CN103621551A - Composite insecticidal composition containing thiamethoxam and profenofos, and use thereof - Google Patents

Abstract

The invention discloses a composite insecticidal composition containing thiamethoxam and profenofos and its application. The insecticidal composition uses thiamethoxam and profenofos as main active ingredients, wherein The weight ratio of phosphorus is 0.1-80:0.5-80. The insecticidal composition can produce relatively high synergistic effect, overcome and delay the resistance of insect pests, has fast insecticidal speed, long-lasting effect, reduces the cost of medicine, and the control effect is obviously higher than that of a single agent. The invention can prevent and control hemiptera pests occurring on crops, especially can be used to prevent and control brown planthoppers and aphids, and its effect is obviously higher than that of a single agent.

Description

A compound insecticidal composition containing thiamethoxam and profenofos and its application

technical field

The invention belongs to the field of pesticides containing heterocyclic compounds, and in particular relates to a compound insecticidal composition containing thiamethoxam and profenofos and its application.

Background technique

Thiamethoxam (Thiamethoxam), chemical name: 3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazin-4-yl fork ( nitro)amine. Thiamethoxam is a neonicotinoid insecticide. The mechanism of action of thiamethoxam is similar to that of imidacloprid. It can selectively inhibit the nicotinic acid acetylcholinesterase receptor in the insect central nervous system, thereby blocking the normal conduction of the insect central nervous system, causing pests Dies when a paralyzing machine appears.

Profenofos (Profenofos), also known as bromochlorophos, polyfenfos, chemical name: O-(4-bromo-2-chlorophenyl)-O-ethyl-S-propyl-phosphorothioate, is Broad-spectrum organophosphate insecticide with quick action. It has better penetration on plant leaves. Its mechanism of action is to inhibit cholinesterase in insects. The structural formula is:

The original drug is light yellow liquid with garlic flavor, boiling point 100℃/1.80Pa, vapor pressure 1.24×10^(-4)Pa(25℃), density 1.455(20℃), KowlogP=4.44, solubility water 28mg/L( 25°C), miscible with most organic solvents, relatively stable in neutral and slightly acidic conditions, unstable in alkaline environments. This variety has three modes of action: contact killing, stomach poisoning and fumigation. It has a wide insecticidal spectrum, low toxicity, and is equally effective against above-ground and underground pests. The control effect of underground pests is particularly outstanding, and it is especially suitable for the production of pollution-free vegetables.

However, the resistance of pests such as brown planthoppers and aphids gradually increases under the current long-term use of pesticides, and the effect of single-dose pesticides on pest control gradually decreases. The inventors have found through research that the synergistic compounding of pesticides is an effective measure to expand the control spectrum and improve the control effect, and no insecticidal composition related to thiamethoxam and profenofos has been found so far.

Contents of the invention

The object of the present invention is to provide a compound insecticidal composition containing thiamethoxam and profenofos, the insecticidal composition is a multifunctional insecticidal composition for preventing and controlling Hemiptera pests.

Another object of the present invention is to provide the application of the insecticidal composition in the preparation of insecticides for controlling resistant Hemiptera pests, especially for the preparation of insecticides for planthoppers and aphids.

The purpose of the present invention is achieved through the following technical solutions:

A compound insecticidal composition containing thiamethoxam and profenofos, the insecticidal composition uses thiamethoxam and profenofos as main active ingredients, wherein the weight ratio of thiamethoxam and profenofos is 0.1~ 80:0.5~80, preferably 0.5~10:4~30, more preferably 1~10:1~10 in weight ratio, most preferably 1~10:1 in weight ratio. The compound insecticidal composition may only contain the active ingredients thiamethoxam and profenofos, or other components may be added to the active ingredients during use or preparation, and the active ingredients in the insecticidal composition are present in a synergistically effective amount composition.

In the compound insecticidal composition of the present invention, the weight percentage of both thiamethoxam and profenofos in the compound insecticidal composition is 3%-80%. Preferably 5%~55%, most preferably 10%~40%.

