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All Journal Majalah Patologi Indonesia Sumatera Medical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Laksmi, Lidya Imelda
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Description Of Bag Load With Antropometry Of Elementary School Students Krishna Moorthi, Priya Darshini; Machrina, Yetty; Laksmi, Lidya Imelda; Yaznil, Muhammad Rizki
Sumatera Medical Journal Vol. 3 No. 1 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i1.3336

Abstract

Background. Low back pain is one of the most common health problem among school students. Carrying heavy backpack to school is one of the cause of low back pain. Objectives. To identify the bag load carried by the students and antropometry of the students. Method. This research is a descriptive observasional with cross sectional method. Data used is a primer data which is from 268 students by measuring their body weight, height, bag weight and also by interviewing them using interview guidelines. Results. The results obtained from 268 elememtary school students of Siti Hajar mostly have normal nutritional status. The average bag weight at level I (6.071%), level II (8.510%) and level III (10.812%) where the majority of bag loads compared to elementary school antropometry were included in the mild category 47.6% at level I, 74.7% at level II and 84.3% at level III eventhough there were some children in the heavy category. 88.8% of children carry their school bags using two shoulders, with a duration of time <30 minutes (61.7%). Respondents who experienced back pain (4.9%) and who did not experience back pain (95.1%). Conclusions. The weight of Siti Hajar Elementary School children bag against antropometry has not exceeded the recommended load limit. Key words. Bag load, antropometry, cross-sectional, interview
Fracture Risk Assessment Tool (Frax Tool) Scores in Type 2 Diabetes Mellitus Patients in Haji Hospital Medan T. Shafira; Rangkuti, Deske Muhadi; Laksmi, Lidya Imelda; Rachmatsyah, M. Yusuf
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 1 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i1.14889

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia resulting from defects in insulin secretion and/or insulin action. Bone fragility in T2DM, which mirrored bone mineral density and bone mass reduction. Classical diagnosis of osteoporosis in T2DM is performed by dual-energy X-ray absorptiometry (DXA) and the risk of fracture can be assessed using the FRAX tool (Fracture Risk Assessment Tool). The purpose of the study was to assess the risk of osteoporosis using FRAX tool calculation (without BMD) in T2DM patients at the endocrine metabolic clinic of Haji Hospital Medan. Method: Descriptive observational with a cross-sectional study approach using primary and secondary data from the medical records of the Endocrine and Metabolic Clinic of Haji Hospital Medan in September-October 2023.Results: Of the 80 respondents with a risk of major osteoporosis, there were 77 respondents (96.3%) with low risk, 3 respondents (3%) with moderate risk, and no respondents with high risk (0%). The FRAX score for the risk of hip fracture received a low risk of 72 respondents (90%). At the same time, the high-risk was 8 respondents (10%).Conclusion: The majority of T2DM patients at Haji Hospital Medan are at low- risk for major osteoporosis and hip fracture
High Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Correlates with High Grade of Clear Cell Renal Cell Carcinoma Rezeki, Dewi Sri; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Alferraly, T. Ibnu; Lukito, Joko S.; Betty, Betty
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.581

