Delimasari, Trisakti Halimah
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THE EFFECTS OF TAMOXIFEN AND CHEMOTHERAPY AFTER SURGERY ON THE RECURRENCE AND SURVIVAL OF BREAST CANCER PATIENTS WITH POSITIVE HORMONE RECEPTOR: A META-ANALYSIS Delimasari, Trisakti Halimah; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the most common type of cancer suffered by women in the world. The combination of tamoxifen and chemotherapy significantly reduces the risk of recur­rence and mortality in breast cancer patients. This study aimed to analyze how effective the com­bination of tamoxifen and chemotherapy after surgery to reduce the risk of recurrence and mortality in breast cancer patients with positive hormone receptor.Subjects and Method: This study used systematic review and meta-analysis. The researcher collected articles from the Pubmed journal database. The subjects of the study were women with breast cancer after surgery. The dependent variable was recurrence and survival (mortality). The independent variables were tamoxifen and chemotherapy. Data were analyzed based on the fixed and random effects model using RevMan 5 software.Results: There were 3 articles with 3,761 women who were involved in the analysis process. The combination of tamoxifen and chemotherapy could reduce the risk of recurrence in women with positive hormone receptor (ER+) breast cancer (HR=0.68; 95%CI=0.58 to 0.80; p=0.001). The combination of tamoxifen and chemotherapy showed weak and non-significant decreasing trend in reducing the risk of mortality in women with ER+breast cancer (HR=0.87; 95%CI=0.73 to 1.03; p= 0.11).Conclusion: The combination of tamoxifen and chemotherapy in women with ER+ breast cancer is effective in reducing the risk of recurrence. However, it does not increase survival.Keywords: tamoxifen, chemotherapy, breast cancer.Correspondence:Trisakti Halimah Delimasari. Program Studi Ilmu Kesehatan Kesehatan, Universitas Sebe­las Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: tri­sak­ti­hd­1994­@g­mail.­com. Mobile: +6285 293 994 629.Indonesian Journal of Medicine (2019), 4(4): 346-353https://doi.org/10.26911/theijmed.2019.04.04.07
Parental Communication as a Protective Factor Against Adolescent Risky Sexual Behavior: A Meta-Analysis Atmojo, Joko Tri; Handayani, Anggun Fitri; Widiyanto, Aris; Mubarok, Ahmad Syauqi; Anasulfalah, Hakim; Delimasari, Trisakti Halimah
Journal of Health Promotion and Behavior Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejhpb.2025.10.03.05

Abstract

Background: Adolescence is a significant developmental stage marked by notable physical, psychological, and social changes. Adolescent reproductive health surveys show that a number of teenagers report engaging in premarital sexual intercourse without fully understanding its social and health consequences. Given this phenomenon, it is crucial to understand the factors that can protect them from risky sexual behaviors, particularly starting from the family. This study aimed to estimate the impact of family communication on risky sexual behavior in adolescents. Subjects and Method: This research is a meta-analysis and systematic review using the PRISMA diagram with PICO frame work (P= adolescent; I = parental communication; C= no parental communication; O= risky sexual behavior). Primary studies were searched through several indexing databases, including PubMed, Google Scholar, and ScienceDirect. Keywords used to facilitate the search for articles include: “parental participation,” or “parental communication,” or “family interaction,” or “sexual risk” or “sexual risk behavior” AND “adults” or “adolescents.” The inclusion criteria for this study are articles published using a cross-sectional study design up to 2024. The statistical analysis used in this study was conducted using the RevMan 5.4 meta-analysis program with both fixed effect and random effect approaches to present the data in the form of forest plots and funnel plots. Results: A total 9 Articles were included in the meta-analysis. The results of the study show that adolescents with low family participation in sexual education, or in the absence of parental communication, are 1.46 times more likely to engage in risky sexual behavior compared to adolescents who receive sexual education or have parental communication, and this result is statistically significant (aOR= 1.46; CI 95%= 1.43 to 1.49; p<0.001). Conclusion: adolescents with low family participation in sexual education, or in the absence of parental communication are more likely to engage in risky sexual behavior compared to adolescents who receive sexual education or have parental communication.