The compound insecticidal composition of the present invention uses thiamethoxam and profenofos as the main active ingredients and pesticide adjuvants and excipients to be prepared into any dosage form allowed on the pesticide, and the dosage form is preferably emulsion, suspension, wettable Powders, aqueous emulsions, microemulsions and water-dispersible granules.

The aforementioned pesticide adjuvants applicable to the present invention are not particularly limited, including but not limited to calcium dodecylbenzenesulfonate, emulsifier 600#, polyoxyethylene polyoxypropylene block compound (such as agricultural milk 33 ^# ), nonylphenol polyoxyethylene ether, etc., the aforementioned excipients applicable to the present invention are not particularly limited, including but not limited to mineral spirits, water, antifreeze (such as propylene glycol), deionized water, etc. One or more of the above auxiliary agents and excipients can be used. The "%" mentioned in the present invention are all mass percentages.

The compound insecticidal composition of the present invention has a good control effect on various Hemiptera and Lepidoptera pests that are prone to resistance such as brown planthopper and stem borer; ) of drug resistance.

The application of the above compound insecticidal composition in the preparation of insecticides for preventing and controlling resistant Hemiptera pests, especially in the preparation of insecticides for controlling planthoppers or aphids, has remarkable effects.

Compared with the prior art, the present invention has the beneficial effects: (1) Compared with a single agent, the composition has obvious synergistic effect on resistant Hemiptera pests such as brown planthopper and aphid, and overcomes and delays the resistance of pests, Expand the control spectrum, kill insects quickly, and significantly improve the control effect; (2) reduce the cost of control labor and medication; (3) can replace highly toxic pesticides; (4) both quick-acting and long-acting; Compared with profenofos single agent, the production and use cost of oxazine is lower; (6) the effect of inhibiting the resistance of hemiptera pests to pesticides is significantly higher than that of its single agent use.

Detailed ways

The present invention will be further described below in conjunction with embodiment, but does not limit the present invention in any way.

Example 1:

Weigh 30 g of thiamethoxam and profenofos, 4 g of calcium dodecylbenzenesulfonate, 3 g of phenethylphenol polyoxyethylene ether, and vegetable oil to 100 g. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to prepare thiamethoxam profenofos emulsifiable concentrate with a main active ingredient weight percentage of 30%. The specific ratios of thiamethoxam and profenofos are shown in Tables 1 and 2.

The rice stem dipping method was used for indoor synergistic bioassay, and the resistant brown planthopper was selected as the target pest. Each treatment was repeated 3 times, and 60 heads were treated at each concentration. Concentration LC ₅₀ , use the LC ₅₀ value to calculate the co-toxicity coefficient according to Sun Yunpei's method, the results are shown in Table 1:

Table 1 Toxicity determination of thiamethoxam and profenofos compound and single-dose resistant N. lugens planthopper

It can be seen from Table 1 that the co-toxicity coefficients of the combination of thiamethoxam and profenofos are both greater than 120, showing a good synergistic effect, and the synergistic effect is the most obvious when thiamethoxam and profenofos are 3:1 .

Indoor synergistic bioassay was carried out by dipping leaves and insects. Resistant wheat aphids were selected as the target pests. Each treatment was repeated 3 times. The toxicological regression equation and lethal intermediate concentration LC ₅₀ of each agent-resistant N. lugens planthopper were calculated by the probability value method. Use the LC ₅₀ value to calculate the co-toxicity coefficient according to Sun Yunpei's method, and the results are shown in Table 2:

Table 2 Toxicity determination of thiamethoxam and profenofos compound and single agent against resistant aphids

It can be seen from Table 2 that the compounding of thiamethoxam and profenofos has a co-toxicity coefficient of more than 120 on wheat aphids, showing a good synergistic effect. When thiamethoxam and profenofos are 3:1, The synergistic effect is most obvious.