Abstract

Background Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in renal cell tumors (RCT). This is a very aggressive cancer, often diagnosed at advanced stage leading to increase morbidity and mortality rates. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX-4) expression plays role in the regulation of several cancer types. The expression of NOX-4 is associated with a poorer degree of differentiation and a shorter survival in RCT. Therefore, NOX-4 expression is predictor of prognosis and potential therapeutic target. Research on the correlation of NOX-4 expression in RCTs is still very limited, while Correlation of NOX-4 expression in ccRCC does not exist yet.   Objective To assess the relationship between NOX-4 expression and ISUP grading in ccRCC.   Method In this study, 30 slide samples and ccRCC paraffin blocks were diagnosed histopathologically at Department of Anatomic Pathology of H. Adam Malik General Hospital from January 2012 to April 2022. All clinicopathological data were taken from medical records/pathology archives. The expression of NOX-4 immunohistochemical was assessed in nucleus and cytoplasm of tumor cells. The assessment was carried out semiquantitatively based on intensity and percentage of expressed tumor cells. The relationship between NOX-4 expression and ISUP grading was assessed using Fisher's exact test.   Results Of the 30 ccRCC samples, high grade ccRCC was found in 21 cases (70%) and strong expression of NOX-4 in cytoplasm and nucleus in 20 cases (66.7%). Strong expression of NOX-4 in high grade ccRCC was found in 17 cases (81.0%). A significant relationship was observed between NOX-4 expression and ISUP grading on ccRCC with a p-value of 0.030 (p<0.05) using Fisher's exact test.   Conclusion There is a significant relationship between NOX-4 expression and ISUP grading in ccRCC. Therefore, NOX-4 expression can be used for the prognosis of ccRCC and therapy development.
Correlation between Reactive Stromal Expression and Histochemical Trichrome Masson Staining with Histopathological Grading in Prostate Adenocarcinoma at Adam Malik Haji Center General Hospital Medan Basrul, Mohd. Yuwanda; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Lubis, M. Nadjib Dahlan; Intan, T. Kemala; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.584

Abstract

Background Adenocarcinoma of the prostate is an invasive carcinoma, composed of neoplastic prostatic epithelial cells with differentiation and secretion arranged in various histomorphological patterns.Quantitative analysis of the elements that make up the stroma in casesprostate adenocarcinomahas been linked to prognostic factors and the Gleason score, which correlates with progression and metastasis, and may contribute to new prognostic feature approaches.   Method Descriptive analytic study with 33 paraffin block samples diagnosed as prostate adenocarcinoma at Haji Adam Malik General Hospital Medan.Assessment is done forsee the relationship between reactive stromal expression using Trichrome Masson and histopathological grading gleason score then determine the scoring score for the stroma around the prostate gland adenocarcinoma lesion stained blue with trichrome masson, a positive score of one (+): if 0-15% stroma is stained blue, positive two (++): if >15%-<50% stroma is stained and triple positive (+++): if >50% stroma is stained blue. The histopathological grading was categorized into grade I (well differentiated: Gleason score ≤6), grade II (moderately differentiated: Gleason score 7 (3+4)), and grade III (poorly differentiated: Gleason score 7 (4+3) and 8 -10).   Results: Reactive stromal expression the most found was positive three (+++) (69.7%) and the most common histopathological grading was grade III (69.7%). There was a significant correlation between reactive stromal expression and histopathological grading in prostate adenocarcinoma (p-value=0.044), namely the worse the cell differentiation, the higher the positive score of reactive stromal expression.   Conclusion Assessment of reactive stromal expression associated with histopathological grading can be used as an indication of prognosis in patients with prostate adenocarcinoma.
Immunohistochemistry Expression Gata3 Based on Subtypes of Ovarian Carcinoma at Haji Adam Malik General Hospital Medan 2019-2021 Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Chrestela, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.604

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women and although comprehensive management with surgery and chemotherapy at an advanced stage, the resistance rate is still low. GATA3 contributes to the progression of malignancy and its expression is one of the predictors in some malignancies, but the results are mixed in ovarian carcinoma. High GATA3 expression is associated with the aggressiveness of tumor growth and poor prognosis of ovarian carcinoma.   Methods This research is an cross-sectional descriptive-analytical study with 33 histological specimens diagnosed with ovarian carcinoma from medical records/archives at H. Adam Malik Hospital Medan. Each sample specimen was stain with GATA3, and several various histopathological subtypes of ovarian carcinoma.   Results From a total of 33 samples, 14 samples were serous carcinoma, 6 samples were mucinous carcinoma, 7 samples were endometrioid carcinoma, and 6 samples were clear cell carcinoma. GATA3 was expressed in 42.5% of serous carcinoma. Positive expression of GATA3 is mostly found in advanced ovarian carcinoma, older age, and histopathological type of serous carcinoma.    Conclusion Immunohistochemistry GATA3 expression was expressed in 42.4% of serous carcinoma, 21.2% in endometrioid carcinoma, 18.2% in clear cell carcinoma, and 18.2% in mucinous carcinoma.   Keywords: ovarian carcinoma, GATA3, immunohistochemistry
The Correlation of Light Chain 3B Immunohistochemical Expression with Histopathological Grading in Colorectal Adenocarcinoma Fiandani, Fatma; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.610

