CN103053584A - Compound insecticidal and bactericidal composition containing dinotefuran and kresoxim-methyl, and application thereof - Google Patents

Abstract

The invention discloses a compound insecticidal and bactericidal composition containing dinotefuran and kresoxim-methyl and its application. The insecticidal and bactericidal composition uses dinotefuran and kresoxim-methyl as main active ingredients, wherein dinotefuran and The weight ratio of kresoxim-methyl is 0.1-85:0.5-85. The insecticidal and fungicidal composition can produce higher synergistic effect, is especially suitable for controlling crop pests and diseases caused by various fungi, and the dosage of the mixture is much lower than the dosage of active compounds alone. In practical application, the dosage of medication is reduced, thereby reducing the cost of medication. The present invention can prevent and treat Hemiptera, Lepidoptera, Coleoptera pests and fungal diseases occurring on crops, especially for preventing and treating rice planthoppers, leafhoppers, aphids, stinkbugs, whiteflies, powdery mildew, rust, blight, rice Pestilence, etc., its effect is significantly higher than its single-dose use. In addition, it has been found that the compositions according to the invention are particularly suitable for treating seeds and protecting them against diseases after germination.

Description

A compound insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl and its application

technical field

The invention belongs to the field of pesticides, and in particular relates to a compound insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl and its application.

Background technique

Dinotefuran is a third-generation neonicotinoid insecticide developed by Mitsui Chemicals. Its chemical structure is very different from that of the existing neonicotinoid insecticides. Its tetrahydrofuryl group replaces the previous chloropyridyl and chlorothiazolyl groups, and it does not contain halogen elements. At the same time, it is also different from nicotine in terms of performance. Therefore, it is currently called "furan nicotine". Dinotefuran chemical name: 1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine, the structural formula is as follows:

The new-generation neonicotinoid insecticide dinotefuran mainly acts on the neurotransmitter system of insects, paralyzing them to death. The agent has a wide insecticidal spectrum, excellent systemic penetration, and shows high insecticidal activity at a very low dose. The agent is very safe to mammals, birds and aquatic organisms, and has no harm to crops. It can be used for many crops such as rice, fruit trees and vegetables. It is highly effective against rice pests brown planthopper, white-backed planthopper, brown planthopper, black-tailed leafhopper, rice spider stinkbug, star stinkbug, rice green stinkbug, red bearded bug, rice negative mixed insect, and rice borer. It is effective against rice stem borer and rice locust. It is highly effective against vegetable and fruit pests such as aphids, mealybugs, scales, scales, vermilion stinkbug, peach borer, orange miner, tea moth, yellow striped flea beetle, and bean miner. Diagonal wax scale, diamondback moth, two black striped leaf beetle, tea yellow thrips, tabaci, yellow thrips, citrus yellow thrips, soybean pod gall midge, tomato leafminer are effective. Dinotefuran has a wide insecticidal spectrum and is very safe to crops, humans, animals and the environment. Combined with various application methods, this pesticide is expected to become a worldwide large-tonnage pesticide.

Kresoxim-methyl, Kresoxim-methyl, trade name Tribe, fungicide, methoxyacrylate sterilizer developed by BASF Co., Ltd., chemical name: (E)-2-methoxyimino-[2-(o Methylphenoxymethyl) phenyl] methyl acetate, structural formula is as follows:

Kresoxim-methyl: acute oral LD _{50 of} rats >5000mg/kg, acute percutaneous LD ₅₀ of rats >2000mg/kg. Rat acute inhalation LC ₅₀ (4h)>5.6mg/L, no irritation to rabbit eyes and skin. Inhibitor of mitochondrial respiration, that is, inhibition of mitochondrial respiration by electron transfer between cytochrome b and C1. It is effective in controlling strains resistant to 14-demethylase inhibitors, benzamides, tricarboxamides and benzimidazoles. Kresoxim-methyl has protective, therapeutic, eradicating, penetrating and systemic activities, and has a very good effect of inhibiting spore germination. And it can degrade quickly in plants, soil and water. It is effective for most diseases caused by pathogenic fungi such as Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes. Such as: grape powdery mildew, wheat rust, potato blight, pumpkin blight, rice blast and other diseases, especially for strawberry powdery mildew, melon powdery mildew, cucumber powdery mildew, pear scab.

Under the condition of long-term single drug use, the resistance of the target to the drug gradually increases, and the effect of a single pesticide on pest control will gradually decrease, which greatly shortens the service life of a good drug. The inventors have found through research that the synergistic compounding of pesticides is an effective measure to expand the control spectrum and improve the control effect to extend the use time of the pesticides, and so far no patents have been found on the insecticidal and fungicidal composition of dinotefuran and kresoxim-methyl.

