CN107006471B - The compound pesticide compositions and application thereof of containing chromafenozide and methoxyfenozide - Google Patents

Abstract

The invention discloses the compound pesticide compositions and application thereof of a kind of containing chromafenozide and methoxyfenozide, and the Pesticidal combination is using ring tebufenozide and methoxyfenozide as active insecticidal components, wherein ring tebufenozide and the weight ratio of methoxyfenozide are 50：1~1：50.The Pesticidal combination can generate higher synergistic function, overcome and delayed pest resistance to insecticide, and desinsection speed is fast, and the lasting period is long, reduce drug cost, and control effect is apparently higher than the use of its single dose.The present invention can prevent the lepidoptera pest occurred on crops, be used especially for prevention bollworm, snout moth's larva, with obvious effects to be used higher than its single dose.

Description

Composite insecticidal composition containing cyrflufenozide and methoxyfenozide and its application

technical field

The invention belongs to the field of pesticides, and in particular relates to an insecticidal composition with fenfenozide and methoxyfenozide as main active ingredients and an application thereof.

Background technique

Chromafenozide, chemical name: N-tert-butyl-N'-(3-methoxy-2-methylbenzoyl)-3,5-dimethylbenzoylhydrazide. It is a dihydrazide insecticide, which inhibits the feeding of pests within a few hours after feeding, and at the same time causes the pests to molt early and lead to death. Cyclofenozide not only has low toxicity to mammals, birds, and aquatic organisms, but also has no effect on arthropods, predatory acarids, spiders, Hemiptera, Coleoptera (beetles), parasites, and the environment.

Methoxyfenozide, molecular formula: C ₂₂ H ₂₈ N ₂ O ₃ . The structural formula is:

Methoxyfenozide is the second generation of dihydrazide insect growth regulators. It has highly selective insecticidal activity against Lepidoptera pests. It has no osmotic effect and phloem systemic activity. It is mainly effective through gastric toxicity, but also has Certain contact and ovicidal activity. Like other bishydrazide insecticides such as cyclofenozide, chlorfenozide and tebufenozide, methoxyfenozide is an ecdysone agonist, which causes lepidopteran larvae to stop feeding and accelerates the molt process , causing the pests to die due to premature molting before maturity.

Insecticide varieties containing a single component often have defects in the control of pesticide pests: continuous use is prone to resistance, narrow insecticidal spectrum, cannot provide comprehensive protection for crops, and the cost of pesticides for farmers is high. The above-mentioned shortcomings can be overcome to a certain extent by combining two or more kinds of various active ingredients. The combination of two or more active ingredients with synergistic effects can improve the control effect, reduce the dosage of active ingredients, save costs, slow down the occurrence of pest resistance, and expand the control spectrum to play a role in multi-pest control. , to reduce the use cost of farmers.

Contents of the invention

The object of the present invention is to provide a compound insecticidal composition containing fenfenozide and methoxyfenozide, which is a multifunctional insecticidal composition for controlling lepidopteran pests.

Another object of the present invention is to provide the application of the insecticidal composition in the preparation of insecticides for controlling resistant Lepidoptera pests, especially the application in the preparation of insecticides for control of cotton bollworm or stem borer.

The purpose of the present invention is achieved through the following technical solutions:

A compound insecticidal composition containing chlorfenozide and methoxyfenozide, the compound insecticidal composition uses chlorfenozide and methoxyfenozide as main active ingredients, wherein chlorfenozide and methoxyfenozide The weight ratio of oxyfenozide is 50:1-1:50.

In this compound insecticidal composition, the weight ratio of fenfenozide (A) to methoxyfenozide (B) is preferably 20:1 to 1:30, more preferably 5:1 to 1:5, and in some In the most preferred technical scheme, the weight ratio of tebufenozide (A) and methoxyfenozide (B) is 50:1, 40:1, 30:1, 20:1, 10:1, 5:1,2 :1, 1:1, 1:5, 1:10, 1:20, 1:30, 1:40, 1:50 to choose from.

The compound insecticidal composition can only contain the active ingredients fenfenozide and methoxyfenozide, and other components can also be added to the active ingredients during use or preparation. The active ingredients in the insecticidal composition can also increase An effective amount is present in the composition.

In the compound insecticidal composition of the present invention, the weight percentage of both fenfenozide and methoxyfenozide in the compound insecticidal composition is 3%-80%. Preferably it is 5% to 55%, most preferably 10% to 40%.

The compound insecticidal composition of the present invention uses fenfenozide and methoxyfenozide as active ingredients or main active ingredients, and pesticide adjuvants and excipients to be formulated into any dosage form allowed in pesticides, and the dosage form is preferably emulsifiable concentrates, suspension concentrates, wettable powders, aqueous emulsions, microemulsions or water-dispersible granules.

