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Hepatotoksik terkait Obat Antituberkulosis pada Pasien Tuberkulosis dan Koinfeksi Tuberkulosis-HIV Azmi, Rizki Nur; Ardiani, Tiara; Siami, Sahra
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 1 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.932 KB) | DOI: 10.36408/mhjcm.v9i1.650

Abstract

BACKGROUND : The side effect of antituberculosis drugs that is toxic to liver cells, called hepatotoxic, needs to be a concern in the treatment of tuberculosis. The presence of these unwanted side effects poses a challenge in treatment because it can lead to discontinuation oh therapy or a change in regimen. Coinfection with HIV is also thought to increase the potential for hepatotoxicity of antituberculosis drugs. OBJECTIVE: This study aims to determine the incidence of hepatotoxicity of antituberculosis drugs in patients with tuberculosis and tuberculosis-HIV coinfection. METHOD : This study is an observational study with a cross sectional design, which was conducted in one of the hospitals in Samarinda City. Sources of research data came from patient medical record in 2018 – 2020. There was 53 tuberculosis patients and 53 tuberculosis-HIV coinfection patients. Differences in live enzyme values (AST and ALT) and severity in the two groups were analyzed by Mann-Whitney and Chi-Square tests. RESULT : The average value of AST and ALT in tuberculosis-HIV coinfection patients were higher than patients without HIV infection, which is AST 127,1 µ/L and ALT 100,7 µ/L. The highest degree of severity experienced by the patient was grade 3 (severe hepatotoxicity). Tuberculosis-HIV coinfection patients with grade 3 severity were 22,6% and tuberculosis patients were 9,4%. The values of liver enzymes and the severity of hepatotoxicity in the two groups of patients were statistically significant with p value < 0,05. CONCLUSION : Tuberculosis-HIV coinfection patients tend to have a higher incidence of hepatotoxicity related to antituberculosis drugs than those without HIV infection.
Pengetahuan dan Perilaku Swamedikasi pada Masyarakat Kota Samarinda Azmi, Rizki Nur; Hanifa, Deasy Nur Chairin; Suwarno, Kafka Navisa; Maharani, Adelya
Media Farmasi Vol 20 No 1 (2024): Media Farmasi Edisi April 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i1.404

Abstract

Self-Medication Knowledge and Behavior in Samarinda City Communities Improper use of drugs in self-medication or self-medication practices can cause serious health problems, such as the emergence of drug side effects, dependence, and others. Good knowledge and behavior can result in rational self-treatment and reduce the dangerous risks of the practice. The aim of this research is to analyze the knowledge and behavior of the people of Samarinda City. The research design used was cross sectional using a questionnaire containing questions to assess knowledge and self-medication behavior. Data collection was carried out in August – September 2023 by distributing questionnaires in various public areas in Samarinda City. The sampling technique used was purposive sampling. The research results obtained from 330 respondents who were the research sample, with the dominant characteristics being 68.2% women, 98.2% adults (19 - 44 years old) and 87.9% having a high school education (SMA). The level of self-medication knowledge was higher in the poor category (79.1%) and the level of self-medication behavior was in the good category (83.3%). Penggunaan obat yang tidak tepat dalam praktik swamedikasi atau pengobatan mandiri dapat menyebabkan masalah kesehatan yang serius, seperti munculnya efek samping obat, ketergantungan dan lain-lain. Pengetahuan dan perilaku yang baik dapat menghasilkan pengobatan mandiri yang rasional dan mengurangi risiko berbahaya dari praktik tersebut. Tujuan penelitian ini ialah menganalisis pengetahuan dan perilaku masyarakat Kota Samarinda. Desain penelitian yang digunakan adalah cross sectional dengan menggunakan kuesioner yang berisi pertanyaan untuk menilai pengetahuan dan perilaku swamedikasi. Pengumpulan data dilakukan pada bulan Agustus – September 2023 dengan menyebarkan kuesioner di berbagai public area di Kota Samarinda. Teknik sampling yang digunakan ialah purposive sampling. Hasil penelitian didapatkan 330 responden yang menjadi sampel penelitian, dengan karakteristik dominan pada perempuan sebanyak 68,2%, berusia dewasa (19 – 44 tahun) sebanyak 98,2% dan memiliki pendidikan terakhir Sekolah Menengah Atas (SMA) sebanyak 87,9%. Tingkat pengetahuan swamedikasi lebih banyak pada kategori buruk (79,1%) dan tingkat perilaku swamedikasi pada kategori baik (83,3%).
EVALUASI DOSIS DAN PROFIL PENGOBATAN PADA PASIEN DIABETES MELLITUS TIPE 2 KOMPLIKASI NEFROPATI DI RUMAH SAKIT DI KOTA SAMARINDA Ruslan, Rainhard Duta Pradana; setiawan, Roni; Hanif, Deasy Nur Chairin; Azmi, Rizki Nur
Jurnal Riset Inossa : Media Hasil Riset Pemerintahan, Ekonomi dan Sumber Daya Alam Vol. 5 No. 01 (2023): Juni
Publisher : Badan Perencanaan Pembangunan Daerah, Penelitian dan Pengembangan Kota Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54902/jri.v5i01.100

