaginal discharge complaint. Divided-dose metronidazole is recommended for treating BV. Keywords:bacterial vaginosis, female sex workers, metronidazole
Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report Danu Yuliarto; Prasetyadi Mawardi; Ambar Mudigdo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16835

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterizedby intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanindeposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to thegeneral population.Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Severalmonths ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinalcomplaints such as nausea or vomiting were previously denied. Dermatological examination in the oriset ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathologicalexamination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patienthad an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, noabnormalities were found and no signs of malignancy were found on histopathological examination.Conclusion: Result of histopathological examination showed an increase in the number of melanocytesin the stratum basale with lined melanocytes. Based on histopathological examination in this patient moreleads to the diagnosis of PJS
Susceptibility of Male who Have Sex with Male to High-Risk Type Human Papillomavirus (HPV) 16 and 18 with Condyloma Acuminata Prasetyadi Mawardi; Danu Yuliarto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.197-202

Abstract

Background: Condyloma acuminatum (CA) or genital warts are sexually transmitted infections caused by human papillomavirus (HPV). It is estimated that CA occurs in >80% of reproductive age in many countries, with the most common subtypes being 6 and 11. Purpose: The aim of the study to reveal the high risk (HR)-HPV in various condyloma acuminata in Dr. Moewardi Hospital. Methods: This study was a cross-sectional analytical observational study that assessed data collection concurrently over time. Specimens were patients diagnosed with condyloma acuminatum, biopsies were performed, and immunohistochemical staining was also performed. The sampling technique used sequential sampling, and the inclusion criteria included patients who came to our hospital for treatment. Results: The majority of the male sample was MSM. According to HIV status, 6 (30%) male patients were found to be positive. Immunohistochemistry showed that 15% of the samples were HR-HPV. Statistical test results for HR-HPV and low-risk (LR) HPV were significant, p-value = 0.038. Conclusion: Condyloma acuminatum is a sexually transmitted infection that usually occurs at the same time as HIV infection. In our study all patients with HR-HPV were MSM.
Prosedur Pembedahan pada Hiperhidrosis Aksilaris dengan Teknik Tumesen Liposuction-Curettage Danu Yuliarto; Wibisono Nugraha; Moerbono Mochtar; Ammarilis Murastami
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.739 KB) | DOI: 10.56951/medicinus.v35i1.86

Abstract

Hyperhidrosis is an excessive sweat production due to autonomic nerve dysfunction that occurs in areas with higher concentration of eccrine gland such as palms, soles of the feet, and axilla. Management of hyperhidrosis includes pharmacological and nonpharmacological approach. Patients with severe focal hyperhidrosis should consider surgical treatment or botulinum toxin injection. Tumescent liposuction with curettage is one of surgical technique option for the treatment of axillary hyperhidrosis. Case: A 32-year-old woman with complaint of excessive sweating, especially in the axillary area. The patient had received oral therapy from a dermatologist prior, but there was no improvement, so the patient was advised to undergo a surgical procedure. In this patient the tumescent liposuction-curettage procedure was performed. Discussion: Treatment of hyperhidrosis with both topical and systemic agents generally provides only temporary suppression of hyperhidrosis. In severe, disturbing cases, the treatment of choice for axillary hyperhidrosis is the surgical procedure. Combination of liposuction-curettage surgical method using tumescent anesthesia is relatively simple and safe. Reduction of apocrine gland secretion after liposuction-curettage takes a relatively long time. This surgical technique has many advantages, such as relatively minimal injury dan short recovery period. Follow-up after this combined liposuction-curettage procedure should be performed subjectively and objectively at 3, 6, and 12 months postoperative.
Kromoblastomikosis Penyakit Jamur yang Terabaikan Danu Yuliarto; Achmad Satya Negara; Harijono Kariosentono; Nugrohoaji Dharmawan; Nurrachmat Mulianto
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.116

Abstract

Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue caused by pigmented or dematiaceous fungi. This disease is endemic in tropical and subtropical regions such as Asia, Africa, and Latin America. Chromoblastomycosis is more common in adult men who work in agricultural areas, work as gardeners, or as carpenters. The diagnosis of chromoblastomycosis is confirmed by the finding of muriform cells or medlar bodies obtained from skin scrapings, microscopic culture, or tissue histopathological examination. The clinical feature varies, the initial lesion is a papule that spreads slowly over several months or years, and then this lesion will form a plaque with atrophic center. Many patients go undiagnosed at the early stage of the disease because this stage is rarely seen. Treatment of chromoblastomycosis includes surgery for the initial lesion and pharmacological therapy using antifungal agent such as itraconazole, the most commonly used drug for the treatment of chromoblastomycosis. The prognosis for chromoblastomycosis is poor, except on new lesions.
Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Co-Authors Achmad Satya Negara Agung Triana Hartaty Alfina Rahma Ambar Mudigdo Ammarilis Murastami Ardelia Dyah Ayu Dharmawan, Nugrohoaji Eka Devinta Novi Diana Endra Yustin Frieda Harijono Kariosentono Moerbono Mochtar Nurrachmat Mulianto Prasetyadi Mawardi Prasetyadi Mawardi Rini Hastuti Wibisono Nugraha Willa Damayanti