The aforementioned pesticide adjuvants applicable to the present invention are not particularly limited, including but not limited to calcium dodecylbenzenesulfonate, 600#, polyoxyethylene polyoxypropylene block compound (such as Nongru 33 ^# ) , nonylphenol polyoxyethylene ether, etc., and the aforementioned excipients applicable to the present invention are not particularly limited, including but not limited to mineral spirits, water, antifreeze (such as propylene glycol), deionized water, and the like. The above auxiliaries, excipients and other auxiliary materials can be used alone or in combination.

The compound insecticidal composition of the present invention has good control effect to various Hemiptera and Lepidoptera pests which are easy to produce resistance to rice planthopper and stem borer; resistance to tebufenozide).

The application of the above compound insecticidal composition in the preparation of insecticides for controlling resistant Lepidoptera pests, especially in the preparation of insecticides for preventing and controlling cotton bollworms or borers, has remarkable effects.

Compared with the prior art, the present invention has the beneficial effects: (1) Compared with a single agent, the composition has obvious synergistic effect on resistant lepidopteran pests such as cotton bollworm and stem borer, and overcomes and delays the resistance of pests , expand the control spectrum, kill insects quickly, and obviously improve the control effect; (2) reduce the cost of control labor and medication; (3) can replace highly toxic pesticides; (4) both quick-acting and long-acting; Compared with a single agent of methoxyfenozide, tebufenozide has lower production and use costs; (6) the effect of inhibiting the increased resistance of lepidopteran pests to pesticides is significantly higher than that of single agent use.

Detailed ways

The present invention will be further described below in conjunction with embodiment, but does not limit the present invention in any way.

Indoor test:

Indoor synergistic bioassay was carried out by feed poisoning method, and resistant cotton bollworm and rice stem borer were selected as target pests. Each treatment was repeated 3 times, and 60 heads were treated at each concentration. The probability value method was used to calculate the resistance of cotton bollworm and rice The toxicological regression equation of rice stem borer and the lethal intermediate concentration LC ₅₀ , using the LC ₅₀ value to calculate the co-toxicity coefficient according to Sun Yunpei's method, the specific method is as follows:

Take a single dose in the mixture as the standard dose (usually select the one with the lower LC50) for calculation:

Single-dose toxicity index = standard drug LC50/some single-dose LC50×100

Theoretical toxicity index = toxicity index of single agent A × proportion of single agent A in the mixture + toxicity index of single agent B × proportion of single agent B in the mixture

Measured toxicity index = LC50 value of standard single agent / LC50 value of mixed agent × 100

Co-toxicity coefficient = measured toxicity index / theoretical toxicity index × 100

Grading of co-toxicity coefficient: when CTC is greater than 120, the mixture has synergistic effect, when CTC is less than 80, it is antagonistic, and when CTC is between 80-120, it is additive.

The results are shown in Tables 1 and 2:

Table 1 Toxicity determination of the combination of cyclofenozide and methoxyfenozide and single agent against resistant cotton bollworm

It can be seen from Table 1 that the co-toxicity coefficients of the combination of fenfenozide and methoxyfenozide are both greater than 120, showing a good synergistic effect.

Table 2 Toxicity determination of cyclofenozide and methoxyfenozide compound and single agent against Chilorrhizae

It can be seen from Table 2 that the co-toxicity coefficients of the combination of fenfenozide and methoxyfenozide are both greater than 120, showing a good synergistic effect.

Field efficacy test:

The described embodiment 1-12 is carried out control cotton bollworm and rice stem borer drug efficacy test, contrast agent is 24% methoxyfenozide SC and 5% chlorfenozide SC, according to the dilution factor in table 3 and 4 Dilute, and check the results of 3 days, 7 days, and 14 days after the medicine. The processing results are shown in Tables 3 and 4:

Table 3: Field test results of the combination of cyclofenozide-methoxyfenozide against resistant cotton bollworm

Table 4: Field test results of the combination of cyclofenozide-methoxyfenozide against rice stem borer

The field drug efficacy results show that the chlorfenozide·methoxyfenozide composition has excellent control effects on cotton bollworm and rice stem borer, and the control effects are better than those directly acting on single-dose varieties.

Example 1:

Weigh 50g of tebufenozide, 1g of methoxyfenozide, 3g of phenethylphenol polyoxyethylene ether phosphate, Nongru 33 ^# 2g, 600#1g, 150# solvent oil 13g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water-based emulsions and mix at high speed to form a chlorfenozide-methoxyfenozide water-emulsion with a main active ingredient of 51% by weight.

Example 2:

Weigh 30g of tebufenozide, 1g of methoxyfenozide, 3g of phenethylphenol polyoxyethylene ether phosphate, Nongru 33 ^# 2g, 600#1g, 150# solvent oil 13g, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water-based emulsions and mix at high speed to form a chlorfenozide-methoxyfenozide water-emulsion with a main active ingredient of 31% by weight.

