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Jeffrey I. Gordon

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Jeffrey I. Gordon
Born (1947-10-04) October 4, 1947 (age 78)
New Orleans, LA
NationalityAmerican
Alma materOberlin College
University of Chicago School of Medicine
Known forCharacterizing role of human gut microbiome in health and disease
AwardsLouisa Gross Horwitz Prize (2017)
Copley Medal (2018)
Balzan Prize (2021)
Princess of Asturias Award (2023)
Albany Medical Center Prize (2023)
Scientific career
FieldsBiomedical Science
InstitutionsWashington University School of Medicine
Websitegordonlab.washu.edu

Jeffrey I. Gordon[1] is the Dr. Robert J. Glaser Distinguished University Professor and Director of The Edison Family Center for Genome Sciences & Systems Biology at Washington University School of Medicine.[2] He is considered to be the "father" of human microbiome research.[3] His studies of healthy and undernourished children living in low- and middle-income countries have yielded insights about how the gut microbiome develops in the first several years after birth, and evidence that disrupted gut microbiome development is a contributing cause of childhood undernutrition.[4][5]

Gordon and his group's work has advanced scientific understanding of the human gut microbiome as a microbial "organ" that affects human health and disease beyond gastrointestinal health.[6] Their work has entailed developing experimental and computational approaches for dissecting the vast complexity and dynamism of the gut microbiome to identify microbial effectors of postnatal growth, discovering food formulations and their bioactive molecules that repair undernourished children’s gut microbiomes, and characterizing how microbiome repair in these children has effects that extend beyond the walls of the gut to influence regulators of muscle, bone, and brain development plus immune and metabolic functions. Overall, this work illustrates the importance of understanding that human health reflects an integration of activities of our human and microbial cells and genes.[4][5]

Much of Gordon's work has focused on addressing the global health challenge of childhood undernutrition.[7] Central questions that Gordon and his lab are pursuing include how our gut microbial communities influence human health, what interventions will repair microbial communities for an individual or a population to optimize healthy development, and how to create local infrastructures to deliver treatment in affordable, culturally acceptable, appetizing foods.[8] He and his team identified underdeveloped gut microbiota as a contributing cause of childhood malnutrition[9] and found that therapeutic food aimed at repairing the gut microbiome is more effective than a widely used standard therapeutic food to treat childhood malnutrition.[10] Unlike standard therapeutic foods, these microbiome-directed foods improve long-term effects of malnutrition, including problems with metabolism, bone growth, immune function and brain development.[10]

Education and career

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Gordon was born in New Orleans, Louisiana, and grew up in Connecticut. He earned his Bachelor of Arts from Oberlin College (1969) and his Doctor of Medicine from the University of Chicago (1973). After receiving his MD, Gordon completed his clinical training in internal medicine and gastroenterology at Washington University School of Medicine and was a post-doctoral fellow in the Laboratory of Biochemistry at the National Cancer Institute, part of the National Institutes of Health (NIH). He then joined the faculty at Washington University, where he has spent his entire academic career.[11] Gordon was first a member of the Departments of Medicine and of Biological Chemistry (1981-1990), then served as Head of the Department of Molecular Biology and Pharmacology (1991-2003). Currently his primary faculty appointment is in the Department of Pathology and Immunology.[12] Since 2004, Gordon has served as the founding director of The Edison Family Center for Genome Sciences & Systems Biology.[13]

Early scientific research

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Gordon's early work focused on how the gastrointestinal epithelium is continuously renewed throughout life, and how its component cell types express different functions as they differentiate depending upon where they are located along the length of the gut.[14][15][16] This early work employed transgenic mice to study regulation of developmental-stage specific, cell type-specific and spatial patterns of gene expression using members of the fatty acid binding protein gene family as models.[15][16]

During this time he also  played a pivotal role in the study of protein N-myristoylation, a process by which the 14 carbon fatty acid, myristate, is covalently attached to an N-terminal glycine residue of proteins involved in cell signaling and other functions. Gordon's group was instrumental in characterizing the substrate specificity of N-myristoyltransferase (Nmt), its catalytic mechanism and its atomic structure.[17] His genetic and biochemical studies provided evidence that Nmt is essential for the viability of fungi that are opportunistic pathogens and yielded enzyme inhibitors that functioned as anti-fungal agents.[17]