Contents of the invention

The object of the present invention is to provide a kind of high-efficiency and low-toxic compound insecticidal and bactericidal composition containing dinotefuran and kresoxim-methyl, and this insecticidal composition is to control Hemiptera, Coleoptera, Lepidoptera pests and fungal diseases. Multifunctional insecticidal and fungicidal composition.

Another object of the present invention is to provide the application of the insecticidal and fungicidal composition in the preparation of insecticidal and fungicidal drugs for the control of resistant Hemiptera, Coleoptera, Lepidoptera pests and various fungal diseases, especially in the preparation of insecticidal and fungicidal drugs for the control of rice fly Insecticides and fungicides for lice, leafhoppers, stinkbugs, whiteflies, aphids, and powdery mildew, rust, blight, and rice blast.

The purpose of the present invention is achieved through the following technical solutions:

A high-efficiency and low-toxic compound insecticidal and bactericidal composition containing dinotefuran and kresoxim-methyl. The weight ratio is 0.1-85:0.5-85. The active ingredients in the insecticidal and bactericidal composition are present in the composition in a synergistically effective amount.

The weight ratio of dinotefuran and kresoxim-methyl in the synergistic insecticidal composition is preferably 1-50:1-50, more preferably 1-10:20-40.

In the composition of the present invention, dinotefuran and kresoxim-methyl account for 2-80% by weight of the composition. Preferably it is 5-50%, most preferably 10-40%.

The insecticidal and fungicidal composition of the present invention takes dinotefuran and kresoxim-methyl as the main active ingredients and pesticide adjuvants and excipients to be formulated into any dosage form allowed on the pesticide, and the dosage form is preferably emulsion, suspension, Wettable powders, aqueous emulsions, microemulsions and water-dispersible granules.

The auxiliary agent can be one of calcium dodecylbenzenesulfonate, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block compound (such as Nongru 33 ^# ), nonylphenol polyoxyethylene ether or Multiple combinations, excipients include isopropanol, mineral spirits, mineral spirits, water, antifreeze (such as propylene glycol), deionized water and the like. The above auxiliaries, excipients and other auxiliary materials can be used alone or in combination.

The insecticidal and fungicidal composition can produce a higher synergistic effect, and is especially suitable for preventing and controlling crop pests and diseases caused by various fungi, and the dosage of the mixture is greatly lower than that of the active compound alone, that is, the activity of the mixture is greater than that of the single active compound. The activity of the components has a good control effect on a variety of Hemiptera, Coleoptera, Lepidoptera pests and fungal diseases that are prone to resistance to rice planthoppers, leafhoppers, aphids, etc.; and inhibits pests or fungi against a single Development of resistance to agents (either dinotefuran or kresoxim-methyl).

The application of the above-mentioned insecticidal and fungicidal composition in the preparation and control of resistant Hemiptera, Coleoptera, Lepidoptera pests and fungi, especially in the control of leafhoppers, stinkbugs, whiteflies, planthoppers and aphids or powdery mildew and rust , blight, and rice blast all have significant effects. The "%" mentioned in the present invention are all mass percentages.

Compared with the prior art, the present invention has the beneficial effects: (1) Compared with a single agent, the composition is resistant to Hemiptera, Coleoptera, Lepidoptera pests such as rice planthoppers, leafhoppers, aphids and fungal diseases such as Fungal diseases such as powdery mildew, rust, blight, and rice blast have obvious synergistic effects, overcome and delay drug resistance, expand the control spectrum, and significantly improve the control effect; (2) reduce the labor and drug costs for control; (3) can It can replace highly toxic pesticides; (4) has the functions of controlling insects and preventing diseases; (5) compared with dinotefuran and kresoxim-methyl single agent, the cost of production and use is reduced; (6) inhibits Hemiptera, Coleoptera, The resistance of lepidopteran pests to pesticides is enhanced, and the generation of fungal drug resistance is inhibited, and its effect is significantly higher than that of a single agent.

Detailed ways

The present invention will be further described below in conjunction with embodiment:

The expected activity of a combination of two active compounds can be calculated as follows (see colby, S.R.; Weed 15, page 20-22, 1967)

like

X = Mortality when active compound A is used at an application rate of m ppm, expressed as a percentage of the untreated control group.

Y = Mortality rate when active compound B is used at an application rate of n ppm, expressed as a percentage of the untreated control group.