Example 3:

Weigh 20g fenfenozide, 1g methoxyfenozide, 6g calcium dodecylbenzenesulfonate, 3g phenethylphenol polyoxyethylene ether phosphate, Nongru 33 ^# 2g, 600# 1g, cyclohexanone 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions, and mix them to form a chlorfenozide-methoxyfenozide microemulsion with a main active ingredient of 21% by weight.

Example 4:

Weigh 10g of tebufenozide, 1g of methoxyfenozide, 4g of calcium dodecylbenzenesulfonate, 3g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC, and mix them to form chlorfenozide/methoxyfenozide EC with a main active ingredient of 11% by weight.

Example 5:

Weigh 20g of tebufenozide, 4g of methoxyfenozide, 5g of calcium dodecylbenzenesulfonate, 2g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to form a chlorfenozide-methoxyfenozide EC with a main active ingredient weight percentage of 24%.

Embodiment 6:

Weigh 20g of tebufenozide, 10g of methoxyfenozide, 8g of calcium dodecylbenzenesulfonate, 5g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to form chlorfenozide·methoxyfenozide EC with a main active ingredient of 30% by weight.

Embodiment 7:

Weigh 10g of tebufenozide, 10g of methoxyfenozide, 9g of calcium dodecylbenzenesulfonate, 8g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. The above raw materials are put into a mixing tank according to the conventional method for preparing EC and mixed to form chlorfenozide·methoxyfenozide EC with a main active ingredient of 20% by weight.

Embodiment 8:

Weigh 4g of tebufenozide, 20g of methoxyfenozide, 6g of calcium dodecylbenzenesulfonate, 7g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to form a chlorfenozide-methoxyfenozide EC with a main active ingredient weight percentage of 24%.

Embodiment 9:

Weigh 1g of tebufenozide, 10g of methoxyfenozide, 4g of calcium dodecylbenzenesulfonate, 4g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to form chlorfenozide/methoxyfenozide EC with a main active ingredient weight percentage of 11%.

Example 10:

Weigh 1g of tebufenozide, 20g of methoxyfenozide, 7g of calcium dodecylbenzenesulfonate, 9g of phenethylphenol polyoxyethylene ether, and 150# solvent oil to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to form chlorfenozide·methoxyfenozide EC with a main active ingredient weight percentage of 21%.

Example 11:

Weigh 1g of tebufenozide, 30g of methoxyfenozide, 2g of sodium lignosulfonate, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, siloxane 0.10g, 0.5g of magnesium aluminum silicate, make up to 100g with water, and form a chlorfenozide-methoxyfenozide suspension concentrate whose main active ingredient is 31% by weight under the action of a sand mill.

Example 12:

Weigh 1g of fenfenozide, 50g of methoxyfenozide, 8g of sodium lignosulfonate, 2g of sodium lauryl sulfate, 5g of ammonium sulfate, 5g of polyvinyl alcohol, 2g of borax, and 21g of diatomaceous earth. According to the water dispersible granule method, the chlorfenozide·methoxyfenozide water dispersible granule whose main active ingredient is 51% by weight is formed.

Claims (9)

1. a compound insecticidal composition containing chlorfenozide and methoxyfenozide, is characterized in that this compound insecticidal composition is insecticidal active ingredient with chlorfenozide and methoxyfenozide, wherein, The weight ratio of chlorfenozide to methoxyfenozide is 50:1~1:50. 2. The compound insecticidal composition containing chlorfenozide and methoxyfenozide according to claim 1, characterized in that the weight ratio of chlorfenozide and methoxyfenozide is 20:1 ~1:30. 3. The compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 2, characterized in that the weight ratio of fenfenozide and methoxyfenozide is 5:1 ~1:5. 4. The compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 1, characterized in that both fenfenozide and methoxyfenozide are in the compound insecticidal composition The weight percentage is 3%~80%. 5. the compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 4, is characterized in that both fenfenozide and methoxyfenozide are in the compound insecticidal composition The weight percentage is 5%~55%. 6. The compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 1, characterized in that the compound insecticidal composition uses chlorfenozide and methoxyfenozide as insecticidal compounds. Active ingredients and pesticide adjuvants are formulated into dosage forms allowed on pesticides. 7. The compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 6, is characterized in that said dosage form is emulsifiable concentrate, suspension concentrate, emulsion in water, wettable powder, microemulsion or water Disperse granules. 8. The application of the compound insecticidal composition containing fenfenozide and methoxyfenozide according to claim 1 in the preparation of insecticides for controlling resistant lepidopteran pests. 9. The application according to claim 8, characterized in that: the compound insecticidal composition is used in the preparation of insecticides for controlling cotton bollworm or stem borer.