The Gordon lab's transgenic and genetic mosaic mouse models provided evidence that spatial patterns of gene expression in gut epithelial cell lineages were dependent in part on cues from the environment.[18] In the early 1990s, he turned to the gut's community of micro-organisms (microbiota) and their collective genes (microbiome) to search for these cues. In a simplified model of the human gut ecosystem that employed germ-free mice colonized with a single prominent human gut bacterial symbiont (Bacteroides thetaiotaomicron), his lab showed that this bacterium could direct a postnatal developmental program of expanding production of fucose-containing polysaccharides in the small intestinal epithelium but only if the organisms had functional genes for utilizing these host polysaccharides.[19][20] His follow-up functional genomics study of gnotobiotic mice colonized with just B. thetaioatomicron disclosed how a gut symbiont could influence many other aspects of gut biology.[21] By sequencing the B. thetaiotaomicron genome,[22] they found a repertoire of genes encoding enzymes that degrade polysaacharides; the number and type of these enzymes greatly exceeded those encoded in the human genome. This information enabled them to show in gnotobiotic mice how this organism can adaptively forage dietary and host glycans depending upon the diets they consumed.[23] B. thetaiotaomicron has subsequently become a leading model organism for dissecting the genetic and metabolic underpinnings of the symbiotic relationship between members of the gut microbiota and their human hosts – including how members sense/acquire/metabolize dietary polysaccharides.

These findings led his group to colonize germ-free animals with defined microbial communities of increasing complexity composed of cultured, genome-sequenced human gut microbiota members, so that questions about how members cooperate and compete in different nutrient environments to shape host physiology could be addressed. Encouraged by results obtained from these types of models, Gordon was lead author of an influential 2005 National Human Genome Research Institute white-paper entitled "Extending Our View of Self: the Human Gut Microbiome Initiative (HGMI)".[24] In 2007, the Human Microbiome Project was listed on the NIH Roadmap for Medical Research as one of the New Pathways to Discovery.

Gordon's efforts to link gut microbiome function to nutritional status initially focused on obesity and its associated metabolic dysfunction. This work involved characterization and subsequent transplantation of gut microbial communities from obese and lean mice, and later obese and lean twins including twin pairs discordant for obesity, into germ-free mice to characterize the effects of diet components on microbial community function and host physiology and metabolism.[25][26][27][28][29][30] These preclinical models and subsequent pilot clinical studies have been used to develop microbiome-targeted snack food prototypes composed of combinations of polysaccharides from sustainable sources that could improve microbiome function.[31][32][33]

Current research

[edit]

Gordon and his team are characterizing the role of the gut microbiome in childhood undernutrition (wasting, stunting or a combination of the two), testing the hypothesis that healthy growth of infants and children depends in part on coordinated co-development of the gut microbiome and host organ systems.[34][35] Gordon's work indicates that the healthy development of microbial communities in the gut during infancy is correlated with a child's healthy growth and development overall.[36]

Birth cohort studies performed by Gordon and collaborators, primarily in Bangladesh in collaboration with Tahmeed Ahmeed at the International Centre for Diarrhoeal Disease Research, Bangladesh (iccdr,b),[37][38] as well as studies of Malawian twins showing significant difference (discordance) for undernutrition,[39][40] identified that a normal program of postnatal gut microbiota development in healthy individuals is disrupted in undernourished children. Their research further showed that the disrupted microbial communities of undernourished children are not repaired with current nutritional interventions.[41][42][43][44] By transplanting microbiota from healthy and undernourished children into germ-free mice fed diets of the human microbiota donors, Gordon's lab identified bacterial strains associated with key facets of postnatal growth and development.[45] These strains become therapeutic targets for repairing the microbial communities of undernourished children.[46][47]

To develop affordable and scalable treatments, Gordon and his group used gnotobiotic mice and piglets to screen combinations of foods given to 12-18-month-old Bangladeshi children. The microbial communities of the test animals were colonized with gut microbial organisms from undernourished Bangladeshi children.[48][49] This effort yielded microbiota-directed food (MDCFs) prototypes that modulated the fitness and expressed metabolic activities of targeted age-and growth-discriminatory bacterial strains. Randomized controlled clinical trials performed in Bangladeshi children with wasting showed that compared to a commonly used therapeutic food (ready-to-use supplementary food), the microbiota-directed food produced significantly greater growth, even though its caloric density was lower than that of the traditional therapeutic food.[50][51][52][53] Additionally, this superior growth response was accompanied by superior microbiota repair and alterations in levels of plasma protein biomarkers and mediators of musculoskeletal development, neurodevelopment, metabolism, and immune function.[54][55][56] Gordon's team has also identified the bioactive components of the microbiota-directed food, their microbial therapeutic targets, and how these microbial targets can produce novel metabolic effectors of host physiology.[57][58][59]