Abstract

The number of Diabetes Milletus cases in the city of Samarinda is 3.04%. One of the complications of uncontrolled DM can cause nephropathy. DM patients with diabetic nephropathy are described as having chronic albuminuria of 300 mg/24 hours on 2 visits 3 to 6 months. The purpose of this study was to look at the profile and treatment evaluation of patients with Diabetes Mellitus Type 2 complications of nephropathy at a hospital in Samarinda City. The method in this study is non-experimental observational with a descriptive design. With a cross-sectional approach using retrospective data, namely looking at data based on medical records of patients with Diabetes Mellitus Type 2 complications of nephropathy at a hospital in Samarinda City. The results of a study conducted at Samarinda City Hospital with a sample of 94 type 2 DM patients with nephropathy complications who were treated at inpatient installations from January 2021 to March 2022. The percentages were obtained based on gender, namely men (45.74%) ) and women (54.26%). The age range of patients with nephropathy DM is between 18-60 years with the most incidence being 41-60 (57.45%). The treatment profile obtained the greatest results using insulin, namely novorapid insulin (43.43%), lantus (19.74%) ), levemir (13.16%). while the oral drug, sulfonylrea (Gliquidone) 30 mg (13.16%). In this study there were 789 (97.65%) correct doses of 808 drugs and 19 (2.35%) incorrect doses. drug cases that require adjustment of drug dosage because it is influenced by the GFR value. Keywords: Type 2 Diabetes Mellitus, Dosage Evaluation, Nephropathy Complications, Treatment Profile.
PENGOLAHAN NUGGET IKAN KEMBUNG SEBAGAI UPAYA PENINGKATAN STATUS GIZI ANAK Azmi, Rizki Nur; Hanifa, Deasy Nur Chairin; Putra, Aditya Rian Riady; Sarah, Aulia; Regita, Geta
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 4 No 2: Mei-Agustus 2024
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v4i2.3412