E = Mortality when active compounds A and B are used at application rates of m and n ppm, expressed as a percentage of the untreated control group.

but:

E＝X+Y-(XY/100)

If the actual insect mortality exceeds the calculated value, the mortality of the combination is additive, ie there is a synergistic effect.

Example:

The rice stem dipping method was used for indoor bioassay, and the resistant rice planthopper was selected as the target pest. Each treatment was repeated 3 times, and each concentration was treated with 60 heads. The results are shown in Table 1.

Table 1: Indoor activity of dinotefuran-Kysstrobin complex against rice brown planthopper

Example:

Indoor synergistic bioassays were carried out by soaking leaves and insects, and resistant wheat aphids were selected as target pests. Each treatment was repeated 3 times, and 60 test insects were treated at each concentration. The results are shown in Table 2:

Table 2: Indoor activity of dinotefuran-Kysstrobin compound on aphids

Example:

Indoor synergistic bioassay was carried out by dipping leaves and insects, and the resistant rice stinkbug was selected as the target pest. Each treatment was repeated 3 times, and 60 test insects were treated at each concentration. The results are shown in Table 3:

Table 3: Indoor activity of dinotefuran-kresoxim-methyl complex on rice stink bugs

Example

Taking Magnaporthe grisea as the test object, the colony diameter method was used to calculate the activity of the multi-pathogen bacteria. The results are shown in Table 4.

Table 4: Indoor antibacterial activity of dinotefuran-kresoxim-methyl compound against rice blast

The bactericidal and insecticidal composition was used in the field drug efficacy test, and 30 L of medicinal solution was applied per mu to further verify the synergistic effect of the composition. The results are shown in Table 5.

Table 5: Field test results of dinotefuran-kresoxim-methyl compound against rice brown planthopper and rice blast

The indoor bioassay and field efficacy results show that the dinotefuran·kresstrobin composition has excellent control effects on resistant rice brown planthoppers, stinkbugs, aphids and rice blast, and the control effects are better than those of single-dose varieties. The combination of strytostrobin and dinotefuran has obvious synergistic effect.

The two active compounds can be processed into any permissible dosage form. The preparations processed by the two active ingredients are described below with specific examples, but the preparations that can be processed by the two active ingredients are not limited to the following list.

Example 2:

Weigh 5g of dinotefuran, 50g of kresoxib, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of Nongru 33 ^# , 1g of alkylphenol polyoxyethylene ether, 13g of solvent oil, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water emulsion, and mix at high speed to prepare a water emulsion with a main active ingredient of 55% by weight.

Example 3:

Weigh 2g of dinotefuran, 30g of kresoxim-methyl, 6g of calcium dodecylbenzenesulfonate, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of agricultural milk 33 ^# , 1g of alkylphenol polyoxyethylene ether, iso Propanol 10g, add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing microemulsions, and mix them to prepare a dinotefuran-kresoxim-methyl microemulsion with a weight percentage of 32% as the main active ingredient.

Example 4:

Weigh 1g of dinotefuran, 5g of kresoxib, 3g of phenylethylphenol polyoxyethylene ether phosphate, 2g of Nongru 33 ^# , 1g of alkylphenol polyoxyethylene ether, 13g of mineral spirits, and add water to 100g. Put the above raw materials into a mixing tank according to the conventional method for preparing water emulsion, and mix at high speed to prepare a water emulsion with a main active ingredient of 55% by weight.

Example 5: Weigh 50 g of dinotefuran, 20 g of kresoxim-methyl, 5 g of calcium dodecylbenzenesulfonate, 2 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix to form a preparation with a mass percentage of 70% dinotefuran-kysstrobin emulsifiable concentrate.

Example 6: Weigh 20g of dinotefuran, 8g of kresoxim-methyl, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, and 0.10g of siloxane , magnesium aluminum silicate 0.5g, make up to 100g with water, make the main active ingredient weight percentage under the effect of sand mill and be 42% dinotefuran-kysstrobin suspension concentrate

Example 7: Weigh 0.2 g of dinotefuran, 50 g of kresoxim-methyl, 9 g of calcium dodecylbenzenesulfonate, 8 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to prepare the emulsifiable concentrate whose main active ingredient is 50.2% by weight of dinotefuran-kresstrobin.

Embodiment 8: Weigh 1g dinotefuran, 9g kresoxim-methyl, 8g sodium lignosulfonate, 2g sodium lauryl sulfate, 5g ammonium sulfate, 5g polyvinyl alcohol, 2g borax, diatomaceous earth make up to 100g, and The above raw materials are made into water-dispersible granules with a main active ingredient weight percentage of 7% dinotefuran-kresoxim-methyl according to the method of water-dispersible granules.