Example 2: Weigh 5g of thiamethoxam, 50g of profenofos, 3g of phenethylphenol polyoxyethylene ether phosphate, Nongru 33 ^# 2g, 600#1g, 13g of mineral spirits, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing an aqueous emulsion, and mix at high speed to prepare a thiamethoxam profenofos aqueous emulsion with a main active ingredient weight percent of 55%.

Embodiment 3: take by weighing 18g thiamethoxam, 2g profenofos, calcium dodecylbenzenesulfonate 6g, phenethylphenol polyoxyethylene ether phosphate 3g, agricultural milk 33 ^# 2g, emulsifier 600 ^# 1g, Cyclohexanone 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions and mix them to prepare thiamethoxam profenofos microemulsions with a main active ingredient weight percentage of 20%.

Carry out the efficacy test of controlling rice brown planthopper to embodiment 3, contrast agent is 20% profenofos WP (wettable powder) and 20% thiamethoxam WP (wettable powder), dilute according to the dilution multiple in table 3, drug After checking the results of 3 days and 7 days, the processing results are shown in Table 3:

Table 3: Field test results of thiamethoxam-profenofos complex against rice brown planthopper

The results of field efficacy showed that the combination of thiamethoxam·profenofos had excellent control effect on resistant brown planthopper, and the control effect was better than that of single-dose varieties and better than the effect of each single product directly at the same time.

Carry out control cotton aphid field efficacy test to embodiment 3, contrast agent is 20% profenofos EC (emulsifiable concentrate) and 20% thiamethoxam AS (aqua), dilute according to the dilution multiple in table 3, check after medicine The results of 3 days and 7 days, the processing results are shown in Table 4:

Table 4: Field test results of thiamethoxam-profenofos complex against cotton aphids

Field drug efficacy results show that the thiamethoxam·profenofos composition has excellent control effects on cotton aphids, and the control effects are better than those of single-dose varieties and better than the effects of each single product at the same time.

Example 4: Weigh 1 g of thiamethoxam, 5 g of profenofos, 4 g of calcium dodecylbenzenesulfonate, 3 g of phenethylphenol polyoxyethylene ether, and solvent oil to 100 g. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrates, and mix them to prepare thiamethoxam profenofos emulsifiable concentrates whose main active ingredients are 6% by weight.

Example 5: Weigh 50 g of thiamethoxam, 20 g of profenofos, 5 g of calcium dodecylbenzenesulfonate, 2 g of phenethylphenol polyoxyethylene ether, and 100 g of solvent oil. Put the above raw materials into a mixing tank according to the conventional method for preparing an emulsifiable concentrate, and mix them to prepare thiamethoxam profenofos emulsifiable concentrate with a main active ingredient weight percentage of 70%.

Example 6: Weigh 2 g of thiamethoxam, 40 g of profenofos, 8 g of calcium dodecylbenzenesulfonate, 5 g of phenethylphenol polyoxyethylene ether, and 100 g of solvent oil. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to make thiamethoxam profenofos emulsifiable concentrate with a main active ingredient weight percentage of 42%.

Example 7: Weigh 0.2 g of thiamethoxam, 50 g of profenofos, 9 g of calcium dodecylbenzenesulfonate, 8 g of phenethylphenol polyoxyethylene ether, and 100 g of solvent oil. Put the above raw materials into a mixing tank according to the conventional method for preparing EC and mix them to prepare thiamethoxam profenofos EC with a main active ingredient weight percentage of 50.2%.

Example 8: Weigh 5 g of thiamethoxam, 0.5 g of profenofos, 6 g of calcium dodecylbenzenesulfonate, 7 g of phenethylphenol polyoxyethylene ether, and 100 g of solvent oil. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to make thiamethoxam profenofor emulsifiable concentrate with a main active ingredient weight percentage of 5.5%.

Example 9: Weigh 5 g of thiamethoxam, 30 g of profenofos, 4 g of calcium dodecylbenzenesulfonate, 4 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrates, and mix them to prepare thiamethoxam profenofos emulsifiable concentrates whose main active ingredients are 35% by weight.