Abstract

Kurangnya gizi dalam periode 1000 hari pertama kehidupan merupakan penyebab utama terjadi stunting yang berdampak pada banyak permasalahan kesehatan terhadap masa depan anak. Protein hewani seperti ikan kembung memiliki potensi dalam pemenuhan gizi anak. Ikan ini juga dapat diolah menjadi bentuk nugget yang disukai anak. Dalam kegiatan ini dilakukan pengabdian kepada masyarakat berupa sosialisasi pembuatan nugget ikan kembung. Kegiatan dilakukan di Kelurahan Sidodadi, Kota Samarinda, Provinsi Kalimantan Timur. Peserta kegiatan meliputi orang tua dan pengasuh balita di daerah tersebut. Hasil kegiatan didapatkan adanya peningkatan pengetahuan yang signifikan dari uji statistik dengan nilai p 0,005 dan tingkat kesukaan dalam uji hedonik terhadap nugget ikan kembung didapatkan suka pada aspek warna, aroma, tekstur, rasa, dan tampilan secara keseluruhan
Analysis of Risk Factors For Anemia and Neutropenia Post-Chemotherapy in Patients with Acute Lymphoblastic Leukemia at Samarinda Hospital Aisyah, Siti; Azmi, Rizki Nur
Jurnal Ilmu Kesehatan Vol 12 No 2 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Chemotherapy is the main therapy in the treatment of acute lymphoblastic leukemia and can change the body's hematological parameters during therapy. Haematological side effects that commonly occur after chemotherapy include anemia and neutropenia. The aim of this study was to determine the risk factors for anemia and neutropenia in patients with acute lymphoblastic leukemia after chemotherapy. This research is retrospective analytic with cross sectional data collection methods. The type of data used is secondary data from medical records of patients diagnosed with acute lymphoblastic leukemia. Data were analyzed using SPSS version 25.0. The research results obtained from this study were that there was a significant relationship between chemotherapy regimen and the incidence of anemia in acute lymphoblastic leukemia patients (p=0.001), and a significant relationship was found between age and chemotherapy regimen and the incidence of neutropenia in acute lymphoblastic leukemia patients (p= 0.005 and p=0.011). The conclusion obtained is that risk factors for chemotherapy regimens have a significant relationship between the incidence of anemia. In addition, the risk factors of age and chemotherapy regimen have a significant relationship between the incidence of neutropenia. Risk factors aged 12-25 years have the opportunity to increase the risk of neutropenia by 0.231 times greater than risk factors for chemotherapy regimens.
Hubungan Tingkat Kepatuhan Meminum Obat Dengan Nilai Tekanan Darah Pada Pasien Hipertensi Geriatri Di Puskesmas Segiri Kota Samarinda Fathimah, Umi; Azmi, Rizki Nur; Abdissalam, Erfan
Jurnal Farmasi SYIFA Vol 3 No 2 (2025): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v3i2.776

Abstract

Hipertensi merupakan salah satu penyakit yang paling sering muncul di negara berkembang seperti Indonesia. Penyakit hipertensi pada geriatri diindikasikan ketika hasil pengukuran tekanan darah sistolik ≥ 150 mmHg dan tekanan darah diastolik ≥ 90 mmHg. Prevalensi hipertensi di Kalimantan Timur berdasarkan diagnosis dokter sebanyak 39,30% dari jumlah total penduduk usia ≥18 tahun. Sedangkan angka kasus hipertensi berdasarkan data Dinas Kesehatan Kota Samarinda  tahun 2024 sebanyak 69.156 kejadian. Penyebab ketidakpatuhan lansia dalam meminum obat antihipertensi diantaranya disebabkan oleh kesibukan dalam bekerja, penurunan daya ingat terkait waktu pemberian obat, efek samping dari pengobatan seperti mengantuk, pusing, rasa mual selama mengonsumsi obat antihipertensi serta penghentian pengobatan saat keadaan membaik. Tujuan penelitian ini untuk mengetahui adanya hubungan tingkat kepatuhan meminum obat dengan nilai tekanan darah pada pasien hipertensi di Puskesmas Segiri Kota Samarinda. Penelitian ini merupakan jenis penelitian kuantitatif yang dirancang dengan menggunakan studi cross sectional. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan jumlah sampel minimum 61 responden. Analisis yang digunakan adalah uji Spearman Rank Corellation. Data yang didapatkan dari pengisian kuesioner Morisky Medication Adherence Scale (MMAS-8) dan nilai tekanan darah di analisis univariat dan bivariat. Hasil yang di dapatkan adalah nilai p = 0,000 dengan nilai koefisien korelasi 0,438. Hasil tersebut disimpulkan bahwa terdapat hubungan cukup kuat antara kepatuhan meminum obat terhadap nilai tekanan darah pasien hipertensi geriatri di Puskesmas Segiri Kota Samarinda.