Together with studies of Bangladeshi infants with severe wasting[60] and of the small intestinal microbiota of stunted Bangladeshi children,[61] this work has revealed a causal link between gut microbiome development in the first years of life, and healthy growth and development in children. "When a child's gut microbiome is underdeveloped, their overall growth can stagnate, leading to malnutrition with further detrimental effects on immunity, metabolism, bone growth and brain development," Gordon has said.[62] He has further said there is a critical window in early childhood when interventions with beneficial foods could help shape the development of the gut microbiome in a way that promotes healthy growth overall.[63] Gordon and his team's work also has yielded a generally applicable translational medicine pipeline for establishing whether disruptions in microbiome composition and expressed functions are related to disease states, and for linking the molecular components of food and microbiome function to human health.

Honors

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Gordon is a member of the National Academy of Sciences,[64] the American Academy of Arts & Sciences,[65] the National Academy of Medicine,[66] and the American Philosophical Society.[67] He is the recipient of a number of awards including:

Gordon has received honorary doctorates from the University of Gothenburg (2011),[78] the University of Chicago (2014),[79] and Norwegian University of Life Sciences (2024).[80]

References

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  1. ^ Akademien
  2. ^ "Gordon CV". Lab of Jeffrey I. Gordon | WashU Medicine. June 26, 2020. Archived from the original on December 3, 2024. Retrieved February 25, 2025.
  3. ^ "Jeffrey I. Gordon: 2021 Balzan Prize for Microbiome in Health and Disease". Fondazione Internazionale Premio Balzan. Retrieved February 25, 2025.
  4. ^ a b "Jeffrey I. Gordon: 2021 Balzan Prize for Microbiome in Health and Disease". Fondazione Internazionale Premio Balzan. Retrieved February 25, 2025.
  5. ^ a b "Jeffrey I. Gordon, Peter Greeberg and Bonnie L. Bassler, Princess of Asturias Award for Technical and Scientific Research". Fundación Princesa de Asturias. July 6, 2023. Archived from the original on February 25, 2025. Retrieved February 25, 2025.
  6. ^ Strait, Julia Evangelou (February 8, 2024). "Gordon receives Nemmers Prize". WashU Medicine. Retrieved February 25, 2025.
  7. ^ Lewis, Talia (September 15, 2022). "Jeffrey Gordon Receives Inaugural Hamburg Award for Pioneering Contributions to Microbiome Research - National Academy of Medicine". National Academy of Medicine. Archived from the original on September 27, 2023. Retrieved February 25, 2025.
  8. ^ "Jeffrey I. Gordon". Research Profiles at Washington University School of Medicine. Retrieved February 25, 2025.
  9. ^ Strait, Julia Evangelou (February 18, 2016). "Targeting gut microbes may reverse effects of childhood malnutrition". WashU Medicine. Retrieved February 25, 2025.
  10. ^ a b Strait, Julia Evangelou (December 13, 2023). "Gut bacteria of malnourished children benefit from key elements in therapeutic food". WashU Medicine. Retrieved February 25, 2025.
  11. ^ "Gordon CV". Gordon Lab at WashU Medicine. June 26, 2020. Retrieved September 28, 2025.
  12. ^ "People of the School of Medicine". Washington University Bulletin. Retrieved September 28, 2025.
  13. ^ "Symposium Video Links". Genome Sciences & Systems Biology. August 20, 2024. Retrieved September 28, 2025.