Example 9: Weigh 5 g of dinotefuran, 30 g of kresoxim-methyl, 4 g of calcium dodecylbenzenesulfonate, 4 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix to prepare the emulsifiable concentrate whose main active ingredient is 35% dinotefuran-kresoxim-methyl.

Example 10: Weigh 20g of dinotefuran, 5g of kresoxim-methyl, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, and 0.10g of siloxane , magnesium aluminum silicate 0.5g, make up to 100g with water, make the main active ingredient weight percentage under the effect of sand mill and be 42% dinotefuran-kysstrobin suspension concentrate.

Example 11: Weigh 30g of dinotefuran, 12g of kresoxim-methyl, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether and its sulfate, 0.15g of xanthan gum, 5g of ethylene glycol, and 0.10g of siloxane , magnesium aluminum silicate 0.5g, make up to 100g with water, make the main active ingredient weight percentage under the effect of sand mill and be 42% dinotefuran-kysstrobin suspension concentrate.

Embodiment 12: Take by weighing 2g dinotefuran, 5g kresoxim-methyl, 8g sodium lignosulfonate, 2g sodium lauryl sulfate, 5g ammonium sulfate, 5g polyvinyl alcohol, 2g borax, 28g diatomaceous earth, the above raw materials The 7% dinotefuran-kysstrobin water-dispersible granule was formed according to the water-dispersible granule method.

Example 13: Weigh 3g dinotefuran, 15g kresoxim-methyl, lignin 10g, sodium alkylnaphthalene sulfonate 2g, add diatomaceous earth to 100g, mix the above raw materials in an ultrafine pulverizer, and make main The weight percentage of active ingredients is 20% dinotefuran and kresoxim-methyl wettable powder.

Example 14: Weigh 2g dinotefuran, 18g kresoxim-methyl, lignin 10g, sodium alkylnaphthalene sulfonate 2g, add diatomaceous earth to 100g, mix the above raw materials in an ultrafine pulverizer to form 20% Dinotefuran and Kresoxim-methyl wettable powder.

Example 15: Weigh 7 g of dinotefuran, 70 g of kresoxim-methyl, 4 g of calcium dodecylbenzenesulfonate, 3 g of phenethylphenol polyoxyethylene ether, and 100 g of mineral spirits. Put the above raw materials into a mixing tank according to the conventional method for preparing emulsifiable concentrate, and mix them to prepare the emulsifiable concentrate whose main active ingredient is 77% dinotefuran-kresoxim-methyl.

Claims (10)

1. A compound insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl, characterized in that the insecticidal and fungicidal composition takes dinotefuran and kresoxim-methyl as main active ingredients, wherein dinotefuran and kresoxim The weight ratio of ester is 0.1-85:0.5-85. 2. The insecticidal and fungicidal composition according to claim 1, characterized in that the weight ratio of dinotefuran and kresoxim-methyl is 1-50:1-50. 3. The insecticidal composition according to claim 2, characterized in that the weight ratio of dinotefuran and kresoxim-methyl is 1-10:20-40. 4. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl according to claim 1, characterized in that the weight percentage of dinotefuran and kresoxim-methyl in the composition is 2-80. %. 5. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl according to claim 4, characterized in that the weight percentage of dinotefuran and kresoxim-methyl in the composition is 5-50. %. 6. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl according to claim 5, characterized in that the weight percentage of dinotefuran and kresoxim-methyl in the composition is 10-40. %. 7. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl according to claim 1, characterized in that it takes dinotefuran and kresoxim-methyl as main active ingredients and pesticide adjuvants and excipients It can be formulated into any dosage form allowed on the pesticide. 8. The synergistic insecticidal and bactericidal composition containing dinotefuran and kresoxim-methyl according to claim 7, characterized in that the formulation is emulsifiable concentrate, suspension concentrate, water emulsion, wettable powder, microemulsion or water dispersion Granules. 9. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl of claim 1 is used in the preparation of insecticidal and fungicidal drugs for preventing and controlling resistant Hemiptera pests, Lepidoptera, Coleoptera pests and fungal diseases Applications. 10. The synergistic insecticidal and fungicidal composition containing dinotefuran and kresoxim-methyl according to claim 9 is used in the preparation and control of aphids, whiteflies, leafhoppers, stinkbugs, planthoppers or powdery mildew, rust, blight, rice Application of pesticidal and fungicidal drugs against plague.