Example 10: Weigh 20 g of thiamethoxam, 5 g of profenofos, 7 g of calcium dodecylbenzenesulfonate, 9 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrates, and mix them to prepare thiamethoxam profenofos emulsifiable concentrates whose main active ingredients are 25% by weight.

Example 11: Weigh 30g of thiamethoxam, 12g of profenofos, 2g of sodium lignosulfonate, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, siloxane 0.10g of alkanes, 0.5g of magnesium aluminum silicate, make up to 100g with water, make the thiamethoxam profenofos suspension concentrate that the weight percentage of main active ingredient is 42% under the effect of sand mill.

Embodiment 12: Weigh 2g thiamethoxam, 5g profenofos, sodium lignosulfonate 8g, sodium lauryl sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomaceous earth 21g, the above The raw materials are made into thiamethoxam profenofos water dispersible granules with a main active ingredient of 14% by weight according to the water dispersible granule method.

Example 13: Weigh 50 g of thiamethoxam, 3 g of profenofos, 4 g of calcium dodecylbenzenesulfonate, 3 g of phenethylphenol polyoxyethylene ether, and 100 g of solvent oil. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to make thiamethoxam profenofos emulsifiable concentrate whose main active ingredient is 53% by weight.

Example 14: Weigh 20g of thiamethoxam, 4g of profenofos, lignin 10g, sodium alkylnaphthalene sulfonate 2g, add diatomaceous earth to 100g, mix the above raw materials in an ultrafine pulverizer, and make main The weight percentage of active ingredient is 24% thiamethoxam profenofos wettable powder.

Example 15: Weigh 7 g of thiamethoxam, 70 g of profenofos, 4 g of calcium dodecylbenzenesulfonate, 3 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to make thiamethoxam profenofos emulsifiable concentrate whose main active ingredient is 77% by weight.

Embodiment 16: Take by weighing 60g thiamethoxam, 5g profenofos, sodium lignosulfonate 8g, sodium lauryl sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 13g, the above raw materials are pressed The water-dispersible granule method prepares the thiamethoxam profenofos water-dispersible granule whose main active ingredient is 65% by weight.

Claims (10)

1. containing a compound pesticide compositions for Diacloden and Profenofos, it is characterized in that it is main active ingredient that this compound pesticide compositions be take Diacloden and Profenofos, wherein, the weight ratio of Diacloden and Profenofos is 0.1 ~ 80:0.5 ~ 80.

2. the compound pesticide compositions containing Diacloden and Profenofos according to claim 1, is characterized in that described Diacloden and the weight ratio of Profenofos are 0.5 ~ 10:4 ~ 30.

3. the Synergistic insecticidal compositions containing Diacloden and Profenofos according to claim 2, is characterized in that the effective ingredient Diacloden of this Pesticidal combination and the weight ratio of Profenofos are 1 ~ 10:1 ~ 10.

4. the Synergistic insecticidal compositions containing Diacloden and Profenofos according to claim 3, is characterized in that the effective ingredient Diacloden of this Pesticidal combination and the weight ratio of Profenofos are 1 ~ 10:1.

5. the compound pesticide compositions containing Diacloden and Profenofos according to claim 1, is characterized in that the two weight percentage in this compound pesticide compositions of Diacloden and Profenofos is 3% ~ 80%.

6. the compound pesticide compositions containing Diacloden and Profenofos according to claim 5, is characterized in that the two weight percentage in this compound pesticide compositions of Diacloden and Profenofos is 5% ~ 55%.

7. the compound pesticide compositions containing Diacloden and Profenofos according to claim 1, is characterized in that this compound pesticide compositions take Diacloden and Profenofos and be mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.

8. the compound pesticide compositions containing Diacloden and Profenofos according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.

9. the compound pesticide compositions containing Diacloden and Profenofos claimed in claim 1 is prevented and treated the application on the insecticidal materials of resistance Semiptera insect in preparation.

Compound pesticide compositions containing Diacloden and Profenofos according to claim 9 in preparation, anti-ly eliminate aphis, the application on the insecticidal materials of plant hopper.