  14. ^ Mills, Jason C.; Andersson, Niklas; Hong, Chieu V.; Stappenbeck, Thaddeus S.; Gordon, Jeffrey I. (November 12, 2002). "Molecular characterization of mouse gastric epithelial progenitor cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (23): 14819–14824. Bibcode:2002PNAS...9914819M. doi:10.1073/pnas.192574799. ISSN 0027-8424. PMC 137502. PMID 12409607.
  15. ^ a b Mysorekar, Indira U.; Lorenz, Robin G.; Gordon, Jeffrey I. (October 4, 2002). "A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes". The Journal of Biological Chemistry. 277 (40): 37811–37819. doi:10.1074/jbc.M205300200. ISSN 0021-9258. PMID 12138109.
  16. ^ a b Nappier, Terri (March 3, 2017). "The father of the microbiome". The Source. Retrieved August 2, 2025.
  17. ^ a b Lodge, Jennifer K.; Jackson-Machelski, Emily; Devadas, Balekudru; Zupec, Mark E.; Getman, Daniel P.; Kishore, Nandini; Freeman, Sandra K.; McWherter, Charles A.; Sikorski, James A.; Gordon, Jeffrey I. (February 1997). "N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase". Microbiology. 143 ( Pt 2) (2): 357–366. doi:10.1099/00221287-143-2-357. ISSN 1350-0872. PMID 9043113.
  18. ^ Hermiston, M. L.; Wong, M. H.; Gordon, J. I. (April 15, 1996). "Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system". Genes & Development. 10 (8): 985–996. doi:10.1101/gad.10.8.985. ISSN 0890-9369. PMID 8608945.
  19. ^ Bry, L.; Falk, P. G.; Midtvedt, T.; Gordon, J. I. (September 6, 1996). "A model of host-microbial interactions in an open mammalian ecosystem". Science. 273 (5280): 1380–1383. Bibcode:1996Sci...273.1380B. doi:10.1126/science.273.5280.1380. ISSN 0036-8075. PMID 8703071.
  20. ^ Hooper, L. V.; Xu, J.; Falk, P. G.; Midtvedt, T.; Gordon, J. I. (August 17, 1999). "A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem". Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9833–9838. Bibcode:1999PNAS...96.9833H. doi:10.1073/pnas.96.17.9833. ISSN 0027-8424. PMC 22296. PMID 10449780.
  21. ^ Hooper, L. V.; Wong, M. H.; Thelin, A.; Hansson, L.; Falk, P. G.; Gordon, J. I. (February 2, 2001). "Molecular analysis of commensal host-microbial relationships in the intestine". Science. 291 (5505): 881–884. Bibcode:2001Sci...291..881H. doi:10.1126/science.291.5505.881. ISSN 0036-8075. PMID 11157169.
  22. ^ Xu, Jian; Bjursell, Magnus K.; Himrod, Jason; Deng, Su; Carmichael, Lynn K.; Chiang, Herbert C.; Hooper, Lora V.; Gordon, Jeffrey I. (March 28, 2003). "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis". Science. 299 (5615): 2074–2076. Bibcode:2003Sci...299.2074X. doi:10.1126/science.1080029. ISSN 1095-9203. PMID 12663928.
  23. ^ Sonnenburg, Justin L.; Xu, Jian; Leip, Douglas D.; Chen, Chien-Huan; Westover, Benjamin P.; Weatherford, Jeremy; Buhler, Jeremy D.; Gordon, Jeffrey I. (March 25, 2005). "Glycan foraging in vivo by an intestine-adapted bacterial symbiont". Science. 307 (5717): 1955–1959. Bibcode:2005Sci...307.1955S. doi:10.1126/science.1109051. ISSN 1095-9203. PMID 15790854.
  24. ^ Gordon JI, Ley RE, Wilson RK, Mardis E, Xu J, Fraser CM, & Relman DA. (2005). Extending Our View of Self: the Human Gut Microbiome Initiative (HGMI) [White paper]. National Human Genome Research Institute. https://www.genome.gov/Pages/Research/Sequencing/SeqProposals/HGMISeq.pdf
  25. ^ Ley, Ruth E.; Bäckhed, Fredrik; Turnbaugh, Peter; Lozupone, Catherine A.; Knight, Robin D.; Gordon, Jeffrey I. (August 2, 2005). "Obesity alters gut microbial ecology". Proceedings of the National Academy of Sciences of the United States of America. 102 (31): 11070–11075. Bibcode:2005PNAS..10211070L. doi:10.1073/pnas.0504978102. ISSN 0027-8424. PMC 1176910. PMID 16033867.
  26. ^ Turnbaugh, Peter J.; Ley, Ruth E.; Mahowald, Michael A.; Magrini, Vincent; Mardis, Elaine R.; Gordon, Jeffrey I. (December 21, 2006). "An obesity-associated gut microbiome with increased capacity for energy harvest". Nature. 444 (7122): 1027–1031. Bibcode:2006Natur.444.1027T. doi:10.1038/nature05414. ISSN 1476-4687. PMID 17183312.