Abstract

Background Colorectal cancer ranks third highest of all malignancies worldwide and ranks fourth out of the 10 most common cancers encountered in Indonesia. More than 90% of colorectal cancers are adenocarcinoma type. The mechanism of autophagy has a dual role in tumorigenesis, namely as a tumor suppressor and as a tumor promoter. Microtubule-associated protein 1 light chain 3B (LC3B) is one of the widely used autophagy markers. The role of autophagy requires further research so that LC3B can be considered as one of the predictors of prognosis, especially in colorectal adenocarcinoma. The aim of this research is to determine the correlation of Light Chain 3B immunohistochemical expression with histopathological grading of colorectal adenocarcinoma. Methods Cross-sectional analytic study of 41 samples diagnosed with colorectal carcinoma at H. Adam Malik General Hospital Medan. Staining was performed using a polyclonal antibody rabbit Light Chain 3B immunohistochemistry (GeneTex) which would appear positive in the cytoplasm of tumor cells at a dilution of 1: 500. LC3B expression was assessed semiquantitatively with low and high expression categories. Data analysis was tested with the Spearman correlation test. Results LC3B immunohistochemical expression has a very strong correlation with the histopathological grading of colorectal adenocarcinoma and in a positive direction where the higher the colorectal adenocarcinoma grade, the higher the LC3B immunohistochemical expression, and vice versa (p=0,0001; r=0,763). Conclusion There was a significant relationship between LC3B immunohistochemical expression and histopathological grading of colorectal adenocarcinoma.
The Correlation between Matrix Metalloproteinase-9 (MMP-9) Immunohistochemical Expression and Histopathological Subtypes of Basal Cell Carcinoma: A Correlation between Matrix Metalloproteinase-9 (MMP-9) Immunohistochemical Expression and Histopathological Subtypes of Basal Cell Carcinoma Aisyah, Siti; Intan, T. Kemala; Alferraly, T. Ibnu; Betty, Betty; Soekimin, Soekimin; Laksmi, Lidya Imelda
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.644

Abstract

ABSTRACT Background Basal cell carcinoma (BCC) is a non-melanocytic skin cancer originating basal layer of the epidermis and/or hair follicles that shows an increasing global incidence. Disease growth is slow, rarely metastasizes but has the ability to invade and destroy deeper surrounding tissues. Low mortality, but high morbidity. Matrix metalloproteinases are enzymes that can degrade various extracellular matrix components. In skin, MMP-9 expression may be increased by prolonged ultraviolet exposure. UV radiation is one of the causes of BCC. Method Analytic study with a cross sectional approach on 40 surgical samples diagnosed as BCC and then performed with MMP-9 immunohistochemical staining. The data obtained were processed with statistical software and the relationship between the immunohistochemical expression of MMP-9 with histopathological subtypes of basal cell carcinoma was used the Somers'd statistical test. Results The expression of MMP-9 in the lower risk BCC group with the weakest expression was 37.5%, the most common nodular BCC subtype was 27.5%. The higher risk BCC group with the strongest expression was 20.0%, the most common infiltrating BCC was 17.5%. There was a significant relationship between the immunohistochemical expression of MMP-9 with histopathological subtypes of basal cell carcinoma, p value <0.0001 (p<0.05). Conclusion This study proves that there is a significant relationship between the expression of MMP-9 with histopathological subtypes of basal cell carcinoma, so it can be considered as an additional marker to predict the recurrence.
HUBUNGAN EKSPRESI PD-L1 DAN DENSITAS TILS PADA SUBTIPE KARSINOMA OVARIUM: CORRELATION OF PD-L1 EXPRESSION AND TILS DENSITY IN OVARIAN CARCINOMA SUBTYPES Kadri, Sayed Muhammad; Mariedina, Causa Trisna; Betty; Laksmi, Lidya Imelda; Lubis, Nadjib Dahlan
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.926