  27. ^ Ley, Ruth E.; Turnbaugh, Peter J.; Klein, Samuel; Gordon, Jeffrey I. (December 21, 2006). "Microbial ecology: human gut microbes associated with obesity". Nature. 444 (7122): 1022–1023. Bibcode:2006Natur.444.1022L. doi:10.1038/4441022a. ISSN 1476-4687. PMID 17183309.
  28. ^ Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya; Cantarel, Brandi L.; Duncan, Alexis; Ley, Ruth E.; Sogin, Mitchell L.; Jones, William J.; Roe, Bruce A.; Affourtit, Jason P.; Egholm, Michael; Henrissat, Bernard; Heath, Andrew C.; Knight, Rob; Gordon, Jeffrey I. (January 22, 2009). "A core gut microbiome in obese and lean twins". Nature. 457 (7228): 480–484. Bibcode:2009Natur.457..480T. doi:10.1038/nature07540. ISSN 1476-4687. PMC 2677729. PMID 19043404.
  29. ^ Faith, Jeremiah J.; McNulty, Nathan P.; Rey, Federico E.; Gordon, Jeffrey I. (July 1, 2011). "Predicting a human gut microbiota's response to diet in gnotobiotic mice". Science. 333 (6038): 101–104. Bibcode:2011Sci...333..101F. doi:10.1126/science.1206025. ISSN 1095-9203. PMC 3303606. PMID 21596954.
  30. ^ Ridaura, Vanessa K.; Faith, Jeremiah J.; Rey, Federico E.; Cheng, Jiye; Duncan, Alexis E.; Kau, Andrew L.; Griffin, Nicholas W.; Lombard, Vincent; Henrissat, Bernard; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; Semenkovich, Clay F.; Funai, Katsuhiko; Hayashi, David K. (September 6, 2013). "Gut microbiota from twins discordant for obesity modulate metabolism in mice". Science. 341 (6150) 1241214. doi:10.1126/science.1241214. ISSN 1095-9203. PMC 3829625. PMID 24009397.
  31. ^ Patnode, Michael L.; Beller, Zachary W.; Han, Nathan D.; Cheng, Jiye; Peters, Samantha L.; Terrapon, Nicolas; Henrissat, Bernard; Le Gall, Sophie; Saulnier, Luc; Hayashi, David K.; Meynier, Alexandra; Vinoy, Sophie; Giannone, Richard J.; Hettich, Robert L.; Gordon, Jeffrey I. (September 19, 2019). "Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans". Cell. 179 (1): 59–73.e13. doi:10.1016/j.cell.2019.08.011. ISSN 1097-4172. PMC 6760872. PMID 31539500.
  32. ^ Delannoy-Bruno, Omar; Desai, Chandani; Raman, Arjun S.; Chen, Robert Y.; Hibberd, Matthew C.; Cheng, Jiye; Han, Nathan; Castillo, Juan J.; Couture, Garret; Lebrilla, Carlito B.; Barve, Ruteja A.; Lombard, Vincent; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A. (July 2021). "Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans". Nature. 595 (7865): 91–95. Bibcode:2021Natur.595...91D. doi:10.1038/s41586-021-03671-4. ISSN 1476-4687. PMC 8324079. PMID 34163075.
  33. ^ Delannoy-Bruno, Omar; Desai, Chandani; Castillo, Juan J.; Couture, Garret; Barve, Ruteja A.; Lombard, Vincent; Henrissat, Bernard; Cheng, Jiye; Han, Nathan; Hayashi, David K.; Meynier, Alexandra; Vinoy, Sophie; Lebrilla, Carlito B.; Marion, Stacey; Heath, Andrew C. (May 17, 2022). "An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome". Proceedings of the National Academy of Sciences of the United States of America. 119 (20) e2123411119. Bibcode:2022PNAS..11923411D. doi:10.1073/pnas.2123411119. ISSN 1091-6490. PMC 9171781. PMID 35533274.
  34. ^ "Research Abstract". Gordon Lab at WashU Medicine. September 17, 2024. Retrieved September 15, 2025.
  35. ^ Yatsunenko, Tanya; Rey, Federico E.; Manary, Mark J.; Trehan, Indi; Dominguez-Bello, Maria Gloria; Contreras, Monica; Magris, Magda; Hidalgo, Glida; Baldassano, Robert N.; Anokhin, Andrey P.; Heath, Andrew C.; Warner, Barbara; Reeder, Jens; Kuczynski, Justin; Gordon, Jeffrey I.; et al. (2012). "Human gut microbiome viewed across age and geography". Nature. 486 (7402): 222–227. doi:10.1038/nature11053. ISSN 1476-4687.
  36. ^ Strait, Julia Evangelou (April 19, 2024). "International trials underway for childhood malnutrition therapy developed at WashU". WashU Medicine. Retrieved September 15, 2025.
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  38. ^ Raman, Arjun S.; Gehrig, Jeanette L.; Venkatesh, Siddarth; Chang, Hao-Wei; Hibberd, Matthew C.; Subramanian, Sathish; Kang, Gagandeep; Bessong, Pascal O.; Lima, Aldo A.M.; Kosek, Margaret N.; Petri, William A.; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Osterman, Andrei L.; et al. (July 12, 2019). "A sparse covarying unit that describes healthy and impaired human gut microbiota development". Science. 365 (6449) eaau4735. doi:10.1126/science.aau4735. PMC 6683326. PMID 31296739.
  39. ^ Smith, Michelle I.; Yatsunenko, Tanya; Manary, Mark J.; Trehan, Indi; Mkakosya, Rajhab; Cheng, Jiye; Kau, Andrew L.; Rich, Stephen S.; Concannon, Patrick; Mychaleckyj, Josyf C.; Liu, Jie; Houpt, Eric; Li, Jia V.; Holmes, Elaine; Nicholson, Jeremy; et al. (2013). "Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor". Science. 339 (6119): 548–554. doi:10.1126/science.1229000. PMC 3667500. PMID 23363771.
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  41. ^ Subramanian, Sathish; Huq, Sayeeda; Yatsunenko, Tanya; Haque, Rashidul; Mahfuz, Mustafa; Alam, Mohammed A.; Benezra, Amber; DeStefano, Joseph; Meier, Martin F.; Muegge, Brian D.; Barratt, Michael J.; VanArendonk, Laura G.; Zhang, Qunyuan; Province, Michael A.; Petri Jr, William A.; et al. (2014). "Persistent gut microbiota immaturity in malnourished Bangladeshi children". Nature. 510 (7505): 417–421. doi:10.1038/nature13421. ISSN 1476-4687. PMC 4189846.
  42. ^ Raman, Arjun S.; Gehrig, Jeanette L.; Venkatesh, Siddarth; Chang, Hao-Wei; Hibberd, Matthew C.; Subramanian, Sathish; Kang, Gagandeep; Bessong, Pascal O.; Lima, Aldo A.M.; Kosek, Margaret N.; Petri, William A.; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Osterman, Andrei L.; et al. (July 12, 2019). "A sparse covarying unit that describes healthy and impaired human gut microbiota development". Science. 365 (6449) eaau4735. doi:10.1126/science.aau4735. PMC 6683326. PMID 31296739.
  43. ^ Smith, Michelle I.; Yatsunenko, Tanya; Manary, Mark J.; Trehan, Indi; Mkakosya, Rajhab; Cheng, Jiye; Kau, Andrew L.; Rich, Stephen S.; Concannon, Patrick; Mychaleckyj, Josyf C.; Liu, Jie; Houpt, Eric; Li, Jia V.; Holmes, Elaine; Nicholson, Jeremy; et al. (2013). "Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor". Science. 339 (6119): 548–554. doi:10.1126/science.1229000. PMC 3667500. PMID 23363771.
  44. ^ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275) aad3311. doi:10.1126/science.aad3311. PMC 4787260. PMID 26912898.
  45. ^ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275) aad3311. doi:10.1126/science.aad3311. PMC 4787260. PMID 26912898.
  46. ^ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275) aad3311. doi:10.1126/science.aad3311. PMC 4787260. PMID 26912898.
  47. ^ Planer, Joseph D.; Peng, Yangqing; Kau, Andrew L.; Blanton, Laura V.; Ndao, I. Malick; Tarr, Phillip I.; Warner, Barbara B.; Gordon, Jeffrey I. (2016). "Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice". Nature. 534 (7606): 263–266. doi:10.1038/nature17940. ISSN 1476-4687.
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  74. ^ Princess of Asturias Awards 2023
  75. ^ Albany Medical Center Prize 2023
  76. ^ Nemmers Prize in Medical Science 2024
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  80. ^ Norges miljø- og biovitenskapelige universitet (December 6, 2024). Professor Jeffrey Gordon Honorary Doctor at NMBU 2024. Retrieved September 28, 2025 – via YouTube.
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