Abstract

Background: PD-L1 and tumor-infiltrating lymphocytes (TILs) are essential components of the tumor microenvironment, playing key roles in modulating immune responses against ovarian carcinoma. However, the relationship between these two markers remains underexplored, especially across different histopathological subtypesMethods: A cross-sectional analytical study was conducted on 40 ovarian carcinoma cases using immunohistochemistry. PD-L1 expression and TIL density were evaluated in both intratumoral and stromal compartments. The Somers’ D test was used to analyze the correlation between variables.Results: Most patients were aged 40–50 years and presented with stage I disease. The predominant histopathological subtype was serous carcinoma. Intratumoral and stromal TIL densities were mostly low (77.5% and 72.5%, respectively). Positive intratumoral PD-L1 expression was observed in only 5% of cases, while no stromal PD-L1 expression was detected. No statistically significant correlation was found between PD-L1 expression and TIL density, either overall or by subtype.Conclusion: No significant correlation was observed between PD-L1 expression and TIL density in ovarian carcinoma subtypes. The variability in their expression suggests immune microenvironment heterogeneity, supporting the need for separate evaluation of these biomarkers and individualized approaches to immunotherapy. AbstrakLatar Belakang: PD-L1 dan TILs merupakan komponen utama dalam mikrolingkungan tumor yang berperan penting dalam regulasi respons imun terhadap karsinoma ovarium. Hubungan antara keduanya masih jarang dikaji, khususnya pada berbagai subtipe histopatologi.Tujuan: Menilai hubungan antara ekspresi PD-L1 dan densitas TILs pada beberapa subtipe karsinoma ovarium.Metode: Penelitian cross-sectional analitik pada 40 kasus karsinoma ovarium menggunakan pewarnaan imunohistokimia. Ekspresi PD-L1 dan densitas TILs dianalisis pada area intratumoral dan stromal. Uji korelasi Somers’ D digunakan untuk menilai hubungan antar variabel.Hasil: Mayoritas pasien berusia 40–50 tahun dan berada pada stadium klinis I, dengan subtipe terbanyak adalah serous carcinoma. Densitas TILs intratumoral dan stromal sebagian besar tergolong rendah (77,5% dan 72,5%). Ekspresi PD-L1 intratumoral positif ditemukan pada 5% kasus, sedangkan ekspresi PD-L1 stromal tidak ditemukan. Tidak terdapat hubungan yang bermakna antara ekspresi PD-L1 dan densitas TILs, baik secara keseluruhan maupun berdasarkan subtipe.Kesimpulan:Tidak ditemukan korelasi signifikan antara ekspresi PD-L1 dan densitas TILs pada subtipe karsinoma ovarium. Variasi pola ekspresi antar subtipe mencerminkan heterogenitas imun tumor, sehingga diperlukan evaluasi terpisah PD-L1 dan TILs sebagai biomarker serta pendekatan individualisasi dalam terapi imun.
Co-Authors Alamanda, Intan Nefia Alferraly, T. Ibnu Basrul, Mohd. Yuwanda Betty betty betty Chrestela, Jessy Chrestella, Jessy Delyuzar, Delyuzar Fiandani, Fatma Intan, T. Kemala Kadri, Sayed Muhammad Krishna Moorthi, Priya Darshini Lubis, M. Nadjib Dahlan Lukito, Joko S. Mariedina, Causa Trisna Nadjib Dahlan Lubis Rachmatsyah, M. Yusuf Rangkuti, Deske Muhadi Rezeki, Dewi Sri Siti Aisyah Soekimin Soekimin, Soekimin T. Shafira Yaznil, Muhammad Rizki Yetty Machrina